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Sutisna Himawan
Department of Pathology Anatomic, Faculty of Medicine, Universitas Indonesia, Jakarta
Health Professions Medicine & Pharmacology

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 1 
The history of pathology in Indonesia Himawan, Sutisna
Medical Journal of Indonesia Vol 4, No 1 (1995): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1227.379 KB) | DOI: 10.13181/mji.v4i1.883

Abstract

[no abstract available]
Possible factors influencing high serum Prostate-specific Antigen (PSA) in Indonesian patients with Benign Prostatic Hyperplasia (BPH) Rahardjo, Djoko; Pakasi, Levina S.; Birowo, Ponco; Gardian, Siti T.K.; Himawan, Sutisna
Medical Journal of Indonesia Vol 10, No 1 (2001): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (811.921 KB) | DOI: 10.13181/mji.v10i1.4

Abstract

Benign prostatic hyperplasia (BPH) cases in Indonesia frequently associated with high serum prostate specific antigen (PSA). To explore possible factors that could increase serum PSA level, we performed a retrospective, cross-sectional study on 805 consecutive patients in Sumber Waras and Dr. Cipto Mangunkusumo Hospitals from 1994 to 1997. Clinical manifestations were evaluated and prostate biopsies were performed if indicated. Complete histopathological data were only available in 82 BPH patients with no urinary retention from 1998-1999 and a thin section of paraffin blocks of BPH patients which still could be found from 1994-1999 was analyzed using flow cytometer to obtain the S-phase fraction as a parameter of proliferative activity, From 805 patients, 461 (57%) presented with urinary retention and need to be catheteized. Catheteization significantly increased PSA level if compared to noncatheterized patients (16.3 vs. 6,8 ng/mL, p= 0,000). Another data of 82 uncatheteized patients from 1998-1999 has revealed that 79 patients (96.3%) had chronic prostatitis and 19 (23.2%) showed the presence of prostatic-intraepithelial neoplasia (PIN) with an increase of PSA level (5.4 ng/mL). The S-phase fraction of BPH without PIN cases was significantly higher in cases with PSA > 4 ng/ml than patients with PSA ≤ 4 ng/ml (I3.1% vs. 8.9%, p=0,008). As conclusion, the high serum PSA level was mostly due to urethral catheteization and increased prostate volume. There was a tendency of increasing PSA in subclinical inflammation and PIN. Cases with high PSA also showed high proliferative activities which is suggestive of mitogenic activity. (Med J Indones 2001; 10:22-8)Keywords: BPH, high PSA, PIN, proliferative activity, s-phase fraction
Autopsy findings in severe malaria – a case report Afandi, Dedi; Sampurna, Budi; Sutanto, Inge; Marwoto, J. W.; Chairani, Nurjati; Himawan, Sutisna; W, Rawina; Riyanto, Ivan
Medical Journal of Indonesia Vol 17, No 3 (2008): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (728.674 KB) | DOI: 10.13181/mji.v17i3.315

Abstract

Severe malaria, caused by Plasmodium falciparum infection, has a high mortality rate and is the main cause of death in malaria. Since clinical autopsy is unpopular in Indonesia, autopsy examination in malaria cases is rarely done. We reported a forty three year old woman from non endemic area that was dead because of severe malaria. Diagnosis was concluded from autopsy, histopathology, and toxicology. (Med J Indones 2008; 17: 210-5)Keywords: Plasmodium falciparum, cerebral malaria, black water fever
Multiple cysticercus nodules in skin and brain in a Balinese woman: A case report Margono, Sri S.; Himawan, Sutisna; Purnama, Teddy A.; Subahar, Rizal; Hamid, Abdulbar; Ito, Akira
Medical Journal of Indonesia Vol 11, No 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.905 KB) | DOI: 10.13181/mji.v11i3.65

Abstract

A case of multiple subcutaneous and cerebral cysticercosis in a 33-year-old Balinese female, is reported. The patient suffered from seizures since adolescence, which was not treated. Since three years before admission she started developing multiple nodules in the skin, starting from her forehead and since a year ago also in other parts of the head and body such as shoulders, chest and back. Serum sample tested against cysticercus antigen by immunoblot assay against antigen of Taenia solium was positive. The copro-antigen test was also positive, indicating the presence of the adult worm in the intestines. The patient was treated with praziquantel for the adult T. solium infection and thereafter with albendazole for the larval stages, which resulted in obvious reduction of the cerebral cysts and most of the subcutaneous nodules disappeared. However the adult worm was not recovered in the 24 hours stool specimen and after one year the immunoblot test was still positive. (Med J Indones 2002; 11: 169-73) Keywords: cysticercosis, Taenia solium, praziquantel, albendazole
Pathological features of glomerulonephritis in Jakarta Himawan, Sutisna
Medical Journal of Indonesia Vol 11, No 1 (2002): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (662.989 KB) | DOI: 10.13181/mji.v11i1.49

Abstract

All cases of renal biopsies received during a 10-year period from 1990-1999 were collected and analyzed. There were a totat of 1344 cases, comprising 390 pediatric cases, 9 I 8 adult cases and 36 cases of unknown age. Immunofluorescence microscopy was performed on 1089 cases (81.0%). The purpose of this study is to have an overview of the pattem and spectrum of glomerular diseases in Indonesia, especially in Jakarta and surroundings, with special emphasis on the cases with nephrotic syndrome, lupus nephritis and IgA nephropathy, and to compare the findings with previous reports from Indonesia and afew other countries. There were 250 cases of childhood nephrotic syndrome and 479 adult cases. The most frequent histopathological appearance in both groups was minimal change disease, i.e. 58.2% and 44.7% respectively. Males were more often affected than females with a ratio of 2.0:1 for children and 1.4:1 for adults. Lupus nephritis comprised 124 cases, among which three cases were not representative. The male to female ratio was 1:7.9. Most cases were in the fourth decade, i.e. 47 cases (38.5%), and the most frequent histopathological appearance was WHO class IV with 71 cases (58.7%). There were 97 cases of IgA nephropathy with an age range between 3 to 58 years. The peak incidence was in the fourth decade with 32 cases (33%). The male to female ratio was L7: I. The most frequent histopathological appearances were diffuse sclerosing lesion 34 cases (35%) and mesangial proliftrative lesion 33 cases (34%). (Med J Indones 2002; 11: 24-9)Keywords: renal biopsy, pathological features, glomerulonephritis, nephrotic syndrome, lupus nephritis, IgA nephropathy
Meconium periorchitis: An unusual cause of newborn scrotal mass Damaledo, Pamela; Himawan, Sutisna
Medical Journal of Indonesia Vol 18, No 4 (2009): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.691 KB) | DOI: 10.13181/mji.v18i4.368

Abstract

A case of meconium periorchitis in a 2-month-old boy is  reported. The patient was delivered normally, only a scrotal mass was noted which became harder in weeks. Clinical and intrauterine ultrasonographic fi ndings were suggestive of a neoplasm and orchidectomy was performed. Microscopic  examination revealed separate nodules of myxoid stroma with varying amounts of calcifi cation separated by fi brous septa. The unexpected diagnosis of meconium periorchitis was confi rmed. This condition is due to infl ammatory reaction from the meconium within the scrotal sac and resulted from an  intrauterine perforation of the gastrointestinal tract. Since solid benign or malignant paratesticular masses cannot be differentiated by ultrasonography, tissue biopsy or fresh frozen tissue examination is required for diagnosis. (Med J Indones 2009; 18: 290-3)Keywords: meconium periorchitis, paratesticular mass, scrotal mass.
Laporan Kasus Leydig Cell Tumor Manuputty, Egi Edward; Umbas, Rainy; Himawan, Sutisna
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1161.763 KB)

Abstract

Leydig cell tumor (LCT) merupakan neoplasma testis yang jarang. Tumor ini meliputi 1-3% dari 2,5 kasus insidens tumor testis per 100.000 orang/tahun. Leydig cell tumor dapat terjadi pada orang dewasa dengan 10% di antaranya berpotensi maligna dan pada usia prapubertas (25%). Berikut ini kami laporkan dua kasus LCT yaitu seorang anak laki-laki berusia 8 tahun dengan pembesaran testis kiri tanpa nyeri selama tiga bulan, disertai pertumbuhan kumis dan ginekomastia. Pemeriksaan testis kiri tampak membesar, keras, permukaan rata, dan tidak terdapat nyeri tekan maupun transiluminasi. AFP l,25ng/ml, (5-hCG <2mIU/, dan testosteron 599,2ng/dl. Tidak tampak metastasis pada foto toraks dan CT scan abdomen. Dilakukan orkidektomi ligasi tinggi melalui inguinal, histopatologi sesuai dengan LCT. Testosteron pascaoperasi lllng/dl. Pasien kedua laki-laki berusia 63 tahun dengan keluhan pembesaran testis kanan selama 1,5 bulan dan riwayat scrotal violation. Pemeriksaan testis kanan teraba massa padat berukuran 4x4cm, berbatas tegas dan tidak terdapat nyeri tekan. AFP 3 ng/mL. CT scan menunjukkan metastasis hati dan pembesaran limfe paraaorta kanan sampai dengan pelvis. Review slide histopatologi sesuai LCT, pasien menolak tindakan lebih lanjut dan meninggal dunia 6 bulan kemudian. Sepengetahuan kami, kedua kasus LCT tersebut merupakan laporan pertama di Indonesia.Kata kunci: leydig, cell, tumor
Isolated petrous apex ectopic craniopharyngioma July, Julius; Wahjoepramono, Eka J.; Himawan, Sutisna; Cahyadi, Alexander
Medical Journal of Indonesia Vol 24, No 4 (2015): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (735.983 KB) | DOI: 10.13181/mji.v24i4.1261

Abstract

Primary ectopic craniopharyngioma is a rare entity. Isolated petrous apex bone location has not been reported previously. This study reports a case of 26-year-old male with right abducent nerve palsy. CT and MRI imaging reveal right petrous apex cystic lesion. No sellar or suprasellar region involvement was found. Endoscopic endonasal transphenoid approach has been successfully performed. Histopathology examination confirms the diagnosis of adamantinomatous craniopharyngioma. So far, it’s probably the first case report of primary ectopic craniopharyngioma isolated in the petrous apex. This case report supports the premise that primary ectopic craniopharyngioma is a multifactorial process that starts with an error from migrated embryological cells.
Co-Authors Abdulbar Hamid Akira Ito Alexander Cahyadi, Alexander Budi Sampurna Dedi Afandi Djoko Rahardjo Egi Edward Manuputty, Egi Edward Eka J. Wahjoepramono Inge Sutanto Ivan Riyanto J. W. Marwoto Julius July Levina S. Pakasi Nurjati Chairani Pamela Damaledo Ponco Birowo Rainy Umbas Rawina W Rizal Subahar Siti T.K. Gardian Sri S. Margono Teddy A. Purnama