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Psychoneuroimmunology Aspects of COVID-19 Pandemic Yuliana Yuliana
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.491 KB) | DOI: 10.36408/mhjcm.v7i1A.456

Abstract

BACKGROUND: In December 2019 the world was struck by an outbreak of a disease in China which is now referred to as Coronavirus disease (COVID-19). COVID-19 disease is a viral infection caused by SARS-CoV-2. This disease has spread very quickly throughout the world, causing significant social and economic impacts. Now this incident is called a pandemic. There are many controversial theories up till now, especially about psychoneuroimmunology aspects. Symptoms caused by this disease vary greatly from the main attack of the respiratory system to neuro immunity system. Immune response is the key factor to invasion of this virus into the human body. OBJECTIVE: The aim of this paper is providing comprehensive understanding regarding psychoneuroimmunology aspects of COVID-19 infection in those variable symptoms. DISCUSSION: Neurological symptoms might start from anosmia, loss of taste (ageusia), delirium, encephalitis, Guillain-Barre syndrome, and stroke. Behavior might be affected with specific symptom such as depression and psychosis. Neuropsychiatric sequelae had been found in past viral pandemics. CONCLUSION: Psychoneuroimmunology aspects will determine the variability of symptoms of each patient. Comprehensive understanding of psychoneuroimmunology perspective will aid in promoting post-pandemic public mental health in order to handle COVID-19 properly and minimize socio-economic impacts.
Peran relaksasi otot progresif untuk penurunan kadar glukosa darah Yuliana Yuliana
Prosiding Seminar Biologi Vol 7 No 1 (2021): PROSIDING BIOLOGI ACHIEVING THE SUSTAINABLE DEVELOPMENT GOALS WITH BIODIVERSITY I
Publisher : Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/psb.v7i1.24701

Abstract

Diabetes melitus merupakan penyakit yang sering dijumpai di Indonesia. Berbagai penelitian dilakukan untuk mencari obat yang tepat bagi penyakit ini. Kombinasi terapi obat-obatan dengan perubahan gaya hidup dan relaksasi otot progresif akan memberikan hasil yang lebih baik jika dibandingkan hanya dengan obat-obatan saja. Namun, teknik relaksasi otot progresif ini belum diketahui secara luas. Tujuan penulisan paper adalah menjelaskan bagaimana relaksasi otot progresif untuk menurunkan kadar glukosa darah. Metode yang digunakan adalah narrative literature review. Artikel didapatkan dari database Science Direct, PubMed, dan Google Scholar. Kriteria inklusi adalah artikel tinjauan pustaka dan penelitian. Kriteria eksklusi adalah tidak terdapatnya artikel lengkap dan belum dilakukan penilaian sejawat. Hasil telaah pustaka menunjukkan bahwa relaksasi otot progresif dapat menurunkan kadar glukosa darah pada sebagian pasien. Teknik untuk melakukan relaksasi otot progresif dengan cara melakukan perubahan kontraksi dan relaksasi secara bergantian dan bertahap pada otot. Teknik ini dapat memperbaiki kesehatan fisik dan mental. Aksis glukosa dari hipotalamus, pituitari, adrenal, dan sistem saraf simpatis mengalami perubahan. Kedua aksis tersebut bereaksi terhadap perubahan fisik atau psikologis, sehingga menyebabkan penurunan kadar glukosa darah. Kesimpulan: Teknik relaksasi otot progresif dapat menurunkan kadar glukosa darah jika dikombinasi dengan terapi farmakologi dan perubahan gaya hidup. Teknik ini dapat dilakukan dengan kontraksi serta relaksasi secara bergantian pada otot dengan tujuan untuk mengatur akses hipotalamus, pituitari, dan adrenal.
PREVALENSI DAN DERAJAT NYERI LEHER AKIBAT PENGGUNAAN TELEPON GENGGAM PADA MAHASISWA PSSKPD FK UNUD BERUMUR 18-23 TAHUN Agus Indra Yudhistira Diva Putra; I Nyoman Gede Wardana; . Yuliana; . Muliani
E-Jurnal Medika Udayana Vol 10 No 10 (2021): Vol 10 No 10(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i10.P03

Abstract

Latar Belakang: Nyeri leher merupakan persepsi sakit yang melibatkan regio servicalis meliputi struktur tulang belakang berupa diskus invertebralis, ligamentum, otot, facet joint dan sistem nervus yang disebabkan oleh trauma repetitif dan akumulatif dari penggunaan leher yang berlebihan. Salah satu pencetus trauma tersebut adalah penggunaan telepon genggam berlebihan. Global Burden Disease menyatakan nyeri leher merupakan salah satu masalah muskuloskeletal keempat yang menyebabkan penderitaan hidup akibat disabilitas Tujuan: Studi ini bertujuan untuk mengetahui prevalensi derajat nyeri leher akibat telepon genggam dan hubungan variabel berupa jenis kelamin, usia, durasi, frekuensi, tingkat angkatan, dan posisi menggunakan telepon genggam pada mahasiswa PSSKPD FK UNUD 18-23 tahun. Metode: Studi ini menggunakan rancangan studi analitik crossectional. Sampel terdiri dari 194 orang berdasarkan kriteria inklusi dan eksklusi. Sampel mengisi kuesioner demografi dan kuesioner NDI yang disebarkan secara daring. Analisa data menggunakan uji chi-square, fishers exact, dan pearson correlation yang dianalisissoftware SPSS 22. Hasil: Mayoritas mahasiswa mengalami derajat nyeri leher ringan akibat telepon genggam (93.3%) dan derajat nyeri leher berat (6.7%). Hasil uji statistik didapatkan terdapat hubungan signifikan antara jenis kelamin (p=0.03) dengan nyeri leher akibat telepon genggam (p<0.05). kata kunci: derajat nyeri leher, mahasiswa kedokteran, telepon genggam
Penurunan Kadar Glukosa Darah dan Hitung Sel Kupffer Tikus Hiperglikemik Setelah Pemberian Dekok Daun Salam (INDONESIAN BAY LEAF DECOCTION COULD LOWER FASTING BLOOD GLUCOSE LEVEL ON HYPERGLYCEMIC RATS AND LOWER KUPFFER CELL COUNT) Yuliana .; Tangking Widarsa
Jurnal Veteriner Vol 15 No 4 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.101 KB)

Abstract

Diabetes mellitus (DM) is a metabolic syndrome due to pancreas failure to produce insulin, thereforehyperglycemia is the hallmark of DM. There is hyperglycemia in this disease. In the world, there isaround143 million diabetes mellitus patients. One of the deathcause in diabetes mellitus is chronic liver disease.Herbal medicine is thought to give less side effect than sintetic medicine. A traditional plant that hashypoglicemia property is decoction of Indonesian bay leaves. This study was aimed to study effectivity ofIndonesian bay leaf decoction in decreasing blood glucose level, pancreas and liver hemorrhage scores, andKupffer cell count on alloxan-induced Wistar rats. This Control Group Design used twenty four rats (threemonth old). The rats were divided randomly into four groups, i.e.: control, 1 mL of Indonesian bay leafdecoction (0.9 g/kg body weight (BW)), 2 mL of Indonesian bay leaf decoction (1.8 g/kg BW), and 3 mL ofIndonesian bay leaf decoction (2.7 g /kg BW). After one week adaptation the rats were inducedwithalloxan,then pretest for fasting blood glucose test was examined. Treatment was given for ten days and posttestblood glucose test was done afterwards. At the end of the experiment, all rats were sacrificed to collectpancreas, kidney, and liver. Those organs were stained with hematoxylin eosin. Levelof fasting bloodglucose, hemorrhage score, on pancreas and kidney and Kupffer cell count were analyzed by using Anova.In conclusion, Indonesian bay leaf decoction may lower fasting blood glucose level on hyperglycemic rats aswell as Kupffer cell count significantly, but it is not likely to give significant result in lowering of pancreasand kidney hemorrhage scores.
Penurunan Osteoclast Epifysis Tulang Radius Mencit Perimenopause dengan Pemberian Estrogen dan Berenang (OSTEOCLAST COUNT DECREASING ON EPIPHYSIS PART OF RADIUS IN PERIMENOPAUSAL MICE ON ESTROGEN AND SWIMMING TREATMENT) Yuliana .; Ida Ayu Dewi Wiryanthini; Nyoman Mangku Karmaya; Tangking Widarsa
Jurnal Veteriner Vol 13 No 4 (2012)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.731 KB)

Abstract

Increasing of life age expectancy has risen many health problem. One of the problem is osteoporosis.This disease can be prevented by estrogen and swimming treatment. Estrogen is not safe to be given inlong term. This study aim was to investigate the decreasing of osteoclast count in estrogen and swimmingtreatment. This study uded Pretest-Posttest Control Group Design with fifty two mice (15-16 months old).The mice were divided randomly into 4 groups, i.e. control, estrogen, swimming and combination group.After 90 days treatment, epiphysis of radius bone was sectioned and stained by haematoxyllin eosin.Osteoclast difference between groups were analyzed by using analysis of variance. Mean of osteoclast incontrol group was 0.12±0.1, and three other groups had the same level, i.e. 0,02±0,06. In conclusion, thedecrease of osteoclast count did not have any significant difference between treatment groups.
Pemberian Ekstrak Methanol Daun Paliasa Menurunkan Kadar Glukosa Darah Tikus Hiperglikemik (METHANOL EXTRACT OF PALIASA LEAVES DECREASES BLOOD GLUCOSE LEVEL HYPERGLYCEMIC RATS ) Yuliana .; Tangking Widarsa; Gede Wiranatha
Jurnal Veteriner Vol 14 No 4 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.18 KB)

Abstract

Diabetes melitus is a disease that often encountered by Indonesian people. It can cause microvascular andmacrovascular complication. Traditional herbal medicine such as paliasa (Kleinhovia hospita L.) leavesextract can decrease blood glucose. This study was aimed to identify the effectiveness of extract paliasaleaves on blood glucose decreasing for aloxan induced Wistar mice. This Control Group Design used twentyeight mice (three months old). The mice were divided randomly into four groups, i.e. control, paliasa250mg/kg body weight (BW), 500 mg/kg BW, and 750 mg/kg BW. After one week adaptation and induced byalloxan, pretest fasting blood glucose test was done. Treatment was given for two weeks and posttest bloodglucose test was done afterwards. The decrease of fasting blood glucose level was analyzed by usinganalysis of varians. Result showed there was significantly higher level of blood glucose decrease in micewith paliasa extract dose of 750mg/kgBB. Mean level of blood glucose decrease on control group was2.9±0.17, paliasa group with dose 250mg/kgBB was 29.28±1.15, paliasa 500 mg/kgBB was 46.7±2.1, danpaliasa 750mg/kgBB was 74.8±1.88.  In conclusion, extract paliasa treatment can decrease fasting bloodglucose level on hyperglycemic rats.
Dynamic myelin regulation as a novel form of neural plasticity . Yuliana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 1 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.696 KB) | DOI: 10.19106/JMedSci005301202107

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Dynamic changes in myelin could optimize information transmission in neuralcircuits and enhance conduction velocity. This review aimed to provide anunderstanding of how dynamic myelin plasticity is important in neuronalactivity and how astrocytes have an important role that is not equal in theperipheral nervous system. Myelin is dynamically regulated by neuronalactivity. It takes part continuously in nervous system plasticity duringdevelopment. Newly differentiating oligodendrocytes can create a new myelinsheath. Mature myelin sheaths can grow again in adults. Oligodendrocytesinteract with astrocytes in the central nervous system through gap junctions.Astrocytes have an important role as synaptic network integrators; therefore,decreasing astrocyte numbers will cause a loss of presynaptic plasticity. Theconcept considers plasticity as a mechanism that depends on myelination.Higher brain functions and myelination interplay in the hippocampus andprefrontal cortex. The mechanism and function of these changes remainpoorly understood. Genetic, neural activity, environment, and axonal activitymight play important roles. Dynamic myelin regulation reveals a new form ofneural plasticity. Myelination is similar to synapse formation and plasticity. Itenables plasticity in the central nervous system and helps improve the learningprocess.
Controversy of angiotensin receptor blockers (ARBs) and angiotensin converting enzymeinhibitors (ACEIs) prescription for hypertension patients in coronavirus disease 2019 (COVID-19) pandemic Yuliana Yuliana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 3 (2020): Special Issue: COVID-19
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.251 KB) | DOI: 10.19106/JMedSciSI005203202006

Abstract

Coronavirus disease 2019 (COVID-19) pandemic has made all the world in a mess. Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 infects human cells through angiotensin-converting enzyme 2 receptors (ACE receptors). Angiotensin-converting enzyme 2 (ACE) is upregulated in diabetes and cardiovascular diseases including hypertension. Hypertension patients commonly consume angiotensin receptor blockers (ARBs) and/or angiotensin-converting enzyme inhibitors (ACEIs) which could increase ACE receptors. It was suspected that the ARBs or ACEIs administration may worsen the clinical outcome for the hypertension patients with COVID-19. However, no clinical trial had significantly revealed how appropriate management and prescription of ARBs and ACEIs for the hypertension patients with COVID-19. The use of ARBs and ACEIs for these patients is still controversy. Studies concerning the side effect of single or combination use of ARBs and ACEIs in the hypertension patients with COVID-19 as well as specific morbidity and mortality are needed. This review was aimed to provide understanding concerning the appropriate management and prescription of ARBs and ACEIs for hypertension patients with COVID-19.
Challenges In Telemedicine Implementation For Pregnancy Care During The Covid-19 Pandemic Yuliana Yuliana
(JKG) Jurnal Keperawatan Global Vol 5 No 2 (2020): JKG (JURNAL KEPERAWATAN GLOBAL)
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jkg.v5i2.156

Abstract

Background: COVID-19 pandemic condition made the consultation shifted from face to face consultation to telemedicine for mild, stable, and follow up cases. In stabile condition of pregnant patients, telemedicine implementation will be beneficial to reduce the COVID-19 transmission risk. The problems are not all patients can implement telemedicine and the reimbursement procedure was hard. The aim of this paper is to describe about challenges in telemedicine implementation for pregnancy care during the COVID-19 pandemic. Methods: this paper is a literature review, Literature was identified from the archives of PubMed, Scopus, and Elsevier. All the literature was published in 2020. The inclusion criteria were the literature should be peer-reviewed and related to the topic of the paper. Keywords were challenges, COVID-19, opportunities, pregnancy, and telemedicine. Results: from 18 articles in this literature review, it was found that challenges in telemedicine are reimbursement, infrastructure, confidentiality, and unfamiliarity for the pregnant patients. Conclusion: Telemedicine can be used for pregnant patient control consultation during the stable condition to minimize the risk of COVID-19 transmission. The implication of this paper is to give insight that telemedicine can be done for stable pregnancy condition to reduce the risk of COVID-19 transmission during the pandemic. The benefits of reducing COVID-19 risk transmission for baby and mother outweigh the challenges and problems such as reimbursement, confidentiality, and technical issues.
Phytochemical Content and Protective Effect of Kleinhovia hospital Leaves Extract on Pancreatic Cytotoxicity in Hyperglycemic Rats Yuliana Yuliana; Sianny Herawati
Jurnal Veteriner Vol 17 No 3 (2016)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.008 KB)

Abstract

Diabetes mellitus is a wide problem nowadays. Many traditional plants are used to overcome thecomplication of this disease. One of them is paliasa (Kleinhovia hospital Linn) leaves. This study aimswere to investigate phytochemical contents and the protective effects of paliasa leaves extract on pancreaticcytotoxicitybased on microscopic lesion such as hemorrhagic score and necrotic appearances, in alloxaninducedhyperglycemic rats. Male Wistar rats (three months old) were divided into four groups consistedofseven rats each. Group I was diabetic control, Group II was diabetic groups, paliasa extract (300mg/kgBW) were given by sonde for a period of 14 days prior to alloxan injection (150 mg/kg intraperitoneal).Group III was diabetic rats given 600 mg/kg BW paliasa extract and group IV was diabetic rats given 900mg for 14 days. At the end of the study, rats were sacrificed. Tissue sample ofpancreaswas then processedfor slide preparation and was stain with hematoxylin eosin.Pancreas hemorrhagic score was divided intofour criteria, focal(score 1), multifocal (score 2), extensive (score 3), and difuse (most severe, score 4).Microscopic examination was done using binocular microscope, at Laboratory ofVeterinaryPathology,Disease Investigation Centre Denpasar, Bali. Data werethenanalyzed by using analysis ofvarians. Study showed that paliasa extract could lower hemorrhagic score on pancreas of diabetic rats,even though it was not significant compared to control group (p 0,205). Phytochemical analysis showedthat paliasa leaves extract contained alkaloid, terpenoid, and flavonoid. Necrotic appearances were variedfrom pycnosis, karyorheksis, karyolysis, and vacuolization. In conclusion, paliasa leave extract may haveprotective effect on pancreas cytotoxicity.