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All Journal Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Kedokteran Translasional
Siti Utari
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Medicine & Pharmacology

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Hubungan antara Kadar Hematokrit dengan Derajat Keparahan Stroke Iskemik Fase Akut pada Pasien di Unit Penyakit Saraf RSUD Dr. Moewardi Agung Wahyu Hidayat; . Suroto; Siti Utari
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Stroke is the main cause of morbidities and the third leading cause of death in the world, also promote the functional disorder of the patient. The increase of hematocrit level is one of risk factor the occurrence of ischemic stroke, by increasing the viscosity and decreasing blood perfusion to the brain. National Institute of Health Stroke Scale (NIHSS) is a parameter used to measure the severity of acute ischemic stroke. This study was proposed to know correlation between hematocrit levels and severity of acute ischemic stroke patients in neurolog ward Dr. Moewardi Hospital. Methods: This was an observational study with cross sectional analytic approach. A total of 44 subjects were selected by purposive sampling, they were acute ischemic stroke patients in neurology ward Dr. Moewardi Hospital. Data were collected by direct interview, examined the patients with NIHSS score and from medical record to got the value of hematocrit. Data analysis used multiple logistic regression models and were processed with Statistical Product and Service Solutions(SPSS) 17.00 forWindows. Results: This study showed a positive correlation and statistically significant between hematocrit levels and severity of acute ischemic stroke patients (r = 0,408; p < 0,009) with moderate correlation strength. Multiple logistic regression analysis showed OR = 8,086; CI 95% 1,108 59,005; and p = 0,039. Confounding factor, e.g smoking, and blood sugar have been controlled. Conclusions: There is moderate correlation between hematocrit levels and severity of acute ischemic stroke patients in neurology ward Dr. Moewardi Hospital. Keywords:Hematocrit levels, Severity of acute ischemic stroke, NIHSS
Protective Effect of Orthosiphon stamineus Benth Leaves Extract against Reheated palm oil-induced Liver Damage in Mice Fitroh Annisah; Bambang Widjokongko; Siti Utari
Nexus Kedokteran Translasional Vol 2, No 2 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Orthosiphon stamineus Benth contains polyphenols, terpenoids, oleanolat acids, and sterols which were thought to protect the liver from free radicals. In present study, Orthosiphon stamineus Benth leaves extract was evaluated for its protective effect on reheated palm oil -induced liver damage in mice. Methods: This was laboratory experimental research with the post test only controlled group design. Twenty five male Swiss webster mice were equally divided into five groups: group I (Kn) received aquadest, group II (Kp) received reheated palm oil, and grup IIIV (P1-P3) received reheated palm oil and multilevel doses of Orthosiphon stamineus Benth leaves extract (3.5 mg, 7 mg, and 14 mg) for 14 days. Mice were sacrificed on the 15th day and histological preparation was made to evaluate histological damage on liver. Liver histological features were assessed by counting the number of hepatocyte on centrolobuler zone undergoing pyknosis, karyorhexis, and karyolysis. Data were analyzed using the One Way ANOVA test (? = 0.05) and the Post Hoc Multiple Comparisons (LSD) test (? = 0.05). Results: The mean liver histological damage score was significantly higher on group of Kp= 74.40 2.074, while group of Kn= 38.20 3,564 as the less. P2 group had fewer numbers of liver histological damage (57.00 4.472) compared to the P1 group (61.00 2.550) and the P3 group (58.60 4.775). The results of One Way ANOVA test showed significant difference between the five groups (p = 0.000) and the results of LSD test showed significant differences between each other group (p < 0.005), except the group of P1-P2, P1-P3, and P2-P3 (p > 0.005). Conclusions: Orthosiphon stamineus Benth leaves extract showed protective effect against the hepatotoxicity induced by reheated palm oil in mice. Orthosiphon stamineus Benth leaves extract with the dose of 7 mg/25 g body weight of mice showed a higher hepatoprotective effect than the dose of 3.5 mg/25 g body weight of mice and 14 mg/25 g body weight of mice. Keywords: Orthosiphon stamineus Benth leaves extract, reheated palm oil, histologic liver damage.
Surveilan Jentik Nyamuk di desa Binaan Puskesmas Ampel II dengan Kejadian DBD Aldebaran Lado; Arif Nur Khasan; Aulia Maulitaningtyas; Bayu Hendro P; Abida Zuhra J; Siti Utari; Dwi Astuti Dian Andarwati; Noor Alifah
Nexus Kedokteran Komunitas Vol 7, No 2 (2018): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Pendahuluan: Demam Berdarah Dengue (DBD) perlu mendapat perhatian serius karena merupakan salah satu penyakit menular dan di beberapa daerah masih sering terjadi kejadian luar biasa. Indonesia merupakan daerah tropis yang menjadi daerah endemis penyebaran kasus penyakit ini. Dilihat dari angka kesakitan DBD di Jawa Tengah lebih rendah dari target nasional. Penelitian ini bertujuan untuk menganalisis parameter entomologis (house index dan container index) dan jenis tempat penampungan air (controllable site dan disposable site).Metode: Penelitian surveilan ini dilakukan di tiga desa meliputi enam dusun di Kecamatan Ampel, Kabupaten Boyolali. Desain penelitian yang digunakan merupakan studi potong lintang (cross-sectional-study) yang bersifat observasi deskriptif. Sampel yang digunakan adalah rumah penderita dan rumah-rumah warga yang di sekitar penderita sejumlah 123 rumah. Analisis data berupa jumlah jentik nyamuk di lokasi penelitian untuk menghitung parameter entomologis. Hasil: Penelitian ini mengambil data house index (HI) dan container index (CI) dari sampel yang digunakan. Kedua hal itu perlu di teliti karena merupakan indikator terjadinya wabah kasus DBD. Hasil penelitian di tiga desa menunjukkan bahwa nilai HI masih tinggi dengan kisaran 18% - 70%, sedangkan nilai CI masih tinggi juga dengan kisaran 25% - 57,95%.Kesimpulan: Dari tiga desa yang teliti semuanya memiliki parameter entomologi house index (HI) masih tinggi yaitu di atas 10% yang menandakan risiko penularan tinggi pada kasus DBD.Kata kunci : DHF; surveillance; house index; container index; mosquito larvae
Hubungan Indeks Massa Tubuh (IMT) dengan Derajat Keparahan Stroke Iskemik pada Pasien di Unit Penyakit Saraf RSUD Dr. Moewardi Aga Suganda; . Suroto; Siti Utari
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Stroke is the third leading cause of death in the world. Approximately 80% of strokes are ischemic strokes. One of the significant prognostic factors causing morbidity of stroke patients is the Body Mass Index (BMI). National Institutes of Health Stroke Scale (NIHSS) is a systematic examination to determine the severity stroke. The aim of this study is to determine the relationship of body mass index (BMI) with ischemic stroke severity in patients at Neurology Ward Dr. Moewardi Hospital. Methods: This was an observational study with cross sectional analytic. A total of 32 subjects were selected by purposive sampling, they were ischemic stroke patients in the Neurology Ward Dr. Moewardi Hospital. Data were collected by direct interview, direct measurement of weight and height also examination of severity stroke patient by using NIHSS score. Data analysis used multiple logistic regression models and were processed with Statistical Product and Service Solutions (SPSS) 17.00 for Windows. Results: Multiple logistic regression showed OR = 17,690; CI 95% 1,190 263,039; and p = 0,037. These results have been earned by controlled the confounding variables of age, blood pressure, blood sugar levels, cholesterol levels and smoking history. Conclusions: Ischemic stroke patients with high BMI score has risk of ischemic stroke severity 17.690 times higher than whose normal BMI score.There is a strong relationship between body mass index (BMI) with the severity of ischemic stroke patients at Neurology Ward of Dr. Moewardi Hospital, the relationship is statistically significant in this study. Keywords:BMI, Stroke Severity, Ischemic Stroke
Co-Authors . Suroto Abida Zuhra J Aga Suganda Agung Wahyu Hidayat Aldebaran Lado Arif Nur Khasan Aulia Maulitaningtyas Bambang Widjokongko Bayu Hendro P Dwi Astuti Dian Andarwati Fitroh Annisah Noor Alifah