Article Per Year (5 Year)
p-Index From 2018 - 2023
1.347
P-Index
This Author published in this journals
All Journal KALAM CENDEKIA PGSD KEBUMEN Jurnal Penelitian Fisika dan Aplikasinya (JPFA) Jurnal Pengajaran MIPA Jurnal Teknik Elektro Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam Telaah Health Notions Jurnal Notariil Makara Journal of Science
Isnaeni Isnaeni
Universitas Negeri Semarang
Astronomy Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Health Notions

 1 
Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model Anti-Inflammatory Drug Isnaeni, Isnaeni; Hendradi, Esti; Mahmudah, Rifaatul
Health Notions Vol 2 No 9 (2018): September 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freeze-drying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content.
Co-Authors Achmad Basori, Achmad Ali Imran Budi Utomo Dahlang Tahir Eddy Bagus Wasito Esti Hendradi Hakimi, Ahmad Reza Kartuti Debora, Kartuti Lestari, Ismira Wahyu Mahmudah, Rifaatul Maria Margaretha Suliyanti Mulyawan, Reynaldi Gilang Nurhasanah, Wahidatun Dewi Rippi Maya Sambudi, Nonny Soraya Shiddiq, Muhandis Siti Fatimah Sutarno Sutarno Tejo Faridh Waloyo