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All Journal Media Kesehatan Masyarakat Indonesia Majalah Kedokteran Bandung
Arfianti Arfianti
Department of Medical Biology, Faculty of Medicine, University of Riau
Medicine & Pharmacology Public Health

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Faktor yang Memengaruhi Kesalahan Persepsi Ibu tentang Status Gizi Anak Arfianti Arfianti; Tri Muhti Puja Kesuma; Muhammad Beni Septima; Riefni Silara Dini; Fifia Chandra
Media Kesehatan Masyarakat Indonesia Vol. 15 No. 4: DESEMBER 2019
Publisher : Faculty of Public Health, Hasanuddin University, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.758 KB) | DOI: 10.30597/mkmi.v15i4.7461

Abstract

Malnutrition is a significant health problem among Indonesian children. Mothers play a very importantrole in the prevention of childhood malnutrition. This study aimed to compare the child’s nutritional statusbased on mothers’ perception and anthropometry measurement and to analyze contributing factors of maternalmisclassification of a child’s weight status. This was an analytical observational study with a cross-sectional design.Research subjects included 250 mothers of grade 4 and 5 students from 6 elementary schools in Pekanbaru cityrecruited by the proportional quota sampling method. The Nutritional status of children was classified accordingto the 2006 World Health Organization (WHO) anthropometry standard. Mothers’ perception of child’s weightstatus was collected using questionnaires. Based on anthropometry measurement, 28% and 10% of children wereoverweight and underweight, respectively. In contrast, according to mothers, 4,8% of children were overweightand 12,8% ofchildren were underweight. As many as 34.8% of mothers had incorrect perceptions about thenutritional status of their children and there was a poor agreement of mothers’ perception and child’s nutritionalstatus (Kappa coefficient of 0,02). Working mothers were more likely to underestimate their child’s weight statuscompared to stay-at-home mothers (p=0,004).
IL-10 Promoter Polymorphism Distribution among HBsAg-Reactive and HBsAg-Nonreactive Blood Donors Rahmat Azhari Kemal; Arfianti Arfianti; Reni Oktora; Bebe Gani; Fauzia Andrini Djojosugito; Winarto Winarto
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (694.508 KB) | DOI: 10.15395/mkb.v52n1.1812

Abstract

Hepatitis B surface antigen (HBsAg) serves as a serological marker for Hepatitis B virus (HBV) infection. People with HBV asymptomatic infection might readily donate blood due to the lack of clinical manifestations. Host immunity contributes to susceptibility and progression of infection. A polymorphism in IL-10 gene promoter, rs1800896, might contribute to host immunity. This study was conducted on May 2019 – January 2020 in Faculty of Medicine, University of Riau on  70 blood samples from donors  in the Indonesian Red Cross Pekanbaru. Out of these samples, 35 were reactive for HBsAg and 35 donors were nonreactive. Genotyping of rs1800896 was conducted using Amplification Refractory Mutation System (ARMS-PCR). In total, The distribution of AA (74.3%), AG (24.3%), and GG (1.4%) genotypes revealed in this study seemed to be similar to genotype distribution among East and South-East Asian populations. While no significant difference was observed on age mean and gender distribution, a significant difference was identified in  genotype distribution between HBsAg status (p-value 0.028) with the percentage of AA genotype was higher among HBsAg-nonreactive donors (85.7%) compared to reactive donors (62.9%). More studies should be conducted to characterize HBsAg-reactive blood donors, including the donor characteristics and the viral genotypes. Such studies should contribute to hepatitis B management in Indonesia. Distribusi Polimorfisme Promoter IL-10 pada Donor Darah dengan HBsAg Reaktif dan Nonreaktif di Pekanbaru Hepatitis B surface antigen (HBsAg) merupakan penanda serologis infeksi virus hepatitis B (HBV). Individu dengan infeksi HBV asimptomatik dapat melakukan donasi darah karena tidak adanya gejala klinis. Imunitas inang berkontribusi pada kerentanan dan perkembangan infeksi. Polimorfisme pada promoter gen IL-10, rs1800896, dapat berkontribusi pada imunitas inang. Penelitian dilakukan pada bulan Mei 2019 – Januari 2020 di Fakultas Kedokteran Universitas Riau. Sampel diambil adalah 70 darah donor dari Palang Merah Indonesia Pekanbaru, 35 sampel reaktif HBsAg dan 35 sampel nonreaktif. Genotipe rs1800896 dilihat berdasarkan Amplification Refractory Mutation System (ARMS-PCR). Pada populasi studi ini, distribusi genotipe AA (74.3%), AG (24.3%), dan GG (1.4%) sesuai populasi Asia Timur dan Tenggara. Walaupun tidak terdapat perbedaan pada rerata umur dan distribusi jenis kelamin, penelitian ini menemukan perbedaan signifikan pada distribusi genotipe antar kelompok status HBsAg (p-value 0.028), yaitu persentase genotipe AA lebih tinggi pada kelompok donor dengan HBsAg nonreaktif (85.7%) dibandingkan kelompok reaktif (62.9%). Studi lebih lanjut perlu dilakukan untuk karakterisasi donor darah dengan HBsAg reaktif, termasuk gneotipe donor dan virus. Informasi tersebut diharapkan dapat bermanfaat pada manajemen hepatitis B di Indonesia.
Co-Authors Bebe Gani Fauzia Andrini Djojosugito Fifia Chandra Muhammad Beni Septima Rahmat Azhari Kemal Reni Oktora Riefni Silara Dini Tri Muhti Puja Kesuma Winarto Winarto