Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Biologi Edukasi : Jurnal Ilmiah Pendidikan Biologi JURNAL ILMU KEFARMASIAN INDONESIA
Nastiti Kusumorini
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Education Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Microscopic Analysis of The Lung in Male Rat (Rattus Norvegicus) Exposed to Cigarettes Smoke Adrien Jems Akiles Unitly; Nastiti Kusumorini; Srihadi Agungpriyono; Aryani Sismin Satyaningtijas; Arief Boediono
Biologi Edukasi: Jurnal Ilmiah Pendidikan Biologi Vol 10, No 2 (2018): Biologi Edukasi: Jurnal Ilmiah Pendidikan Biologi
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.415 KB)

Abstract

This research aimed to study on the microscopic changes of lungs in male rat that exposured to cigarette smoke. A factorial CRD with periode of treatment and sample collection was applied in this study. An exposure of cigarette smoke was carried out at 10 cigarettes/rat/day for 2.5 hours in an smoking chamber. Group N is untreated animals. Group 20d is exposed animals with cigarette smoke for 20 days consectitively and released from the cigarette smoke exposure for 20 days. Group 40d is exposed animals for 40 days and released from the cigarette smoke for 40 days. Group 60d is exposed animals for 60 days similar as above. Data collection was carried out twice : after exposure and after redeasing the cigarette smoke exposure. The parameters of observation microscopic analysis of lungs included weight wet of lung and change of lung histopathologic.The results show decreased weight wet of lung, increased number of blackish particulate deposits in the cytoplasm of alveoli at 40d and 60d considered as tar deposit, an increased activity of inflammatory cells of male rats after exposing which were unable to recover after releasing of cigarette smoke exposure.  
(The Effectiveness of Gambier Extract (Uncaria gambir (Hunter) Roxb.) as Hepatoprotective in Rat (Rattus norvegicus L.) Induced CCl4) FAHRI FAHRUDIN; DEDY DURYADI SOLIHIN; NASTITI KUSUMORINI; SRI NINGSIH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (792.231 KB)

Abstract

Fungsi hati sebagai detoksifikasi sangat rentan terhadap kerusakan hati secara akut maupun kronis yang dapat menyebabkan terjadinya fibrosis hati. Salah satu pendekatan dalam pengobatan fibrosis hati adalah menggunakan antioksidan dari bahan alam. Ekstrak gambir terbukti mengandung senyawa fenolik yang bersifat antioksidan. Tujuan penelitian ini adalah mengetahui potensi gambir sebagai hepatoprotektor pada hewan model fibrosis hati. Sebanyak 45 ekor tikus jantan galur Sprague-Dawley dibagi menjadi sembilan kelompok yang terdiri dari D1 (menerima ekstrak gambir 13 mg/200 g bb + CCl4), D2 (ekstrak gambir 25 mg/200 g bb + CCl4), D3 (ekstrak gambir 53 mg/200 g bb + CCl4), K+1 (polifenol 25 mg/200 g bb + CCl4), K+2 (ektrak obat campuran 302 mg/200 g bb + CCl4), K- (CCl4), KG (hanya menerima ekstrak gambir 53 mg/200g bb), KP (menerima minyak kelapa), KN (kontrol normal). CCl4 (0,1 ml/kg bb) diberikan dua kali seminggu. Semua sampel diberikan secara oral (1 ml/kg bb) selama enam minggu perlakuan. Parameter yang dianalisis adalah aktivitas enzim hati, kadar malondialdehid dan glutation hati serta histopatologi hati. Hasil penelitian menunjukkan ekstrak gambir mampu memperbaiki kerusakan hati. Ekstrak gambir yang diberikan berpotensi sebagai hepatoprotektor yang signifikan (p<0,05) dibandingkan dengan kelompok kontrol negatif (K-). Ekstrak gambir yang efektif sebagai hapatoprotektor adalah dosis ekstrak gambir 26 mg/200 g bb (D2).
Co-Authors A.S. Satyaningtijas Adrien Jems Akiles Unitly Arief Boediono FAHRI FAHRUDIN SRI NINGSIH Srihadi Agungpriyono TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN