Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal e-Journal Pustaka Kesehatan
Bagus Indra Kusuma
Fakultas Kedokteran, Universitas Jember
Health Professions Library & Information Science

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Pengaruh Pemberian Gel Doksisiklin terhadap Jumlah Makrofag pada Proses Penyembuhan Dermatitis Paederus akibat Racun Tomcat (Paederus sp.) pada Mencit (The Effect of Doxycycline Gel Application toward the Number of Macrophage in Dermatitis Paederus He Bagus Indra Kusuma; Al Munawir; Septa Surya Wahyudi
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Paederus dermatitis is an acute skin irritation caused by skin contact with toxins in the rove beetle (Paederus sp). Pederin poison was previously thought derived from the rove beetle's body. Based on other studies, poison pederin obtain from the symbiotic rove beetles and Pseudomonas aeruginosa which is able to secrete the matrix metalloprotease (MMP). Doxycycline is an antibiotic act as an inhibitor of MMP. This study aimed to verify the effect of Doxycycline gel to the number of macrophages in healing process Paederus dermatitis due to poison of rove beetle (Paederus sp.). The study design was a quasy experimental design using 40 mice (Mus musculus), were divided into 4 groups. Normal control group, negative control group, P1 group was given doxycycline 1%, and P2 group was given doxycycline 5%. Experimental animals were terminated on day 1, 3, 5, 7, and 15. The result of One Way Annova test on the number of macrophages on day 1, 3 and 5 showed a significance of 0.00 (p<0.05). This study showed that there was a significant difference in the effect of doxycycline gel to the number of macrophages in healing process of Paederus dermatitis. Keywords: dermatitis paederus, doxycycline gel, macrophages
Co-Authors Al Munawir septa surya wahyudi, septa surya