Yuli Hermansyah
Fakultas Kedokteran, Universitas Jember

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Uji Aktivitas Fraksi Diklorometana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo (The Activity Test of Dichloromethane Fraction of Bangle (Zingiber cassumunar Roxb.) Methanolic Extract as Complement Edda Rachmadenawanti; Bagus Hermansyah; Yuli Hermansyah
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

World Malaria Report reported that Malaria threats 40% of world population in six regions and ninety seven endemic countries. This study aimed to investigate the activity of dichloromethane fraction of Bangle as a complementary therapy of malaria in vivo. This was true experimental laboratories study using 28 mice of Balb/c, divided into seven groups. Five treatment groups were given five dose of dichloromethane fraction of Bangle methanolic extracts as imunostimulant before malaria infection and during malaria therapy by combining with malaria standard therapy. K(+) group was given malaria standard therapy. K(-) group was not given any therapy after infection. Inhibition percentage of malaria parasite in K(-) was 0 and K(+) was 24,74%. The treatment group of 0,09 mg/grBW had the highest inhibition percentage, as many as 88,19%. It declined by decreasing dose of fraction. The result of pearson correlation showed very strong correlation (r=0,880). The Ic50 value of dichloromethane fraction of Bangle methanolic extract as a complementary therapy was 0,008 mg/grBW. In conclusion, dichloromethane fraction of Bangle methanolic extract had immunostimulant effect and antimalarial activity in vivo.   Key words: bangle, complementary therapy, inhibition percentage, malaria
The Effect of Hemodialysis on Kinetic Segment of Left Ventricular in Stage V Chronic Kidney Diseases Patients Systriana Esi Kamasita; Suryono Suryono; Yudha Nurdian; Yuli Hermansyah; Edy Junaidi; Mohamat Fatekurohman
NurseLine Journal Vol 3 No 1 (2018): May 2018
Publisher : Faculty of Nursing, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/nlj.v3i1.6506

Abstract

Chronic kidney disease (CKD) stage V attacks other organs such as heart that can cause cardiovascular disease (CVD). One of them is CVD caused by CKD stage V that is the kinetic segment of left ventricle. Cardiovascular disease occurs due to excess fluid and buildup of uremic toxin. Chronic kidney disease stage V can not be cured so it requires therapy that is hemodialysis (HD). Hemodialysis can reduce excess fluid, uremic toxin, and maintain electrolyte balance in stage V stage. Improved fluid and decreased uremic toxin can reduce the burden of the heart and strain so that blood supply to certain myocardial areas increases and the left ventricular kinetic segment increases. The purpose of this study is to determine the effect of HD on left ventricular kinetic changes in CKD stage V patients in dr. Soebandi hospital in Jember. The research design used was quasi-experimental one group pretest-postest design. The sample was 30 patients. Respondents were determined by nonprobability sampling technique with purposive sampling method. The data used are primary data and secondary data. Data analysis using Wilcoxon test. Based on the results of the study, the distribution of the sample based on the age of the most in the range of 45-54 years, based on the sex obtained more women, based on the duration of hemodialysis obtained the period of most hemodialysis> 24 months and based on blood pressure before and after hemodialysis obtained patients with hypertension. Hypothesis test using Wilcoxon test got p-value (0.000). From the results of the analysis can be concluded that there is influence of hemodialysis on kinetic segment of left ventricle in patient of CKD stage V in dr. Soebandi hospital in Jember.