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Layanan Komplementer di Klinik Universitas Mulawarman pada Pengembangan Usaha Produk Intelektual Kampus Ismail, Sjarif; Paramita, Swandari; Aminyoto, Meiliati; Kosala, Khemasili; Bakhtiar, Rahmat
Jurnal SOLMA Vol 7 No 2 (2018)
Publisher : Uhamka Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29405/solma.v7i2.2119

Kegiatan pengabdian kepada masyarakat melalui Program Pengembangan Usaha Produk Intelektual Kampus (PPUPIK) telah dilaksanakan di Universitas Mulawarman dengan dibentuk Layanan Komplementer di Klinik Universitas Mulawarman. Tujuan kegiatan PPUPIK ini adalah diversifikasi usaha di Klinik Universitas Mulawarman untuk meningkatkan perolehan pendapatan secara mandiri dan bermanfaat untuk masyarakat, serta memberikan kesempatan dan pengalaman kerja kepada  mahasiswa dengan memberikan layanan komplementer di Klinik Universitas Mulawarman. Sebelum dibukanya layanan komplementer dilakukan analisis SWOT untuk mendapatkan gambaran keberhasilan, dan hasil analisis disimpulkan layak untuk dibuka. Layanan komplementer meliputi akupunktur (tusuk jarum) dan jamu (herbal), resmi dibuka tanggal 02 Mei 2018. Jumlah kunjungan sampai akhir bulan Agustus adalah 110 dan jumlah pasien yang berobat 47 orang dengan total pendapatan sebesar Rp. 3.777.900,-. Karakterisik pasien yang berobat perempuan (88,2%) dan pria (11,8%), sebagian besar berhubungan dengan kelainan muskuloskeletal diikuti obesitas, dan dispepsia, hampir semua menyukai jamu dan lebih dari 50% mendapat terapi jamu. Pada pasien yang kontrol ulang telah merasakan manfaat dari pengobatan komplementer yang didapatkan baik yang mendapat pengobatan jamu, akupunktur dan gabungan akupunktur dan jamu. Mahasiswa Fakultas Kedokteran juga telah dilibatkan untuk membantu pelayanan dalam hal pemeriksaan fisik tekanan darah. Luaran PPUPIK yang telah dicapai adalah jasa layanan komplementer di Universitas Mulawarman telah diterapkan dan menghasilkan pendapatan, publikasi di jurnal nasional (accepted) dan buku pedoman pengobatan herbal (draf), dua paten sederhana telah didaftarkan dan satu granted paten hasil mediasi.

UJI AKTIVITAS ANTIBAKTERI DAN ANALISIS BIOAUTOGRAFI KROMATOGRAFI LAPIS TIPIS EKSTRAK ETANOL DAUN SRIKAYA (ANNONA SQUAMOSA L) TERHADAP ENTEROCOCCUS FAECALIS SECARA IN VITRO Isti Daristivia Jangnga; Portuna Putra Kambaya; Khemasili Kosala
ODONTO : Dental Journal Vol 5, No 2 (2018): December 2018
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.5.2.102-109

Background: Endodontic treatment is a treatment to maintain teeth that have undergone pulp or periapical infections to stay as long as possible in the oral cavity and restore them to their original form and function in the mastication system. The main causes are bacteria Enterococcus faecalis. The purpose of this study is to investigate the effect of extract srikaya leaves on the growth of Enterococcus faecalis bacteria in vitro and to analyze secondary metabolites that have antibacterial activity.Method: Experimental study used Kirby Bauer diffusion test. The researchdesign was post test only control group design and Bioautography TLC design. There was 5 treatment groups : concentration 25%, 50%, 75% extract of ethanol of srikaya leaves, positive control group (chlorhexidine gluconate 0,2%), and negative control group ( DMSO 10%). Statistical analysis used One Way Anova and Post Hoc Test Tukey.Results: Extract of Srikaya Leaves can inhibit the growth of Enterococcus faecalis bacteria in concentrations of 25%, 50%, and 75% and detectablesecondary metabolites show inhibit zone.Conclusion: The extract of ethanol leaves of srikaya (Annona squamosa L) have the effect of inhibiting the growth of Enterococcus faecalis bacteria and secondary metabolites have effect in inhibiting bacterial growth.

In vitro Exploration of Vasodilation Activity of the Methanol Extract of the Coptosapelta flavescens Korth stem Khemasili Kosala; Sjarif Ismail; Ika Fikriah; Agustina Rahayu Magdalena
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.843 KB)

ABSTRACTIntroduction: Coptosapelta flavescens Korth is a liana plant of the Rubiaceae genus. In East Kalimantan it is known as Akar Tambolekar or Merung. Its stem is ethnobotanically used as herbs to treat high blood pressure but it has not been scientifically proven yet.Method: This study aims to prove the activity of Coptosapelta flavescens stem (BCF) extract as an antihypertensive by using a blood vessels isolated organ model through the action mechanism as a vasodilator. BCF was taken from Paser Regency, East Kalimantan Province. The extraction was macerated using methanol solvent, then concentrated using a vacuum rotavapour at the temperature of 50C. Vasodilator activity was tested using a 3 mm long rat aorta isolated organ with endothel put into Krebs Henselheit solution at 37C, pH 7.4 and fed by carbogen gas. The aorta is contracted using a phenylephrine solution, after the contraction reached its peak and plateaued, the extract solution or the extracts solvent solution (as control) was added cumulatively and the aortic tone activity was observed. The results were expressed in percent of aortic contractility.Results: The results showed that BCF extract caused an increase in the reduction of aortic contractility percentage as extract concentration increase. Conclusion: This proves that BCFs methanol extract can cause vasodilation in blood vessels with endothelium.Keyword: Coptosapelta flavescens, antihypertensive, extract, isolated aorta, vasodilator

Layanan Komplementer di Klinik Universitas Mulawarman pada Pengembangan Usaha Produk Intelektual Kampus Sjarif Ismail; Swandari Paramita; Meiliati Aminyoto; Khemasili Kosala; Rahmat Bakhtiar
Jurnal SOLMA Vol. 7 No. 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Kegiatan pengabdian kepada masyarakat melalui Program Pengembangan Usaha Produk Intelektual Kampus (PPUPIK) telah dilaksanakan di Universitas Mulawarman dengan dibentuk Layanan Komplementer di Klinik Universitas Mulawarman. Tujuan kegiatan PPUPIK ini adalah diversifikasi usaha di Klinik Universitas Mulawarman untuk meningkatkan perolehan pendapatan secara mandiri dan bermanfaat untuk masyarakat, serta memberikan kesempatan dan pengalaman kerja kepada mahasiswa dengan memberikan layanan komplementer di Klinik Universitas Mulawarman. Sebelum dibukanya layanan komplementer dilakukan analisis SWOT untuk mendapatkan gambaran keberhasilan, dan hasil analisis disimpulkan layak untuk dibuka. Layanan komplementer meliputi akupunktur (tusuk jarum) dan jamu (herbal), resmi dibuka tanggal 02 Mei 2018. Jumlah kunjungan sampai akhir bulan Agustus adalah 110 dan jumlah pasien yang berobat 47 orang dengan total pendapatan sebesar Rp. 3.777.900,-. Karakterisik pasien yang berobat perempuan (88,2%) dan pria (11,8%), sebagian besar berhubungan dengan kelainan muskuloskeletal diikuti obesitas, dan dispepsia, hampir semua menyukai jamu dan lebih dari 50% mendapat terapi jamu. Pada pasien yang kontrol ulang telah merasakan manfaat dari pengobatan komplementer yang didapatkan baik yang mendapat pengobatan jamu, akupunktur dan gabungan akupunktur dan jamu. Mahasiswa Fakultas Kedokteran juga telah dilibatkan untuk membantu pelayanan dalam hal pemeriksaan fisik tekanan darah. Luaran PPUPIK yang telah dicapai adalah jasa layanan komplementer di Universitas Mulawarman telah diterapkan dan menghasilkan pendapatan, publikasi di jurnal nasional (accepted) dan buku pedoman pengobatan herbal (draf), dua paten sederhana telah didaftarkan dan satu granted paten hasil mediasi.

Mechanism of Vasorelaxation Induced by Coptosapelta flavescens Stems Extract in Rat Thoraric Aorta Sjarif Ismail; Khemasili Kosala; Ika Fikriah; Agustina Rahayu Magdaleni
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Coptosapelta flavescens Korth. is a liana plant from the Rubiaceae family. In East Kalimantan, it is also known as â€œAkar Tambolekarâ€ or â€œMerungâ€, it is called â€œakarâ€ or root as its trunk spreads like a root. The plantâ€™s stems are used by ethnic Dayak in East Kalimantan to overcome high blood pressure and it has been proven to induce vasorelaxation on blood vessels, but the its action mechanism in the endothelial or vascular smooth muscle cells (VSMC) are unknown. Vasorelaxation on the blood vessels could be mediated by endothelial or by the VSMC. This research aims to study in vitro which of them is the mechanism of action of Coptosapelta flavescens Stems (CFS) extract. CFS were taken from the secondary forest in Paser Regency, East Kalimantan Province. Its simplicia were macerated with methanol solvent for three days and twice repeated. Vasorelaxation activity of the blood vessels was tested with ratsâ€™ isolated thoracic aorta with endothelial and with the endothelial removed (endothelium-denuded). Both aorta of 3 mm length were soaked into Krebs-Henselheit solution at 37Â°C, pH 7.4 and aerated with carbogen gas. After they have acclimatized, both aortas were contracted with phenylephrine solution, after reaching peak contraction and plateau, the solution of extract or its solvent (Control) was administered in cumulatively increasing doses. The results show that CFS extracts induce vasorelaxation both in the endothelial-intact aorta and in the endothelial-denuded aorta. At high concentrations, the vasorelaxation activity in the endothelial-intact aorta was weaker than that on endothelial-denuded aorta. This study proves that action mechanism of blood vesselsâ€™ vasorelaxation induced by the methanol extract of CFS were more dominantly mediated by the blood vessels smooth muscle; and at high concentrations the endothelial actually weakened the VSMC vasorelaxation activity. Further study is necessary on the mechanism of action vasorelaxation through the modulation of intracellular or extracellular calcium ion channels of VSMC Keywords: Coptosapelta flavescens, vasorelaxation, extract, aorta, in vitro

Evaluation of Synergistic Effect of Kaempferia galanga L. Rhizome Extracts on the Antibiotic Activity Antibiotics against Bacterial Pathogens Almira Fahrinda; Sjarif Ismail; Khemasili Kosala; Ika Fikriah; Yuniati Yuniati
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Background: aromatic ginger rhizome (Kaempferia galanga L.) is a member of Zingiberaceae family, has been known to have an antibacterial effect is used for everyday cooking spices, but the synergistic effect on broad spectrum antibiotics was unknown. Objective: this research was conducted to find out the synergistic effect of Kaempferia galanga L. Rhizome extract (KGR) on some broad-spectrum antibiotics against gram positive and negative bacterial pathogens in vitro. Method: KGR was taken from farmers in Samarinda City, East Kalimantan Province, Indonesia. Extraction by maceration with ethanol solvent. Antibacterial activity test of KGR ethanol extract, antibiotic and synergistic effect using Mueller-Hinton agar, Kirby-Bauer disc diffusion method on ampicillin, cefuroxime, chloramphenicol, ciprofloxacin, and meropenem antibiotics against Staphylococcus aureus and Escherichia coli. Results were expressed in percentage increase of the inhibition zone. Statistical test with t-test, significantly different if p<0.05. Results: KGR ethanol extract showed increase the percentage of antibiotic inhibition zone, ampicillin being the highest and the weakest of ciprofloxacin in E. coli; meropenem being the highest and the weakest of ciprofloxacin in S. aureus, statistically significant different tests on antibiotic ampicillin (E. coli), meropenem and cefuroxime. Conclusion: KGR ethanol extract showed synergistic effect on antibiotic ampicillin (E. coli), meropenem and cefuroxime in S. aureus and E. coli.

Acute Toxicity Assay from Seeds and Flesh of Tarap Fruit (Artocarpus odoratissimus Blanco) Ethanolic Extract against Daphnia magna Larvae Crissty Magglin; Ika Fikriah; Khemasili Kosala; Hadi Kuncoro
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.240

Tarap (Artocarpus odoratissimus Blanco) is one of the plants in the tropics that are consumed by dayak tribe in East Kalimantan. Toxicity tests on seeds and bark have been done but there is no data regarding the acute toxicity of Artocarpus odoratissimus Blanco seeds and flesh of fruit causing the need for acute toxicity tests. This Research to know the acute toxic effects of tarap (Artocarpus odoratissimus Blanco) seed and flesh extracts on larvae of Daphnia magna. Tarap seeds and flesh (Artocarpus odoratissimus Blanco) was taken from dayak market in Samarinda, is East Kalimantan, Indonesia. The seeds and flesh of the tarap fruit are extracted by maceration with ethanol solvent. An acute toxicity test was performed by exposing Dapnia magna larvae aged ? 24 hours with a solution of the experimental group and the control group for 48 hours. Toxicity test results are expressed in percentage of immobilization of larvae of Daphnia magna calculated by probit test to obtain EC50 (Half maximal effective concentration) values. Extracts are toxic if the EC50 value > 1000ppm. EC50 Ethanol extract of tarap seeds obtained values ( 3922,301 ± 324,590 ) for EC50 24h and ( 2964,498 ± 412,498 ) for EC50 48h. The EC50 value of ethanol extract from flesh of tarap fruit is ( 12224.514 ± 2186. 899 ) EC50 24h and ( 6165,235 ± 1940,006 ) EC50 48h.Ethanol extract of tarap fruit and flesh is non toxic to larvae of Daphnia magna.

Epidemiologi Karakteristik Pasien Covid-19 di Kalimantan Utara: Epidemiology Characteristics of Covid-19 Patients in North Kalimantan Aulia Seftiya; Khemasili Kosala
Jurnal Sains dan Kesehatan Vol. 3 No. 5 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Coronavirus Disease (COVID-19) adalah suatu penyakit yang disebabkan jenis virus terbaru dari (SARS-CoV-2) yang ditemukan di akhir Desember 2019 di kota Wuhan, Provinsi Hubei, Tiongkok. Di Indonesia kasus COVID-19 pertama kali ditemukan pada tanggal 2 Maret 2020. Kasus COVID-19 di Indonesia terus meningkat seiring waktu, hingga sampai bulan Agustus 2020 telah dikonfirmasi 130.718 kasus dan 5.903 kematian pada 34 provinsi di Indonesia. Penelitian ini bertujuan untuk menganalisis secara restrospektif karakteristik kasus serta hubungan variable tersebut. COVID-19 melalui portal resmi informasi COVID-19 di Kalimantan Utara. Subjek penelitian ini dipilih dengan metode purposive sampling sehingga diperoleh 3.146 subjek. Sebagian besar pasien COVID-19 adalah laki-laki (57,5%), usia terbanyak terjadi pada kelompok usia 31-40 tahun (24%). Persebaran kasus COVID-19 paling banyak terjadi karena transmisi lokal (45,6%) sehingga berdampak pada peningkatan kasus COVID-19. Lonjakan kasus terjadi paling banyak pada bulan Desember tahun 2020 (60.6%). Terdapat hubungan antara variable usia dan waktu terhadap kematian dengan nilai p = 0,000 ( p < 0,05) sedangkan pada variable jenis kelamin menjelaskan bahwa tidak terdapat hubungan dengan kematian, dimana hasil p = 0,761 (p > 0,05).

UJI AKTIVITAS ANTIBAKTERI DAN ANALISIS BIOAUTOGRAFI KROMATOGRAFI LAPIS TIPIS EKSTRAK ETANOL DAUN SRIKAYA (ANNONA SQUAMOSA L) TERHADAP ENTEROCOCCUS FAECALIS SECARA IN VITRO Isti Daristivia Jangnga; Portuna Putra Kambaya; Khemasili Kosala
Odonto : Dental Journal Vol 5, No 2 (2018): December 2018
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Endodontic treatment is a treatment to maintain teeth that have undergone pulp or periapical infections to stay as long as possible in the oral cavity and restore them to their original form and function in the mastication system. The main causes are bacteria Enterococcus faecalis. The purpose of this study is to investigate the effect of extract srikaya leaves on the growth of Enterococcus faecalis bacteria in vitro and to analyze secondary metabolites that have antibacterial activity.Method: Experimental study used Kirby Bauer diffusion test. The researchdesign was post test only control group design and Bioautography TLC design. There was 5 treatment groups : concentration 25%, 50%, 75% extract of ethanol of srikaya leaves, positive control group (chlorhexidine gluconate 0,2%), and negative control group ( DMSO 10%). Statistical analysis used One Way Anova and Post Hoc Test Tukey.Results: Extract of Srikaya Leaves can inhibit the growth of Enterococcus faecalis bacteria in concentrations of 25%, 50%, and 75% and detectablesecondary metabolites show inhibit zone.Conclusion: The extract of ethanol leaves of srikaya (Annona squamosa L) have the effect of inhibiting the growth of Enterococcus faecalis bacteria and secondary metabolites have effect in inhibiting bacterial growth.

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