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All Journal Jurnal Ilmiah Akuntansi dan Bisnis Paediatrica Indonesiana Jurnal Teknologi Hasil Pertanian Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Riset Teknologi Pencegahan Pencemaran Industri BKM Public Health and Community Medicine

Sutaryo Sutaryo

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Author-ID : 2929278

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Energy Engineering Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Determinan Efektivitas Audit Internal di Inspektorat Provinsi Jawa Timur Sutaryo Sutaryo
Jurnal Ilmiah Akuntansi dan Bisnis Vol 13 No 1 (2018)
Publisher : Fakultas Ekonomi dan Bisnis, Universitas Udayana bekerjasama dengan Ikatan Sarjana Ekonomi Cabang Bali

This effectiveness of internal audit conducted by the Local Government Inspectorate of East Java Province. The purpose of the research conducted is to obtain empirical evidence on the factors that affect the effectiveness of internal audits conducted by the Local Government Inspectorate. The data used in this study comes from questionnaires obtained from 159 respondents. This study, the dependent variable used is the effectiveness of internal audit, while the independent variables used are professional expertise, quality of audit work, career and promotion, support from leadership, and scope of internal audit work. Based on the results of the research note that the quality of audit work, support from the leadership and the scope of internal audit work has a significant influence on the effectiveness of internal audit, while professional and career skills and promotion have no effect on the effectiveness of internal audit in the Local Government Inspectorate of East Java Province. Keywords: Effectiveness of internal audit, professional expertise, quality of audit work, support from leadership, and scope of internal audit work.

Circumcision in boys with mild Hemophilia A â€“ the Yogyakarta experience Pudjo Hagung Widjajanto; Ridwan Tjandra Sugiarto; Sutaryo Sutaryo; Kaiser Ali
Paediatrica Indonesiana Vol 47 No 2 (2007): March 2007
Publisher : Indonesian Pediatric Society

Background In boys with hemophilia, there is a risk ofhemorrhage resulting from circumcision. There has been nostandardised management in Indonesia. We report our experiencewith 4 hemophiliac boys who underwent circumcision at Dr.Sardjito General Hospital, Yogyakarta, in south-central Java.Objective To develop a safe, practical and accessible method toprevent bleeding in boys with hemophilia undergoing circumcisionin Indonesia.Methods Written informed consent was obtained from parentsrequesting the procedure. All boys had mild Hemophilia A (VIII:C level >7.8 U/ml) diagnosed at a median age of 4.4 years (range0.75â€“9 years). Median age at time of circumcision was 7.5 years(range 0.8â€“12 years).Results There were no intraoperative or post-circumcisionbleeding problem encountered in any of the patients, who weredischarged from hospital three days post-surgery. On follow upeight days and 12 days post-circumcision, they remained free ofcomplications.Conclusion Circumcision can be safely performed in boys withmild Hemophilia A following adequate pre-operative planningand prophylactic therapy. A standardised protocol for theYogyakarta Bleeding Disorders Program. evolving from thisexperience, is being planned.

Early detection of anemia among school children using the World Health Organization Hemoglobin Color Scale 2006 Desy Rusmawatiningtyas; Dwikisworo Setyowireni; Sri Mulatsih; Sutaryo Sutaryo
Paediatrica Indonesiana Vol 49 No 3 (2009): May 2009
Publisher : Indonesian Pediatric Society

Background The high prevalence of anemic children in Indonesiais caused by the high incidence of diseases caused by parasiticinfection such as malaria as well as iron deficiency. Early detectionis needed for early intervention in order to allow optimal growthand development. A simple, economic, and practical tool forearly detection of anaemic children is needed. The WHOrecommended a Hemoglobin Color Scale as a suitable tool forthe detection of anemia.Objective To assess the sensitivity, specificity, and predictivevalues of the WHO Hemoglobin Color Scale for early detectionof anemic children.Methods A cross sectional diagnostic test was conducted inelementary school age children. Samples consisting of two drops ofvenous blood on paper were assessed by two observers (pediatrician& paramedic) using the Hemoglobin Color Scale to visuallydetermine the level of hemoglobin. In addition, the hemoglobinlevel was also measured using a Hematology Analyzer to allow thevisual test results to be compared to the results obtained using thegold standard of analysis. Agreement between these two methodsof analysis was examined using the Cohen's kappa.Results Hemoglobin levels < 11.5 g/dL were detected in 15 of124 (12%) elementary school children. The sensitivity, specificity,positive and negative predictive values when using the HemoglobinColor Scale were 93%, 100%, 100% and 99% respectively for thefirst observer and 100%,99%,93%, and 100% respectively for thesecond observer. The Cohen's Kappa value was 0. 76.Conclusion The WHO Hemoglobin Color Scale 2006 couldbe used as an early detection method for anemia in children.

Translocation ETS leukemia-acute myeloid leukemia 1 (TEL-AML1) gene fusion in childhood acute lymphoblastic leukemia Sri Mulatsih; Yeow Liang; Allen Yeoh; Sutaryo Sutaryo; Sunarto Sunarto
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Background Acute lymphoblastic leukemia (ALL) in childrenis a heterogeneous disease with different subtypes based on their cellular and molecular characteristics. This condition wouldinfluence the treatment outcome and subsequent risk for relapse. Accurate assignment of individual patients to risk groups is a critical issue for better outcome. TEL-AML1 gene fusion is themost frequent in childhood ALL.Objective The aim of this study was to investigate the incidenceofTEL-AML1 children with ALL in Sardjito Hospital.Methods This was a cross sectional study. In this preliminarystudy, we used nested reverse-transcriptase polymerase chainreaction (RT-PCR) to analyze the present of TEL-AML1 genefusion in bone marrow sample of childhood ALL patients.Results We analyzed 41 samples. Out of these, 30 (73%) wereamplified. Twenry three out of 30 ALL patients with good medicalrecord were analyzed for this gene fusion. Out of 30 patients, there were five patients (17%) with TEL-AML1-positive gene fusion and 25 (83%) were TEL-AML1-negative. Among five patients with TEL-AML1-positive gene fusion, four patients (80%) were one year to less than 10 year old. All of the patients (100%) were with leukocyte < 50x109/L.Conclusions TEL-AML1 gene fusion was found in 17 % ofsamples. This gene fusion was more frequent in standard risk group (based on age and leukocyte). These data must be clarified with more samples. RT-PCR must be apply in all center as one part of improving diagnostic quality, especially in managing leukemia patients.

Intestinal obstruction mimicking intra-abdominal hemorrhage in a teenager with familial thrombocytopenia: a case report Sutaryo Sutaryo; Kaiser Ali; Untung Widodo; Nunik Agustriyani; Edy Moeljono; Mark Belletrutti
Paediatrica Indonesiana Vol 43 No 3 (2003): May 2003
Publisher : Indonesian Pediatric Society

Inherited bleeding disorders are a heterogeneousgroup of disease that is complicated byhemorrhagic episodes, spontaneous, and post-traumatic. Included in this category of conditionsare Familial Thrombocytopenias (FT). FT are aheterogeneous group of inherited disorders that varyin severity with regard to the degree of reduction inplatelet counts and in expression of bleedingmanifestations. As in acquired thrombocytopenias, FTpatients are at risk for hemorrhagic complications.Rarely, patients with inherited non-thrombocytopeniableeding disorders can develop complications of acuteabdomen 1,2 which present as intraabdominalhemorrhage. We report a case of intestinal obstructionmimicking an uncomplicated intraabdominalhemorrhage in a teenager with FT.

High frequency of the 3R/3R polymorphism in the thymidylate synthase enhancer region in Indonesian childhood acute lymphoblastic leukemia IDG Ugrasena; Sutaryo Sutaryo; Edy Supriadi; Laura Vroling; Jacqueline Cloos; Jan Hendrik Hooijberg; AJP Veerman
Paediatrica Indonesiana Vol 46 No 3 (2006): May 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.3.2006.103-12

Background Deoxyuridylate monophosphate (dTMP) is neces-sary for DNA synthesis and thymidylate synthase (TS) is an im-portant target of cancer chemotherapy. Ethnic variations of thepolymorphic tandem repeat sequence in the enhancer region ofthe TS promoter has previously been described to influence theoutcome of acute lymphoblastic leukemia (ALL). A triple repeat isassociated with a higher TS gene expression than a double re-peat, resulting in poorer outcome of ALL patients treated with anti-folate methotrexate (MTX).Objective In this study, we determined the incidences of TS andmethylenetetrahydrofolate reductase (MTHFR) polymorphism andethnic variations between Indonesian and Caucasian ALL cellsamples obtained at diagnosis. Furthermore, we determined theinvolvement of TS polymorphisms in MTX sensitivity using athymidilate synthase inhibition assay (TSIA).Methods ALL cell samples were obtained at diagnosis from 101Indonesian and 157 Caucasian children treated with MTX prospec-tively. Genotyping for TS and MTHFR was analyzed by Genescanand Lightcycler. TS polymorphism was determined by PCR assayand MTHFR polymorphism and was analyzed by melting curveanalyses on lightcycler.Results Homozygous TS triple repeats were more than twice ascommon in Indonesian samples (76.3%) than in Caucasian samples(33.1%). Heterozygotes of the MTHFR mutations were seen in 15%of the screened Indonesian samples.Conclusion There are significant ethnic variations in TS generegulatory elements of leukemic cells. A difference was found be-tween the MTX sensitivity and a double or triple repeat in the Cau-casian ALL group. The samples with a triple repeat show a shift intheir distribution towards hypersensitivity to MTX. Further investi-gation on Indonesian samples may give insight in the role of poly-morphisms in MTX sensitivity

Apoptotic cell identification: An in-vivo study during induction treatment of childhood acute lymphoblastic leukemia Pudjo H Widjajanto; AJP Veerman; Sutaryo Sutaryo
Paediatrica Indonesiana Vol 46 No 5 (2006): September 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.5.2006.195-8

Background Acute lymphoblastic leukemia (ALL) in children hashigh cure rate but it can cause death due to the side effects oftreatment or to the disease itself. Thus the evaluation on responseof treatment is important and may predict the prognosis. Sinceapoptosis can be induced by chemotherapy, it is thought that thenumber of leukemic cells that undergo apoptosis may reflect drugsensitivity and cytoreduction rate, thus it may correlate with prog-nosis.Objective To detect apoptotic cells in peripheral blood of childrenwith ALL during the first week of treatment.Methods We conducted a cross sectional study on 58 childrenwith newly diagnosed ALL treated in Department of Child Health,Sardjito Hospital, Yogyakarta. Apoptotic cells were detected onsmears of buffy coat made from peripheral blod and stained withMay-Grunwald Giemsa. The apoptotic cells viewed under light mi-croscope within 12 time points during 7 days after treatment started.Results Apoptotic cells were identified in 3 of 58 patients withindex range of 4.2% to 36.2%.Conclusion Apoptotic cells can be detected in peripheral bloodwith simple method. The explanation of why not all blood smearsviewed showed these cells need further study. It may due to themethods or the apoptotic process itself.

A five-year review of children with neuroblastoma at Dr. Sardjito General Hospital, Yogyakarta, Indonesia Sutaryo Sutaryo; Scolastika Dita Kristian
Paediatrica Indonesiana Vol 59 No 3 (2019): May 2019
Publisher : Indonesian Pediatric Society

Background Neuroblastoma is the third most common tumor in children, after leukemia and retinoblastoma. The disease presents with a wide range of symptoms. Objective To assess the clinical profiles of children with neuroblastoma at Dr. Sardjito General Hospital from 2012-2016. Methods A retrospective review of all children with neuroblastoma under 18 years of age in the Childrenâ€™s Ward of Dr. Sardjito General Hospital, Yogyakarta from 2012-2016. Patients diagnosed and treated in other hospitals were excluded. Data were taken from the Yogyakarta Pediatric Cancer Registry (YPCR) and medical records. Outcomes were assessed by patient status: alive, died, or lost to follow-up. Results A total of 40 subjects were included in this study. Six (15.0%) patients were diagnosed at <1 year of age, 26 (65.0%) patients at 1 to <5 years of age, 6 (15.0%) patients at 5 to <10 years of age, and 2 (5.0%) patients at â‰¥10 years of age. The male to female ratio was 1.5:1. Four (10.0%) patients had stage IV-S, 34 (85.0 %) patients had stage IV, and 2 (5.0 %) patients had stage II/III of the disease. Proptosis (40.0%) and abdominal mass (35.0%) were the most common chief complaints. Eight (20.0%) patients were alive at the end of observation, 15 (37.5%) died, and 17 (42.5%) were lost to follow-up. The deaths were mostly caused by sepsis. Conclusion Most patients are diagnosed at the age of 1 to <5 years, with a median age of 3 years. Proptosis is the most common chief complaint. Most patients present in stage IV. Overall survival rate is very low. The high numbers of lost to follow-up should be noted.

Metastatic pancreatic ductal adenocarcinoma in a teenage girl: A rare disease Sutaryo Sutaryo; Scolastika Dita Kristian
Paediatrica Indonesiana Vol 60 No 6 (2020): November 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.6.2020.341-4

Pancreatic ductal adenocarcinoma (PDAC) is highly uncommon in patients < 20 years of age, at less than 0.1% of population.1 Pancreatic tumors in children and adolescents can develop from endocrine or exocrine cells. The tumor types include solid pseudopapillary tumor, ductal adenocarcinoma, pancreatoblastoma, acinar cell carcinoma, and pancreatic endocrine neoplasm (malignant and benign).2 Other types of tumors may be attached to it or secondarily engage the gland or emerge from other kinds of non-pancreatic cells inside the pancreas. The prevalent type of classic PDAC in adults is highly uncommon in children. We report here on a fifteen-year old girl with metastatic pancreatic ductal adenocarcinoma (mPDAC), who presented with abdominal discomfort and jaundice.

KESAHIHAN DIAGNOSTIK HEMOGLOBIN RETIKULOSIT UNTUK DETEKSI DEFISIENSI ZAT BESI DI KEHAMILAN (Diagnostic Validity of Reticulocyte Hemoglobin for Iron Deficiency Detection in Pregnancy) Tri Ratnaningsih; Budi Mulyono; Sutaryo Sutaryo; Iwan Dwiprahasto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1282

Entering the second trimester of pregnancy, more iron is required due to the increase in erythrocyte mass, plasma volume andthe development of fetus as well as chorion. Iron is needed the most in the third trimester. The existing hematological iron stageparameters can only detect iron deficiency in the latest stage. The aim of this study was to know the assessment validity of Ret-Heexamination as a new parameter to diagnose iron deficiency in pregnant women with anemia, as well as a screening tool for those interm pregnancy without anemia. The research design was cross sectional. The subjects were women in term pregnancy, gathered fromPKU Muhammadiyah Hospital, Bantul Yogyakarta from May to November 2013. A seven (7) mL blood sample was taken from thecubital vein of the subjects. Two mL of the sample was tested for routine hematological examination using an EDTA tube, while theRet-He was assessed using an automatic hematological instrument Sysmex XT-2000-i (Symex Corporation, Kobe, Japan). The serumof the remaining five (5) mL was used to check the serum iron and TIBC to obtain the saturation value (Tsat) using Cobas analyzerC501 (Roche Diagnostics, Germany), while the serum ferritin (SF) was examined using Minividas. The subjects were classified into two(2) groups based on the Hb levels, namely: anemia (Hb<11 g/dL) and those who did not (Hb≥11 g/dL). Furthermore, they were alsoclassified into two (2) groups based on transferrin saturation values: iron deficient (Tsat <9%) and normal (Tsat ≥9%). From 291subjects, 59 (20.3%) were found to have anemia and 232 (79.7%) did not. The cut off value of Ret-He to diagnose iron deficiency inpregnant women with anemia was 29.8 pg (82% sensitivity and 72% specificity). Meanwhile, the cut-off value of Ret-He for irondeficiency screening in pregnant women without anemia was 29.8 pg, with a sensitivity and specificity of 92% and 87% respectively.The Ret-He holds a good diagnostic validity to detect iron deficiency in pregnancy, with or without anemia.

Co-Authors A Purnomoadi Agung Purnomoadi AJP Veerman Akhmad Nurahkman Allen Yeoh Budi Mulyono Charles Parningotan Haratua Simanjuntak Desy Rusmawatiningtyas Dwikisworo Setyowireni Edy Moeljono Edy Supriadi Endang Purbowati I Gusti Bagus Wiksuana IDG Ugrasena Iqbal Syaichurrozi Iwan Dwiprahasto Jacqueline Cloos Jan Hendrik Hooijberg Kaiser Ali Laura Vroling M. Fakhri Basyir Mark Belletrutti N Krisdiyanty Nabilah Nabilah Nadlirotun Luthfi Nunik Agustriyani Pudjo H Widjajanto Pudjo Hagung Widjajanto Putri Kurnia Villta Rafi Muhammad Farraz Retno Adiwinarti Ridwan Tjandra Sugiarto Rifah Nur Hasanah Scolastika Dita Kristian Sunarto Sunarto TATI NURHAYATI Tri Ratnaningsih Untung Widodo Yeow Liang

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