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Gaharu Leaf Water Extract Reduce MDA and 8-OHdG Levels and Increase Activities SOD and Catalase in Wistar Rats Provided Maximum Physical Activity Parwata, I Made Oka Adi; Manuaba, Ida Bagus Putra; Sutirtayasa, I Wayan Putu; Wita, I Wayan
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

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Background: Oxidative stress occurs due to an imbalance of the number of free radicals by the number of endogenous antioxidant produced by the body i.e. Superoxide Dismutase (SOD), Gluthathione Peroxidase (GPx), and Catalase. The imbalance between the number of free radicals and antioxida nts can be overcome with the end ogenous antioxidant intake that exogenous oxidative stress can be reduced. O ne of exogenous antioxidants is natural Gaharu leaf water extract. Objective: This research focus on the effect of Gaharu leaf water extract in reducing MDA and 8- OHdG and increase the activity of SOD and Catalase. Methods: This study was an experimental with post only controls group design. Experiment was divided into 5 groups of w istar rats, each consisting of 5 animals, i.e. negative control group without extract [K (-)], treatment 1 treated 50 mg/ kg BW/day of the extract (T1), treatment 2 treated 10 0 mg/ kg BW/day of the extract (T2), treatment 3 treated 200 mg/ kg BW/day of the extract (T3), and positive control group [K (+)] treated with vitamin Cat a dose 50 mg/ kg BW/day. All groups treated for 10 weeks. Every day, before treatment, each group was given a maximum swimming activity for 1.5 hours for 10 weeks. ELISA was used to measure MDA, 8-OHdG, SOD , and C atalase activities . Result: The research results showed that treatment of extract of leaves of Gaharu with an higher dose from 50 mg/kg BW up to 200 mg/ kg BW significantly decline (p

HIGH MYELOPEROXIDASE LEVEL AS A PROGNOSTIC FACTOR CARDIOVASCULAR EVENTS AT SIX MONTH IN PATIENTS PRESENTING WITH ACUTE CORONARY SYNDROME Budiana, I Putu Gede; Wita, I Wayan; Widiana, I Gede Raka
Medicina Vol 46 No 1 (2015): Januari 2015
Publisher : Medicina

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Cardiovascular disease (CVD) is the highest leading cause of death worlwide. Inflammation has beenimplicated in all stages in the evolution of atherosclerotic plaques. Myeloperoxidase (MPO) is anenzyme linked to both inflammation and oxidative stress. The aim of this study was to assess wetherhigh level of MPO is a prognostic factor of cardiovascular events at six month in patients presentingwith acute coronary syndrome (ACS). This study was a prospective cohort study, which took place atSanglah General Hospital Denpasar from 10 December 2011 until 10 December 2012. Subjects of thisstudy were 60 ACS patients which were enrolled by consecutive sampling. MPO levels was measuredat the first admission and the cardiovascular events during six month were observed. Sixty sampleswere involved in this study, 9 unstable patients (11%), 11 NSTEMI patients (18.3%), and 40 STEMIpatients (66.7%). In 6 months observation, there was 14 (23.3%) patients had cardiovascular events.Nine patients (15%) had high MPO levels and 51 patients (85%) had low MPO levels. The result of thisstudy were the ACS patients with high levels of MPO were tend to have more adverse cardiac events [hazard ratio (HR) 1.4; 95 % confidence interval (CI) 0.39 to 5.22; P = 0.591]. The relationship betweenMPO levels and incident cardiovascular event according to ARR (absolute risk reduction) was 11.76 %and NNT (number need to treat) was 8. High MPO levels gives benefit of long term prognostic inpatients with acute coronary syndrome. [MEDICINA 2015;46:16-21].Penyakit kardiovaskular merupakan penyebab kematian tertinggi di seluruh dunia. Inflamasimemegang peranan pada stadium pembentukan plak aterosklerosis. Myeloperoxidase (MPO) adalahenzim yang berhubungan dengan inflamasi dan stres oksidative. Tujuan penelitian ini adalah untukmengetahui kadar MPO yang tinggi sebagai faktor prognostik kejadian kardiovaskular dalam 6 bulanpada penderita sindrom koroner akut (SKA). Penelitian ini merupakan kohort prospektif, yangbertempat di RSUP Sanglah dari 10 Desember 2011 sampai 10 Desember 2012. Sampel penelitianadalah 60 orang yang diambil secara consecutive sampling. Sampel yang memenuhi kriteria inklusidiperiksa kadar MPO saat masuk rumah sakit dan diamati kejadian kardiovaskular (KKV) selama 6bulan. Enam puluh penderita SKA yang dilibatkan dalam penelitian ini terdiri dari 9 orang pasienAPTS (15 %), 11 orang pasien NSTEMI (18,3 %) dan 40 orang pasien STEMI (66,7 %). Dalam pengamatanselama 6 bulan, didapatkan sebanyak 14 (23,3 %) orang pasien yang mengalami KKV. Sebanyak 9orang (15%) dengan kadar MPO tinggi dan 51 orang (85%) dengan MPO rendah. Pada penelitian inididapatkan bahwa pasien SKA dengan kadar MPO tinggi memberikan outcome yang lebih tinggidibanding dengan kadar MPO yang rendah (HR 1,4; IK 95 % 0,39-5,22; P = 0,591). Besar efek dari MPOterhadap KKV yang diukur dengan ARR (absolute risk reduction) adalah 11,76 % dan NNT (numberneed to treat) sebesar 8. Kadar MPO yang tinggi memberikan manfaat dalam prognostik jangka panjangpada pasien SKA. [MEDICINA 2015;46:16-21].

ORAL INTAKE OF SARDINELLA LONGICEPS OIL THE DECREASE OF TNF-? AND IL-6 LEVELS IN ATHEROSCLEROTIC WISTAR RAT Wahjuni, S.; Sudewa, A.A.G.; Wita, I Wayan; Astawa, I.N. Mantik
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Lifestyle changes to consumption of variegated instant food may be associated several heath hazards, such as obesity, dyslipidemia, and atheroschlerosis. This study was conducted to investigate the effects of orally administered Sardinella longiceps oil as an anti inflammatory agent on the serum levels of TNF-? and IL-6 considered as biomarkers for atherosclerosis.The study design is an true experimental with randomized pretest and posttest control group design, using 50 Wistar rat equaly divided into 5 groups, i.e. placebo control group 0% and 4 treatment groups each treated daily with 10%, 15 %, 20 % and 25 % fish oil respectively for 6 weeks. Before the treatment was started, all rats were orally fed daily with a high cholesterol diet for 13 weeks to induce atherosclerosis. Our study showed that the intake of 20% fish oil had resulted in the significantly greatest decrease of 45,63 % in the TNF-? serum levels,from 28.62 ± 1.25 to 15.56 ± 7.20 ?g/mL and similar significant decrease 15,42% in of IL-6 serum levels from 134.64 ± 1.98 to 113.87 ± 4.30 ?g/mL. The overall results of our study seemed to imply than in the Wistar rats, oral intake of Sardfinella longiceps oils signifacantly decreased serum levels of TNF-? and IL-6 probably through their anti-inflamatory effects. Futher research to determin the magnitude of effects sardinella longiceps oils on the serum levels TNF-? and IL-6 human.

RISKS FOR PERIPHERAL ARTERIAL DISEASE IN THE ELDERLY WITH TYPE 2 DIABETES MELLITUS : Their Correlation with High Sensitivity C-reactive Protein and Ankle-Brachial Index Ayu Tuty Kuswardhani, Raden; Wita, Wayan; Bakta, Made; Santosa, Anwar
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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The Indonesian elderly population has been projected to increase up to about four-fold inthree decades (1990-2020). As a consequence of this population trend, the increased prevalence ofdegenerative diseases would be inevitable; this would include the prevalence of peripheral arterialdisease.This study aims to identify the correlation of diverse risk factors, either traditional or nontraditional,with the ankle-brachial index scores, and the correlation of novel non-traditional riskfactor, e.i. high sensitive C-reactive protein with the prevalence of perioheral arterial disease in theelderly, age 60-80 years old, with type 2 diabetes mellitus.Among the 146 elderly patients with type 2 diabetes mellitus, and based on measurement ofthe ABI score, approximately 30.9% of them had PAD. Some traditional and non-traditional riskfactors having a significant correlation with the ankle-brachial index score, were age (r = -0.396, p <0.001 for right ABI; r = -0.509, p < 0.001 for left ABI), supine systolic blood pressure (r= -0.268, p =0.012 for right ABI; r = -0.267, p = 0.013 for left ABI), 2-hour post-prandial blood glucose (r= -0.252, p = 0.018 for right ABI), and hsCRP (r = -0.280, p = 0.011 for right ABI; r = -0.402, p <0.001 for left ABI); whereas other risk factors like obesity based on waist circumference and BMI,non-supine systolic blood pressure, fasting blood glucose, HbA1C, duration of diabetes, plasma lipidsdid not show statistically significant different odd ratios. After linear regression test for risk factorshaving significant correlations with ABI, age and hsCRP were found to influence the ABI scores.Based on a case-control study, risk factors which, to some extent, had statistically significant valuesas risk factors, include older age (? 70 years old; OR = 7.737 [CI = 2.515-23.805]; p < 0.001),relatively high supine diastolic blood pressure (? 90 mmHg; OR = 6.882 [CI = 0.789-60.060]; p =0.048), and high concentration of hsCRP (> 3 mg/L; OR = 4.420 [CI = 1.287-15.181]; p = 0.013).Among these statistically significant risk factors, after logistic regression test analysis, only the age ofthe patient appeared to have significant influence on the prevalence of PAD.In conclusion, this study demonstrates a negative correlation between hsCRP and ABI score;and high levels of hsCRP appeared to be a risk factor for PAD. The age of the patient, however,appeared to be the strongest risk factor for PAD.

PENERAPAN KONSELING BEHAVIORAL DENGAN TEKNIK MODELING UNTUK MENINGKATKAN SELF CHANGE SISWA KELAS VIII.6 SMP NEGERI 2 SINGARAJA ., I Wayan Wita; ., Prof. Dr. I Ketut Dharsana,M.Pd; ., Dra. Made Sulastri, M.Pd.
Jurnal Jurusan Bimbingan Konseling Undiksha Vol 3, No 1 (2015): Jurnal Ilmiah Bimbingan Konseling
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jibk.v3i1.5521

Penelitian ini merupakan jenis penelitian tindakan (Action Research In Counseling) yang bertujuan untuk mengetahui peningkatan self change siswa kelas VIII.6 SMP Negeri 2 Singaraja setelah dilaksanakan penerapan konseling behavioral dengan teknik modeling. Subjek penelitian ini adalah siswa kelas VIII 6 SMP Negeri 2 Singaraja. Penelitian ini terdiri dari 4 siklus dimana masing-masing siklus melalui tahap identifikasi, diagnosa, prognosa, konseling/treatment, evaluasi/follow up, dan refleksi. Proses pengambilan data dalam penelitian ini menggunakan kuesioner self change pola skala linkert dan dianalisis secara deskriptif serta menggunakan buku harian. Berdasarkan hasil analisis, ditemukan bahwa kategori self change siswa pada siklus I sampai siklus 3 adalah katagori sangat rendah 16 orang (41%), sedang 12 orang (30%), kategori tinggi 12(30%) orang, dan kategori sangat tinggi 6 orang (15%), . Jika dibandingkan dengan kategori skor self change siswa pada siklus IV sebagai berikut siswa dengan kategori sangat tinggi 36 orang (92%), kategori tinggi 3 orang (8%) dan tidak ada siswa yang memiliki kategori sangat rendah, rendah, dan sedang. Ini menunjukkan sudah ada peningkatan secara signifikan. Jadi dapat disimpulkan bahwa konseling behavioral dengan teknik modeling efektif digunakan untuk meningkatkan self change siswa kelas VIII.6 SMP Negeri 2 Singaraja. Kata Kunci : konseling behavioral, teknik modeling, self change. This study is an action research (Action Research In Counseling) which aims to determine the increase in self change VIII.6 grade students of SMP Negeri 2 Singaraja after the application of behavioral counseling undertaken by modeling techniques. The subjects were students of class VIII 6 SMP Negeri 2 Singaraja. The study consisted of four cycles in which each cycle through the stages of identification, diagnosis, prognosis, counseling / treatment, evaluation / follow-up, and reflection. The retrieval of data in this study using a questionnaire self linkert scale pattern change and analyzed descriptively and using a diary. Based on the analysis, it was found that the category of self-change the students in the first cycle to cycle 3 is very low category of 16 people (41%), while 12 people (30%), high category 12 (30%) of people, and the very high category 6 people (15%). When compared with the category of self-change students' scores on the fourth cycle of the following students with very high category 36 people (92%), high category 3 (8%) and no student who has a category of very low, low, and medium. It shows already a significant improvement. So it can be concluded that behavioral counseling with an effective modeling techniques are used to enhance the students' self change VIII.6 grade SMP Negeri 2 Singaraja keyword : behavioral counseling, modeling techniques, self-change.

DEFISIENSI SELENIUM (SE) SEBAGAI FAKTOR RISIKO DILATED CARDIOMYOPATHY (DCM) DI RUMAH SAKIT UMUM PUSAT (RSUP) SANGLAH, BALI : STUDI KASUS – KONTROL Luh Nyoman Ananda Mahayati; I Wayan Wita
E-Jurnal Medika Udayana Vol 8 No 5 (2019): Vol 8 No 5 (2019): Vol 8 No 5 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Selenium (Se) merupakan salah satu mineral yang paling sering dikaitkan dengan DCM, terutama setelah kejadian endemik penyakit Keshan di Cina. Penelitian ini dilakukan untuk mengetahui apakah defisiensi selenium merupakan faktor risiko terjadinya DCM di RSUP Sanglah, Bali. Penelitian ini menggunakan desain kasus-kontrol retrospektif, dimana data diperoleh dengan wawancara menggunakan kuesioner SQFFQ yang berisi riwayat konsumsi bahan-bahan makanan tertentu dan penelusuran lebih lanjut terhadap karakteristik demografis dan klinis subyek penelitian dilakukan dengan rekam medis. Total 60 subyek penelitian terbagi menjadi 30 orang sebagai kelompok kasus dan 30 orang sebagai kelompok kontrol. Konsumsi selenium harian ditemukan lebih tinggi pada kelompok kasus dibandingkan kelompok kontrol (45,54?g vs 28,11?g). Konsumsi selenium tidak memengaruhi terjadinya DCM (OR = 1; IK 95% = 0,98-1,03; p = 0,43). Dua variabel menunjukkan hubungan yang signifikan dengan DCM, diantaranya hipertensi (OR = 10; IK 95% = 2,94; p = <0,001) dan merokok (OR = 5,69; IK 95% = 1,59-20,33; p = 0,007). Faktor genetik, DM tipe 2, PJK, dan konsumsi alkohol menunjukkan nilai OR >1 namun tidak memiliki hubungan yang signifikan secara statistik dengan DCM. Kemoterapi ditemukan sebagai faktor protektif. Defisiensi selenium bukan merupakan faktor risiko terjadinya DCM sehingga terdapat faktor risiko lain yang kemungkinan lebih berpengaruh terhadap terjadinya DCM. Hasil penelitian ini diharapkan dapat digunakan sebagai data dasar penelitian lebih lanjut guna mengetahui faktor-faktor risiko DCM. Kata kunci : Defisiensi selenium, dilated cardiomyopathy/DCM, penyakit Keshan

GAMBARAN FAKTOR RISIKO HIPERTENSI PADA MASYARAKAT DI DESA UNGASAN, KECAMATAN KUTA SELATAN, KABUPATEN BADUNG Ni Putu Elsinthia Suryaningsih; I Wayan Wita; I Nyoman Wiryawan; Made Satria Yudha Dewangga
E-Jurnal Medika Udayana Vol 11 No 1 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.v11.i01.p14

ABSTRAK Hipertensi sebagai penyakit degeneratif yang masih menjadi tantangan besar di dunia, begitu juga di Indonesia karena prevalensinya yang terus meningkat tiap tahunnya. Hipertensi bisa ditimbulkan akibat berbagai macam faktor. Komplikasi yang dapat ditimbulkan seperti stroke, gagal ginjal, kerusakan pada mata, ataupun coronary heart disease. Penelitian ini bertujuan untuk mengetahui gambaran faktor risiko pada penderita hipertensi di Desa Ungasan. Rancangan deskriptif sebagai metode yang digunakan dalam penelitian ini dengan studi potong lintang dan teknik consecutive sampling. Populasi dalam penelitian adalah masyarakat berusia ? 18 tahun dengan mengidap hipertensi yang berdomisili di Desa Ungasan, dan didapatkan jumlah sampel sebanyak 140 orang. Pengambilan data dilakukan dengan pemeriksaan tekanan darah dan wawancara menggunakan kuesioner terstruktur. Berdasarkan hasil penelitian berdasarkan derajat hipertensi didapatkan responden lebih banyak berada pada kelompok hipertensi derajat satu yaitu 104 responden (52%). Prevalensi hipertensi lebih banyak pada kelompok usia ? 40 tahun 112 responden (80%), berjenis kelamin perempuan 81 responden (57.9%), memiliki riwayat keluarga dengan hipertensi 104 responden (74.3%), sering mengkonsumsi garam 114 responden (81.4%), sering mengkonsumsi lemak 121 responden (86.4%), bukan perokok 102 responden (72.9%), dan sering beraktivitas fisik 95 responden (67.9%). Dapat dilakukan penelitian lanjutan dengan menggunakan hasil penelitian ini sebagai data acuan. Kata Kunci: Hipertensi, Faktor Risiko, Desa Ungasan

KARAKTERISTIK PENDERITA SINDROMA KORONER AKUT DI RSUP SANGLAH DENPASAR TAHUN 2016 Made Diska Radisti Diputra; I Wayan Wita
E-Jurnal Medika Udayana Vol 7 No 10 (2018): Vol 7 No 10 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Sindroma koroner akut (SKA) merupakan dekompensasi jantung akut akibat suplai darah yang mengandung oksigen ke jantung tidak adekuat. Sindroma koroner akut merupakan penyakit penyebab utama kematian di dunia. Penelitian ini bertujuan untuk mengetahui karakteristik pasien sindroma koroner akut di RSUP Sanglah Denpasar tahun 2016. Penelitian ini merupakan penelitian deskritif cross sectional yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Data yang diperoleh berupa data sekunder rekam medis pasien periode April 2016 – Desember 2016. Data dianalisis dengan menggunakan program SPSS. Hasil penelitian menunjukkan bahwa jenis kelamin terbanyak adalah laki-laki sebanyak 92 pasien (84,4%) dengan rerata usia sebesar 56,42 ± 12,059 tahun. Proporsi jenis SKA yaitu ST-Elevation Myocardial Infarction (STEMI) sebanyak 66 pasien (60,6%), Non-ST Elevation Myocardial Infarction (NSTEMI) sebanyak 5 pasien (4,6%) dan Unstable Angina Pectoris (UAP) sebanyak 38 pasien (34,9%). Proporsi riwayat penyakit terdahulu yaitu memiliki riwayat hipertensi sebanyak 67 pasien (61,5%), memiliki riwayat Diabetes Mellitus (DM) sebanyak 25 pasien (22,9%), yang memiliki riwayat gangguan fungsi ginjal sebanyak 32 pasien (29,4%). Pasien yang memiliki ketiga riwayat penyakit tersebut sebanyak 8 pasien, sedangkan yang tidak memiliki riwayat penyakit terdahulu sebanyak 27 pasien. Riwayat sosial terbanyak adalah memiliki riwayat merokok sebesar 57 pasien (52,3%) dan tidak memiliki riwayat keluarga sebanyak 95 orang (87,2%). Proporsi terbesar adalah gula darah sewaktu normal (83,5%) dan kadar kolesterol High-Density Lipoprotein (HDL) rendah (52,3%). Keadaan sewaktu pulang terbanyak adalah pulang berobat jalan (88,1%) dengan lama rawatan rerata 5,91 ± 2,459 hari. Kata-kata kunci : Karakteristik Penderita, Sindroma Koroner Akut

Evaluation of Cardiometabolic Factors Affecting Chronotropic Incompetence: A Cross-Sectional Retrospective Study in Sanglah General Hospital, Bali Gusti Ngurah Prana Jagannatha; AA Ayu Dwi Adelia Yasmin; I Wayan Agus Surya Pradnyana; Stanly Kamardi; I Nyoman Wiryawan; I Wayan Wita
Jurnal Kardiologi Indonesia Vol 43 No 1 (2022): Indonesian Journal of Cardiology: January - March 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1189

Background: Recent studies have identified that chronotropic incompetence is correlated with poor cardiometabolic health and systemic inflammation that results in exercise intolerance, impaired quality of life and death due to cardiovascular disease (CVD). Unfortunately, there’s still paucity of data regarding cardiometabolic factors associated with chronotropic incompetence. The purpose of this study was to identify the cardiometabolic factors associated with chronotropic incompetence. Methods: This study was a cross-sectional retrospective study using cardiac treadmill stress test data at Sanglah General Hospital from May 2018 - May 2020 and 136 patients were enrolled. Data analysis used SPSS version 21. Pearson chi-square test was used to compare categorical variables based on cardiometabolic risk factors in chronotropic incompetence. Results: Patients were divided based on the characteristics of age, gender, smoking status, body mass index, coronary artery disease, heart failure, hypertension, dyslipidemia, type 2 diabetes mellitus (T2DM), the levels of HbA1C, total cholesterol, LDL, HDL, and triglyceride. In this study, it was found that T2DM (PR 2.29; 95%CI 1.16–3.37), HbA1C (PR 3.13; 95%CI 2.31-4.22), dyslipidemia (PR 1.773; 95%CI 1.170–2.687), high total cholesterol (PR 2.396; 95%CI 1.650-3;481), and high LDL level (PR 1.853, 95%CI 1.229-2.794) were significantly associated with chronotropic incompetence (all p-value <0.05), while other factors were not significantly related. Conclusion: Chronotropic incompetence can impair quality of life and contribute to cardiovascular mortality. However, T2DM, high HbA1C, dyslipidemia, high total cholesterol and LDL levels were found to be associated with chronotropic incompetence. This may contribute to higher cardiovascular risk attributed to those factors.

Problem diagnostik seorang penderita endokarditis infektif dengan komplikasi perdarahan intrakranial: Sebuah laporan kasus Franky Simarmata; Ida Bagus Aditya Nugraha; I Wayan Wita; Dwijo Anargha Sindhughosa
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Introduction: Infective Endocarditis (IE) is a disease frequently affecting heart valves. The diagnosis is relatively simple, however it could be difficult in unspecific symptoms. Intracranial complications of patients with IE rarely happen.Case: The case was a 64 years-old male with sudden decrease of consciousness 12 hours prior to admission and diagnosed as a hemorrhagic stroke. He had a history of heavy smoking for about 10 years. Infective Endocarditis (IE) was diagnosed by Duke Criteria, and from this patient we found the vegetation at mitral valve with diameter 1.09 x 0.73 cm. Treatment for the patient is antibiotic according to sensitivity test of blood culture. The patient was discharged with improvement of condition. However, in approximately three months after discharge, the patient got hospitalized again due to the same condition and passed away.Conclusion: Infective endocarditis is a relatively rare disease. In our case we had a definite IE patient with a spectrum of neurological events complicating this disease. The presence of cerebral hemorrhage complications makes the patient's prognosis worse. Pendahuluan: Endokarditis Infektif (IE) merupakan penyakit yang umumnya menyerang katup jantung. Diagnosis pada umumnya relatif sederhana, namun dapat menjadi sulit gejala yang ditemukan tidak spesifik. Komplikasi intrakranial pasien dengan IE jarang terjadi.Laporan Kasus: Seorang laki-laki 64 tahun dengan penurunan kesadaran mendadak 12 jam sebelum masuk rumah sakit (MRS) dan didiagnosis sebagai stroke hemoragik. Pasien memiliki riwayat perokok berat selama kurang lebih 10 tahun. Endokarditis infektif (IE) di diagnosis dengan kriteria Duke, dan dari pasien ini ditemukan vegetasi pada katup mitral dengan diameter 1,09 x 0,73 cm. Pengobatan untuk pasien adalah antibiotik berdasarkan uji sensitivitas kultur darah. Pasien dipulangkan dengan kondisi perbaikan. Namun, sekitar tiga bulan setelah keluar, pasien kembali dirawat di rumah sakit karena kondisi yang sama dan meninggal dunia.Simpulan: Endokarditis infektif merupakan penyakit yang relatif jarang. Dalam laporan kasus ini, pasien dengan spektrum kejadian neurologis yang menyulitkan penyakit IE. Adanya komplikasi perdarahan otak membuat prognosis pasien semakin buruk.

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