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Ulrike Holzgrabe
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences

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Tyrosinase Inhibition Type of Isolated Compounds Obtained from Pachyrhizus erosus Endang Lukitaningsih; Muhammad Bahi; Ulrike Holzgrabe
Aceh International Journal of Science and Technology Vol 2, No 3 (2013): December 2013
Publisher : Graduate Program of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.611 KB) | DOI: 10.13170/aijst.2.3.1063

Abstract

Abstract - In Indonesia, Bengkoang (Phacyrhizus erosus) have been used as one of cosmetics especially as sun screening and skin whitening materials. Six active compounds in Bengkoang with antioxidant and skin whitening activities have been isolated, namely daidzein, daidzin, genistin, (8,9)-furanyl-pterocarpan-3-ol, 4-(2-(furane-2-yl)ethyl)-2-methyl-2,5-dihydro-furane-3-carbaldehyde and 2-butoxy-2,5-bis(hydroxymethyl)-tetrahydrofurane-3,4-diol. According to literatures, the type of their tyrosinase inhibitory activity has not yet reported. The determination of whitening activity of each compound was evaluated by the evaluation of Lineweaver-Burk plot. The result showed that five compounds had competitive inhibitory activity and 8,9-furanyl-pterocarpan-3-ol showed a non-competitive inhibition. Keywords: Pachyrhizus erosus, tyrosinase, competitive inhibition and non-competitive inhibition
Co-Authors Endang Lukitaningsih Muhammad Bahi