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All Journal Jurnal Biologi Udayana Jurnal Ilmu Dasar BERKALA SAINSTEK BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) BIOTROPIC The Journal of Tropical Biology BIOEDUSCIENCE Biota Bioscientist : Jurnal Ilmiah Biologi

Susantin Fajariyah

Jurusan Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Jember

Author-ID : 2976175

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Education Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Physics Social Sciences

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DIURETICS EFFECT OF AVOCADO LEAF (Persea americana Mill.) ETHANOL EXTRACT ON THE GASTRIC HISTOLOGY OF WISTAR MALE RATS (Rattus norvegicus) Dwi Erlinda; Mahriani Mahriani; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 1 (2020): August 2020
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v7i1.3007

Irregular urine output triggers kidney stone disease. One way to cure it is by using synthetic diuretic compounds. The use of synthetic diuretic drugs for a long time can cause side effects, namely gastric damage. Therefore, research is needed to determine the diuretic effect of ethanol extract of avocado leaves (Persea americana) and its effect on the histological structure of the gastric of male rats. Avocado leaf extract is made by maceration method, using 70% ethanol and then evaporated. Wistar male rats were divided into 5 treatment groups namely negative control (aquadest), positive control (furosemide), avocado leaf extract dose of 50 mg / kg body weight, 100 mg / kg body weight, and 150 mg / kg body weight with oral administration for 15 days. The volume of urine was measured for 24 hours, then the mice were sacrified on the 16th day. Gastric organs were taken for histological observation by the paraffin method and Hematoxylin and Eosin (H&E) staining. The results showed that the optimum avocado leaf ethanol extract was a dose of 100 mg/kg showed a diuretic effect but did not affect the histological structure of the gastric.

EFFECT OF PERIWINKLE (CATHARANTHUS ROSEUS) LEAF EXTRACT ON LIVER HISTOLOGY OF MICE (MUS MUSCULUS L) AFTER ASPARTAME INDUCE Mahriani Mahriani; Rosita Dewi Wulandari; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 8, No 2 (2022): Februari 2022
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v8i2.5161

Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of periwinkle leaves (Catharanthus roseus L) on aspartame-induced liver histology. This study used 24 male mice divided into 4 groups, namely negative control (K-) without treatment; Positive control (K +) treatment of aspartame; D1: treatment of aspartame and periwinkle extract doses of 0.42 mg/kg. D2: aspartame and periwinkle extract doses of 0.84 mg/kgbb. Administration of aspartame dose of 0.2 mg /kgbb by intraperitoneal for 14 days followed by gavage administration of periwinkle leaf extract for 12 days. The liver was taken on the 27th day by surgery, then made slide histology with Hematoxylin-Eosin staining. The results show that the administration of Catharanthus roseus leaf extract at a dose of 0.84 mg/kgbw in aspartame-induced mice was effective in reducing hepatocyte damage, namely hydrophilic degeneration and necrosis.

Toksisitas Ekstrak n-heksana Serbuk Gergaji Kayu Sengon (Albizia falcataria l. Forberg) terhadap Mortalitas Serangga Penggerek Buah Kopi (Hypothenemus hampei ferr.) (Scolytidae: Coleoptera) Purwatiningsih Purwatiningsih; Firna Putri Mandasari; Susantin Fajariyah
Biotropic : The Journal of Tropical Biology Vol. 3 No. 1 (2019): Biotropic, Volume 3, Nomor 1, 2019
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Research on the toxicity of n-hexane extract of Albizia falcataria sawdust against Hypothenemus hampei has been conducted. The method of research was contact method. The concentrations used in the experiment were control (aquadest); 0.25%; 0.5%; 1%; 2%; and 4%. Every concentration was sprayed on the female imago. Observations were performed 120 hours after treatment. The results showed that there was an effect of the length of observation time and concentration on the mortality of H. hampei (GLM Test α= 5%). The time of observation and concentration of A. falcataria sawdust n-hexane extract has positive correlation on H. hampei mortality. Therefore, the longer the treatment time, the more H. hampei mortality is increased. The mortality of H. hampei also increased with increasing concentration given. At a concentration of 4%, extract of A. falcataria sawdust has high toxicity which causes the highest mortality (> 92%).

Efek ekstrak etanol kedelai hitam (Glycine soja) terhadap ketebalan dermis mencit (Mus musculus L.) pasca unilateral ovariektomi Isna Kurotul Akyun; Susantin Fajariyah; Mahriani Mahriani
Jurnal Biologi Udayana Vol 23 No 2 (2019): JURNAL BIOLOGI UDAYANA
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Estrogen is a steroid hormone produced by the ovaries. Estrogen is a hormone that triggers collagensynthesis by fibroblast.Collagen has affects for thickness of dermis.Estrogen deficiency can lead disruptioncollagen synthesis, so has an impact on decline dermis thickness. Unilateral ovariectomy is the act ofremoval of one ovary in the female reproductive system and is a model for estrogen deficiency. Thecondition of estrogen deficiency can be overcome by giving phytoestrogens. Black soybean seed is one ofphytoestrogens source. The purpose of this study was to determine the effect of black soybean extract afterovariectomy on increasing on dermis thickness (Mus musculus L.). The dosage of black soybean ethanolextract used was 0.31 g / ml / day and 0.63 g / ml / day administered orally (gavage) for 20 days. The resultsshowed a dose of 0.31 g / ml / day may and 0.63 g / ml / day increase dermis thickness of mice.

Keanekaragaman Jenis Echinoidea di Zona Intertidal Pantai Jeding Taman Nasional Baluran Muhammad Aris Ilman Huda; S. Sudarmadji; Susantin Fajariyah
BERKALA SAINSTEK Vol 5 No 2 (2017)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v5i2.5531

Zona intertidal merupakan daerah yang terletak diantara pasang tertinggi dan surut terendah, yang mewakili peralihan dari kondisi lautan ke kondisi daratan. Luas zona intertidal sangat terbatas, akan tetapi memiliki faktor lingkungan yang sangat bervariasi, sehingga memiliki keanekaragaman organisme yang tinggi salah satunya adalah kelas Echinoidea. Kelas Echinoidea termasuk dalam anggota Filum Echinodermata yang tersebar mulai dari daerah intertidal sampai laut dalam. Echinoidea umumnya menghuni ekosistem terumbu karang dan padang lamun. Pantai Jeding merupakan pantai yang terletak di wilayah Taman Nasional Baluran yang masih belum pernah dilakukan penelitian mengenai keanekaragaman Echinoidea. Penelitian ini bertujuan untuk mengetahui keanekaragaman dan kesamarataan jenis Echinoidea di zona intertidal Pantai Jeding Taman Nasional Baluran. Metode yang digunakan dalam pengambilan sampel adalah metode transek-plot sistematis. Hasil penelitian didapatkan 8 jenis Echinoidea yang terdiri 4 ordo, 6 famili, 8 genus dan 8 spesies. Memiliki indeks Keanekaragaman (H’) jenis yang tergolong sedang dan Indeks kesamarataan (J’) Jenis yang tergolong sedang.Kata Kunci: Zona Intertidal, Echinoidea, Keanekaragaman, Pantai jeding.

The Diversity of Holothurioidea in the Intertidal Zone of the Pancur Shore of the Alas Purwo National Park Riya Wulan Afrely; Moh. Imron Rosyidi; Susantin Fajariyah
Jurnal ILMU DASAR Vol 16 No 1 (2015)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Holothurioidea well known as Sea Cucumber is one of the classes from the Echinodermata phylum. Sea cucumbers are benthic animals that move slowly. Currently they already identified about 1135 species. Their existence usually associated with abiotic factors such as water salinity, temperature, pH, wave motion, light intensity and the substrate. The ability of the Holothurioidea to adapt to the abiotic factors will affect species diversity. The research aims is to determine the species diversity in the intertidal zone at Pancur Shore of the Alas Purwo National Park. It includes the species composition, species diversity index and the index of equality The study was conducted on 14th-21st of June 2014, by using systematic plotting transect method. The results found: one order, one family, two generas and eight species. The Species diversity index of Holothurioidea at Pancur Shore is low (0.930) and the equality index classified uneven (0.447).Keywords: Holothurioidea, intertidal, diversity, evennes

The Effect of Cinnamon (Cinnamomum burmanii) Aqueous Extract on Pancreas Structure of Diabetic Mice (Mus musculus) Strain Balb-C Ika Dewi Kusumaningtyas; Susantin Fajariyah; Eva Tyas Utami
Jurnal ILMU DASAR Vol 15 No 2 (2014)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

The objectives of this study were to observe effect and the effective dose of cinnamon (Cinnamomum burmanii) aqueous extract on pancreas structure of strain Balb-C mice (Mus musculus) diabetic after alloxan exposure. A total of 30 strains Balb-C mice (Mus musculus L.) were divided into 5 groups. Negative control group was not induced by alloxan and a positive control group was induced alloxan 0,15 mg/g bw intraperitoneally for 9 days. The treatment group was divided into 3 groups was induced alloxan 0,15 mg/g bw and given an aqueous extract of cinnamon at a dose of 0,73 mg/g bw; 1,09 mg/g bw and 1,45 mg/g bw orally for 7 days. Mice were dissected pancreas histhological taken using paraffin method and Haematoxylin-eosin (HE) stain. The result showed giving aqueous extract of cinnamon gave a strong effect in the repairing of pancreas structure after giving the alloxsan and the most effective aqueouse xtract of cinnamon with dose of 0,73 mg/g bb was able to repair the structure of mice's pancreas after giving the alloxan. Keywords: Cinnamon, pancreas structur,diabetic mice

The Effect of Synthetic Estrogen on Hepar Stucture And Level of SGOT and SGPT of Balb’C Female Mice (UMus musculus) Susantin Fajariyah; Eva Tyas Utami; Yunita Arisandi
Jurnal ILMU DASAR Vol 11 No 1 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.087 KB)

The objectives of this study were to observe the effect of synthetic estrogen (diethylstilbestrol/DES) on hepar structure and level of SGOT as well as SGPT of female mice (Mus musculus). Mice were gavage by DES dose 0.084 μg/g bb, 0.168 μg/g bb, 0.336 μg/g body weight, sesame oil and control. DES was treated by gavage for 15 days. Observation were performed liver structure contain of number of normal hepatocyte, and hepatocyte disruption (picnosis, vacuole cell, and necrosis), also SGOT-SGPT level. The result showed that DES effected to the disruption of hepatocyte particularly necrosis was relativity high in 0,168 μg/g bb DES treatment. SGOT and SGPT level on blood increased after DES treatment.

The Effect of Ethanol Extract Turmeric Rhizome (Curcuma Longa) to Histologycal Structure of Rat Rectum Induced Dextran Sodium Sulphate (DSS) Lidia Maziyyatun Nikmah; Susantin Fajariyah; M. Mahriani
Jurnal ILMU DASAR Vol 20 No 1 (2019)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Turmeric (Curcuma longa) is a plant that people use as a traditional medicine to treat some diseases such as: anti-inflammatory, antidiarrhea, antioxidants, hepatoprotector, and others. One of the main chemical compounds contained in turmeric and has a role as anti-inflammatory is curcumin. This study was conducted to determine the effect of ethanol extract of turmeric rhizome (Curcuma longa) on the histologycal structure of rat rectum induced by Dextran Sodium Sulphate (DSS). Wistar strain rats was divided into three groups: negative control group, positive control group (1% DSS), and DSS treatment group 1% + ethanol extract of turmeric rhizome dose 200mg/KgBB. DSS is given ad libitum, while ethanol extract of turmeric rhizome is given orally. We used paraffin method and Haematoxilyn Eosin staining to make the preparation organ. The data were analyzed using One Way ANOVA test, Duncan Multiple Range Test (DMRT) test, and correlation test. The result of this study is DSS administration has an effect on decreasing average of crypt, number of Goblet cell, and depletion of rectal mucous layer. While treatment of extract turmeric rhizome can increase height of crypt and number of Goblet cell in rectal mucosal layer of rat. Keywords: Extract of turmeric rhizome, DSS, rectum, Rattus norvegicus

Curcumin Effectivity on Hepar and Reproductive Organ Recovery Male Mice (Mus musculus L) after Methoxychlor Exposure Mahriani Mahriani; Susantin Fajariyah; Eva Tyas Utami
Biota Vol 13 No 1 (2020)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v13i1.196

Methoxychlor (MXC) is an insecticide (DDT derivates) that has the potential for bioaccumulation in mammal and causes a disruptive effect on the hepar and reproductive system. This study was done to find out the benefits of curcumin as a natural ingredient to overcome the negative impact of Methoxychlor (MXC) on hepar and male reproductive organ of Balb’C mice (Mus musculus L). The study was carried out in a Completely Randomized Design (CRD) Posttest Only Control Group Design used four treatments and six replications. The curcumin treatment after administration of MXC was carried out by gavage with curcumin doses: 0.05; 0,1; and 0.2 mg/g body weight, every day for two weeks, respectively. Histological observations of the liver, and testis was performed using the paraffin method and Hematoxylin Eosin stained. The results showed that MXC exposure caused liver disruption by increasing the number of pycnotic necrotic hepatocytes and hydrophic degeneration hepatocytes. On the male reproductive organ, MXC caused testis impairment by reducing the number of Sertoli cells and Leydig cells, spermatogenic cell counts, and the diameter of seminiferous tubules. The administration of curcumin at doses of 0.1 mg/g bw in mice exposed to methoxychlor can reduce the number of hydrophic degeneration hepatocytes and tend to reduce the number of pycnotic hepatocytes; and also increase the number of Sertoli cells, the number of spermatogenic cells, and the diameter of the seminiferous tubules, and tend to reduce the amount of Leydig cells. Curcumin treatment tends to recover hepar dan testis disruption of mice that were exposed by MXC.

Co-Authors Bella Dwi Arifianti Dewi Syaibatul Aqlina Dwi Erlinda Eva Tyas Utami Firna Putri Mandasari Ika Dewi Kusumaningtyas Isna Kurotul Akyun Lidia Maziyyatun Nikmah Mahriani Mahriani Mahriani Mahriani Mahriani Mahriani Moh. Imron Rosyidi Muhammad Aris Ilman Huda Purwatiningsih Purwatiningsih Riya Wulan Afrely Rosita Dewi Sudarmadji Sudarmadji Yunita Arisandi

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