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Perbedaan Tingkat Depresi antara Lansia yang Tinggal bersama Keluarga di Dusun Diro dengan Lansia di Panti Sosial Tresna Werdha Yogyakarta Unit Budi Luhur Dicky Budi Nurcahya; . Suparman; Lilik Wijayanti
Nexus Kedokteran Komunitas Vol 2, No 1 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: The population of elders is gradually increasing. The United Nation stated that the elders population is increasing around 77,37% during 2005 till 2025 and Indonesia is the country which is contribute to the high number of its percentage. Depression is a psychiatric disorder that most commonly occurs to the elders. The place where they are living is one factor that may lead to the depression. Some elders are residing in the home with his family and some others are residing within a nursing house. This study is aimed to determine the differences in rates of depression between the elders who living with a family in Diro Village and elders who staying in Tresna Werdha Nursing House the unit of Budi Luhur, Yogyakarta. The study is expected to provide useful input to family members and nursing staff about the psychological condition of the elders. Methods: This study was observational analytic cross-sectional approach. The subjects were elders in Diro village and Tresna Werdha Nursing House the unit of Budi Luhur, Yogyakarta that met the inclusion criteria and were willing to answer the questionnaire study. Depression scores measured using the GDS-SF. Sampling is done by simple random sampling. Data obtained in a total of 35 samples in Diro Village and 35 samples in Tresna Wredha Nursing House the unit of Budi Luhur, Yogyakarta. Samples were then analyzed by unpaired t test using Statistical Product and Service Solutions (SPSS) 17.0 for Window. Results: Data differences in rates of depression between elders living with a family in Diro Village and those living in Tresna Werdha Nursing House the unit of Budi Luhur, Yogyakarta tested by unpaired t test, it was found p = 0,028 (p < 0,05). Conclusions: There were significant differences between the rates of depression in elders living with a family in the Diro Village and Tresna Werdha Nursing House the unit of Budi Luhur, Yogyakarta with p = 0,028 (p < 0,05). Keywords: elders, depression, GDS-SF

Hubungan Antara Stres Psikologis Dan Olahraga Terhadap Terjadinya Dismenore Primer Pada Mahasiswi Fakultas Kedokteran Universitas Sebelas Maret Mutiara Rizky Ananda; Eric Edwin Y; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Prevalence of primary dysmenorrhea in the adolescent in Surakarta is 87,7% and 15% of women in Indonesia complained that their activity were interrupted due to dysmenorrhea. Psychological stress and irregular sports allegedly have connection in increase the incidence of primary dysmenorrhea. This research aims to know the relation between psychological stress and exercise against the occurrence of primary dysmenorrhea. Methods: This study is analytical observational with cross sectional approach, and using primary data. This study using medical student of 2010, 2011, 2012 at Sebelas Maret University as sample, taken by simple random sampling methods about 62 samples. Data analysis using Chi Square test and binary logistic regression. Results: Result of data analysis using Chi Square test shows p value for the relationship of psychological stress with primary dysmenorrhea is 0,013 whereas p value of relations sports with primary dysmenorrhea is 0,009. For the results of the analysis data using binary logistic regression found that psychological stress has OR = 0,352 whereas exercise has OR = 3,808. Conclusions: Based on result of the study can be concluded that there is a relationship between psychological stress and exercise against the occurrence of primary dysmenorrhea in the medical student of Sebelas Maret University Surakarta. Keywords: Psychological Stress, Exercise, Primary Dysmenorrhea.

Hubungan Derajat Aktivitas Fisik pada Laki-Laki dengan Kejadian Stroke Iskemik di RSUD Dr Moewardi Surakarta Yusuf Budi Hermawan; Agus Soedomo; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background : Stroke is a disease caused high morbidity and mortality rate in low-middle income countries. Low physical activity is one of the risk factors for ischemic stroke. The impact of low physical activity is high level of NADPH, atherosclerosis, and vascular elasticity disorder. Global Physical Activity Questionnaire version 2 (GPAQv2) is a questionnaire released by WHO which has been especially designed to measure the physical activity of people in developing countries. The aim of this study is to determine the correlation between man physical activities and ischemic stroke in Dr Moewardi Hospital Surakarta. Methods: This was an analytical observational study with case control approach. This study was conducted during May - July 2013 at the Neurology Department of Dr. Moewardi Hospital Surakarta. Subjects were acute ischemic stroke patients in neurology ward of Dr. Moewardi Hospital Surakarta which were taken by using fixed disease sampling. Data were collected by interviewed patients based on GPAQv2 questionnaire. Data analysis used multivariate with double logistic regression and have been processed by Statistical Product and Service Solution (SPSS) 16.00 for Windows. Results: This study showed statistically significant (p=0,036) between man physical activities and acute ischemic stroke in Neurology Department Dr. Moewardi Hospital Surakarta. Age and smoking as comfounding factors have been controlled. Male patients with low physical activity had 13.95 times (OR = 13.95; CI 95% 1.19 163.58) to develop ischemic stroke than ones with adequate physical activity. Conclusion:Men who use to have less physical activity more likely to develop ischemic stroke. Keywords : level of physical activity, acute ischemic stroke, GPAQv2

Perbedaan Tingkat Depresi Saat Menjalani Pembinaan Intra Mural dengan Saat Menjalani Pembimbingan pada Warga Binaan Pemasyarakatan Elga Putri Indanarta; Mohammad Fanani; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Correctional coached people, both in intra mural and in parole coaching are vulnerable to get depression. Depression is a syndrom of depressed mood with sympthoms and signs of pathologic sadness and suffering components. This study aimed to proof the difference of depression levels between inmates who are in intra mural coaching and correctional clients who are in parole coaching that inmates are higher than correctional clients. Methods: This analytic study was observational with cross-sectional approach. 20 inmates who are in intra mural coaching at Class I Detention Center Surakarta (group 1) and 10 ex-inmates who had intra mural coached in Class I Detention Center Surakarta that now under parole coaching as correctional clients by Class II Correctional Center Surakarta (group 2) were taken as samples by total sampling from available population. The primary data were collected by questionnaire of Beck Depression Inventory that answered by the respondens after received some instructions. The data were analyzed using t test on Statistical Package for the Social Sciences (SPSS) version 16.0 for Windows. Results: Group 1 had depression score (meandeviation standart) 23.857.13 and group 2 had 13.107.25. t test showed that depression levels of those groups were significantly different with p=0.002 (p<0.05). Conclusion: There is a statistically significant difference between depression level on inmates who are in intra mural coaching and on clients who are in parole coaching under the supervision of correctional system. Inmates who are in intra mural coaching had higher level of depression than ex-inmates who are in parole coaching as correctional clients. Keywords: depression, inmates, clients, correctional coached people

Hubungan Antara Kadar Feritin Dengan Kadar ALT dan AST Pada Pasien Thalasemia di RSUD Dr. Moewardi Valentina Lakhsmi Prabandari; Muhammad Riza; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Thalassemia major patients need a regular blood transfusion that may cause an iron overload and vital organ dysfunction. This was an observational analytic study to analyze the relationship between ferritin level and transaminase enzymes level in thalassemia patients at Dr.Moewardi General Hospital. A positive relation may remind doctor to pay attention of liver function in thalassemia major patients. Methods: The research was an observational analytic study with cross sectional approach during April-June 2013 in Dr. Moewardi General Hospital. The samples was taken using exhaustive sampling and all were children with beta thalasemia major. These patients had a regular blood transfusion, high ferritin level (>1000 ng/l) and iron chelating agents usage. Ferritin level as independent variable was measured with ELFA method. Transaminase enzymes as dependent variables were measured with IFCC method. These variables were analyzed with Pearson correlation, diagnostic odds ratio and linier regression. Results: Thirty thalassemia patients test results of ferritin, ALT and AST level were collected. Eighteen patients had a very high ferritin level (?3000 ng/l) and the other twelve patients ferritin level were between 1000-3000 ng/l. Eighteen patients had a high ALT level and seventeen patients had a high AST level. Pearson analysis showed a significant result between ferritin and ALT level (p=0.043) also between ferritin and AST level (p=0.028). Pearson correlation strengths were moderate (0.373 and 0.401). Odds ratio between ferritin level with ALT and AST level were 3.333 and 3.111. Conclusions: There was a positively moderate correlation between ferritin level and both ALT and AST level in thalassemia patients in Dr. Moewardi General Hospital. Odds ratio analysis showed that ferritin level above 3000 ng/l is a risk factor of ALT and AST level elevation. Keywords: Thalassemia, iron overload, ferritin, transaminase

Pengaruh Ekstrak Daun Teh (Camellia sinensis, Linn. var. Assamica) terhadap Mortalitas Cacing Ascaris suum, Goeze Ahmad Afiyyuddin N; Cr. Siti Utari; Lilik Wijayanti
Nexus Kedokteran Translasional Vol 2, No 1 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Camellia sinensis, Linn. var. Assamica leaves contain tannin that have been known to have anthelmintic effect. This study aimed to determine the effect of Camellia sinensis, Linn. var. Assamica leaves extract toward death time of Ascaris suum, Goeze. Methods: The study was a laboratory experimental research using the post-test only controlled group design. Subjects were Ascaris suum, Goeze. The sampling technique used was purposive random sampling. Subjects were divided into 7 groups, each group using 4 worms, replication performed 5 times. Saline solution was used in negative control group, pirantel pamoate 5 mg/ml was used in positive control group, while the treatment group used Camellia sinensis, Linn. var. Assamica leaves extract concentration of 50%, 60%, 70%, 80%, and 90%. Worms immersed in the test solution at 25 ml and incubated at 37C. Observations were made every 1 hour and counted dead times of all worms. Data were analyzed with regression linier and probit analysis. Results: Observations of total deaths mean time Ascaris suum, Goeze negative control for 48 hours, the positive control 1 hours 10 minutes, the concentration of 50%, 60%, 70%, 80%, 90% for 10 hours 24 minutes, 9 hours 12 minutes, 7 hours 12 minutes, 5 hours 12 minutes and 4 hours. Linear regression test results show that the variation of the concentration affects long worm death. Probit analysis results obtained LC50 and LT50 Camellia sinensis, Linn. var. Assamica leaves extract is 67,183% and 3 hours 46 minutes. Conclusions: Based on this study, it can be concluded that of Camellia sinensis, Linn. var. Assamica leaves extract affects mortality of Ascaris suum, Goeze, the increasing of extract concentration is inversely proportional with the death time of worms. Keywords: Camellia sinensis, Linn. var. Assamica leaves extract, Ascaris suum, Goeze.

Hubungan Multi Paritas dengan Tingkat Kejadian Kanker Serviks di RSUD Dr Moewardi Totok Siswanto; Eric Edwin Yuliantara; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Cervical cancer is one of the most common cancer found in women and ranks second all cancers in women in the world. Multi parity thought to be one of the risk factors for cervical cancer. Hormonal and anatomical changes that occur in multi parity may increase the risk of cervical cancer by a variety of mechanisms. The purpose of this study was to determine the incidence rates of cervical cancer are associated with multi parity status. Methods: The type of research is an case-control. The samples in this study were patients with cervical cancer and other gynecological diseases with a total sample of 60 people. Measuring instrument used was a questionnaire, and then performed the data analysis with multiple logistic regression analysis. Result: Found a statistically significant association between the multi-parity status with the incidence of cervical cancer. People with multi-parity status have an increased risk for cervical cancer was 8.986 times greater than women with non-multi-parity status (p = 0.003, OR = 8.986). Conclusion: Based on research of woman with multi parity status will have the risk of having cervical cancer by 8,986 times compared to women with non-multi-parity status. Key Words: multi parity, cervical cancer

Perbedaan Kecemasan antara Kecerdasan Emosi Tinggi dan Kecerdasan Emosi Rendah pada Mahasiswa Angkatan 2010 yang Menghadapi Skripsi di Fakultas Kedokteran UNS Adinda Ferinawati; Yusvick M. Hadin; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Anxiety is a state of excessive tension or inappropriate tension which is characterized by feelings of worry, uncertainty, or fear. Anxiety can be overcome with good emotional intelligence. Of the five areas that exist in emotional intelligence, self recognizing and managing emotions are the aspects who have a big role to overcome anxiety. This study aimed to determine whether there is a difference of anxiety between high emotional quotient and low emotional quotient of students year of 2010 doing mini thesis in Medical Faculty of UNS. Method: This research was an analytical descriptive research using cross sectional approach. The subjects were Medical Faculty students year of 2010 of Sebelas Maret University. Data were collected by using purposive sampling method within inclusion and exclusion criterias. Emotional quotient was measured by Emotional Quotient questionnaire, while anxiety was measured by Taylor Manifest Anxiety Scale. For assesing and finding honesty in answering questions given, was used L-MMPI scale questionnaire. Sixty samples were obtained and analyzed using Chi-Square test through SPSS 20.0 version for Windows program. Result: The result of research showed that 23 students (76.7 %) who have low emotional quotient were feeling anxious and 7 students (23.3 %) who have low emotional quotient were not feeling anxious. While 9 students (30 %) who have high emotional quotient were feeling anxious and 21 students (70 %) who have high emotional quotient were not feeling anxious. Chi-Square test showed the result of p = 0.000 and Odds Ratio = 7.667. Conclusion: There is a significant difference of anxiety between high emotional quotient and low emotional quotient of students year of 2010 doing mini thesis in Medical Faculty of UNS. Keywords: Anxiety, emotional quotient, students doing mini thesis

Uji Sitotoksik Ekstrak Daun Andrographis paniculata Ness. pada Kultur Limfosit T Pasien Systemic Lupus Erythematosus Dedi Febriandaru; Ratih Puspita Febrinasari; Lilik Wijayanti
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Systemic Lupus Erythematosus or SLE is a chronic autoimmune disease with varied clinical manifestations. SLE prevalence in Indonesia is being dominated with female, especially in their productive age. Certain etiology of SLE is still unknown until now, but genetic factors and immune system are being estimated as the primary factors. The first line therapy of SLE is cyclophosphamide. Unfortunately if being consumed more than six months, cyclophosphamide has several side effects, like bone marrow depression, infections, alopecia, hemorrhagic cystitis, and infertility. Because of that side effects, herbal medicine is being developed nowday. One of them is Andrographis paniculata Ness. leaf. The aim of this study was quantitative cytotoxic test for Andrographis paniculata Ness. leaf on T lymphocyte culture of Systemic Lupus Erythematosus. Methods: This study was anexperimental study. Subjects in this study were patients with SLE who appropriated SLEs criterias and normal people without allergy and autoimmune diseasess history. This study was done by doing T lymphocyte culture from intravenouss blood sample and observing cells absorbance with ELISA reader. Collected data were used for determining live cells percentage (IC50) and analyzed with Statistical Product and Service Solution (SPSS) 11.00 for Windows. Mean resistance data was tested by linear regression test. Results:The result showed that IC50 dose of Andrographis paniculata Ness. leaf extract treatment on SLE samples was smaller than the normal people. In Andrographis paniculata Ness. leafs extract treatment, IC50 in SLE = 0.00074 and in normal people = 0.19584. Conclusion: Andrographis paniculata Ness.leaf extract had stronger cytotoxic effect on T lymphocyte culture of patients with SLE than the normal people. Keywords: Systemic lupus erythematosus, Andrographis paniculata Ness. leaf extract, T lymphocytes, IC50

Efek Anti Fungi Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana, Linn.) Terhadap Pertumbuhan Candida Albicans Secara In Vitro Puspaningrum .; FX.Bambang Sukilarso S; Lilik Wijayanti
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: This study aimed to know the inhibitory effect of the etanol extract of mangosteen rind (Garcinia mangostana, Linn.) on the growth of Candida albicans in vitro. Methods: The method used in this study was quasi-experimental laboratory research. The subject was the ethanol extract of the mangosteen fruit (Garcinia mangostana Linn.) rind. Candida albicans grown on sabouraud dextrose agar were treated with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100% of the ethanol extract of mangosteen rind (Garcinia mangostana, Linn.), as well as fluconazole 25?g (drugs that were already on the market) as positive control for 24 hours at 37 C on petri dish. The data of diameter of inhibition zone obtained were analyzed with regression-correlation test using SPSS 11.5 for windows. Results: The diameters of inhibition zone on culture of Candida albicans treated with the ethanol extract of the mangosteen fruit with concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, and fluconazole 25?g were 0 mm, 0 mm, 1.75 mm, 1.75 mm, 2.00 mm, 2.00 mm, 3.00 mm, 3.50 mm, 3.75 mm, 3.75 mm and 0 mm, in a row. The regression-correlation analysis showed that the correlation (r) between the diameter of inhibition zone and the levels of ethanol extract of mangosteen rind was 0.936 (p 0.000). Conclusion: The ethanol extract of mangosteen rind (Garcinia mangostana, Linn.) had antifungal effect on the growth of Candida albicans in vitro. Keywords: antifungal effects, ethanol extract of mangosteen rind (Garcinia mangostana Linn.), Candida albicans.

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