Ermi Girsang
Faculty of Medicine, Universitas Prima Indonesia

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Potentials of rose (Rosa damascena) petals and receptacles extract as antioxidant and antihyaluronidase Desi Yustra Sari Dewi; Chrismis Novalinda Ginting; Linda Chiuman; Ermi Girsang; Rr. Anisa Siwianti Handayani; Wahyu Widowati
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (64.115 KB) | DOI: 10.12928/pharmaciana.v10i3.16406

Abstract

Free radicals affect aging by unspecific lead breakdown to macromolecules, like DNA, lipids, and proteins. The degradation of the extracellular matrix affects skin aging and correlated with the hyaluronidase enzyme. Rose (Rosa damascena) petal extract and rose receptacle extract can scavenge free radicals, thus hindering the aging process. This study examines phenolic and flavonoid content, the antioxidant, anti-hyaluronidase potential owned by rose petal extract (RPE), and rose receptacle extract (RRE) inhibiting skin aging. In this study, Hydrogen peroxide (H2O2) scavenging activity assay was done to analyze the antioxidant activity while the hyaluronidase inhibitory assay analyzed antiaging activity. The characteristic of RPE and RRE were measured the phenolics and flavonoids content. The phenolics content of  RPE and RRE were 9.66 μg GAE/mg RPE and  4.31  μg GAE/mg RRE, respectively, while the flavonoids content of  RPE and RRE respectively 1.22 μg QE/mg RPE and 0.59 μg QE/mg RRE. The median inhibitory (IC50) of H2O2 scavenging of RPE (207.99 µg/mL) was more active than RRE (348.24 µg/mL). RPE's anti-hyaluronidase (IC50: 51.68 µg/mL) is as effective as RRE (IC50: 51.98 µg/mL). Antioxidant and antiaging activities possessed by RPE and RRE are promising natural agents for aging therapy.
Role of Surf Redfish (Actinopyga mauritiana) in Wound Incision Healing Activities of Diabetic Mice Moriza Lesmana; Ermi Girsang; Ali Napiah Nasution; Adrian Adrian
Majalah Kedokteran Bandung Vol 54, No 1 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n1.2588

Abstract

It is estimated that 6% of the US population suffer from diabetes with 15% of them experience diabetic foot. Several studies have explored the various benefits of sea cucumber for human being, including its antioxidant nature. This study aimed to investigate the effect of surf redfish, one species of the sea cucumbers, in diabetic wound healing. This was an animal experimental study performed at the Pharmacology and Pharmaceutical laboratory of the Faculty of Pharmacy, Universitas Tjut Nyak Dhien Medan, Indonesia, during the period of February- July 2019. Twenty five mice in diabetic condition were divided into five groups: control, standard, ethanol extract of surf redfish-1, ethanol extract of surf redfish-2, and ethanol extract of surf redfish-3 3. The surf redfish was obtained from Lamreh Village in Aceh and the ethanol was extracted using the maceration method. The parameters used for evaluating the efficacy of surf redfish ethanol extract were blood glucose level, length of wound incision, and histopathological features. Surf redfish extract presented a significant reduction of blood glucose level which that followed the increase in the dose of the ethanol extract (p-value <0.05) where the most significant reduction was seen in the group with the highest dose on the last day. This trend was also seen for the length of the wound, where the reduction was significantly higher in treatment groups when compared to control (p-value <0.05). The histological study also confirmed the improvement in the clinical appearance of wound by showing significantly increased fibroblast cell number and collagen density (p-value <0.05). Overall, the surf redfish can help better incision's wound healing in diabetic condition.
H2O2-Scavenging Activity and Hyaluronidase Inhibition Scutellarin and Apigenin in Basil Leaf Extract Lydia Yusuf; Ermi Girsang; Ali Napiah Nasution; Cut Elvira; Satrio Haryo Benowo Wibowo; Wahyu Widowati
Jurnal Kedokteran Brawijaya Vol. 31 No. 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.1

Abstract

The potential utilization of flavonoid compounds, especially scutellarin, and apigenin, contained in basil (Ocimum basilicum L.) leaf extract to manage the aging effects on the skin, that occurs because of over-activated hyaluronidase enzyme and oxidative stress due to hydrogen peroxide (H2O2) radicals, is not well known. This study was conducted to assess the H2O2 scavenging activity and the inhibition of hyaluronidase from scutellarin and apigenin at various concentrations. The study was conducted by measuring H2O2 scavenging inhibition and hyaluronidase inhibition of scutellarin and apigenin in various concentrations using the spectrophotometry method. The various activity was tested using the One-Way ANOVA test followed by Tukey post hoc test. IC50 values were calculated based on linear regression equations of H2O2 scavenging inhibition and hyaluronidase inhibition. The analysis showed the highest H2O2 scavenging activity was found in scutellarin with IC50 158.76 μg/mL. Scutellarin has greater scavenging activity than apigenin. Hyaluronidase inhibition of scutellarin with IC50 35.25 µg/mL, while apigenin was 162.86 µg/mL. Scutellarin has higher hyaluronidase inhibition activity than apigenin. Antioxidant and antiaging effects of basil leaf extract caused by phytochemical compounds contained, especially scutellarin.
Prevalence and Determinants of Stunting Incidence in Toddlers Tiorismasni Zai; Ermi Girsang; Sri Lestari Ramadhani Nasution; Chrismis Novalinda Ginting
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 2: June 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.004 KB) | DOI: 10.30604/jika.v7i2.917

Abstract

The incidence of stunting in children under five is still the main cause of death in children under five in the world because the impact of stunting is not only on health problems but is closely related to the level of intelligence of children. This study aims to determine the prevalence and investigate the determinants of stunting in children under five. This study is quantitative research with a cross-sectional design. The population of this study was all mothers of children under five who visited the Mandrehe Barat Non-Inpatient Puskesmas in 2021, and the research sample was 200 mothers of children under five. Data was collected directly by distributing questionnaires to mothers of children under five. Then, continued with the process of data analysis with the chi-square test and binary logistic regression. The results showed that exclusive breastfeeding (p= less than 0.001; PR= 9.5; 95% CI 6.788-22.948), feeding patterns (p= less than 0.001; PR = 7.6; 95%CI 4.833-12.266), and consumption of vitamin A and zinc during pregnancy (p= less than 0.001; PR = 4.4; 95%CI 3.172-6.043) had a significant effect on the incidence of stunting, but a history of low birth weight (p= 0.785; PR= 1.08; 95% CI 0.372-3.306) and history of infectious disease (p=0.111; PR=1.5; 95%CI 0.978-2.441) were not significant for the incidence of stunting. Furthermore, the dominant factor in the incidence of stunting shows that toddlers who are stunted are 5.7 times more likely not to be given exclusive breastfeeding compared to toddlers who are not stunted. Thus, mothers of children under five are expected to take the time to visit health services by bringing their children under five to monitor their growth and development of children such as height and weight according to the child's age. Abstrak: Kejadian stunting pada anak balita hingga saat ini masih merupakan penyebab utama kematian pada anak balita di dunia, karena dampak stunting bukan hanya pada masalah kesehatan, namun, sangat erat kaitannya pada tingkat kecerdasan anak. Penelitian ini bertujuan untuk mengetahui prevalensi dan menyelidiki determinan kejadian stunting pada balita. Studi ini merupakan penelitian kuantitatif dengan desain crossectional. Populasi penelitian ini adalah seluruh ibu balita yang berkunjung di Wilayah Puskesmas Non Rawat Inap Mandrehe Barat Tahun 2021, dan sampel penelitian sebanyak 200 orang ibu balita. Pengumpulan data dilakukan secara langsung dengan menyebarkan kuesioner kepada ibu balita. Kemudian, dilanjutkan dengan proses analisis data dengan uji Chi Square dan regresi logistik biner. Hasil penelitian menunjukkan bahwa pemberian ASI Eksklusif (p=kurang dari 0,001;PR=9,5;95%CI 6,788-22,948), pola pemberian makan (p= kurang dari 0,001; PR=7,6; 95%CI 4,833-12,266), dan konsumsi vitamin A dan Zinc pada masa kehamilan (p= kurang dari 0,001;PR=4,4; 95%CI 3,172-6,043) berpengaruh signifikan terhadap kejadian stunting, namun riwayat BBLR (p=0,785; PR=1,08;95% CI 0,372-3,306) dan riwayat penyakit infeksi (p=0,111; PR=1,5; 95%CI 0,978-2,441) tidak signifikan terhadap kejadian stunting. Selanjutnya, faktor dominan terhadap kejadian stunting menunjukkan bahwa balita yang mengalami stunting 5,7 kali kecenderungannya tidak diberi ASI Eksklusif dibanding dengan balita yang tidak mengalami stunting. Dengan demikian, kepada ibu balita diharapkan agar melungkan waktu untuk berkunjung ke tempat pelayanan kesehatan dengan membawa anak balita untuk memantau tumbuh kembang anak seperti tinggi dan berat badan sesuai usia anak.
Pengaruh Job Demand Control-Support dan Protection Motivation Terhadap Kepatuhan Pengisian Berkas Rekam Medis Rawat Inap di RSU ESHMUN MEDAN Sri Lestari Ramadhani Nasution; Muhammad Maulidin; Ermi Girsang
Journal of Health Science and Prevention Vol. 7 No. 2 (2023): JHSP vol 7 No 2 - 2023
Publisher : State Islamic University of Sunan Ampel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/jhsp.v7i2.989

Abstract

An important indicator to determine the quality of service in a hospital is about the completeness of the hospital's medical record files. There are many problems arise due to incomplete medical record files and do not recorded neatly and regularly. The incident is due to lack of medical team awareness in recording all information or actions that would be given to the patient. The aim of this study is to analyse the effect of Job Demand-Control-Support and Protection Motivation on compliance in filling out Medical Record files at RSU ESHMUN Medan 2023. This study uses quantitative research method which is analytical in nature. The total sampling of this study is 115 active nurses at RSU ESHMUN Medan. The result of the study informs that there are very strong and significant effect among Job Demand-Control-Support and Protection Motivation on compliance in filling out Medical Record files at RSU ESHMUN Medan 2023. The variable that has the most influence on Obedience with filling in inpatient medical record files at RSU ESHMUN in 2023 is the Protection Motivation variable. It is recommended to RSU ESHMUN Medan to improve the administration pattern in order to all of nurses have the same job demands and receive the same support.