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Aziza Icksan
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Health Professions Medicine & Pharmacology

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Journal : Medical%20Journal%20of%20Indonesia

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The accuracy of Aziza’s scoring system in limited slice non-enhanced thoracic CT for the diagnosis of adult pulmonary tuberculosis Icksan, Aziza; Faisal, Arif; Syahruddin, Elisna
Medical Journal of Indonesia Vol 26, No 1 (2017): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (468.852 KB) | DOI: 10.13181/mji.v26i1.1432

Abstract

Background: Tuberculosis (TB) is still a major cause of morbidity and mortality in Indonesia. Thus, a fast and accurate method in diagnosing pulmonary TB (PTB) is needed, especially in adult smear-negative-TB cases. The purpose of this study was to determine the accuracy of a novel scoring system (Aziza’s score) using clinical data and characteristic abnormalities that are found in the limited slice non-enhanced thoracic CT.Methods: This was a prospective cross-sectional study. A limited slice non-enhanced thoracic CT was performed to establish a diagnosis of PTB in patients with suspected PTB and to assess the diagnostic value of the scoring system. A reference standard used in this study was the clinical expertise of two pulmonologists. The scoring system was analyzed using bivariate and multivariate Cox regression analysis.Results: 84 of 130 suspected PTB patients were diagnosed as PTB. They were diagnosed based on pulmonary characteristic abnormalities that were found in the limited slice non-enhanced thoracic CT. The scoring system was analyzed using bivariate and multivariate Cox regression analysis. The total scores which were equal to or more than 29 could diagnose PTB with the accuracy of 96.1% (95% CIs=91.3–98.3), sensitivity of 96.5% (95% CIs=90.1–98.8), and specificity of 95.6% (95% CIs=90.1–98.8), This novel scoring method was name as an Aziza’s scoring system.Conclusion: Aziza’s scoring system performed in the limited slice non-enhanced thoracic CT has a higher accuracy compared to the reference standard for the diagnosis of adult PTB.
Co-Authors Agung Wibawanto Ahmad Hudoyo Dian Atmaja, Dian Dian Yulianti Elisna -, Elisna Elisna Syahruddiin, Elisna Elisna Syahruddin Elisna Syahrudin, Elisna Faisal - Faisal, Arif Frans -, Frans Heriawati -, Heriawati Heriawati Hidayat Heriawaty Hidajat, Heriawaty Heriawaty Hidayat, Heriawaty Joedo Prihartono Maryastuti -, Maryastuti Pudjo Astowo, Pudjo Reny Luhur, Reny Ruth E Sembiring, Ruth E Ruth E.S. -, Ruth E.S. Sutjahjo Endarjo, Sutjahjo