Heni Rachmawati
Research Group of Pharmaceutics School of Pharmacy, Bandung Institute of Technology

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Influence of Artocarpus communis Leave Extract on the Physical Characteristic of Pellet Heni Rachmawati; Tjandrawati Mozef; Shafiqah Adam
Jurnal Matematika & Sains Vol 15, No 3 (2010)
Publisher : Institut Teknologi Bandung

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Abstract

Artocarpus communis (Forst.) is popularly known in English as breadfruit tree because of the bread-like texture of its edible fruits. The leaves are potential for fever and liver disorders and it also possesses significant anti-platelet and anti-inflammatory activities. The aim of this study is to formulate ethyl acetate extract of Artocarpus communis leaves into a solid dosage form. Pelletization was developed to formulate the extract. The formula was prepared using various ratios of extract (5, 10, 15 and 20 %) with PVP as a binder and Avicel pH101 as a filler. The influence of extract concentration was studied on the pellet characteristics. Pellet was prepared by extrusion-spheronization technique. In order to produce pellet with optimum diameter (500-900 µm), the moisture of the extrudates must be around 40%, with spheronizer speed of 800-900 rpm for 1.5 minutes. In particular for flow property, all pellets containing more than 5% of Artocarpus communis leaf extract were better (> 8 g/s) over blank pellets (< 4 g/s). In conclusion, the presence of extract in the pellet formulas improved the physical characteristic of pellet. The self binding property of the extract is suggested as a key parameter for this improvement.
PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN--SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL Citra Ariani Edityaningrum; Heni Rachmawati
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.476 KB) | DOI: 10.12928/pharmaciana.v5i1.2286

Abstract

Curcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the -cyclodextrin forming curcumin--cyclodextrin nanoparticle. The formula showed particle size of 156.8 ± 38.3 nm, polydispersity indexof 0.174 ± 0.026, and zeta potential of -17.3  0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p<0.01) and 1.41-fold (p<0.05), after storage at25 and 40 oC, respectively.
PENGEMBANGAN SISTEM PEMBAWA ALBUMIN NANOPARTIKEL UNTUK SILIMARIN DAN KAJIAN SIFAT FISIK SERTA PROFIL PELEPASANNYA SECARA IN VITRO Rini Ambarwati; Heni Rachmawati
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 7, No 2 (2017): Fitofarmaka Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.755 KB) | DOI: 10.33751/jf.v7i2.773

Abstract

Silimarin merupakan senyawa flavonolignan yang berasal dari tumbuhan Silybum marianum (Asteraceae). Silimarin memiliki efek farmakologi sebagai antikanker dan hepatoprotektor, tetapi senyawa ini memiliki kelarutan yang rendah dalam air. Tujuan penelitian ini adalah mengembangkan formulasi silimarin dalam sistem pembawa nano dengan teknik desolvasi. Pembawa yang digunakan adalah serum albumin (bovine serum albumin/BSA). Kombinasi silimarin dalam BSA diharapkan dapat meningkatkan efikasi silimarin sebagai anti kanker karena permeabilitas BSA yang lebih baik pada sel kanker. Evaluasi standar terhadap nanopartikel silimarin-BSA meliputi ukuran dan distribusi ukuran partikel, zeta potensial, morfologi nanopartikel, kristalinitas, sifat termal, spektroskopi inframerah, efisiensi penjeratan serta profil pelepasan silimarin dari BSA nanopartikel pada 2 media berbeda (HCl 0,1 N PBS pH 7,4). Nanopartikel BSA- silimarin memiliki ukuran partikel 174,23 13,94 nm; distribusi ukuran partikel 0,185 0,052; efisiensi penjeratan 90,54 0,098 %; loading capacity 30,18 0,036 % dan zeta potensial -1,62 mV. Hasil analisis menggunakan DSC (differential scanning calorimetry), XRD (X-ray diffraction) dan spektroskopi inframerah menunjukan bahwa nanopartikel silimarin berhasil terenkapsulasi di dalam nanopartikel BSA, dan BSA-silimarin memiliki bentuk amorf. Setelah 1 jam uji pelepasan, terdapat sebanyak 21,89% silimarin terlepas dalam HCl 0,1 N dan 54,84% silimarin terlepas dalam PBS pH 7,4 sehingga dapat disimpulkan bahwa silimarin-BSA memiliki kelarutan yang baik dalam air. Oleh karena itu, perlu dilakukan pengujian lebih lanjut untuk mengkaji akt ivitas serta perilaku silimarin-BSA in vivo untuk mengkonfirmasi data in vitro.
COUNSELING ABOUT THE PROCESS OF REMOVING THESMELL OF CATFISH OIL TO BE PROCESSED INTO JELLYCANDY IN TULUNGAGUNG: PENYULUHAN TENTANG PROSES PENGHILANGAN BAU MINYAK LELE UNTUK DIOLAH MENJADI PERMEN JELLY DI TULUNGAGUNG Heni Rachmawati; Ali Iqbal Tawakal; Damar Rasti Adhika; Annis Catur Adi; Wizara Salisa; Anna Smdyah Putri; Amirah Adlia
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 5 No. 1 (2023): JUNE 2023
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/dc.V5.I1.2023.1-7

Abstract

ABSTRAK Latar belakang: Intensitas kegiatan industri penepungan ikan lele menghasilkan berbagai produk samping dalam jumlah besar, yaitu tulang/duri, minyak, dan kulit. Hasil-hasil samping tersebut jika tidak diolah akan menjadi limbah organik yang mengganggu lingkungan. Oleh karena itu, pada kegiatan pengabdian masyarakat ITB 2022 yang dilakukan bersama PT Rumah Inovasi Natura bertujuan untuk memanfaatkan salah satu limbah tersebut, yaitu minyak ikan. Minyak ikan lele sebagaimana minyak ikan lainnya, mempunyai aroma yang sangat tidak sedap sehingga tidak disukai, padahal kandungan senyawa aktifnya sangat bagus untuk pertumbuhan dan perkembangan kecerdasan. Tujuan: Tujuan kegiatan pengabdian masyarakat ini adalah melakukan penjernihan minyak ikan lele menggunakan bentonit agar dihasilkan minyak yang lebih jernih dan tidak berbau. Selanjutnya, minyak tersebut diolah menjadi permen yuppy sehingga lebih disukai oleh anak-anak. Metode: Kegiatan pengabdian tersebut dikemas dalam berbagai bentuk kegiatan: penyuluhan dan pelatihan kepada masyarakat di kabupaten Tulung Agung, meliputi masyarakat dari kelompok PKK, IKM (industri kecil menengah), murid SMKN 1, serta murid PAUD. Khusus untuk murid PAUD, mereka diberikan permen yuppy minyak ikan dan nasihat pentingnya makan minyak ikan untuk kepintaran. Hasil: Hasil kegiatan pengabdian masyarakat mendapatkan respon yang sangat baik dari berbagai kalangan masyarakat yang diikutsertakan pada program ini. Kesimpulan: Kegiatan pengabdian ini menghasilkan produk pangan yang berpotensi digunakan sebagai sarana suplementasi minyak ikan lele yang mengandung berbagai bioaktif yang baik untuk membantu meningkatkan perkembangan kecerdasan anak. Kata kunci: Minyak Ikan Lele, Permen, Bentonit, Tulung Agung, Kecerdasan Mental ABSTRACT Background: The intensity of the activity of catfish flour industry produces various by-products in large quantity, namely bones/thorns, oil, and skin. These by-products, if not treated, will become organic waste that disturbs the environment. Therefore, the ITB 2022 community service activity carried out with PT Rumah Inovasi Natura aims to utilize one of these wastes, namely fish oil. Catfish oil, like other fish oils, has a very unpleasant aroma that is not liked, even though the content of active compounds is very good for the growth and development of intelligence. Objective: The purpose of this community service is to purify catfish oil using bentonite so that the oil produced is clearer and odorless. Furthermore, the oil is processed into sweet candy so that it is preferred by children. Methods: The service activities are packaged in various forms of activities: counseling and training for the community in Tulung Agung district, including people from the PKK group, IKM (small and medium industries), SMKN 1 students, and PAUD students. Especially for PAUD students, they were given fish oil yuppy candy and advice on the importance of fish oil for intelligence. Results: The results of community service activities received a very good response from various groups of people who were included in this program. Conclusion: This service activity produces food products that can be used as a means of supplementing catfish oil which contains various good bioactives to help improve the development of children's intelligence. Keywords: Catfish Oil, Candy, Bentonite, Tulung Agung, Mental Intelligence