Mohamad Nur Ibrahim
Jurusan Perikanan FPIK Universitas Haluoleo Kendari

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Mastosit Perivaskuler Berperan Sebagai Vasodilator Pembuluh Darah pada Mesenterium Tikus Ibrahim, Mohamad Nur; Soleh, Miftahu; Widjajanto, Edi
Jurnal Kedokteran Brawijaya Vol 25, No 3 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1004.696 KB) | DOI: 10.21776/ub.jkb.2009.025.03.8

Abstract

Mastocyt  degranulated  can  cause  vasodilatation  of  blood  vessels,  but  it  is  unclear  whether  there  is  a relationship  between the  number of mastocyt with a diameter of blood vessels. This study aims to  determine the  relationship  between the  number of mastocyt pherivascular and diameter of blood vessels.  This research is  in  vivo  exploratory  research  in    Wistar  rat  mesentery which was sensitated  with ovalbumin.  The  diameter  of blood  vessels  at  mesentery  preparate  were  measured  microscopically  using  a  micrometer  scale  standards.  At large  diameter  of  blood  vessels   (2.860  ±  0.348),  the  number  of  mastocyt was 12.3  ±  2.3.  At  medium diameter of blood vessel (1.276 ± 0.198), the  number of mastocyt was 4.4 ± 0.5. Blood vessels with small diameter (0.961 ± 0.043), the  number of mastocyt was 3.5 ± 1.3. Calculations area on the  microscope visual field  was divided into  four  areas (counting area), there  were zone 1, zone 2, zone 3 and zone 4. Statistical analysis showed  that  the  correlation  between  the  number  of  mastocyt  at   zone  1  and  the  diameter  of  blood  vessels  was 0,904 at 1% significance level.  Similar to  that  at zone 2 (r=0,892),  zone 3 and zone 4 (r=0,940).  We conclude there  was  a  significant  relationship  between  the  number  of  mastocyt  and  the  diameter  of  blood  vessels. Keywords:  mastocyt  pherivascular,  diameter  of  blood  vessels
Karboksimetil Kitosan Menurunkan Degranulasi Mast Cell yang Diinduksi Oleh Ovalbumin Ibrahim, Mohamad Nur; Widjajanto, Edi; Permatasari, Nur; Sabarudin, Akhmad
Jurnal Kedokteran Brawijaya Vol 25, No 1 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.792 KB) | DOI: 10.21776/ub.jkb.2009.025.01.2

Abstract

ABSTRACTOvalbumin is known as mast cell degranulating agent through the FCεRI aggregation. Carboxymethylchitosan (CMCs), a biocompatible cationic polymer was evaluated to reduces mast cell degranulation inducedby ovalbumin. In this experiment, wistar rats were darboxymethyl chitosanivided into 5 groups which consist of 1 control group and 4allergen groups. Among the allergen groups, 3 groups were treated with carboxymethyl chitosan/CMCs(doses : 0,25 mg, 0,50 mg and 1,00 mg) for 22 days. The result showed a significant (P<0,01) reduction inmast cell degranulation in allergen groups. This finding indicate that CMCs possesses antiinflammationactivity mediated by reducing of mast cell degranulation.Keywords : ,c mast cell degranulation