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All Journal Medical Journal of Indonesia Indonesian Journal of Cancer Jurnal Keamanan Nasional Arsitekno
Bambang Karsono
RS. Kanker Dharmais
Arts Civil Engineering, Building, Construction & Architecture Energy Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Social Sciences

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T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases Taroeno-Hariadi, Kartika W.; Tatsumi, Eiji; Hardianti, Mardiah S.; Furuta, Kaho; Syampurnawati, Meilani; Karsono, Bambang; Ishikawa, Takayuki; Yabe, Hiroki; Nagai, Ken-Ichi; Takahashi, Takayuki; Kishimoto, Yuji
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.291 KB) | DOI: 10.13181/mji.v14i3.189

Abstract

Blast crisis (BC) transformation in chronic myelogenous leukemia (CML) can involve each differentiation lineage of the hematopoietic system, i.e. granulocyte, monocyte, erythrocyte, megakaryocyte, and lymphocyte lineage. The lymphoid blast crisis (BC) leukemia cells usually belong to B-lineage, commonly having the phenotype of Pre-B stage of the B-lineage, in which cell-surface immunoglobulin (sIg) is not yet expressed. In contrast, T-lineage BC of CML is extremely rare. The objective of this study is to describe the fenotype, fusion transcript of bcr-abl, TdT, and cytoplasmic CD3 in T-lineage BC CML cases. Case report study. This report shows a simple summary of 4 cases of T-lineage BC of CML which have been collected in the phenotypic and genotypic analysis study for 17 years (1987-2004). In all cases, the chromosomal analysis revealed the presence of t(9;22)(q34;q11) at presentation. Cell surface analysis were done at diagnosis. Cases’ mononuclear cells stored as 10% DMSO were retrieved to be performed reverse transcription (RT) PCR BCR-ABL multiplex to demonstrate the presence of the fusion transcript of bcr-abl. RT-PCR was also performed for detecting the expression of cytoplasmic CD3ε and terminal deoxynucleotydil transferase (TdT). The results of cell surface antigen (CSA) at presentation showed that 1 case was CD7+, CD5-, and CD2-; 1 case CD7+, CD5+, and CD2-; and 2 cases CD7+, CD5+ and CD2+ indicating that all these T-lineage BC of CML cells show the phenotype of pre-(pro-) thymic stage phenotype. In the present study, two cases showed b2a2, one e1a2, and one negative bcr-abl transcript. The RT-PCR revealed the presence of CD3ε mRNA in all cases, and TdT mRNA in only one case. These results can constitute a basis for the future analysis of T-lineage BC of CML from now on. (Med J Indones 2005; 14: 184-9)Keywords: chronic myelogenous leukemia (CML), blastic crisis (BC), T-lineage, bcr-abl fusion gene, CDε, TdT
Efficacy and Safety of In-Asia-Manufactured rhG-CSF 300 mcg As Primary Prophylaxis for Prevention of CHOP Chemotherapy-induced Severe Neutropenia in Elderly Patients with Lymphoma Non-Hodgkin Reksodiputro, Harryanto; Djoerban, Zubairi; Tambunan, Karmel L.; Sudoyo, Aru W.; Widjanarko, Abidin; Atmakusuma, Djumhana; Syafei, Syafrizal; Prayogo, Nugroho; Hukom, Ronald; Ranuhardy, Dody; Jack, Zakifman; Harsal, Asrul; -, Noorwati S; Karsono, Bambang; Effendi, Shufrie; Tadjoedin, Hilman
Indonesian Journal of Cancer Vol 3, No 1 (2009): Jan - Mar 2009
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (790.74 KB)

Abstract

Penelitian open-label, non-komparatif ini dilakukan untuk mengevaluasi efektivitas dan keamanan recombinant human G-CSF produksi Asia sebagai profilaksis primer dalam pencegahan neutropenia derajat berat pada pasien usia lanjut (>60 tahun) dengan limfoma non-Hodgkin (LNH) derajat sedang dan lanjut (stadium II,III,IV) yang mendapat terapi CHOP (siklofosfamid, doksorubisin, vinkristin). Profilaksis primer recombinant human G-CSF (rhG-CSF) produksi Asia dapat mengurangi median durasi neutropenia derajat 4 pada siklus sitostatistika ke-1 dan ke-2 menjadi tiga hari, sementara median durasi neutropenia derajat 3 pada siklus sitostistika ke-1 menjadi dua hari dan pada siklus sitostatistika ke-2 menjadi dua setengah hari, dari median durasi neutropenia grade 4 dan grade 3 tanpa G-CSF, yaitu empat dan lima hari berurutan. Febrile neutropenia ditemukan pada 7 pasien yang mendapat rhG-CSF produksi Asia (24.1%), lebih rendah jika dibandingkan studi tanpa rhG-CFS (31.3-34% FN). Tiga pasien mendapat rhG-CSF produksi Asia (10,3%) dirawat inap akibat febrile neutropenia, lebih rendah jika dibandingkan rawat inap pada studi tanpa rhG-CSF (24-28%). Kejadian yang tidak diinginkan terbanyak adalah mual dan muntah yang terjadi pada 9 (31%) pasien. Sebagai kesimpulan, penggunaan rhG-CSF produksi Asia untuk profilaksis primer pada pasien LNH usia lanjut yang mendapat regimen CHOP dapat mengurangi durasi neutropenia, mengurangi kejadian febrile neutropenia, dan angka rawat inap akibat febrile neutropenia.Kata kunci : Efektivitas, keamanan, G-CSF, LNH pada usia lanjut
Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study Karsono, Ramadhan; Purwanto, Denni Joko; Haryono, Samuel J.; Karsono, Bambang; Sari, Lenny; Pratiwi, Yulia; Aryandono, Teguh
Indonesian Journal of Cancer Vol 12, No 4 (2018): October-December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (891.03 KB) | DOI: 10.33371/ijoc.v12i4.604

Abstract

Background: There are no data of efficacy comparison between primary systemic therapy in stage 3B and 4 breast cancer patients in Indonesia. This study compared long term outcomes of breast cancer patients treated with neoadjuvant hormonal therapy (NAHT) and those treated with neoadjuvant chemotherapy (NACT)Methods: This was a cohort study conducted from 2011 to 2017. A total of 122 patients with stage 3B and 4 breast cancer received NAHT (n = 62) or NACT (n = 60) within a 6 cycles for NACT and 6 months for NAHT were included. Patients were excluded if they had a mastectomy before treatment, were pregnant, had been given hormonal therapy or chemotherapy before, had a contra-indication of chemotherapy, had a contra-indication of salpingo-oophorectomy bilateral for premenopausal patients, and declined to enter this study. The primary outcome of this study was overall survival. The outcomes were analysed using Kaplan-Meier for survival analysis and cox proportional hazard regression to estimate the hazard ratio.Results: There was a statistically significant difference in overall survival (p = 0.038). Median overall survival for NAHT patients was 1265 days and for NACT patients was 654 days. The hazard ratio showed NACT patients had a higher risk than NAHT patients (1.7 95% CI 1.03 – 2.9). Pathological complete response rate was higher in the NACT group than in the NAHT group (3.3% vs. 0%).Conclusions: Neoadjuvant hormonal therapy was superior to neoadjuvant chemotherapy in term of overall survival.
GERAKAN ISLAM RADIKAL DI SULAWESI SELATAN: POLA REKRUTMEN DAN POLA GERAKAN KOMITE PERSIAPAN PENEGAKAN SYARIAT ISLAM (KPPSI) DAN LASKAR JUNDULLAH Karsono, Bambang
Jurnal Keamanan Nasional Vol 4, No 2 (2018): November
Publisher : Pusat Kajian Keamanan Nasional (Puskamnas) Universitas Bhayangkara Jakarta Raya (UBJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31599/jkn.v4i2.417

Abstract

Preparatory Committee for the Upholding of Islamic Law (KPPSI) was established on 28 May 2000. Laskar Jundullah is an autonomous body under the KPPSI, but there is no effective coordination between Laskar Jundullah and KPPSI. In recruitment, membership of the KPPSI takes place openly, whereas Laskar Jundullah is more closed. This research explains the relationship between the two organizations, intended as a reference model to understand radical religious movements in the region. The data collected through interview, literature reviews, papers and related news. This study shows that an Islamic organization is not free from intact with radical Muslim groups. In fact, loose structure its even makes the organization more vulnerable to being used by the radical groups.
HISTORICAL ANALYSIS OF URBANITY ON THE WATERFRONT Karsono, Bambang
Arsitekno Vol 2, No 2 (2013): Jurnal Arsitekno
Publisher : Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/arj.v2i2.1244

Abstract

Since the dawn of the civilization, water plays an important role in human life. Water covers 75% of the earth surface and sustains virtually every life form on it. From the early days of human settlement, the banks of themajor rivers such as the Nile, Tigris, Euphrates, Indus and Hwang Ho became the cradle of civilizations. It is here the culture developed and the pattern and morphology of urban settlement became the source of ourknowledge. This paper attempts to overview the main developmental periods of waterfronts around the world. It discusses on the fundamental periods and events which shaped the city water-borne activities and explained how those events influenced the nature of public space on the waterfronts. The port-city that developed since then will be analyzed corresponding to the historical events that are related to the city development. A few cases studies will be shown in order to present a valuable descriptive situation. Corresponding to the above issues, a continuous process that took place in the development of the waterfront will be discussed extensively.
Co-Authors Abidin Widjanarko Aru W. Sudoyo Asrul Harsal, Asrul DENNI JOKO PURWANTO, DENNI JOKO Djumhana Atmakusuma, Djumhana Dody Ranuhardy, Dody Eiji Tatsumi Harryanto Reksodiputro, Harryanto Haryono, Samuel J. HILMAN TADJOEDIN, HILMAN Hiroki Yabe Kaho Furuta Karmel L. Tambunan Karsono, Ramadhan Kartika W. Taroeno-Hariadi Ken-Ichi Nagai Lenny Sari, Lenny Mardiah S. Hardianti Meilani Syampurnawati Nadia Farhanah Syafhan Noorwati S -, Noorwati S Nugroho Prayogo Ronald Hukom Shufrie Effendi, Shufrie Syafrizal Syafei, Syafrizal Takayuki Ishikawa Takayuki Takahashi Teguh Aryandono Yahdiana Harahap Yuji Kishimoto Yulia Pratiwi Zakifman Jack, Zakifman Zubairi Djoerban