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Sri Rahayu
Fakultas Ilmu Kesehatan Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Midpro

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Serum Caspase-3 And Tissue Of Cervical Intraepithelial Neoplasia (CIN) In Wistar Rats With Diethylstilbestrol Induction Sri Rahayu; Iting Iting
Jurnal MIDPRO Vol 12, No 2 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i2.171

Abstract

Diethylstilbestrol (DES) is a synthetic estrogen hormone that is useful as hormone replacement therapy, but long-term use of DES in cervical epithelium triggers cervical intraepithelial neoplasia (CIN). CIN can develop into cervical cancer. Cervical cancer is associated with the potential for invasion and metastasis, with the gold standard is histopathological examination. Accurate diagnosis and prediction of malignancy are important issues in clinical management, including the identification of biomarkers. Caspase or Cytosolic Aspartate-Specific Cysteine Proteases (caspase) are a group of proteases that facilitate apoptosis. Caspase-3 is a key mediator of the apoptotic process that acts as an anti-cancer. Exposure to DES in rats can trigger cervical intraepithelial neoplasia. In stage CIN I, it does not need therapy because 80% of cell dysplasia can return to normal. In CIN II & III stages can develop into cancer cells (true cervical cancers precursors). CIN is called pre-cancerous cells, and it can develop into cancerous if left untreated.  However, not all women who experience CIN will suffer cancer. The study used female Wistar rats strains for 3-5 days in age, administration a DES dose 1500 μgram/KgBB for 35 days. Then examined caspase-3 contained in serum and tissue through the ELISA method. The independent t-test result showed that there was no significant difference between caspase-3 in serum and tissue with p> 0.05.
Co-Authors Acep Bahrum Kamil Ai Yeyeh Rukiah Ajeng Puspita Dewi Anastasya Rizky Meilawathie Chalisya Vanya Advaita Citra Resita Dian Hakip Nurdiansyah Eman Sulaeman Faizal Auladi Rivianto Herdiana Verliani Ibtihal Qomariyyah Luthfiyyah Ina Ratnasari Irma Yanti Iting Iting Iting Iting Iting Iting Jekmal Malau Kiki Agisni Maria Alia Rahayu Mulidini Mulidini Munir Alinu Mulki Naila Aphrodite Nanda Ayu Yuliani Nanda Puspitasari Narsih Widianingsih Nelly Apriningrum Nelly Apriningrum Opi Rofiyah Rd. Heri Solehudin Rohanah Rohanah Salsabila Granadha Nibullah Shinta Puspa Dwiyanti Siti Fatimah Widya Ningrum Siti Nuriah Syifa Khairunnisa Tiara Cinta Amelia Triska Juniasari Yousef Bani Ahmad Yuni Novalini Rahayu Zahra Putri Zuyyinna Alya Abbas