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All Journal e-Journal Pustaka Kesehatan Jurnal Ilmu Kesehatan Masyarakat Journal of Agromedicine and Medical Sciences NurseLine Journal Asyahid Journal of Islamic and Quranic Studies (AJIQS)
Ali Santosa
Fakultas Kedokteran Universitas Jember
Religion Humanities Economics, Econometrics & Finance Education Environmental Science Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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Karakteristik Intake Kalori dan Gula Darah pada Penderita Diabetes II yang Berpuasa Ramadhan dan Tidak Berpuasa Ramadhan Santosa, Ali
IKESMA Vol 10, No 1 (2014)
Publisher : FKM - UNEJ

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Abstract

Fasting is unfavorable situation for people with diabetes mellitus (DM) type 2 because it can lead to hyperglycemia and hypoglycemia when breaking before breaking the fast. Therefore, setting the proper feeding schedule, the amount of calories consumed, as well as administration and dosage schedules should be adjusted when the patient fasting. Types of observational studies with treatment of patients with type 2 diabetes who Ramadan fasting through consecutive sampling. One group of data taken during fasting compared to 2 months later the same group of data taken when non fasting. The data retrieved is the number of calories consumed daily and blood glucose levels sunset, 2 hours after sunset meals, predawn, and 2 hours postmeal. Based on the test paired samples T-test in patients with type 2 diabetes obtained significant differences in caloric intake while fasting against nonfasting  (p-value<0.05). The pattern also shows differences in caloric intake during after the sunset meals (69 %) compared to when the predawn (31 %). Blood glucose levels found significant differences between the fasting and nonfasting (p-value<0.05). Mean blood glucose levels when not fasting total of 190.05 mg/dl higher than the mean fasting total of 168.22 mg/dl. When fasting blood glucose levels rise in average at sunset meals and predawn of 75.11 mg/dl and 59.84 mg/dl respectively. When nonfasting blood glucose rise at breakfast higher at 63.08 mg/dl than at dinner by 24.46 mg/dl. Incidence of hypoglycemia during fasting four times as many (10.8%) than when nonfasting (2.7%). Patients with type 2 diabetes mellitus is obtained: the number of calories and blood glucose profile that fasting is lower than that is nonfasting; there is a positive relationship between the rise in blood sugar to rise in the level of calories. Ramadan fasting in patients with type 2 diabetes mellitus is positive dietary therapy but little risk of mild hypoglycemia when sunset and hyperlycemia when sunset meals. Keywords : Diabetes Mellitus II, fasting Ramadan , calories, blood glucose profiles, hypoglycemia.
Hubungan antara Tingkat Depresi dengan Kualitas Hidup Pasien Chronic Kidney Disease yang Menjalani Hemodialisis di RSD dr. Soebandi Jember (Correlation between Level of Depression and Quality of Life of Chronic Kidney Disease Patients During Hemodialysis Nindhya Kharisma Putri; Justina Evy Tyaswati; Ali Santosa
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Chronic Kidney Disease (CKD) is secondary disease with irreversible process of progressive reduction in kidney function, one of the therapy is hemodialysis which can cause psychological disorders. The most frequently occured is depression that can reduce quality of life of CKD patients. The aim of this research was to analyze the correlation between level of depression and quality of life of CKD patients during hemodialysis therapy. This research used Cross Sectional Design with 30 respondents. The data were collected from hemodialysis policlynic at dr. Soebandi hospital Jember. The level of depression was measured using HDRS questionnair, and quality of life was measured using WHOQOLBREF questionnair. The result showed that 50% respondents had mild depression (23,3% respondents had good quality of life and 26,7% respondents had bad quality of life), 23,3% respondents were moderate depression (3,3% respondents had good quality of life and 20% respondents had bad quality of life), while 26,7% respondents were severe depression who had bad quality of life. The Spearman correlation test showed that the significance (p) of this test was 0.010 with -0.464 correlation coefficient (r). It can be concluded that there were correlation between level of depression and quality of life of CKD patients during hemodialysis therapy at dr. Soebandi regional hospital Jember. Keywords: Chronic Kidney Disease (CKD), depression, quality of life, hemodialysis.
Efek Ekstrak Etanol Kayu Manis (Cinnamomum burmannii) terhadap Kadar MDA Ginjal pada Tikus Wistar Hiperglikemi (The Effect of Cinnamon (Cinnamomum burmannii) Ethanolic Extract on Kidney MDA in Hyperglycemic Wistar Rats) Vidya Muqsita; Elly Nurus Sakinah; Ali Santosa
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Cinnamon contains natural antioxidant polyphenols. Polyphenols reduces lipid peroxidation by lowering levels of MDA. This study aimed to prove the effect of ethanolic extract of cinnamon (Cinnamomum burmannii) on decreasing kidney MDA levels of rat. This research was true experimental post-test only control group design. Twenty five rats 2-3 months of age, were divided into 5 groups: K(-) without alloxan induction, K(+) was induced with alloxan 100 mg/kg, group P1, P2, and P3 were induced with alloxan 100 mg/kg and cinnamon ethanolic extract 200 mg/kg, 400 mg/kg and 600 mg/kg, respectively for 7 days. At the end of the treatment, MDA concentration of kidney was measured by using ELISA method. The average of kidney MDA level were K(-), K(+), P1, P2, and P3 grups were 1.8923 ng/g, 1.8926 ng/g, 1.8926 ng/g, 1.8925 ng/g, and 1.8926 ng/g, respectively. Data was analysed using One Way ANOVA, and resulted p = 0.238. The conclusion was cinnamon ethanolic extract could not reduce kidney MDA levels in hyperglycemic wistar rat induced with alloxan. Keywords: Cinnamomum burmannii, polyphenols, alloxan, MDA
Uji Efektivitas Beras Herbal Forte terhadap Penurunan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 (Study of the Herbal Rice Forte Effectiveness on Decreasing Blood Glucose of Diabetes Mellitus Type 2 Patient) Gema Akbar Wakhidana; Ancah Caesarina Novi Marchianti; Ali Santosa
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6789

Abstract

Diabetes mellitus is metabolic diseases characterized by hyperglycemia caused by disturbances in insulin secretion or insulin activity. Herbal Forte Rice is rice synthetic material composed of main purple sweet potato and corn flour. It contains antioksidan, fiber, resistant starch and having moderate glycemic index. This study aimed to determine the effectivity of Herbal Forte Rice on decreasing blood glucose levels of patients type 2 DM. It used a cross-over design, the role of research subjects was both as control and treatment groups. Total sample of this research consisted of 60 samples. The treatment group was given Herbal Forte Rice for 7 days in 2 consecutive meals, while the control group did not receive any intervention. The results showed the average level of Fasting Blood Glucose (FBG) beginning and end of the treatment group 179.76 mg/dL and 138.7 mg/dL; FBG beginning and end of the control 180.87 mg/dL and 187.63 mg/dL; 2 hours post prandial Blood Glucose (2hppBG) levels of beginning and end of the treatment group 284.37 mg/dL and 183.8 mg/dL; 2hppBG levels beginning and end of the control 280.57 mg/dL and 284.13 mg/dL. This study concludes that Herbal Forte Rice effective on decreasing blood glucose levels of patients type 2 DM. Keywords: diabetes mellitus, Rice Herbal Forte, GDP and GD2PP
Uji Aktivitas Protein Isolat Biji Melinjo (Gnetum gnemon) sebagai Antihipertensi secara In Vivo Kartika Tari Azhar; Tri Agus Siswoyo; Ali Santosa
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Hipertensi merupakan suatu keadaan seseorang ketika terjadi peningkatan tekanan darah sistolik ≥ 140 mmHg dan/atau tekanan darah diastolik ≥ 90 mmHg. Pengobatan jangka panjang hipertensi menimbulkan beberapa efek samping sehingga diperlukan suatu alternatif pengobatan untuk hipertensi, misalnya dengan protein isolat biji melinjo. Penelitian ini bertujuan untuk mengetahui efek antihipertensi dari protein isolat biji melinjo pada tikus hipertensi. Tikus wistar diinduksi dengan prednison 1,5 mg/kgBB dan NaCl 2% selama 7 hari kemudian diberi perlakuan. Terdapat 7 kelompok perlakuan, kelompok K merupakan tikus normal, kelompok K(-) adalah tikus hipertensi tapi tidak diberi perlakuan, kelompok K(+) adalah tikus hipertensi dan diberi kaptopril 2,5 mg/kgBB pada hari ke-8, kelompok P1, P2, P3, dan P4 merupakan tikus hipertensi dan masing-masing diberikan protein isolat biji melinjo dengan dosis 5 mg/kgBB, 10 mg/kgBB, 20 mg/kgBB, dan 30 mg/kgBB pada hari ke-8. Tekanan darah diukur sebelum dan setelah diberi perlakuan tiap 1 jam selama 5 jam. Data dianalisis secara statistik menggunakan uji Kruskal Wallis dan Mann. Dari hasil penelitian menunjukkan bahwa protein isolat biji melinjo tidak dapat menurunkan tekanan darah tikus model hipertensi.   Kata kunci: Antihipertensi, Gnetum gnemon, Protein Isolat, Tekanan Darah 
Karakteristik Intake Kalori dan Gula Darah pada Penderita Diabetes II yang Berpuasa Ramadhan dan Tidak Berpuasa Ramadhan Ali Santosa
Jurnal Ilmu Kesehatan Masyarakat Vol 10 No 1 (2014)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Abstract

Fasting is unfavorable situation for people with diabetes mellitus (DM) type 2 because it can lead to hyperglycemia and hypoglycemia when breaking before breaking the fast. Therefore, setting the proper feeding schedule, the amount of calories consumed, as well as administration and dosage schedules should be adjusted when the patient fasting. Types of observational studies with treatment of patients with type 2 diabetes who Ramadan fasting through consecutive sampling. One group of data taken during fasting compared to 2 months later the same group of data taken when non fasting. The data retrieved is the number of calories consumed daily and blood glucose levels sunset, 2 hours after sunset meals, predawn, and 2 hours postmeal. Based on the test paired samples T-test in patients with type 2 diabetes obtained significant differences in caloric intake while fasting against nonfasting  (p-value<0.05). The pattern also shows differences in caloric intake during after the sunset meals (69 %) compared to when the predawn (31 %). Blood glucose levels found significant differences between the fasting and nonfasting (p-value<0.05). Mean blood glucose levels when not fasting total of 190.05 mg/dl higher than the mean fasting total of 168.22 mg/dl. When fasting blood glucose levels rise in average at sunset meals and predawn of 75.11 mg/dl and 59.84 mg/dl respectively. When nonfasting blood glucose rise at breakfast higher at 63.08 mg/dl than at dinner by 24.46 mg/dl. Incidence of hypoglycemia during fasting four times as many (10.8%) than when nonfasting (2.7%). Patients with type 2 diabetes mellitus is obtained: the number of calories and blood glucose profile that fasting is lower than that is nonfasting; there is a positive relationship between the rise in blood sugar to rise in the level of calories. Ramadan fasting in patients with type 2 diabetes mellitus is positive dietary therapy but little risk of mild hypoglycemia when sunset and hyperlycemia when sunset meals. Keywords : Diabetes Mellitus II, fasting Ramadan , calories, blood glucose profiles, hypoglycemia.
The Correlation between Fat Consumption and Atherogenic Index on Type 2 Diabetes Melitus Patients in dr. Soebandi Hospital Mega Ratnasari; Ali Santosa; Dwita Aryadina Rahmawati
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6317

Abstract

One of the risk factor that can be changed in type 2 diabetes melitus is food consumption. Fat is one of the macronutrients that have significant influence in consumption. Unhealthy diet can be a trigger to macrovascular complication that is coronary heart disease (CHD) which started with atherosclerosis. Atherogenic index is a good predictor for CHD. This study aims to determine the correlation between fat consumption with atherogenic index in DMT 2 patients at RSD dr. Soebandi. This is an analitic observational study with cross sectional design, using 74 type 2 diabetes melitus patients from Internal Poly at RSD dr. Soebandi who met inclusion and exclusion criteria. Fat consumption were obtained with 24-hours food recall interview and atherogenic index were obtained from TG and HDL levels in medical record. The average of fat consumption is 34,01% and as much 33 subjects (44,6%) have high risk of CHD (AI>0,21). Spearman correlation test between fat consumption with atherogenic index is p=0,025 which mean there is significant correlation between fat consumption and atherogenic index in type 2 diabetes melitus patients at RSD dr. Soebandi Keywords: DM Type 2, fat consumption, carbohydrate consumption, atherogenic index
Antibacterial Activity of Ethanolic Extract from Tempuyung Leaf (Sonchus arvensis L.) againts Salmonella typhi by In Vitro Study Rinda Yanuarisa; Dini Agustina; Ali Santosa
Journal of Agromedicine and Medical Sciences Vol 2 No 2 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Tifoid fever caused by Salmonella typhi (S. typhi) is endemic disease in Indonesia. S. typhi begin to resist to chloramphenicol, so it is necessary to study about natural material as traditional medicine such as tempuyung. The aim of this research was to study antibacterial activity and Minimum Inhibitory Concentration (MIC) of ethanolic extract from tempuyung leaf (Sonchus arvensis L.) againts growth of S. typhi. This research used quasy experimental methods with post test only control group design. Treatment consisted of 8 concentrations with 5 replications was 2,5 µg/disc, 5 µg/disc, 10 µg/disc, 20 µg/disc, 30 µg/disc, 40 µg/disc, 60 µg/disc, and 80 µg/disc. As much as 10 µl from each concentration was dropped into disc and placed in Mueller Hinton Agar. Then incubated for 18 hours to 37oC. Observation of bacterial inhibition zone by using a caliper. Result of this research that the leaf extract at a concentration 10 µg/disc, 20 µg/disc, 30 µg/disc, 40 µg/disc, 60 µg/disc, and 80 µg/disc can inhibit the growth of Salmonella typhi. Minimum Inhibitory Concentration of ethanolic extract from tempuyung leaf was 10 µg/disc qualitatively and 4,43 µg/disc quantitatively. Key words: Sonchus arvensis L., Salmonella typhi, antibacterial
The Activity of Ethanolic Extract of Cyclea barbata Miers as Inhibitor of Bacterial Biofilm Formation of Salmonella typhi Dimes Atika Permanasari; Elly Nurus Sakinah; Ali Santosa
Journal of Agromedicine and Medical Sciences Vol 2 No 2 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Biofilm is a matrix consist of extracelullar polysaccharides from the replication of microbial cells that are irreversibly attached on the cell surface. Biofilm in bacteria S.typhi strain DT104 contains food substance for protection. Biofilm can be attached to the clutery, causing food contaminaton. Cyclea barbata Miers is a plant has flavonoid that can inhibited bacteria biofilm formation. Flavonoid is phenolic compounds that has function as antibacterial by forming complex compounds disturbing the integrity of cell membranes and inhibiting biofilm. This study aims to determine the activity of the Cyclea barbata Miers as inhibitor of S.typhi DT 104 biofilm formation. This study used Quasy Experimental design with completely randomized design This study used 28 samples consist of 5 doses groups (0.29 mg/ ml, 0.33 mg / ml, 0.40 mg / ml, 0.50 mg / ml, 0.67 mg / ml), positive group (a bacterial suspension with H2O2) and negative group (a bacterial suspension with H2O) The result showed that the increasing doseof extract will decrease the biofilm formation revealed by decreasing of Optical Density and showed One Way Anova test resulted p = 0.004. In conclusion, the ethanolic extract of Cyclea barbata Miers was able to inhibit S.typhi DT 104 biofilm formation and there was a correlation between the concentration of ethanoic extract of Cyclea barbata Miers and inhibition of S.typhi biofilm formation. Key words: biofilm, Cyclea barbata Miers, S.typhi
Renoprotective Activity of Morinaga Oleifera Lamk Toward Kidney Injury Rats Induced by Streptozotocin Giovani Gianosa; Suryono Suryono; Ali Santosa
NurseLine Journal Vol 7 No 1 (2022): May 2022
Publisher : Faculty of Nursing, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/nlj.v7i1.22116

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion. Chronic hyperglycemia in diabetes causes dysfunction and failure of various organs of the body such as the kidneys, eyes, nerves, heart and blood vessels. The purpose of this study was to analyze how the effect of the treatment given by Moringa leaves on diabetes mellitus conditions, especially on glomerular histopathological damage. In this study, to make diabetic mice using the induction of streptozotocin after which Moringa leaves were given as a form of treatment. The dosage of Moringa leaf extract was divided into 5 groups, namely 62.5mg / kg, 125mg / kg, 250mg / kg, 500mg / kg, and 1000mg / kg doses. The histopathological image obtained will be assessed using scoring, and for data analysis using the Kruskal-Wallis test and followed by the post hoc test using the Mann-Whitney test. The results of this study indicate that there is an effect of giving Moringa leaf extract on glomerular histopathological damage. The results of the Kruskal-Wallis data analysis test showed significant results, namely p = 0.001, after the data obtained were significant data, then it was continued with the post hoc test using the Mann-Whitney test with significant results when compared with negative controls ranging from the 125mg / kg dose group 1000mg / kg.
Co-Authors . Suryono Ancah Caesarina Novi Marchianti Athiyah Fi Ramadani Ayi Yunus Rusyana Dimes Atika Permanasari Dini Agustina Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Gema Akbar Wakhidana Giovani Gianosa Justina Evy Tyaswati Kartika Tari Azhar Mega Ratnasari Nindhya Kharisma Putri Pipiet Wulandari Rinda Yanuarisa Tri Agus Siswoyo Vidya Muqsita Yadi Janwari