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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal ILMU DASAR e-Journal Pustaka Kesehatan Jurnal Kesehatan Masyarakat Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Damianus Journal of Medicine Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya Universa Medicina Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) Journal Of Vocational Health Studies Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Al-sihah: The Public Health Science Journal SRIWIJAYA JOURNAL OF MEDICINE Journal of Health Sciences JHECDs: Journal of Health Epidemiology and Communicable Diseases JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jember Medical Journal (JMJ)
Bagus Hermansyah
Departemen Parasitologi, Fakultas Kedokteran, Universitas Jember, Jl. Kalimantan No.37, Kampus Tegal Boto, Kabupaten Jember, Jawa Timur, 68121
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Bioactivity of a Compound of Standardized Bangle (Zingiber cassumunar Roxb.) Extract Fraction as a Complimentary Therapy to Prevent Malaria Complications Hermansyah, Bagus; Utami, Wiwien Sugih
Journal of Agromedicine and Medical Sciences Vol 1, No 2 (2015)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Malaria is still a major problem in the international and national scale. World Health Organization (WHO) states that based on World malaria report, world cases of malaria reached 216 million and an estimated of 655 thousand people died, in 2010. Overproduction of pro-inflammatory cytokines by phagocytic cells and activated endothelial cells occurs In the severe malaria. Bangle (Zingiber cassumunar Roxb.) has the potential to be developed as a new complementary therapy that is expected to prevent fatal malaria complications. The research objective is to test in vivo, the activity of a compound of standardized Bangle (Zingiber cassumunar Roxb.) fraction extract as a complementary therapy along with standard anti-malarial drug, artemisin. This is a true experimental study using twenty-five mice Balb / C male which are divided into five groups; the negative control group, positive control group treated KI, II, and III stimulation with each of the compounds of standardized fraction extract of bangle ( FEBT-h, FEBT-dcm, FEBT-m) for 14 days. Oneway ANOVA test showed the result of p = 0.01 (p <0.05). Continued with LSD test that showed the most significant in lowering the degree of parasitaemia is the group of methanol (FEBT-m).Keywords: Zingiber cassumunar Roxb, fractionated extracts, complementary therapies, malaria
Uji Aktivitas Fraksi N-Heksana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo (The Activity Test of N-Hexane Fraction of Bangle (Zingiber cassumunar Roxb.) Methanolic Extract as Complementary Thera Sarah Andriani; Bagus Hermansyah; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Malaria is one of endemic disease in Indonesia that caused many deaths. Immune system plays important rules in preventing malaria severity. Bangle has been proven as an immunostimulant and could reduce parasitaemia in malaria infection. This study aimed to determine the activity of n-hexane fraction of bangle methanolic extract as complementary therapy of malaria. This study used 28 mice, divided into one positive control group, one negative control group, and five treatment groups. Bangle stimulation before induction was given to five treatment groups with dose: 0,005625mg/grbw, 0,01125mg/grbw, 0,0225mg/grbw, 0,045mg/grbw, and 0,09mg/grbw for 14 days. Plasmodium berghei induction was given to all groups, and then treatment groups were given ACT and bangle fraction, and positive control group was given ACT without fraction for three days. Parasitaemia was observed everyday, then plasmodium growth inhibition percentation was counted. Bangle fraction stimulation gave lower parasitaemia at the begining and Pearson correlation test showed strong positive correlation between dose of bangle fraction and plasmodium growth inhibition percentation (p<0,01). We can conclude that n-hexane fraction of bangle methanolic extract was active as complementary therapy of malaria (IC50=0,013 mg/grbb). Keywords: malaria, bangle, n-hexane, complementary therapy
The Larvacidal Activity of Ethanol Extracts of Phyllanthus acidus Leaves on The Culex quinquefasciatus Instar III/IV Larvae Afifatun Hasanah; Bagus Hermansyah; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.6842

Abstract

Culex quinquefasciatus was one of a vector of filariasis disease caused by filarial worm infection. Mode of transmission was through mosquito bites that contain filaria worm. To overcome the problem in terms of eradicating the mosquito larvae was by searching for safe biological materials for humans and the environment, one of them was Phyllanthus acidus leaves. The purposes of this research were to know whether the ethanol extract of Phyllanthus acidus leaves have larvicidal activity on Culex quinquefasciatus instar III / IV larvae and to know the lethal concentration 50 (LC50) ethanol extract of Phyllanthus acidus leaves on Culex quinquefasciatus instar III / IV larvae within 24 hours. This study used true experimental method with post test only controlled group design with 1 positive control group (Temephos), 1 negative control group (Aquades and DMSO), and 5 treatment groups (0.0625%; 0.125%; 0.25%, 0.5% and 1% extract) respectively 20 Culex quinquefasciatus instar III/IV larvae. The result of regression test of inverse to know the effect of leaf extract of ceremai to the death of Culex quinquefasciatus larvae obtained R2=0909 which was mean the effect of ethanol extract of Phyllanthus acidus leaves to the number of the death of Culex quinquefasciatus larvae equal to 90.9%. The result of probit test obtained LC50 result of 0.189% with 95% confidence interval (0.142% -0.233%).
Association between Personal Hygiene and Incidence of Soil-Transmitted Helminthiasis among Workers at Widodaren Plantation in Jember Regency Zulaikha Rizqina Rahmawati; Bagus Hermansyah; Erfan Efendi; Yunita Armiyanti; Yudha Nurdian; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.9593

Abstract

Soil-Transmitted Helmithiasis is an infection caused by intestinal nematode worms which in the process of transmission requires soil as media to fullfil its life cycle from non-infective forms to infective forms. The number of infections is influenced by personal hygiene. Personal hygiene consists of the habit of washing hands, cutting nails, eating, defecating and ownership of latrines, and the use of personal protective equipment. This study used a cross sectional research design conducted at Widodaren Plantation with 68 people of samples. Stool examination was determined by kato-katz method, sedimentation, and floatation to detect the presence of Soil-Transmitted Helminth (STH) eggs, while personal hygiene was assessed using questionnaires. Questionnaire and stool examination datas were processed using SPSS data analysis with chi-square method. The results of this study found 26 respondents who were positive for soil-trasmitted helminthiasis infection. The most frequent worm species obtained in this study were Ascaris lumbricoides (57.7%), followed by multiple infections between Hookworm and A. lumbricoides (21.3%), and Hookworm (19.2%). In the chi-square analysis the results were significant between personal hygiene and soil-transmitted helminthiasis with p value of 0,000 (p <0.05). So, it can be concluded that a bad personal hygiene factor has a significant relationship to the incidence of Soil-Transmitted Helminthiasis at Widodaren Plantation. Keywords: Personal hygiene, STH, plantation
Sensitivity and Specificity of Nested PCR for Diagnosing Malaria: Cases in Several Areas of Indonesia Arifin, Samsul; Fitri, Loeki Enggar; Sujuti, Hidayat; Hermansyah, Bagus; Endharti, Agustina Tri; Burhan, Niniek; Candradikusuma, Didi; Sulistyaningsih, Erma; Tuda, Josef Sem Berth; Zein, Umar
Journal of Tropical Life Science Vol 8, No 2 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.08.02.11

Abstract

Indonesia is still included in high endemic area of malaria infection. Early detection as well as appropriate and quick treatment is needed to be able to prevent and treat malaria in Indonesia. Laboratory examination using a microscopic method is still used as the gold standard to diagnose malaria cases. However, the morphology similarity of some Plasmodium species and the number of parasites that can be seen under microscopy causes malaria diagnosis become difficult if only relying on microscopy diagnostic method. The purpose of this study is to analyze the sensitivity and specificity of nested PCR compared to microscopic examination in diagnosing malaria cases. A cross-sectional study has been carried out in some areas of Indonesia and the microscopic analysis as well as nest PCR was done in Laboratory of Parasitology and Laboratory of Central Biomedical Faculty of Medicine, Universitas Brawijaya, Malang East Java Indonesia. A total of 149 blood samples from patients with clinical symptoms of malaria had been obtained from Sumatra, Sulawesi and East Java during December 2011 to December 2013. From 149 sample, 81.9% samples were diagnosed malaria positive by microscopy examination, whereas the PCR results showed that 90.6% of samples were positive. Nested PCR sensitivity is 97.5%, and microscopy 88.2%. Nested PCR specificity is 40.7%, whereas microscopy 78.5%. PPV and NPV for nested PCR are 88,2% and 78.5% respectively, and for microscopy are 97.5% and 40.7% respectively. Nested PCR has a higher sensitivity than microscopy in diagnosing malaria and is able to detect mixed infection better than microscopic examination. However, it is statistically less specific than microscopy examination.
The Association between Environmental Sanitation and Soil Transmitted Helminths (STH) Coinfection of Tuberculosis Patients in Panti District, Jember Regency Nita Alfianti; Yunita Armiyanti; Bagus Hermansyah; Enny Suswati; Dini Agustina; Diana Chusna Mufida
Journal of Ners and Midwifery Vol 7, No 3 (2020)
Publisher : STIKes Patria Husada Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26699/jnk.v7i3.ART.p354-361

Abstract

Tuberculosis (TB) is a contagious infectious disease caused by the bacteria Mycobacterium tuberculosis. More than 80% of TB cases attack the pulmonary organs and the rest are extra-pulmonary TB. Indonesia is one of the countries with the high number of tuberculosis cases besides India, China, the Philippines, and Pakistan. Aside from being a country with a high TB incidence, Indonesia is also an endemic country for helminth infections, especially Soil-Transmitted Helminths (STH). The high prevalence of STH infections in Indonesia allows STH coinfection in TB patients to cause decreasing immunity, thus affecting the outcome of TB infection. STH infection is very closely related to environmental sanitation. The purpose of this study was to identify and determine the association of environmental sanitation risk factors to the coinfection of Soil-Transmitted Helminths (STH) in tuberculosis patients in Panti District, Jember Regency. This type of research was observational research with cross-sectional analytic design. Of the 49 TB patients who were undergoing treatment at the Panti Health Center, 32 people were willing to be respondents, but only 25 people collected stool samples. Fisher's test results showed that the incidence of intestinal co-infection in TB patients in Panti District, Jember Regency was 12% and was caused by two STH species, namely A. lumbricoides and Hookworm. Environmental sanitation in TB patients was mostly good, e.g 54.5% of respondents had good environmental sanitation, but there was no significant association between environmental sanitation and the incidence of intestinal co-infection in TB patients in Panti District, Jember Regency (p> 0.05).
Description of Leukocytes Differential Count in Coffee Plantation Workers Silo Subdistrict that Infected by Soil-transmitted Helminths Desi Dwi Cahyani; Yunita Armiyanti; Cicih Komariyah; Bagus Hermansyah; Yudha Nurdian
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.9620

Abstract

Helminthiasis caused by soil transmitted helminths (STH) are still a serious health problem in the world and in Indonesia. Indonesia has a prevalence that varies between 2.5%-62%. This infection can cause blood disorders such as leukocytosis, eosinophilia, and changes in hemoglobin levels. The purpose of this study was to describe the leukocyte count of coffee plantation workers that infected by STH. This research was an observational descriptive study, using a cross sectional design and was conducted at the coffee plantation in Silo subdistrict. Stool examination was conducted by the concentration method (sedimentation and flotation) to determine the presence of STH infection, while for leukocyte count, we used the differential count method. The results of examination on 101 feces samples showed 26.7% (27/101) of workers were positively infected with STH, with details of the STH type of hookworm by 92.6% (25/27), and the remaining were double infections by Ascaris lumbricoides and hookworm as much as 7.4 % (2/27). Examination of leukocyte count showed, 17 workers with hookworm infection had abnormal leukocyte count i.e eosinophilia and neutrophilia, while 8 workers were normal. All workers with double infection (2 workers) had abnormal leukocyte count i.e eosinophilia and neutrophilia. These results can be influenced by the chronicity of the infection or the intensity of the infection. Keywords: Chronic Kidney Disease, sodium, re-use hemodialyzer
Bioactivity of a Compound of Standardized Bangle (Zingiber cassumunar Roxb.) Extract Fraction as a Complimentary Therapy to Prevent Malaria Complications Bagus Hermansyah; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol 1 No 2 (2015)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Malaria is still a major problem in the international and national scale. World Health Organization (WHO) states that based on World malaria report, world cases of malaria reached 216 million and an estimated of 655 thousand people died, in 2010. Overproduction of pro-inflammatory cytokines by phagocytic cells and activated endothelial cells occurs In the severe malaria. Bangle (Zingiber cassumunar Roxb.) has the potential to be developed as a new complementary therapy that is expected to prevent fatal malaria complications. The research objective is to test in vivo, the activity of a compound of standardized Bangle (Zingiber cassumunar Roxb.) fraction extract as a complementary therapy along with standard anti-malarial drug, artemisin. This is a true experimental study using twenty-five mice Balb / C male which are divided into five groups; the negative control group, positive control group treated KI, II, and III stimulation with each of the compounds of standardized fraction extract of bangle ( FEBT-h, FEBT-dcm, FEBT-m) for 14 days. Oneway ANOVA test showed the result of p = 0.01 (p <0.05). Continued with LSD test that showed the most significant in lowering the degree of parasitaemia is the group of methanol (FEBT-m).Keywords: Zingiber cassumunar Roxb, fractionated extracts, complementary therapies, malaria
THE RELATION OF PERSONAL HYGIENE WITH THE RISK OF OCCURRENCE OF SOIL-TRANSMITTED HELMINTH CO-INFECTION IN TB PATIENTS IN THE WORKING AREA OF THE JENGGAWAH HEALTH CENTER IN JEMBER REGENCY Ellen Ocktavironita; Bagus Hermansyah; Angga Mardro Raharjo; Diana Chusna Mufida; Dini Agustina; Muhammad Ali Shodikin
Majalah Kedokteran Sriwijaya Vol 52, No 2 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i2.11977

Abstract

Tuberculosis (TB) and soil-transmitted helminth (STH) infections are infectious diseases with a high prevalence in Indonesia. STH co-infection in TB patients can worsen the prognosis of TB disease due to the dysregulation of the immune response. The high prevalence of STH infections in Indonesia is caused by environmental factors such as poor personal hygiene habits. Jenggawah Subdistrict is an area with a high number of TB cases in Jember Regency and most of the area is in the form of agricultural fields and plantations that have a suitable humidity and temperature for the development of STH. The purpose of this study was to determine the relationship of personal hygiene risk factors with the risk of STH co-infection in TB patients in the work area of the Jenggawah Health Center in Jember Regency. This study used an observational analytic design with a cross sectional method and was conducted from September to December 2019. The research was conducted at the TB Polyclinic in Jenggawah Health Center in Jember Regency with a total sample of 26 respondents who were given a personal hygiene questionnaire. Stool examination was conducted at the Laboratory of Parasitology FK UNEJ using sedimentation and flotation methods. The results showed the incidence of STH co-infections was 15.3%, good personal hygiene was 57.7%, and bad personal hygiene was 42.3%. Fisher exact test results showed that there was no significant relationship between personal hygiene risk factors and the risk of the occurrence of STH co-infection in TB patients in the working area of the Jenggawah Health Center in Jember Regency (p = 1,000).
PERAN PROTEIN PILI 11 kDa Streptococcus pneumoniae SEBAGAI PROTEIN HEMAGLUTININ DAN ADHESIN Mufida, Diana Chusna; Salsabila, Yuna Annisa; Suswati, Enny; Hermansyah, Bagus; Agustina, Dini
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 7 No. 1 (2020): June 2020
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29122/jbbi.v7i1.3930

Abstract

Role of Pili Protein 11 kDa of Streptococcus pneumoniae as Hemagglutinin and Adhesin Protein Streptococcus pneumoniae has pili which play roles in adhesion, colonization of nasopharyngeal epithelial cells, and phagocytic inhibition of immune cells. This study aimed to determine the characteristics of the 11 kDa pili protein as hemagglutinin and adhesin, as well as their immune responses. The 11 kDa pili protein from S. pneumoniae was isolated by SDS-PAGE, purified by electroelution and dialysis. Hemagglutination and adhesion tests were carried out on the protein, and western blotting of the polyclonal antibody immune responses were evaluated. Hemagglutination test showed that the 11 kDa pili protein played a role in the hemagglutination process up to 2-time dilution. Adhesion test showed there was a correlation between the dose of the protein and the bacteria attached to the epithelial cells. The Pearson correlation test showed a P value of 0.010 and a correlation coefficient of R = -90.919. Quadratic regression test produced R2 = 0.974. Western blotting test showed that 11 kDa pili protein polyclonal antibodies recognized 67 kDa and 11 kDa pili proteins. The study concluded that the 11 kDa S. pneumoniae pili protein acted as hemagglutinin and adhesin, and the polyclonal antibody protein responded to 67 pDa and 11 kDa BM pili proteins.Keywords: adhesin, hemagglutinin, pili, protein 11 kDa, Streptococcus pneumoniae ABSTRAKStreptococcus pneumoniae memiliki pili yang berperan dalam adhesi, kolonisasi sel epitel nasofaring, serta sebagai inhibitor fagositosis sel imun. Penelitian ini bertujuan mengetahui karakteristik protein pili 11 kDa sebagai hemagglutinin dan adhesin serta respons imunnya. Protein pili 11 kDa dari bakteri S. pneumoniae diisolasi secara SDS-PAGE, dipurifikasi dengan elektroelusi dan dialysis. Uji hemaglutinasi dan adhesi dilakukan pada protein tersebut, serta dievaluasi respon imun poliklonal antibodinya secara western blotting. Uji hemaglutinasi menunjukkan protein pili 11 kDa berperan dalam proses hemaglutinasi hingga pengenceran 2 kali. Uji adhesi menunjukkan korelasi antara dosis protein dan bakteri yang menempel pada sel epitel. Uji korelasi Pearson menunjukkan P value 0,010 dan koefisien korelasi R = -0,919. Uji regresi Quadratic menghasilkan R2 = 0,974. Uji Western blotting menunjukkan antibodi poliklonal protein pili 11 kDa mengenali protein pili 67 kDa dan 11 kDa. Penelitian ini berkesimpulan protein pili 11 kDa S. pneumoniae berperan sebagai hemaglutinin dan adhesin, serta antibodi poliklonal protein tersebut memberi respons terhadap protein pili BM 67 kDa dan 11 kDa. 
Co-Authors Achmad Nazalal Furqon Aditya Primadana Adiz Dwiputra Rahmadhan Afifatun Hasanah Agustina Tri Endharti Ahmad Hasbi Al-Muzaky Angga Mardro Raharjo Asis Fitriana Billy Jusup Kurniawan Burhan, Niniek Cholis Abrori, Cholis Cicih Komariyah Desi Dwi Cahyani Diana Chusna Mufida Didi Candradikusuma Dina Helianti Dinda Ayu Wanodya Supriatiningsih Dini Agustina Dwita Aryadina Dwita Aryadina Rachmawati Edda Rachmadenawanti El Milla, Kardiana Izza Ellen Ocktavironita Elly N Sakinah Enny Suswanti ENNY SUSWATI Erfan Efendi Erma Sulistyaningsih Erma Sulistyaningsih Fitri, Nadya Eka Habib Mustofa Habibi, Ali Hanu Neda Septian Heni Fatmawati Heni Fatmawati Hidayat Sujuti Irawan Fajar Kusuma Ivan Iqbal Baidowi Jauhar Firdaus Kesy Sasta Handani Kristianningrum Dian Sofiana Lailatis Shofia Laksmi Indreswari Laksmi Indreswari Loeki Enggar Fitri M. Ali Shodikin Made Masagung Kawiartha Muhamad Dwi Eka Putra Muhammad Afiful Jauhani Muhammad Alif Taryafi Muhammad Dimas Arya Candra Permana Muhammad Ryznar Faisal Nur Luqmani Nexia Nevarachell Onny Amirsyah Nidya Husna Kholidah Nita Alfianti Nurul Furqooniyah Pralampita, Pulong Wijang Rena Normasari Rezza Putri Mahartika Salsabila, Yuna Annisa Samsul Arifin Saputra, Antonius Dwi Sarah Andriani Selly Silfana Liensa septa surya wahyudi, septa surya Shofia, Lailatis Siti Zulaikha Sugiyanta Sugiyanta Tristianti, Farmitalia Nisa Tuda, Josef Sem Berth Umar Zein Wiwien Sugih Utami Wiwien Sugih Utami Wiwin Sugih Utami Yoga Setyo Yonas Hadisubroto Yudha Nurdian Yuli Hermansyah Yuli Hermansyah Yuna Annisa Salsabila Yunita Armianti Yunita Armiyanti Zahrah Febianti Zulaikha Rizqina Rahmawati