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EFEKTIVITAS EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL TIKUS PUTIH JANTAN (Rattus norvegicus L.) YANG DIINDUKSI PAKAN TINGGI LEMAK Cornelia Ayu Putri; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 1 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.72 KB)

Abstract

Muntingia calabura L. leaves contains saponin and flavonoid that can reduce blood cholesterol levels. This study aimed to examine the effect and the effective dose of M. calabura L. leaves extract to decrease total cholesterol levels of white rats induced by high-fat diet. Extract was found by using ethanol 96% in maseration method. Before doing a different treatment , all the subjects were given a high-fat meal for 14 days to increase the blood total cholesterol levels. The subject were twenty five rats divided into 5 groups as follow: negative control (0.5% Na-CMC), positive control (Simvastatin 1.8 mg/200 g BW), ethanol M. calabura L. leaves extract in various concentration (50; 100; 150 mg/kg BW). All rats were given a different oral treatment for 14 days. Rats blood was taken to measure total cholesterol levels by using Nesco Multicheck Tester on the 7th day after acclimatization, the 14th day after high-fat food induced, and the 7th and 14th day after treatments. The data was analized using non parametric Kruskal Wallis and Mann Whitney statistical test at α = 0.05. The results showed that the ethanol extract of M. calabura L. leaves have an effect to decrease blood total cholesterol levels and the most effective dose to decrease total cholesterol levels were 50 mg/kg BW.
Gastroprotective Effect of Ethanol Stem Bark Extract of Pepolo (Bischofia javanica Blume) Against Aspirin-Induced in Wistar Rat Yuliet Susanto; Rini Saputri; Khildah Khaerati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.35452

Abstract

Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can trigger ulcers and bleed in the gastric mucosa. Pepolo stem bark (Bischofia javanica Blume) was a traditional plant that has been empirically used to treat gastric ulcers. This plant contains secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and triterpenoids with gastroprotective potential. This study aims to determine the gastroprotective effect of pepolo stem bark extract (PSBE) against gastric ulcers of Wistar rat induced by Aspirin. The study used 24 rats grouped into six groups. Aspirin (150 mg/kg BW) was administered orally to all the groups except normal control. After 4 h of induction, normal and negative control received Na CMC 0.5%, while the positive group received Omeprazole (3.6 mg/kg BW). The remaining low, middle, and high dose groups received PSBE (100, 200, and 300 mg/kg BW). The treatment was given orally for eight days. On the 9th day, the rats were dissected and tested on the stomach organs. The parameters measured were scores based on the severity of rat peptic ulcers, ulceration index, and percentage protection ratio. The scoring data were analyzed using the Kruskal-Wallis non-parametric test and post hoc the Mann-Whitney test. The administration of PSBE showed the ability to reduce the ulcer index and increase the percentage of ulcer inhibition significantly compared to the negative control (p<0.05). This study showed that PSBE could be a promising gastroprotective herbal medicine.Key words: Aspirin, pepolo stem bark, gastric ulcer
TERATOGENIK EKSTRAK ETANOL UWI BANGGAI UNGU (Dioscorea alata L.) PADA MENCIT BETINA (Mus musculus) Ihwan Ihwan; Rahmatia Rahmatia; Khildah Khaerati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.37 KB) | DOI: 10.36387/jiis.v5i2.511

Abstract

Teratogenic is an abnormal development on embryo and is the cause of congenital defect or birth defect. This study aims to determine the effect of the addition of Dioscorea alata L. ethanol extracts to the embryo development on pregnant mice whose given orally to 24 mice which divided to 4 treatment groups, they are the normal group (NG) with NaCMC 0.5%; 28 mg/KgBB treatment group; 35 mg/KgBB; 42 mg/Kg BB. The addition of Dioscorea alata L ethanol extracts was done on the sixth day until the 15th day of pregnancy. On the 18th day of pregnancy, Laparaktomi was done to the pregnant mice and the embryo was taken out of the uterus. The observation was done to the fetus numbers, weight weighing of the fetus's body, dan length measurement of the fetus's body. Another observation is the observation of the external organ defect of the embryo. The study results that the addition of Dioscorea alata L ethanol extracts with various doses have no significant effect (P>0.5) to the mice external fetus development. On the examination of the fetus, we can conclude that Dioscorea alata L ethanol extracts don’t give any effect that may cause the defect of the fetus’ external organ.
Uji Efek Antibakteri Ekstrak Etanol Herba Seledri (Apium graveolens Linn.) Terhadap Escherichia coli dan Staphylococcus aureus dan Analisis KLT Bioautografi Khildah Khaerati; Ihwan Ihwan
Biocelebes Vol. 5 No. 1 (2011)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

This research divided into two stage which are the inhibition growth capacity test using agar diffusion method with the incubator period 1 x 24 jam hours as the first stage and second stage testing the TLC-Bioautographic. Sample made with the concentration 0,5%, 1 %, 2% and 4% w/v. The capacity of growth inhibited showed on Staphylococcus aureus and than. The TLC-Bioautographic test to the chromatogram of fractionation result with Chloroform : Metanol (15 : 6) on Escherichia coli 1 active stains with Rf value 0,32, for Staphylococcus aureus resulted 2 active stains with Rf value in a row 0,88 and 0,32 Key words: Antibacteri, Apium graveolens, bioautographic.