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All Journal Jurnal Teknologi Informasi dan Ilmu Komputer Jurnal Respirologi Indonesia Journal of Community Health and Preventive Medicine
Susanthy Djajalaksana
Universitas Brawijaya
Computer Science & IT Engineering Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Rancang Bangun Aplikasi Pengukur Kesehatan Fungsi Paru Manusia Memanfaatkan Microphone Pada Smartphone Wahyu Teja Kusuma; Eko Sakti Pramukantoro; Susanthy Djajalaksana
Jurnal Teknologi Informasi dan Ilmu Komputer Vol 3, No 2: Juni 2016
Publisher : Fakultas Ilmu Komputer, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1164.126 KB) | DOI: 10.25126/jtiik.201632175

Abstract

ABSTRAKPenyakit Paru Obstruktif Kronik (PPOK) adalah penyakit yang ditandai dengan hambatan aliran udara di saluran nafas yang tidak sepenuhnya reversibel. Hambatan aliran udara ini bersifat progresif dan berhubungan degan respon inflamasi paru terhadap partikel gas beracun atau berbahaya [2][16]. Hasil penelitian pada bulan Januari-Desember 2010 menyebutkan bahwa PPOK menduduki urutan ke-3 dari penyakit paru terbanyak yang ada di RS Paru Batu Malang. Sedangkan di  RSU Dr. Saiful Anwar Malang  menduduki urutan ke-5. The Burden Of Disease Study dibawah naungan WHO menyatakan bahwa pada tahun 2030 PPOK akan menempati peringkat ke-3 penyebab kematian di dunia [5][15][16]. Sebagai solusi terhadap masalah tersebut yaitu dengan membangun sebuah aplikasi pengukur kesehatan  fungsi paru manusia memanfaatkan microphone pada smartphone”. Guna mengetahui gangguan ventilasi paru, monitoring pengobatan, dan menilai perkembangan fungsi paru. Media smartphone dipilih karena memiliki teknologi Microphone API yang digunakan untuk menangkap input berupa rekaman suara hembusan napas pengguna. Dan mayoritas masyarakat telah melilikinya. Dari hasil pengujian validasi dapat disimpulkan bahwa aplikasi pengukur kesehatan paru manusia pada media smartphone berhasil diimplementasikan dengan memanfaatkan teknologi microphone. Dari hasil pengujian akurasi yang dilaksanakan di Rumah Sakit Saiful Anwar Kota Malang dapat disimpulkan bahwa ditemukan selisih akurasi Prediksi Nilai Acuan Normal sebesar FEV1 = 0,11 liter; FVC = 0,152432432 liter; FEV1/FVC = 4,742432432 %. Dan selisih akurasi Hasil Pengukuran sebesar FEV1 = -1,545945946 liter; FVC = -2,892432432 liter; FEV1/FVC = 11,52243243 %.Kata Kunci: Penyakit Paru Obstruktif Kronik, Microphone, Smartphone. ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is a disease characterized by air flow resistance in the airway that is not fully reversible. This air flow resistance is progressive and, relating to pulmonary inflammatory response to toxic gases or dangerous particles [2] [16]. The results of the study in January-December 2010 states that COPD ranks 3rd from most existing lung disease Pulmonary Hospital Batu Malang. Meanwhile, in Hospital Dr Saiful Anwar-5 ranks. The Burden Of Disease Study under the auspices of the WHO stated that by 2030 COPD will be ranked as the third leading cause of death in the world [5] [15] [16]. As a solution to these problems is to build an application measuring the health of human lung function utilizing a microphone on a smartphone ". In order to determine pulmonary ventilation disorders, treatment monitoring, and assessing the development of lung function. Media Smartphone Microphone technology chosen because it has an API that is used to capture the input of the user breath sound recordings. And the majority of people have melilikinya. From the results of the validation testing can be concluded that the application of measuring the health of the human lung on a smartphone media successfully implemented by utilizing the microphone. Accuracy of test results conducted at Saiful Anwar Hospital Malang can be concluded that the prediction accuracy differences were found Normal Reference Values for FEV 1 = 0.11 liters; FVC = 0.152432432 liters; FEV 1 / FVC = 4.742432432%. And the difference in the accuracy of measurement results for FEV1 = -1.545945946 liter; FVC = -2.892432432 liter; FEV 1 / FVC = 11.52243243%.Keyword: Chronic Obstructive Pulmonary Disease, Microphone, Smartphone.
Differences in the Expression of miRNA-126 and Interleukin (IL)-13 in Fully Controlled and Not Fully Controlled Asthma Patients Yulia Kartina; Susanthy Djajalaksana; Iin Noor Chozin; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.99

Abstract

Backgrounds: Important finding in the last decades in the field of biology and medicine are micro-RNA (miRNA), including miRNA-126 that are involved in the regulation of interleukin-13 (IL-13) and the T helper 2 cell (Th2) response, the key components of the asthmatic response. The aim of this study is to find the difference in the expression of miRNA-126 and IL-13 serum in fully controlled and not fully controlled groups of stable asthma patients and analyze the relationship between them. Methods: Case-control studies was conducted in 36 stable asthma patients who visited pulmonary outpatient clinic Saiful Anwar Hospital from September 2018 to March 2019. Subjects were divided into 2 groups, each group consisted of 18 fully controlled asthma and 18 not fully controlled asthma patients. The expression of miRNA-126 was measured by the quantitative polymerase chain reaction (q-PCR) and IL-13 using the enzyme-linked immunosorbent assay (ELISA) method. Results: The expression of miRNA-126 was higher in the control group (3.499±2.99) than case group (2.719±2.73), but the difference was not significant (P=0.273). The IL-13 levels were higher in the case group (17.285±9.37) than control group (11.681±5.22), and the difference was significant (P=0.009). However, there was no relationship between the expression of miRNA-126 and IL-13 levels in both groups. Conclusions: There were differences in IL-13 levels, but there were no differences in the expression of miRNA-126 in the two groups. There was no relationship between miRNA-126 expression and IL-13 levels in both groups. (J Respir Indo. 2020; 40(1): 24-32)
Effect of Giving Polyphytopharmaca on Improvement in The Degree of Asthma Control through Reduction of Eosinophils and Interleukin-13 Uncontrolled Asthma Patients Aditya Sri Listyoko; Iin Noor Chozin; Susanthy Djajalaksana
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.109

Abstract

Backgrounds: Bronchial asthma is a heterogeneous disease characterized with chronic airway inflammation. The level of asthma control is an indicator of asthma management outcomes. It is influenced by a complex immunological mechanism, included the role of IL-13 as a key biomarker of inflammation. We investigate the effect of Poly-Phytopharm (Kleinhovia hospita 100 mg, Curcuma xanthorriza 75 mg, Nigella sativa 100 mg and Ophiocephalus striatus 100 mg) on the level of asthma control tests (ACT) score, blood eosinophils, and serum IL-13 on not fully controlled asthma stable patients. Methods: This study used quasi-experimental pre and post test methods, in 15 stable asthma patients who were not fully controlled at the pulmonary outpatient clinic of Dr. Saiful Anwar General Hospital, Malang. Assessment of ACT score, blood eosinophils, and serum IL-13 are carried out before and after supplementation of Poly-Phytopharm three times a day, two capsules respectively for 12 weeks. The ACT was scored by the investigator by direct questioning of patients, the blood eosinophil was measured with blood analysis, and the IL-13 in serum was detected with qPCR method. Results: There is significant increase of ACT score (18.07±2.57 to 22.06±1.83; P=0.001). In subject with baseline eosinophils ≥300 pg/mL (n=9), there were significant reduction in blood eosinophils (653.15±276.77/µL to 460.66±202.04/µL; P=0.038), and a decrease of serum IL-13 (17.69±9.901 pg/ml to 16.17±12.438 pg/ml; P=0.609). Conclusions: The administration of poly-phytopharm for 12 weeks improves ACT level, decreases blood eosinophils, and decrease serum IL-13 on not fully controlled asthma stable patients. (J Respir Indo. 2020; 40(3): 130-8)
Poly-Phytopharm Increases Act Score and Serum miR-126 Relative Expressions, and Decreases Blood Eosinophil Levels in Asthma Patients I Dewa Putu Ardana; Susanthy Djajalaksana; Iin Noor Chozin; Alidha Nur Rakhmani
Jurnal Respirologi Indonesia Vol 39, No 4 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i4.77

Abstract

Background: The levels of asthma control is an indicator of asthma management outcomes. A complex immunological mechanism influences it. We aimed to investigate the effect of Poly-Phytopharm on the asthma control tests (ACT) score, blood eosinophil levels, and miR-126 relative expressions in asthma patients. Methods: Quasi experimental method is used in 15 stable asthma patients who were not fully controlled at the pulmonary outpatient clinic of Dr. Saiful Anwar General Hospital Malang. Assessment of ACT score, blood eosinophil levels, and miR-126 relative expressions are carried out before and after supplementation of Poly-Phytopharm that consist of Nigella sativa 100 mg, Kleinhovia hospita 100 mg, Curcuma xanthorrhiza 75 mg, and Ophiocephalus striatus 100 mg extract, three times a day, two capsules respectively for 12 weeks. The ACT was scored by the investigator by direct questioning of patients, the blood eosinophil level was measured with blood analysis, and the relative expressions of miR-126 was detected with qPCR. Results: There were significant increase of ACT score (18.07±2.57 to 22.06±1.83, P=0.001), decrease in blood eosinophil levels (653.15±276.15 pg/mL to 460.66±202.04 pg/mL, P=0.038), and enhancement of serum miR-126 relative expressions (1.83±1.89 to 5.89±1.34, P=0.038). Conclusion: The administration of Poly-Phytopharm increases ACT score, decreases blood eosinophil levels and increases serum miR-126 relative expressions in not fully controlled stable asthma patients. (J Respir Indo. 2019; 39(4): 231-7)
ANALYSIS OF KNOWLEDGE ON CHRONIC OBSTRUCTIVE LUNG DISEASE Susanthy Djajalaksana; Aditya Sri Listyoko; Maria Kristiani; Tiar Oktavian Effendi; Magdalena Sirait
Journal of Community Health and Preventive Medicine Vol. 2 No. 1 (2022): JOCHAPM Vol. 2 No. 1 2022
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (839.527 KB) | DOI: 10.21776/ub.jochapm.2022.002.01.3

Abstract

ABSTRAKBackground : Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality and disability worldwide and represents a huge economical burden for the healthcare system. By knowing the level of public understanding of this disease, we were able to find out what education could be given to increase understanding about COPD. The aim of this study was to determine the level of knowledge of the non-medical and medical personnel about COPD.Methods : This is descriptive research. The research was conducted cross-sectionally with 200 respondents consisting of 100 medical subjects and 100 non-medical subjects. This research was carried out in the RSSA environment in November 2021. The data collection technique is that respondents filled out a Google Form.Results : The total score of the six categories showed that 73.875% of the medical group and 47.17% of the non-medical group already understood COPD. In all categories, the results of the analysis showing statistical significance (p<0.001).Conclusion : Our study shows significant knowledge about all knowledge of COPD between the general public and medical personnel.Suggestion : socialization to the public about COPD and the importance of the community getting to know COPD in preventive and treatment measures. Keywords: COPD, education, questionnaire 
Co-Authors Aditya Sri Listyoko Harun Al Rasyid I Dewa Putu Ardana Iin Noor Chozin Magdalena Sirait Maria Kristiani Pramukantoro, Eko Sakti Rakhmani, Alidha Nur Tiar Oktavian Effendi Wahyu Teja Kusuma Yulia Kartina