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POTENSI INFUSA DAUN OKRA (Abelmoschus esculentus L. Moench) TERHADAP PENURUNAN KADAR GLUKOSA DARAH MENCIT-INDUKSI ALOKSAN Eva Nor Diana Lestari; Rahmat A Hi Wahid; Nurul Marfu'ah
Media Farmasi: Jurnal Ilmu Farmasi Vol 17, No 1: Maret 2020
Publisher : Universitas Ahmad Dahlan

Diabetes melitus (DM) merupakan suatu penyakit yang ditandai dengan tingginya kadar glukosa dalam darah. Kandungan kimia pada tanaman okra di antaranya 67,50% Î±-selulosa, 15,40% hemiselulosa dan flavonoid yang berefek antidiabetes. Tujuan penelitian untuk mengetahui potensi infusa daun okra terhadap penurunan kadar glukosa darah mencit (Mus musculus) yang diinduksi aloksan. Metode penelitian yang digunakan adalah eksperimental dengan desain Rancangan Acak Lengkap (RAL). Penelitian ini menggunakan 20 ekor mencit jantan berusia tiga bulan yang diinduksi diabetes menggunakan aloksan dan dibagi ke dalam lima kelompok. (1) Kelompok kontrol negatif, diberi aquades, (2) Kelompok kontrol positif, diberi glibenklamide dosis 3 mg/KgBB, dan kelompok (3-5) diberi infusa daun okra dengan dosis 0,2, 0,4, dan 0,6 mL/hari selama 14 hari. Pengukuran kadar glukosa dilakukan setelah 14 hari perlakuan menggunakan glukometer (Easy Touch® GCU). Analisis data menggunakan uji One Way ANOVA dengan tingkat signifikansi 95% (p=0,05). Hasil penelitian menunjukkan infusa daun okra dosis 0,2, 0,4, dan 0,6 mL/hari menurunkan kadar glukosa darah namun tidak bermakna secara statistik p=0,990 (p>0,05). Hasil penelitian dapat disimpulkan bahwa pemberian infusa daun okra dosis 0,2, 0,4, dan 0,6 mL/hari berpotensi menurunkan kadar glukosa darah mencit terinduksi aloksan tetapi tidak signifikan.

Aktivitas Antibakteri Kayu Siwak (Salvadora persica) Fraksi Eter terhadap Bakteri Staphylococcus aureus Secara In Vitro Riza Amalia; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Using miswak is one of sunnah performed by Prophet Muhammad SAW and it contains a variety of compounds including these terpenoids, alkaloids, tannins and flavonoids which function as an antibacterial on the periodontal disease. Therefore, extraction and fractionation process were done to get the active compounds in miswak wood that has antibacterial activity against Staphylococcus aureus. This study is an experimental research with Complete Random Design methods. Ethanol extract separated using miswak from solvent of ether. Screening phytochemicals on thin Layer Chromatography (TLC) and test tube, the antibacterial activity was done using diffusion method with a concentration of 50% v/v, 25% v/v, 12.5% v/v and 6.25% v/v, metronidazole as a positive control and a DMSO as the negative control. The data obtained were then analyzed using One Way ANOVA test. Wood of miswak from ether fraction provide inhibition of 14.6-20.8 mm included strong category. The use of metronidazole as positive controls provide significant inhibitory against Staphylococcus aureus and the solvent DMSO as a negative control did not provide any inhibitory area. As for the description of the zone of inhibition against Staphylococcus aureus bacteria. Miswak wood from ether has antibacterial activity against Staphylococcus aureus with fraction of ether concentration of 12.5% v/v and smallest zone amounting 14.6 mm. Whereas at the greatest concentration found in the inhibition of 50% v/v with the average diameter of the zone of drag of 20.8 mm, with secondary metabolites contained in miswak fraction of ether is these terpenoids, alkaloids and tannins

Pengaruh Steroid Anabolik Methandienone terhadap Kualitas Spermatozoa Tikus Putih (Rattus norvegicus) Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1120

Anabolic steroids are chemical derivative of the testosterone hormone that are commonly used in medical field, but in development it is abused by its users. Methandienone is one type of anabolic steroid that widely used in the world. The anabolic effects can develop muscle formation, but the androgenic effect can suppress testosterone synthesis. Low testosterone will disrupt spermatogenesis and ultimately decrease the quality of spermatozoa production. This study aim to determine effect of anabolic steroid methandienone to quality of spermatozoa in albino rats (Rattus norvegicus). Examination of the quality of spermatozoa was performed on cauda epididymal include speed, motility, viability, and morphology of spermatozoa. The results of this study showed that the average quality of spermatozoa between the control group and the treatment group statistically was not significantly different (P > 0.05). However, average quality of spermatozoa (speed of spermatozoa, percentage of motile spermatozoa, percentage of alive spermatozoa, percentage of normal spermatozoa) also showed a declining trend. Speed of spermatozoa was normal because it is able to move in 1-4 mm/min. Motility and morphology of spermatozoa was normal because the percentage of motile spermatozoa and normal spermatozoa showed more than 50%. Viability of spermatozoa in the treatment group was abnormal because the percentage of alive spermatozoa showed less than 25%.

UJI DAYA HAMBAT EKTRAK ETANOL DAUN SIRIH HIJAU (Piper betle L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Nurul Marfu'ah; Sha’sha’ Luthfiana; Ichwanuddin Ichwanuddin
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 2 (2021): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i2.6650

Bakteri Staphylococcus aureus dapat menyebabkan beberapa gangguan pada kulit. Salah satu tanaman yang memiliki kemampuan antibakteri yaitu sirih hijau yang mengandung senyawa fenol dan turunannya. Tujuan dari penelitian ini yaitu untuk mengetahui potensi antibakteri Staphylococcus aureus dari ekstrak etanol daun sirih hijau (Piper betle L.). Jenis penelitian ini adalah eksperimen dengan 6 perlakuan yaitu K- (CMC-Na 0,5%), K+ (kloramfenikol 50 µg/50 ml), serta ekstrak daun sirih hijau konsentrasi 10%, 20%, 30%, dan 40%. Proses ekstraksi daun sirih hijau dengan metode maserasi dan di uji antibakteri dengan paper disk dan metode difusi. Uji parametrik One Way ANOVA digunakan untuk menganalisis data berupa diameter zona hambat. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirih hijau memiliki potensi sebagai antibakteri Staphylococcus aureus (P<0,05). Kemampuan antibakteri terhadap Staphylococcus aureus paling optimal dimiliki oleh ekstrak etanol daun sirih konsentrasi 40%, dengan rata-rata zona hambat sebesar 3,01 mm (daya hambat lemah).

Uji Toksisitas Sub Akut Iunfusa Daun Afrika (Vernonina amygdalina Del.) terhadap Histopatologi Ginjal Mencit Galur Balb/C Nida Faradisa; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Alloh created everything in this universe to take benefit from it, including African Leaf plant. One of the benefits of this leaf is to treat diabetes mellitus, malaria and dysentery. African leaf contains saponin type compounds, flavonoids and steroid glycosides. Drugs that enter the body will go through the phase of metabolism in the liver and excretion in the kidneys. Kidney that serves to dispose of metabolic waste and body toxins in the form of urine. The purpose of this research is to know the effect of African Leaf infusion on histopathology of mice kidney BALB/c. Samples in the form of BALB / c male strain of mice were 12 samples were divided into 4 treatment types with 3 replications. Treatment of control (aquades), African leaf infusion 10% b/v, 20% b/v and 30% b/v infused orally for 28 days. The data obtained were analyzed by Kruskall Wallis test and the data shows congestion value 0.241 > p 0.05 and hemorragic value 0.070 > p 0.05 which means there is no significant difference between treatment types. Therefore, it can be concluded that African leaf infusion has no effect on histopathology of renal mice BALB/c. However, the trend of results in this study indicates that the increased dose given to mice can reduce congestion and hemorrhage in the kidneys

Uji Toksisitas Sub Akut Infusa Daun Afrika(Vernonina amygdalina Del.) terhadap Histopatologi HatiMencit (Mus musculus) Galur Balb/C Wafa Aufia; Surya Amal; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Allah created everything in this world has its benefits, including plants. African Bitter Leaves (Vernonia amygdalina Del.) is an herbal plant that has been experimented as anticancer, antioxidant, antidiabetic and analgesic with the presence of sesquiterpene lactones, saponins, alkaloids, tannins, polyphenol, monoterpene, Quinones, and Saponins. It is employed as an herbal medicine in infuse preparations. This study aims to investigate the safety standard and the effects of African Bitter Leaves infuse (Vernonia amygdalina Del.) againts the liver histopathology in mice strain BALB/c. This study is an experimental research using Completely Randomized Design (CRD). The practices are grouped into 4 different with 3 times repeatedly. The practices given, among others, control (Aquades 0.25 ml), P1 (doses of 10% b/v), P2 (doses of 20% b/v) and P3 (doses of 30% b/v). The observed object is the liver histopathology in mice strain BALB/c at the centrilobular area, midlobular and periportal, then analysis by one-way ANOVA followed by Tukey's Post hoc test. The results of this study stated that the doses of 10% b/v destroyed 24% cell degeneration and 9% cell necrosis, at a dose of 20% b/v destroyed 53% cell degeneration and 21% cell necrosis, and at doses of 30% b/v destroyed 55% cell degeneration and 40% cell necrosis. Based on ANOVA results it can be concluded that the African Bitter Leaves infuse influence liver histopathology in mice strains BALB/c. Destroyed of liver histology include degenerate cells at doses 10% b/v, 20% b/v, 30% b/v, and necrosis cell at doses 20% b/v and 30% b/v.

Pengaruh Puasa terhadap Jumlah dan Morfologi Spermatozoa Mencit (Mus musculus) Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

One of the benefits of fasting is being able to control testosterone levels in the blood so as not to exceed normal. Normal testosterone levels will produce good quality (morphology, viability, motility) and good quantity (number) of spermatozoa. Therefore, this study was conducted to understand the effect of fasting on the number and morphology of spermatozoa in mice. This study is an experimental study with a completely randomized design trial (CRD) using 5 treatments and 3 replications. The type of treatment given is not fasting (control); middle fasting month of Hijriah for 3 days (13th, 14th and 15th); Monday and Thursday fasting; fasting Daud (a day of fasting a day is not); and fasting every day for 36 days. Male mice used in this study were Balb C strains with an initial weight of 23-26 grams and in the age range of 8-10 weeks. Calculation of the number of epididymal spermatozoa carried out according to WHO procedures in Syamrizal (1995) and morphological observations of spermatozoa carried out included normal and abnormal. Data analysis used is one-way ANOVA with a significance level of 5%. The statistical program used for the analysis was the SPSS 20 program. The results showed that fasting could increase the number and percentage of normal spermatozoa in Balb C strain mice eventhough statistically the increase was not significantly different (sig.> 0.05). Based on the type of fasting that was done, fasting on Thursday Thursday had the highest effect on the increase in the number and percentage of normal spermatozoa. Then followed by fasting every day and fasting of Daud. While the mid-fasting month of Hijriah actually decreases the number and percentage of normal spermatozoa compared to controls.

Uji Efektivitas Seduhan Kopi Biji Okra (Abelmoschus esculentus) terhadap Penurunan Kadar Glukosa Darah pada Mencit yang diinduksi Aloksan Zulvia Faridatul Munawaroh; Rahmat A.H. Wahid; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 2 (2019): September
Publisher : University Of Darussalam Gontor

Diabetes mellitus is a degenerative disease characterized by high blood glucose levels. Various ways that people use for treatment, herbal is one of the choices. God will not create an illness unless Him has created the medicine. One of the plants that is often used to treatment diabetes mellitus is okra plants. Okra seeds could be processed into coffee which is used as a substitute for caffeinated coffee. Based on community experience, so this research to know the effectiveness test of steeping coffee from okra (Abelmoschus esculentus) seeds in alloxan-induced diabetic mice and to know the effective concentration of steeping coffee from okra (Abelmoschus esculentus) seeds in alloxan-induced diabetic mice. This research was an experimental study. The research design used was a Completely Randomized Design (CRD) consisting of 4 treatments and 4 replications. The sample consisted of 16 male mice. The study was divided into 4 groups, The sample consisted of16 male mice and divided into 4 group, giving aquadest as a positive control (PC) while in treatment T1 by giving steeping coffee from okra seeds with a concentration of 1.82 mg/grBW/day, 3.64 mg/grBW/day for T2 and T3 with a concentration of 5.46 mg/mgBW/day for 10 days . Data were analyzed using the SPSS 16.0. According to the results of the One Way ANOVA test with a significance level of 95% were obtained at 0,000 (p = <0.05) which means that, between treatments given by okra seeds coffee, okra seeds coffee were effective against blood glucose levels of mice after alloxan was induced. Based on the three treatments for the administration of okra seeds coffee with various concentrations, group T3 (5.46 mg/mgBW/day) with a significance value of 0,000 (p<0.05) which was the most effective for reducting blood glucose levels in alloxan-induced diabetic mice.

EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN IBU HAMIL DI INSTALASI RAWAT INAP RSIA MUSLIMAT JOMBANG TAHUN 2018 Siska Fatkhul Hidayati; Yulia Dwi Andarini; Nurul Marfu'ah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i2.4959

Penyakit hipertensi dalam kehamilan sampai saat ini masih merupakan masalah dalam pelayanan obstetri di negara Indonesia. Penelitian ini bertujuan untuk mengetahui dan memahami profil penggunaan obat antihipertensi pada pasien hipertensi dalam kehamilan di Instalasi Rawat Inap Rumah Sakit Ibu dan Anak (RSIA) Muslimat Jombang. Tujuan khusus dalam penelitian ini yang ingin dicapai adalah untuk mengetahui karakteristik pasien hipertensi dalam kehamilan, jenis dan golongan obat, jumlah obat antihipertensi yang digunakan, cara pemberian obat, tepat indikasi pasien, tepat obat pasien dan tepat dosis pasien. Penelitian ini termasuk penelitian deskriptif secara observasional non eksperimental. Data yang digunakan dalam penelitian ini adalah data retrospektif dengan melakukan penelusuran data rekam medik pasien hipertensi pada ibu hamil di Instalasi Rawat Inap Rumah Sakit Ibu dan Anak Muslimat Jombang tahun 2018. Data yang diambil meliputi data pasien dan data obat yang digunakan oleh pasien. Dari hasil penelitian diperoleh kasus hipertensi dalam kehamilan sebanyak 40 pasien, pasien yang mendapat terapi obat antihipertensi sebanyak 32,5 % dan pasien yang tidak mendapat terapi obat antihipertensi sebanyak 67,5% menunjukkan ketepatan indikasi berdasarkan standar Queensland Health (Hypertensive Disorders of Pregnancy). Pada penelitian ini pasien yang mendapat terapi obat antihipertensi jenis Furosemid sebanyak 23% dan yang mendapat terapi obat antihipertensi jenis Nifedipin sebanyak 77% menunjukkan ketepatan obat berdasarkan standar Queensland Health (Hypertensive Disorders of Pregnancy). Dari data yang dianalisis di dapatkan bahwa dosis terapi obat antihipertensi jenis Furosemid sebanyak 20-80 mg dan dosis terapi obat antihipertensi jenis Nifedipin sebanyak 5-20 mg juga menunjukkan tepat dosis sesuai standar Queensland Health (Hypertensive Disorders of Pregnancy).

Formulasi Sediaan Sabun Cair Ekstrak Daun Sirih Hijau (Piper battle folium L.) dan Ekstrak Bawang Putih (Allium sativum L.) sebagai Antijamur Candida albicans Rohmah Madya Ayu Fitriana; Solikah Ana Estikomah; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

Islam is a religion that likes cleanliness, in case of body hygiene, clothing, and environment. One of the diseases that arise because it does not keep the body clean is white discharge. Piper bettle folium and Alium sativum are some of the natural ingredients that has the potential as an antifungal. This research aims to see the effect of antifungal Candida albicans extract of Piper bettle folium and Alium sativum after formulated as a liquid soap preparation. Liquid soaps are made by hot process methods with 3 formulations of combination of Piper bettle folium and Alium sativum extract with a ratio of 1) 25%: 75% 2) 50%: 50% 3) 75%: 25%. The evaluation of liquid soap include organoleptic examination, pH, high foam, moisture content, homogeneity, and antifungal power test against Candida albicans fungus. The results of the testing of liquid soap quality of green betel leaf extract and garlic have met the standards SNI (Indonesia’s National Standards) set for the manufacture of liquid soap.The results showed that liquid soap extract of green betel leaf and garlic have antifungal activity against Candida albicans. The result of formulation with the highest inhibition zone is formulation 3 and formulation with the lowest inhibition zone is the formulation 1. The test of this liquid soap activity is higher than fluconazole as the positive control and liquid soap of female area spread in the market.

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