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All Journal Urania Jurnal Ilmiah Daur Bahan Bakar Nuklir Kompak : Jurnal Ilmiah Komputerisasi Akuntansi Jurnal Kefarmasian Indonesia
Gatot Setiawan
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Education Materials Science & Nanotechnology Medicine & Pharmacology

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OPTIMASI pH ALUMINA dan 99Mo DALAM PEMBUATAN GENERATOR 99Mo/99mTc BERBASIS MoO3 ALAM Sulaiman Sulaiman; Yono Sugiharto; Chairuman Chairuman; Gatot Setiawan; Adang Hardi Gunawan
Urania : Jurnal Ilmiah Daur Bahan Bakar Nuklir Vol 24, No 2 (2018): Juni, 2018
Publisher : website

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/urania.2018.24.2.4159

Abstract

OPTIMASI pH ALUMINA dan 99Mo DALAM PEMBUATAN GENERATOR 99Mo/99mTc BERBASIS MoO3 ALAM. Alumina sebagai bahan penyerap telah lama digunakan untuk radioisotop 99Mo pada generator 99Mo/99mTc penghasil 99mTc yang banyak digunakan di kedokteran nuklir untuk keperluan diagnosa. Selama ini alumina digunakan untuk penyerapan 99Mo yang diperoleh dari bahan fisi 235U. Adanya pembatasan penggunaan matriks bahan fisi 235U maka alternatif lain untuk memperoleh 99Mo dengan menggunakan MoO3 alam yang diiradiasi di reaktor nuklir. Radioisotop 99Mo yang dihasilkan dari reaksi ini memiliki sifat tidak bebas pengemban sebagaimana halnya 99Mo dari hasil fisi, karena tidak semua MoO3 yang diiradiasi teraktivasi menjadi 99Mo. Pada aplikasi generator 99Mo/99mTc berbasis MoO3 alam dengan menggunakan kolom alumina, perlu diketahui pH alumina yang optimal dalam penyerapan 99Mo, dan juga pH 99Mo. Pada penelitian ini digunakan tiga variasi kolom generator berbasis alumina yaitu alumina asam, alumina netral, dan alumina basa. Bahan matriks 99Mo juga dilakukan tiga variasi pH yaitu larutan 99Mo dengan pH 4, larutan 99Mo dengan pH 7, dan larutan 99Mo dengan pH 8. Generator dielusi dengan larutan salin dan diamati setiap hari selama 3 hari dan diteruskan setelah dua hari berikutnya selama 2 hari. Penyerapan 99Mo dari MoO3 alam oleh material alumina memberikan hasil penyerapan terbaik pada penggunaan alumina asam dengan larutan 99Mo pada pH 4. Dari ketiga variasi pH larutan Mo yang memberikan yield 99mTc terbaik adalah pada penggunaan larutan 99Mo dengan pH 4. Kolom yang memberikan 99Mo breakthrough terkecil adalah di kolom alumina asam terutama menggunakan larutan 99Mo dengan pH 4. Dengan demikian, untuk menyerapkan 99Mo dari Mo alam dapat digunakan alumina asam dengan menggunakan larutan 99Mo pada pH 4..Kata kunci: 99Mo, alumina, kolom, pH, yield.
Uji Klirens dan Uji Pirogenitas sebagai Bagian dari Penentuan Mutu Biologi Sediaan 90Y-EDTMP Sulaiman Sulaiman; Sri Aguswarini; Karyadi Karyadi; Chairuman Chairuman; Gatot Setiawan; Adang HG; M. Subur
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.352

Abstract

Cancer is one of the causes of death in Indonesia and even the world. Nuclear medicine techniques with radiopharmaceuticals and SPECT are one of the ways to treat cancer, but their use in Indonesia is not yet popular. Radiopharmaceuticals marked with radionuclide emitting beta (β) radiation are proven to be used for cancer therapy, one that has been developed in PTRR-BATAN is 90Y-EDTMP. Yttrium-90 is used in nuclear medicine by utilizing β radiation (E max 2.28 MeV). The β energy which is produced from the decay process of 90Y radionuclides to 90Zr can kill cancer cells. This study aimed to provide information about the substances biological effects so that preventive measures can be taken to protect humans. This study conducted evaluation of the 90Y-marked radiopharmaceutical (90Y produced from a 90Sr / 90Y generator which is 90Y-EDTMP) encompasses clearance test, pyrogen test, and dose safety test in experimental animals. The clearance test utilized mice, the pyrogen test utilized rabbits, and the dose safety test utilized mice. The results of the clearance test showed that 90Y-EDTMP compound which was excreted in 192 hour was 49.70% through urine and 14.59% through feces. The total excretion of 90Y-EDTMP within 192 hours was 64.57%. Based on the results of clearance tests with calculations, 90Y of 90Sr / 90Y generators in 90Y-EDTMP dosage form had 84.2 hours of half-life, 36.5 hours of an effective half-life and 52.7 hours of a residence time. Pyrogen test results showed pyrogen-free. The 90Y-EDTMP dose safety test showed that the dose is safe and not deadly. The development of 90Y-EDTMP is expected to be improved to produce radiopharmaceuticals for cancer therapy in order to make a real contribution in public health services.
AHP Method for Selecting Wood As Furniture Raw Material Gatot Setiawan; Imam Husni Al Amin
Kompak :Jurnal Ilmiah Komputerisasi Akuntansi Vol 13 No 1 (2020): Jurnal Ilmiah Komputer Akuntansi
Publisher : Universitas Sains dan Teknologi Komputer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51903/kompak.v13i1.160

Abstract

Wood is an important element determining the quality of a product on furniture. The lack of knowledge of the furniture industry in this industry causes problems to choose a decision in determining the wood material to produce quality and quality furniture products. Development of a decision support system using the Analytichal Hierarchy Process method uses wood quality feasibility parameters consisting of five criteria, namely Physical Physical Properties, Mechanical Mechanical Properties of Wood, Wood Grade, Wood Age and Wood Substance from several samples. The results of this study were to produce a decision from the data to determine a decision, a decision support system for the purchase of wood materials for a furniture industry company using the Analytichal Hierarchy Process method. After testing, it can be concluded that the decision obtained is appropriate for use by staff and superiors and is ready to be implemented.
Co-Authors Adang Hardi Gunawan Adang HG Chairuman Chairuman Imam Husni Al Amin M. Subur Sri Aguswarini Sulaiman Sulaiman Sulaiman Sulaiman Yono Sugiharto