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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Althea Medical Journal Indonesian Journal of Urology Folia Medica Indonesiana Jurnal Farmasi Klinik Indonesia Journal of Agromedicine and Medical Sciences Health Notions Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JURNAL ILKES (Jurnal Ilmu Kesehatan) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology

Arifa Mustika

Department Of Pharmacology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia

Author-ID : 2762973

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Efek Ekstrak Daun Singawalang (Petiveria alliacea) dalam Menurunkan Kadar Glukosa Darah melalui Peningkatan Ekspresi AMPK-Î±1 pada Tikus Model Diabetes Melitus Mustika, Arifa; Indrawati, Roostantia; Sari, Gadis M.
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Singawalang (Petiveria alliaceae) adalah tumbuhan yang banyak ditemukan di Indonesia dan secaraempiris digunakan oleh penduduk untuk mengobati diabetes melitus. Hingga saat ini, penelitian tentangpengaruh dan mekanisme ekstrak daun Singawalang dalam menurunkan kadar glukosa darah belumbanyak dilakukan. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun Singawalangterhadap penurunan kadar glukosa darah dan ekspresi AMPK-Î±1 pada hati. Jenis penelitian ini adalahpenelitian eksperimental dengan rncangan acak lengkap. Penelitian dilakukan di LaboratoriumFarmakologi dan Terapi dan Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Airlanggapada bulan AprilâAgustus 2015. Hewan coba tikus strain Rattus norvegicus dibuat model diabetesmelitus, diinduksi dengan Streptozotocin. Sebanyak 25 tikus model diabetes melitus dibagi secara acakmenjadi 5 kelompok. Kelompok perlakuan 1, 2 dan 3 adalah kelompok yang memperoleh ekstrak daunSingawalang dengan dosis 90 mg/kgbb, 180 mg/kgbb dan 360 mg/kgbb. Kelompok kontrol positif adalahkelompok yang memperoleh metformin dengan dosis 150 mg/kgbb dan kontrol negatif adalah kelompoktikus yang memperoleh vehikulum. Ekstrak dan metformin diberikan sehari sekali, personde selama 14hari. Pada hari ke-15 setelah terapi, tikus diperiksa kadar glukosa darah dan dieuthanasia untuk diambilorgannya. Ekspresi AMPK-Î±1 dinilai menggunakan imunohistokima. Data yang terkumpul dianalisisdengan ANAVA dan Wilcoxon (Î±=0,05). Hasil penelitian menunjukkan adanya perbedaan kadar glukosadarah yang bermakna antara kontrol negatif dengan dosis 90 mg/kgbb, dosis 360 mg/kgbb, dan kontrolpositif, antara dosis 180 mg/kgbb dengan dosis 360 mg/kgbb dan kontrol positif. Analisis terhadapekspresi AMPK-Î±1 pada hati tikus menunjukkan perbedaan yang bermakna antara dosis 180 mg/kgbbdengan dosis 360 mg/kgbb dan kontrol positif. Simpulan dari penelitian ini adalah ekstrak Singawalangdapat menurunkan kadar glukosa darah pada tikus model diabetes melitus melalui aktivasi AMPK-Î±1.

CORRELATION BETWEEN BLOOD SERUM PSA LEVEL AND MMP-2 IN PROSTATE ADENOCARCINOMA Rahaju, Anny Setijo; Meidi, Aniek; Mastutik, Gondo; Mustokoweni, Sjahjenny; Mustika, Arifa
Indonesian Journal of Urology Vol 23 No 2 (2016)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v23i2.220

Objective: This study aims to prove the correlation between Prostate Specific Antigen (PSA) blood level and Matrix Metalloproteinase-2 (MMP-2) expression in patients with prostate adenocarcinoma. Material & method: Prostate cancer patients’ data from January 2009 to May 2012 were collected at the Department of Pathology, Soetomo General Hospital Surabaya. Data collected included patient medical documents, PSA blood examination, and histopathological examination. Histopathology slides and paraffin blocks of needle biopsies, Transurethral Resection of Prostate (TURP) and radical prostatectomy of prostate cancer patients werere-read, then the samples that met the inclusion criteria were stained by immunohistochemistry using antibodies MMP-2. Results: Data collection was done to obtain data samples of prostate cancer patients in 2009 to 2012 comprising as many as 22 patients between the ages of 52-91 years. Prostate adenocarcinoma in age of 70-79 was found in 8 patients, with a mean age of 68 years. PSA values obtained from medical documents were between 8.6-594.41 ng/ml. Spearman's test performed in this study showed a positive correlation (one-tailed) (correlation coefficient (r) 0431, p < 0.05) between blood PSA level and MMP-2 expression in patients with prostate adenocarcinoma. Conclusion: Blood PSA level correlates positively with MMP-2 expression in prostate adenocarcinoma.

The Effect of Mixed Liquor Administration on The Johnsen’s Score and The Number of Sertoli Cells and Leydig Cells on The Wistar Strain White Rats (Rattus norvegicus) Aqidah Khariri1 , Anny Setijo Rahaju2,4, Arifa Mustika3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13521

To analyze the effect of mixed liquor administration on the Johnsen’s score and the number of Sertoli cellsand Leydig cells on the Wistar strain white rats (Rattus norvegicus). A total of 28 rats were divided into 4groups: C, P1, P2, and P3. Rats were given mixed liquor with different dose, namely P1 (1 ml), P2 (2 ml),and P3 (4 ml) each day for 14 days, then compared to C group which was given 4 ml of distilled water usingan oral gavage. Mixed liquor consists of 20% ethanol and 4% methanol. The histopathological features wereevaluated by the Johnsen’s score, the number of Sertoli cells, and Leydig cells in cross-sectional preparationof rat testicular tissue with 400× magnification. Datas were analyzed using the Kruskal-Wallis test and OneWay ANOVA test with a confidence level of p <0.05. The P3 group had the lowest Johnsen’s score and thenumber of Sertoli cells, 6.442±0.293 and 5.942±0.674, respectively. A significant decrease in increased doseoccurred in the Sertoli cell count but not in the Johnsen’s score. Group P2 had the lowest number of Leydigcells, 6.421±0.360. The administration of mixed liquor caused a decrease in Johnsen’s score and the numberof Sertoli cells and Leydig cells on the Wistar strain white rat (Rattus norvegicus).

Effect of Malus sylvestris Extract on Histopathological Features of Hypercholesterolemic Wistar Rat (Rattus norvegicus) Fatty Liver Nadhifa Tanesha Aufazhafarin1 , Alphania Rahniayu2 , Ema Qurnianingsih3 , Arifa Mustika4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13604

Objective: To evaluate the effect of Malus sylvestris extract on improving the degree of steatosis and portalinflammation histopathological features of hypercholesterolemic Rattus norvegicus strain wistar. Method:Forty-two male rats were divided into 6 groups randomly. Hypercholesterolemic fatty liver induced bygiving high-fat diet (HFD) for 46 days on groups 1 to 5, while group 6 given standard diet with the sameamount of time. Simvastatin was administered in group 2 at a dose of 0.36 mg/day. Groups 3, 4, and 5 weregiven Malus sylvestris extract (MSE) as a treatment at doses of 90 mg/day, 180 mg/day, and 360 mg/day insequential order. Simvastatin and MSE were administered for 14 days, from day 33 to 46. On day 47, all ratswere sacrificed and the liver was removed for histopathological slides preparation with hematoxylin-eosin(HE) staining. Histopathological results were analyzed using Kruskal Wallis test followed by Mann Whitneytest. Result: Histopathological analysis showed that Malus sylvestris extract improved steatosis and portalinflammation features compared to HFD-fed rats in group 1 (p<0,05). Conclusion: Malus sylvestris extractimproved the degree of steatosis and portal inflammation histopathological features of hypercholesterolemicrat fatty liver.

Relationship between Diet, Cosmetics and Degree of Acne Vulgaris in Dermatovenereology Outpatients at Dr. Soetomo General Hospital, Surabaya Mah Zhook Yueng; Diah Mira Indramaya; Arifa Mustika
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Acne vulgaris (AV) is a chronic inflammatory multifactorial disease that involves the pilosebaceous unit. The lesions of acne may be either non-inflammatory (comedones, which are blackheads or whiteheads) or inflammatory lesions (papules, nodules or pustules). The effects of diet and cosmetics on acne are still inconclusive. The objective of this study was to analyse the relationship between diet, cosmetics and the degree of AV.Methods: This was a hospital-based, analytic observational study with cross-sectional design. The subjects were patients from the Outpatient Clinic of Dermatovenereology Department of Dr. Soetomo General Hospital. The questionnaire was filled by the respondents and the degree of AV was graded by the specialist. Results: Among the types of diet, white bread (p=0.039), chocolate (p=0.044) and oily food (p=0.013) are significantly associated with the degree of AV. However, white rice, potatoes and milk were insignificantly related to degree of AV (p>0.05). No significant association was found in cosmetics (cleanser, moisturizer, facial protection, exfoliators and decorative cosmetics) with the degree of AV (p>0.05).Conclusions: The factors that have an influence on the degree of AV are white bread, chocolate and oily food intake.

The Effect of Dandang Gendis Extract (Clinacanthus nutans) on Kidney Histopathological Features of Diabetic Rats Model Miranda Jemyma Mas'ulun; Arifa Mustika; Ema Qurnianingsih
Health Notions Vol 5, No 01 (2021): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn50104

Changes in kidney homeostasis due to diabetes can cause oxidative stress which then caused tissue damage that leads to diabetic nephropathy. Clinacanthus nutans extract is known to contain antioxidants that are reported to play an important role in the body’s defense system against oxidative stress to minimize tissue damage. This study aims to know the effect of Clinacanthus nutans leaf extract administration on kidney histopathological features of the diabetic rats model. A total of 35 rats were induced by streptozotocin which then divided into 5 groups and given Clinacanthus nutans extract with a dose of 75 mg/kgBW, 150 mg/kgBW and 300 mg/kgBW then compare with CMC-Na as control and metformin as standard drug for 14 days. The kidney histopathology was evaluated under a light microscope against the damage criteria that occurred in the proximal tubules of the kidney. As the result the least amout of kidney damage was on treatment group at dose 300 mg/kgBW, followed by extract with dose 75 mg/kgBW, 150 mg/kgBW, and metformin. In conclusion Clinacanthus nutans extract with a dose of 75 mg/kgBW, 150 mg/kgBW, and 300 mg/kgBW can improve the kidney histopathological feature of the diabetic rats model. Keywords: diabetes mellitus; histopathology; diabetic nephropathy; Clinacanthus nutans

Efek Alprazolam Terhadap Jumlah Sel Leydig Mus Musculus Model Stres Kronik Fedelita Aistania Putri; Renny I’tishom; Arifah Mustika
JURNAL ILKES : Jurnal Ilmu Kesehatan Vol 10 No 2 (2019): Jurnal Ilkes (Jurnal Ilmu Kesehatan)
Publisher : STIKES Karya Husada Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35966/ilkes.v10i2.140

Infertility is one of the stress stimulated for couple has been marriage. Misuse hypnotic drugs types of benzodiazepine in alprazolam as their primary drug problem. Benzodiazepine dependence can also affect the central nervous system that interfere with neurotransmitters dopamine and serotonin. Oxidative stress caused by exposure to benzodiazepines can cause interference pro-apoptotic protein balance and anti-apoptotic, with a marked increase in pro-apoptotic protein and a decrease in anti-apoptotic proteins such as in the Leydig cells. Oxidative stress stimulation activates the intrinsic apoptotic pathway. Objective: to see a decrease in the number of Leydig cells of male mice after exposure to the stress with cums method, and the mice would be given anti-anxiety medication therapy was alprazolam with maximum dossage. Materials and methods: The research subject using male mice (Mus musculus) strain Balb-c had aclimitazion proecess and randomize sampling. There were divided into three groups consisting of negative control group (K0), without stress and drugs when spermatogenesis time is positive control group (K1) and treatment group (K2). The mice get a daily alprazolam drugs (alganax) by gavage sonde with maximum dossage (4mg/kg/weight). The measurement’s do after obtained from the testis that has been cut crosswise and do the Hematoxylin-eosin (HE). Calculations carried out under a light microscope (Olympus BX 41). Results: Statistical test in Leydig cell showed that there was significant difference with kruskal walis p=0,000 (p<0,05). Conclusion: administration of alprazolam might decrease the number of Leydig cells of mice Mus musculus model of chronic stress

IN VITRO TEST: Antimicrobial Activity Potential From Ciplukan Fruit (Physalis minima L.) Extract in Methicillin-resistant Staphylococcus aureus (MRSA) Muhammad Hanun Mahyuddin; Arifa Mustika; Gwenny Ichsan Prabowo; Deby Kusumaningrum
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.3645

In Indonesia, in 2006 the prevalence of infections due to MRSA was 23.5%. Physalis minima L. plants are known to have antimicrobial activity because they contain compounds withaferin A which can induce programmed cell death. This research was to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Ciplukan (Physalis minima L.) extract in Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Dilution test with Mueller-Hinton broth medium used for measuring the minimum inhibitory concentration (MIC). Ciplukan fruit extract was dissolved in distilled water, and poured into a test tube with a certain concentration (0.9 g/mL (90%); 0.3 g/mL (45%); 0.15 g/mL (22.5%); 0.075 g/mL (11.25%) and 0.0375 g/mL (5.625%). After being incubated for 24 hours, the bacteria in the test tube were plated on nutrient agar plates, to determine the MBC. The MIC cannot be determined, because the solution in the dilution test tube is disturbed by the color of the extract so that turbidity cannot be observed. From the observations of the minimum bactericidal concentration MBC of the Ciplukan (Physalis minima L.) fruit extract against MRSA was in the P1 tube or equivalent to 0.9 g / ml (90%).

Hubungan penurunan kadar CD4 dengan pola kepekaan mycobacterium tuberculosis terhadap rifampisin pada pasien Ko-Infeksi Tb-HIV di RSUD dr. Soetomo Surabaya Firsta Wahono Febrianto; Deby Kusumaningrum; Arifa Mustika
Jurnal Kedokteran Syiah Kuala Vol 19, No 1 (2019): Volume 19 Nomor 1 April 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i1.9133

Latar Belakang: Mycobacterium tuberculosis banyak menimbulkan masalah kesehatan yang kompleks. Salah satu penyakit yang ditimbulkan adalah Tuberkulosis (TB). Obat untuk mengatasi Tuberkulosis disebut Obat Anti Tuberkulosis (OAT). Namun, sudah banyak Mycobacterium tuberculosis yang mengalami resistensi ganda terhadap obat lini pertama tersebut yang disebut MDR-TB (Multi-drug Resistant TB). Peningkatan kasus MDR-TB kemungkinan disebabkan oleh salah satu faktor risiko TB yaitu infeksi HIV (ko-infeksi TB-HIV). Sayangnya, ada tidaknya hubungan dari infeksi HIV, yang menurunkan kadar CD4, dengan pola kepekaan dari Mycobacterium tuberculosis terhadap Rifampisin di Indonesia belum diketahui secara pasti.Tujuan: Mengetahui hubungan penurunan kadar CD4 dengan pola kepekaan Mycobacterium tuberculosis terhadap Rifampisin pada pasien ko-infeksi TB-HIV di RSUD Dr. Soetomo SurabayaMetode Penelitian: Penelitian ini menggunakan desain penelitian analitik observasional menggunakan studi analitik dengan rancangan cross-sectional. Diperoleh 32 sampel dari rekam medis pasien ko-infeksi TB-HIV di RSUD Dr. Soetomo Surabaya periode 1 Januari - 31 Desember 2016. Data dianalisis dengan uji Chi Square menggunakan aplikasi SPSS.Hasil Penelitian dan Pembahasan: Hasil uji Chi Square antara penurunan kadar CD4 dan pola kepekaan Mycobacterium tuberculosis terhadap RIfampisin menunjukkan tidak adanya hubungan yang signifikan (p=0,544).Kesimpulan: Diperoleh hubungan yang tidak signifikan antara penurunan kadar CD4 (200 sel/mm3) dengan resistensi Mycobacterium tuberculosis terhadap Rifampisin pada pasien koinfeksi TB-HIV di RSUD Dr. Soetomo Surabaya periode Januari-Desember 2016.

HUBUNGAN PENURUNAN KADAR CD4 DENGAN POLA KEPEKAAN MYCOBACTERIUM TUBERCULOSIS TERHADAP RIFAMPISIN PADA PASIEN KO-INFEKSI TB-HIV DI RSUD DR. SOETOMO SURABAYA Firsta Wahono Febrianto; Deby Kusumaningrum; Arifa Mustika
Jurnal Kedokteran Syiah Kuala Vol 19, No 1 (2019): Volume 19 Nomor 1 April 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i1.18044

Abstrak. Latar belakang Mycobacterium tuberculosis banyak menimbulkan masalah kesehatan yang kompleks. Salah satu penyakit yang ditimbulkan adalah Tuberkulosis (TB). Obat untuk mengatasi Tuberkulosis disebut Obat Anti Tuberkulosis (OAT). Namun, sudah banyak Mycobacterium tuberculosis yang mengalami resistensi ganda terhadap obat lini pertama tersebut yang disebut MDR-TB (Multi-drug Resistant TB). Peningkatan kasus MDR-TB kemungkinan disebabkan oleh salah satu faktor risiko TB yaitu infeksi HIV (ko-infeksi TB-HIV). Sayangnya, ada tidaknya hubungan dari infeksi HIV, yang menurunkan kadar CD4, dengan pola kepekaan dari Mycobacterium tuberculosis terhadap Rifampisin di Indonesia belum diketahui secara pasti.Tujuan: Mengetahui hubungan penurunan kadar CD4 dengan pola kepekaan Mycobacterium tuberculosis terhadap Rifampisin pada pasien ko-infeksi TB-HIV di RSUD Dr. Soetomo SurabayaMetode Penelitian: Penelitian ini menggunakan desain penelitian analitik observasional menggunakan studi analitik dengan rancangan cross-sectional. Diperoleh 32 sampel dari rekam medis pasien ko-infeksi TB-HIV di RSUD Dr. Soetomo Surabaya periode 1 Januari - 31 Desember 2016. Data dianalisis dengan uji Chi Square menggunakan aplikasi SPSS.Hasil Penelitian dan Pembahasan: Hasil uji Chi Square antara penurunan kadar CD4 dan pola kepekaan Mycobacterium tuberculosis terhadap RIfampisin menunjukkan tidak adanya hubungan yang signifikan (p=0,544).Kesimpulan: Diperoleh hubungan yang tidak signifikan antara penurunan kadar CD4 (200 sel/mm3) dengan resistensi Mycobacterium tuberculosis terhadap Rifampisin pada pasien koinfeksi TB-HIV di RSUD Dr. Soetomo Surabaya periode Januari-Desember 2016.Kata Kunci: ko-infeksi TB-HIV, Mycobacterium tuberculosis, resisten Rifampisin, CD4. Abstract. Background: Rifampicin-resistance Tuberculosis (TB) case rate is increasing every year, particularly in Indonesia. It is probably caused by the infection of Human Immunodeficiency Virus (HIV) on Tuberculosis patient, called TB-HIV co-infection. However, the association between HIV infection, which can cause decreasing of CD4, and Rifampicin-resistance Mycobacterium tuberculosis in TB-HIV co-infection patients is still not clearly yet. Objective: This study was undertaken to analyze the association between CD4 decreasing and Rifampicin resistance in TB-HIV co-infection patients of Dr. Soetomo General Hospital Surabaya.Methods: A retrospective research with cross-sectional method of TB-HIV co-infection patients’ medical record at Medical Record Center of Dr. Soetomo General Hospital Surabaya from 1 January to 31 December 2016 with 32 samples.Result: Chi Square test shows that there is no association (p=0,544) between CD4 decreasing and Rifampicin-resistance Mycobacterium tuberculosis in TB-HIV co-infection patients of Dr. Soetomo General Hospital Surabaya.Conclusion: There is no association between CD4 decreasing and Rifampicin-resistance Mycobacterium tuberculosis in TB-HIV co-infection patients.Keywords: TB-HIV co-infection, Mycobacterium tuberculosis, Rifampicin resistance, CD4.

Co-Authors Achmad Ilham Rizwani Adelia Handoko Alimsardjono, Lindawati Aniek Meidi, Aniek Anny Setijo Rahaju, Anny Setijo Ardy Hamonangan Naibaho Bambang Purwanto Claudi Artha Deby Kusumaningrum Diah Mira Indramaya Dyah Agesti Ema Qurnianingsih Farros Yuftariq Izzad Afla Fedelita Aistania Putri Firsta Wahono Febrianto Firsta Wahono Febrianto Gadis M. Sari Gondo Mastutik I'tishom, Reny Irda Bella Kenconowungu, Citrawati Dyah Mah Zhook Yueng Miranda Jemyma Mas'ulun Muhammad Arsy Reza Suyudi Muhammad Hanun Mahyuddin Nurlaili Susanti Pamudya Wardhana, Achmad Firdaus Prabowo, Gwenny Ichsan Purwo Sri Rejeki Renny I’tishom Roostantia Indrawati Roostantia Indrawati Roostantia Indrawati, Roostantia Safira Raissa Dwi Putri Sandra Dewi Sitaresmi Sari, Gadis M. Siti Khaerunnisa Sjahjenny Mustokoweni, Sjahjenny Sukarno, Devitya Angielevi Sulistyawati, Sriwijayanti Suryani Dyah Astuti Zumara Ma'rifah Azzahra

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