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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi Kartika Jurnal Ilmiah Farmasi Jurnal Ilmiah Manuntung JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Dwi Nurahmanto
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEKTIVITAS EKSTRAKDAUN BENALU NANGKA (Macrosolencochinchinensis (Lour.) van Tiegh) DALAM MENCEGAH PERTUMBUHAN TUMOR PARU MENCIT BETINA Nurahmanto, Dwi; Meiyanto, Edy
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Cancer was ranked first as the cause of death in all over the world. Chemopreventive sought from traditional preparations for example, various types of plant parasites. This study aims to determine the chemopreventive activity of aqueous extract of leaves of parasites jackfruit ( Macrosolen cochinchinensis ( Lour. ) van Tiegh ) on the growth of lung tumors of mice ( Mus musculus ) female strain Balb / c induced benzo [a ] pyrene . This research was conducted using the method Newborn Mice. Test animals used female mice (Mus musculus) strain BALB / c and benzo [ a] pyrene as carcinogenic compounds. Female mice were divided into 5 groups. Cancer control group were injected with B [ a] P were dissolved in dimethylsulfoxide ( DMSO ) . Solvent control group was given the same volume of DMSO in the control of cancer. The treatment group was divided into three dose groups are a dose of 250, 500, and 750 mg / kg . Extract made after female mice induced B [a] P. Chemopreventive intensity expressed as percentage inhibition of tumors in each group by counting the number of tumor nodules on average per lung in each mouse organs within each group. Statistical analysis used is the analysis of Test homogenity of variances and continued with Mann- Whitney Test. Parasite jackfruit leaf aqueous extract (Macrosolencochincinensis (Lour.) van Tiegh) dose of I, II, and III were able to inhibit development into lung of female mice with the percentage inhibition respectively 50 %, 36.87 %, and 84.57 % .
Optimasi Hidroksipropil Metilselulosa K-4M dan Carbopol® 940 pada Sediaan Patch Dispersi Padat Piroksikam Nurahmanto, Dwi; Shalikha, Nurul; Ameliana, Lidya
Kartika : Jurnal Ilmiah Farmasi Vol 5, No 2 (2017)
Publisher : Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.049 KB) | DOI: 10.26874/kjif.v5i2.121

Abstract

Abstrak Piroksikam merupakan anti inflamasi non steroid (AINS) turunan oksikam yang berkhasiat sebagai analgesik dan antiinflamasi digunakan untuk pengobatan rheumatoid arthritis dan osteoarthritis. Piroksikam menyebabkan masalah pada saluran cerna dan first pass metabolism yang dapat dihindari dengan cara pemberian transdermal patch. Salah satu komponen patch yaitu polimer yang berfungsi untuk mengontrol kecepatan pelepasan obat dari sediaan. Penelitian ini dilakukan untuk menentukan komposisi terbaik dari kombinasi polimer hidroksipropil metilselulosa (HPMC) dan Carbopol terhadap % moisture content (MC) dan flux pelepasan sediaan transdermal patch dispersi padat piroksikam dengan rancangan formula Simplex Lattice Design. Piroksikam dibuat dalam bentuk dispersi padat dengan pembawa PEG 4000 untuk meningkatkan kelarutannya. Rancangan formula patch dispersi padat piroksikam dibuat dengan menggunakan tiga polimer Etil selulosa:HPMC:carbopol dimana yang divariasikan adalah perbandingan HPMC : Carbopol yaitu 1 : 0 ; 0,5 : 0,5 ; 0 : 1. Hasil uji menunjukkan ketiga formula memenuhi persyaratan keseragaman kadar dengan rentang keseragaman 3,735 – 97,349 %. Hasil juga menunjukkan formula 3 menghasilkan patch yang lebih tebal, pH permukaan patch lebih rendah, nilai % moisture content lebih besar dan nilai flux lebih tinggi dibandingkan formula 2 dan formula 3, Formula 3 mempunyai nilai % moisture content yang memenuhi persyaratan sebesar 6,613% dan nilai flux pelepasa yang paling bagus sebesar 32,562 µg/cm2.menit1/2. Hasil penelitian juga menunjukkan formula 1 memiliki keseragaman bobot lebih baik dibandingkan formula 2 dan formula 3. Dapat disimpulkan bahwa komposisi optimum dari kombinasi polimer HPMC dan Carbopol pada sediaan patch dispersi padat piroksikam yaitu formula dengan komposisi polimer HPMC sebanyak 0 mg dan Carbopol sebanyak 75 mg. Kata kunci:     Dispersi padat, patch piroksikam, HPMC, Carbopol Optimization of Hydroxypropyl Methylcellulose K-4M and  Carbopol® 940 in Solid Dispersion Piroxicam Patch Abstract Piroxicam is a non-steroidal anti-inflammatory (NSA) oxysmic derivative as an analgesic and anti-inflammatory agent used for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam causes problems in the gastrointestinal tract and first pass metabolism that can be avoided by giving transdermal patches. One of the patch components is a polymer that serves to control the speed of drug release from the preparation. The present study was conducted to determine the best composition of the combination of hydroxypropyl methylcellulose (HPMC) and Carbopol polymers against% moisture content (MC) and fluxes release of the pyroxicam dispersion transdermal patch dispersion with the design of the Simplex Lattice Design formula. Piroxicam is prepared in the form of a solid dispersion with a PEG 4000 carrier to increase its solubility. The design of a pyroxicam solid dispersion patch formulation was prepared using three ethyl cellulose polymers: HPMC: carbopol wherein the HPMC ratio is computed: Carbopol is 1: 0; 0.5: 0.5; 0: 1. The test results show the three formulas meet the requirements of uniformity of the content with a uniformity range of 3.735 - 97.349%. the results also show formula 3 resulting in thicker patches, lower patch pH surfaces, greater moisture content values and higher flux values than formula 2 and formula 3, Formula 3 has a moisture content value of 6.613% the finest fl ux flux of 32,562 μg / cm2.menit1 / 2. The results also show that formula 1 has better weight uniformity than formula 2 and formula 3. It can be concluded that the optimum composition of HPMC and Carbopol polymer combinations in the preparation of piroxicam solid dispersion patch is a formula with HPMC polymer composition as 0 mg and Carbopol as much as 75 mg.. Key words:      solid dispersion, piroxicam patch, HPMC, Carbopol
OPTIMASI HYDROXYPROPYL METHYLCELLULOSE DAN CHITOSAN PADA TABLET FLOATING-MUCOADHESIVE SIMETIDIN DENGAN METODE DESAIN FAKTORIAL A., Mohammad Zulfikhar; Nurahmanto, Dwi; R.K.S., Lusia Oktora
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.93 KB) | DOI: 10.51352/jim.v5i2.256

Abstract

Cimetidine is an H2 receptor antagonist which can be used to reduce acid secretion in the stomach by inhibiting selective binding of histamine to H2 receptors so that it can reduce the concentration of cyclic-adenosine monophosphate (c-AMP) which plays a role in the proton pump mechanism. The combination of floating and mucoadhesive systems is used to increase drug retention in the stomach so that it can reduce the drug interval and increase bioavailability of the drug. The purpose of this study was to make floating-mucoadhesive cimetidine tablets using Hydroxypropyl Methylcellulose (HPMC) as a floating polymer and chitosan as a mucoadhesive polymer. Tablets are expected to have the ability to maintain the dosage form in the stomach for approximately 12 hours. The evaluations carried out included the flow characteristics and the angle repose of the powder mixture, tablet weight uniformity, tablet hardness, tablet friability, floating lag time, floating duration time and tablet mucoadhesive strength. The responses observed were the ability to float and the mucoadhesive strength of tablets. The tablet release test (dissolution) for the optimum formula was performed to determine the character of tablet release. The optimum amount for HPMC is 146,686 mg and chitosan are 50 mg. The combination of polymers with this amount produces a floating lag time of 43,458 seconds, floating duration time >12 hours and the strength of mucoadhesive is 100 grams. The release of the optimum formula in the 720th minute is about 73,180% following the Higuchi release model with dissolution efficiency (DE720) about 67,855%.
OPTIMASI POLIVINILPIROLIDON DAN CARBOPOL PADA SEDIAAN PATCH DISPERSI PADAT PIROKSIKAM Nurahmanto, Dwi; Sabrina, Friska Wira; Ameliana, Lidya
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.615 KB)

Abstract

Piroxicam, a non steroidal anti inflammatory drugs (NSAID), is an oxicam derivative which can be used for treatment of various rheumatic diseases, such as rheumatoid arthritis and osteoarthritis. Piroxicam patch is an affective approach evading piroxicam?s side effect such as peptic ulcer and first pass metabolism. One of the patch components is polymer that the function is to control the speed of drug release from the patch. The aims of this study were to determine the optimum formula of a combination of polyvinylpyrolidone (PVP) and Carbopol to % moisture content (MC) and the flux release in solid dispersion piroxicam patch using Simplex Lattice Design. Piroxicam was prepared in the form of a solid dispersion in PEG 4000 to increase its solubility. The design formula of solid dispersion piroxicam patch made with the ratio PVP : Carbopol, that were 1 : 0; 0.5 : 0.5; 0 : 1. The optimum formula was chosen with the ratio PVP : Carbopol, 1: 0, which gave the best result of % MC and flux release. The result of % MC was 6.91% and the result of flux release was 35.543 µg/cm2.menit1/2.
PENGARUH PERBEDAAN CHEMICAL PENETRATION ENHANCER PADA PENETRASI TRANSDERMAL PATCH PROMETAZIN HCL Nurahmanto, Dwi
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (647.671 KB) | DOI: 10.51352/jim.v2i2.68

Abstract

This research aims is to create a promethazine HCl patch transdermal drug delivery systems with the most excellent penetration. Transdermal drug delivery can be efficiently used for the active agents which undergo rapid first pass metabolism and oral absorption is often disrupted by nausea and vomiting, hence the transdermal patches of promethazine HCl were prepared by using different penetration enhancers,  propylene glycol, oleic acid and isopropyl alcohol. The prepared formulations were evaluated for thickness, weight variation, moisture content, drug content, morphology, and in vitro permeation studies. The patch morphology studies were performed by Scanning Electron Microscopy (SEM). The amount of promethazine HCl transfered by propylene glycol  25.77 ± 3.0396 ug, isopropil alcohol 25.758 ± 2.9022 ug and oleic acid 25.017 ± 8.1300 ug. The penetration of promethazine HCl patch with oleic acid enhancer, produce the highest penetration than isopropil alcohol and propylene glycol. there was no difference in penetration using propylene glycol and isopropyl alcohol. Oleic acid is the best enhancer for preparations patch containing promethazine HCl although the amount of promethazine HCl contained is the least. The whole formulations comply with the  patch dosage requirements
FORMULASI SEDIAAN GEL DISPERSI PADAT IBUPROFEN : STUDI GELLING AGENT DAN SENYAWA PENINGKAT PENETRASI Nurahmanto, Dwi; Mahrifah, Ifa Rosi; Azis, Rani Firda Nur Imaniah; Rosyidi, Viddy Agustian
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.51 KB) | DOI: 10.51352/jim.v3i1.97

Abstract

ABSTRACT This study aims to determine the effect of using gelling agent and chemical penetration enhancer on the solid dispersion Ibuprofen gel in increasing the transdermal drug penetration. Inhibition of the COX-1 enzyme caused by ibuprofen in oral administration can cause side effects of gastrointestinal disorders, dyspepsia, diarrhea, upper gastrointestinal infections, nausea and bloating, resulting in a topical route to reduce side effects. The gel is prepared using hydroxy propyl methyl cellulose (HPMC) and carbopol® as gelling agents, and also propylene glycol and glycerin as chemical penetration enhancer compounds. The gel evaluation are viscosity, pH, spreadability and penetration flux rate. The value of the formula 3 penetration flux is 1.5383 ± 0.029 ug / cm2.minute, the formula 1 is 1.403 ± 0.055 ug / cm2. minute, the formula 2 is 0.756 ± 0.071 ug / cm2 minute, while the formula 4 is 0.5404 ± 0.106 ug / Cm2. minute. The amount of gelling agent concentration and chemical penetration enhancer compound effect on the value of the flux penetration
Optimasi Hidroksipropil Metilselulosa dan Carbopol terhadap Moisture Content dan Laju Pelepasan Patch Ibuprofen In Vitro (Optimization of Hydroxypropyl Methylcellulose and Carbopol for Moisture Content and Release Rate of Ibuprofen Patch In Vitro) Kristine Dwi Puspitasari; Dwi Nurahmanto; Lidya Ameliana
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Ibuprofen is non steroidal antiinflammatory drug (NSAID) of the propionic acid class which is widely used for the treatment of rheumatoid arthritis. Ibuprofen patch is an effective approach evading ibuprofen's adverse effect in the GI tract and first pass effect. The function of polymer is to control the drug release from the patch. The aims of this study were to determine the effect of hydroxypropyl methylcellulose (HPMC) K4M and carbopol 934 combination on the moisture content (MC), in-vitro drug release, and to obtain the optimum formula of those polymers. Ibuprofen patch were prepared into three formulas based on simplex lattice design with the ratio of HPMC K4M : carbopol 934, that were 1 : 0, 0.5 : 0.5, and 0 : 1. Design expert software was used to obtain the optimum formula of both polymers. The results of this study showed that patch with HPMC K4M : carbopol 934 (0.5 : 0.5) gave the best MC and the in-vitro drug release. The optimum formula was HPMC K4M and carbopol 934 with the ratio of 0.5 : 0.5. Keywords: ibuprofen, patch, HPMC, carbopol
Optimasi Komposisi Polietilen Glikol dan Lesitin sebagai Kombinasi Surfaktan pada Sediaan Nanoemulsi Kafein (Optimization of Polyethylene Glycol and Lecithin Composition as Surfactant Combination in the Caffeine Nanoemulsion) Dessy Dwi Risky Ayuningtias; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i2.5864

Abstract

Caffeine is one of alkaloids that have the potential to skin cancer treatment. Caffeine is hydrophilic with log-P value of 0.07 that makes difficult to penetrate to the stratum corneum. Nanoemulsion is one of system which made to increase drug penetration. Oneof the important component in the nanoemulsion is a surfactant that acts as a unifier between the oil and water phases to form one phase that isotropic and thermodynamically stable. The presence of lipophilic component in the surfactant can affect the skin barrierdisturb, thus increasing penetration. The aims of this study was to find the best composition of the PEG-400 and lecithin as surfactant combination to obtain a nanoemulsion that is safe, stable, and increasing penetration of caffeine. The experiment was conducted using a factorial design method which observed responses of flux value and viscosity deviation. The viscosity deviation and flux were analyzed using Design Expert 10.0 trial to determine the optimal formula of caffeine nanoemulsion. The results obtained optimal formula of nanoemulsion that has composition of PEG-400 as 32% and lecithin as 7% . Prediction of viscosity deviation and flux value of optimal formula was 0,034 cP and 0.514 μg cm-2min-1.Keywords: caffeine, nanoemulsion, PEG-400, lecithin
Optimasi Tween dan Propilen Glikol dalam Self-Nanoemulsifying Drug Delivery System VCO-Minyak Daun Kemangi Feny Dhea Camelia; Dwi Nurahmanto; Budipratiwi Wisudiyaningsih
Pustaka Kesehatan Vol 9 No 3 (2021): Volume 9 No.3, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i3.22582

Abstract

Basil (Ocimum basilica) contains active compounds of essential oils that have volatile properties, so it will affect its antibacterial activity. SNEDDS was chosen as a delivery system to increase essential oil stability. The purpose of this study was to determine the effect of tween 80 concentration, propylene glycol, and their interactions in VCO on SNEDDS of basil leaf oil on response and to determine the antibacterial activity with optimum characteristics. Optimization of tween 80 and propylene glycol was conducted using the VCO oil phase with a factorial design method using design expert software 11 with the response used, namely% transmittance and emulsification time. Verification and characterization were carried out including organoleptic, pH, particle size, particle distribution, then tested for antibacterial activity. The results showed that an increase of tween 80 concentration and a decrease of propylene glycol would increase the transmittance value and decrease the emulsification time. There was no interaction effect between the two. Prediction software design expert 11 showed optimum formula with a clear yellow color appearance, the distinctive odor of basil oil, has an average pH of 6.81 ± 0.03, an average particle size of 19.7 ± 0.16 nm, a particle distribution with an average PDI average of 0.163 ± 0.05. The optimum formula with a concentration of 30 μl has activity against S. thypi with an average inhibition zone diameter of 17.21 ± 1.01 mm.
Optimasi Hidroksipropil Metilselulosa dan Mentol pada Sediaan Gel Dispersi Padat Ibuprofen–Polietilenglikol dengan Metode Desain Faktorial (Optimization of Hydroxypropyl Methyl Cellulose and Menthol in Ibuprofen Gel Solid Dispersion-Polyethyleneglycol usi Maharani Dwi Pratiwi; Dwi Nurahmanto; Viddy Agustian Rosyidi
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5895

Abstract

Ibuprofen is included in non-steroidal anti-inflammatory drug (NSAID) which is used for the treatments of arthritis and inflammation. Ibuprofen gel is an effective approach evading ibuprofen's side effect in GI tract and first pass effect. The aims of this study was to determine the effect of HPMC and menthol combination on viscosity, penetration flux and to obtain the optimum formula.The gel evaluations were organoleptic testing, pH, viscosity, spreadibility test, assay of ibuprofen gel, and in vitro penetration rate. In vitro penetration testing used the paddle type dissolution tester. Furthermore ibuprofen which penetrated through rat skin were analyzed by UV-Vis spectrophotometer. Ibuprofen gel were prepared into four formulas based on factorial design and the data were analyzed using design expert trial 9.0.3. The viscosity testing of F1, Fa, Fb, and Fab were 183.30 ± 14.433,261.67 ± 16.07, 158.33 ± 7.637, and 310.0 ± 13.23 dPa.s. The in vitro penetration rate of F1, Fa, Fb, and Fab were 0.7225, 0.6716, 1.5587 And 1.0702 µg/cm2.minutes. It can be concluded that Fb has the optimum formula. Keyword: optimization, HPMC, menthol, factorial design
Co-Authors A., Mohammad Zulfikhar Ali Djamhuri Ameliana, Lidya Aslyni Putri Suranina Barus Azis, Rani Firda Nur Imaniah Azis, Rani Firda Nur Imaniah Baiq Wahyudyati Karnia Qisti Budipratiwi Wisudiyaningsih Dessy Dwi Risky Ayuningtias desy diana sari Edy Meiyanto Edy Meiyanto Eka Deddy Irawan Eliyatiningsih Eliyatiningsih Eliyatiningsih Eliyatiningsih Erdiansyah, Iqbal Feny Dhea Camelia Haris Raudhatuzakinah Dwiputri Ika Puspitasari Kristine Dwi Puspitasari Maharani Dwi Pratiwi Mahrifah, Ifa Rosi Mahrifah, Ifa Rosi Nofia Elisa Putri Nuri Nuri R.K.S., Lusia Oktora Sabrina, Friska Wira Sabrina, Friska Wira Shalikha, Nurul Taffana Windy Hananta Vega Kartika Sari Viddy Agustian Rosyidi