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Pengaruh Kitosan Cangkang Udang Putih (Penaeus merguiensis) terhadap Jumlah Sel Osteoblas Tulang Femur Tikus Wistar Betina Pasca Ovariektomi (The Effect of White Shrimp (Penaeus merguiensis) Shells Chitosan on the Total Osteoblast of Femoral Female Wista Garinda Chaesaria; Muhammad Hasan
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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One of imbalance disorders of bone formation is osteoporosis. This frequently occurs in postmenopause women because of estrogen deficiency that leads to an increase in osteoclast cell differentiation exceeds osteoblast cell differentiation. Shrimp shell is an export waste that can be used to produce chitosan. Chitosan can increase osteoblast cell differentiation and inhibit the differentiation of osteoclast cell in the bone formation process. The study aimed to determine the effect of chitosan white shrimp shell on the total osteoblasts of femur female wistar rats after ovariectomy. This research was the quasi experimental laboratories research by using female wistar rats that divided into three groups; a non-ovariectomy control, a negative ovariectomy, and an ovariectomy treatment group that was given chitosan 0,05 g/day. After 14 days, the experimental mice were euthanized and osteoblast was calculated. There were 43 osteoblast cells in the control group, 21 osteoblast cells in the negative control group, and 38 osteoblast cells in the treatment group. The data was analysed using one way ANOVA and showed a significant differences between all groups (0,000). It can be concluded that the chitosan of white shrimp shell can increase the osteoblasts femur female wistar rats after ovariectomy. Keywords: osteoporosis, chitosan, osteoblast cell

Pengaruh Pemberian Kitosan Cangkang Udang Putih (Penaeus merguiensis) terhadap Ketebalan Trabekular Femur Tikus Wistar Betina Pasca Ovariektomi (The Effect of White Shrimp (Penaeus merguiensis) Shells Chitosan on the Trabecular Thickness of Femoral Fem Suci Rizalah I; Muhammad Hasan; Septa Surya Wahyudi
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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There are low bone density and defects in bone micro-architecture which led to a significant increases of bone fragility and bone fracture in osteophorosis, due to an oestrogen deficiency in post-menopause woman. Natural polymer which has potential action on bone remodelling is chitosan. Chitosan can reduce the production of IL-1, IL-6, TNF-α and PGE2 osteoclast cell as well as increase osteoblast cell differentiation in bone formation process. The study aimed to determine the effect of chitosan white shrimp shell on the trabecular thickness of femur female wistar rats post-ovariectomy. This research was the quasy experimental laboratory research using female wistar rats that were divided into three groups; a non-ovariectomy as control, a negative ovariectomy, and an ovariectomy treatment group that was given chitosan 0,05 g/day. After 14 days, the experimental mice were euthanized and trabecular thickness was measured. There were 59,53µm, 32,44µm and 78,43µm trabecular thickness in the control group, the negative control group and the treatment group, respectively. The data were analysed using one way ANOVA and they showed a significant differences between all groups (p=0,000). It can be concluded that the chitosan of white shrimp shell can significantly increase trabecular thickness femur female wistar rats post-ovariectomy. Keywords: Osteoporosis, Chitosan, Ovariectomy, Trabecular Thickness

Pengaruh Pemberian Ekstrak Etanol Kakao (Theobroma cacao) terhadap Kadar Malondialdehida Tikus Wistar Jantan Model Fraktur Tulang (The Effect of Cocoa Ethanolic Extract (Theobroma cacao) on Malondialdehyde of Male Rattus novergicus Bone Anas Bakhtiar Diyansah; Erma Sulistyaningsih; Muhammad Hasan
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Fracture is a serious musculoskeletal trauma. The healing process of fracture is disturbed by the oxidative stress, because of imbalance quantity of Reactive Oxygen Species (ROS) and an antioxidant. An antioxidant such as polyphenol, that can be found in cocoa, is needed to suppress oxidative stress. The study aimed to investigate the effect of cocoa ethanolic extract on decreasing oxidative stress by measuring malonaldialdehyde (MDA) concentration in fracture healing process. Trial test were conducted in eleven rats to determine appropriate plaster technique. The study used thirty rats and divided into five groups; the normal group without fracture, the negative control group and three treatment groups with manually fractured on left tibia under anaesthesia and immobilized by leucodur plaster. Each treatment group was treated with cocoa ethanolic extract in a dose of 125 mg/kgBW, 250 mg/kgBW, or 500 mg/kgBW orally, respectively for 21 days. The result showed that there was a significant effect of cocoa ethanolic extract on serum and bone MDA concentration in which MDA concentration decreased after cocoa ethanolic extract treatment. The study concluded that cocoa ethanolic extract had a positive effect on supression of oxidative stress in fracture healing process. Keywords: Cocoa ethanolic extract, polyphenol, fracture healing process, MDA, ROS

Kadar Puncak (Cmax), Waktu Puncak (Tmax), Waktu Paruh (T½) dan Bersihan Teobromin pada Sukarelawan Sehat setelah Pemberian Dark Chocolate Bar Per Oral Nyoman Defriyana Suwandi; Cholis Abrori; Muhammad Hasan
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7620

Dark chocolate contains two derivates of metilxantin, I.e. caffeine (1,3,7-trimetilxantin) and theobromine (3,7 dimetilxantin). Theobromine can be found in plasma. Theobromine concentration in plasma determined not only by drug dosage but also by pharmacokinetic parameters. This research aimed to determine pharmacokinetic parameters by using HPLC (High Performace Liquid Chromatography) method. This study used Quasi Experimental Design by using 16 plasma samples collected at the 0, 1.5, 3, 6, 10, 24 hours. The pharmacokinetic parameter calculations were obtained from the polynomial curve and linear curve of drug concentration in plasma by time. The maximum concentration (Cmax) theobromine on plasma after consumption of dark chocolate bar per oral was 4.173 mg/L. The maximum time (Tmax) was at the 2.501 hours. The half time (t½) theobromine was 4.880 hours. Theobromine clearance in plasma was 14.2 ml/kg/hour. The study has reported pharmacokinetic parameters of theobromine in plasma after eating dark chocolate bars orally. Keywords: Chocolate, half-time, maximum concentration, maximum time, theobromine

Hubungan antara Obesitas dengan Derajat Nyeri pada Penderita Osteoarthritis Lutut di RS Bina Sehat Jember (Relationship between Obesity and Degree of Pain in Knee Osteoarthritis Patients at Bina Sehat Hospital, Jember) Rizka Kusumaningsih; Muhammad Hasan; Irawan Fajar Kusuma
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Osteoarthritis (OA) is an abnormality of cartilage which is marked by clinical and radiological changes. The location OA is mostly at knee joint. In this study, the relationship between Waist-Hip Ratio (WHR) and Body Mass Index (BMI) with the degree of pain in patients with knee OA was investigated, measured by the Visual Analogue Scale (VAS). The study was conducted at Bina Sehat Hospital, Jember. Fifty two samples were taken by purposive sampling with established criteria. The statistical analysis to measure the relationship between BMI and VAS showed p= 0.000, which means there is a significant correlation between BMI and degree of pain in patients with knee OA. While, the relationship between WHR and VAS in male showed p= 0,095, which means there is no significant relationship between WHR and degree of pain in male patienst with knee OA. Analysis of WHR relationship with VAS in female showed p= 0,002, which means that there is a significant association between WHR and degree of pain in female patients with knee OA. It can be concluded that excess of BMI and WHR can increase the pain in patients with knee OA. Keywords: Waist Circumference, Body Mass Index (BMI), Knee Osteoarthritis (OA)

Pengaruh Posisi Kerja terhadap Kejadian Low Back Pain pada Pekerja di Kampung Sepatu Kelurahan Miji-Prajurit Kulon-Mojokerto Khulaida Fatila Hayati; Irawan Fajar Kusuma; Muhammad Hasan
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Low Back Pain merupakan gejala utama yang dilaporkan kepada praktisi kesehatan berkaitan dengan menurunnya produktivitas kerja. Posisi kerja yang ergonomi menjadi faktor penentu terjadinya Low Back Pain. Penelitian ini bertujuan mengetahui adanya pengaruh posisi kerja terhadap kejadian Low Back Pain. Sebanyak 60 responden dibagi menjadi 2 kelompok kerja: berdiri dan duduk. Indeks nyeri diukur dengan Visual Analog Scale (VAS) diikuti dengan Pain Assessment Scale. Data dianalisis dengan Chi Square Test dan didapatkan nilai 0,037. Nilai X2 hitung pada posisi kerja duduk lebih tinggi yaitu 14,267 dibandingkan dengan posisi kerja berdiri yaitu 13,467. Kedua posisi kerja baik berdiri maupun duduk sama-sama mempunyai pengaruh yang signifikan terhadap kejadian Low Back Pain. Namun posisi kerja duduk lebih tinggi pengaruhnya dibanding dengan posisi kerja berdiri. Berdasarkan data hasil penelitian menunjukkan bahwa posisi kerja memang memiliki pengaruh terhadap kejadian Low Back Pain. Kata kunci: posisi kerja, low back pain, kampung sepatu, ergonomi

PENGARUH POSISI KERJA TERHADAP KEJADIAN LOW BACK PAIN PADA PEKERJA DI KAMPUNG SEPATU, KELURAHAN MIJI, KECAMATAN PRAJURIT KULON, KOTA MOJOKERTO Irawan Fajar Kusuma; Ragil Ismi Hartanti; Muhammad Hasan
Jurnal Ilmu Kesehatan Masyarakat Vol 10 No 1 (2014)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Low Back Pain is the main symptom on the report it to health practitioners associated with decreased work productivity. Low Back Pain associated with frequent lifting, carrying, pushing and pulling of heavy goods, frequent or long to bend the body, bending, sitting or standing for long or other body posture is not natural. standing in the long term, the body can only tolerate stood with one position only for 20 minutes. If more than these limits, the elasticity of the tissue will decrease gradually and finally the pressure increased and muscle discomfort arises on the back. The ergonomics work positions be a deciding factor of occurrence of Low Back Pain. This research aims to know the influence of the working position of the genesis of Low Back Pain, and compare the influence of two working positions (standing and seated) against the occurrence of Low Back Pain. Based on data results showed that job position does have an impact on incidence of Low Back Pain. Evidenced by the results of the statistical test of Chi Square Test Crosstab values X2 count or value of the Pearson Chi-Square Test is 8,480 and the Degree of Freedom (df) is worth 3. And the value of Asymp. Sig (2-sided) is 0,037. The second comparison results analysis of the position of sitting and standing work, then both positions work standing or sitting equally had a significant influence on the incidence of Low Back Pain. However, when compared in more detail, seated position has the more influence than the standing position , it can be proved by the results of Chi Square Test Crosstab, the value of X2 count on higher seating position work i.e. 14,267 compared with 13,467 standing work position. Keywords: working position, low back pain, ergonomy

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