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EFFECTS OF PHYSICAL ACTIVITY Fast Interval Training AND PROVISION OF MELINJO SKIN EXTRACT (Gnetum gnemon) ON EXPRESSION OF URAT1 TRANSPORTER, GLUT9 AND SGLT2 IN HYPERURICEMIA INSULIN RESISTANCE Armansyah Maulana Harahap; Yetty Machrina
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.29105

Abstract

Observational studies and randomised controlled studies suggest Increased prevalence of hyperuricemia is a decrease in physical activity and high consumption of purines. Disruption of urate reabsorption causes changes in the main functions of transporter proteins in the proximal tubule membrane. One of them is the intake of URAT1 and efflux by GLUT9 and also for the expression of SGLT2. Insulin resistance causes disturbances in glucose uptake in (SGLT2) and urate. The mechanism of glucose uptake can be mediated by exercise and effect of melinjo skin extract. A Technical Expert Panel (TEP) of 2 medical specialist and expertise of disorder the urinary system performed the review using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “Hyperuricemia” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms “Exercise” and “Melinjo skin extract”. TEP is considered for eligibility articles published within the last 10 years, including original research, in particular in vitro studies, and animal and clinical studies in English. Results: Of the 90 identified studies, TEP included 15 studies, 8 animals, and 4 clinical studies and 3 Review. Conclusion: Our scoping review describes and summarizes the important role of exercise and the effect of melinjo peel extract in modulating uric acid levels, Insulin resistance and up-and-down regulation of urate transportersKeyword: Hyperuricemia, URAT1, GLUT9, SGLT2, Exercise
The Correlation Between Consuming Fast Food And Obesity Of Primary School-Aged Children In SD Al-Azhar Medan Muhammad Qori An-Nabil; Yetty Machrina
Jurnal Syntax Fusion Vol 2 No 02 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : Rifa' Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i02.171

Abstract

Fast food is high calorie foods and is preferred by children, especially in the primary level. Extensive consumption of fast food can lead to obesity. In Indonesia the prevalence of obesity in primary school-aged children increases from 5.0 % to 16.0% this increase is due to the habit of consuming fast food. To determine the correlation of fastfood consumption with obesity on primary school-aged children. This research is analytic applying case control study design. The data of weight and height are collected by anthropometric measurements using Body Mass Index (BMI), within distributing questionnaires for nutritional status and physical activity while the fastfood consumption will be held by Food Frequency Questionnaires (FFQ) method. Hypotheses were analyzed by Chi-Square test results. The Chi-Square test results showed that there was a correlation between the frequency of fast food and the incidents of obesity (0.05). The result of the Chi-Square test showed that there was a correlation between the portion of fast food and the incident of obesity (0.05). There is a frequency correlation often consume fast food to the incident of obesity p value 0.01. There is correlation between large portions of fast food consumption to the incident of obesity with p value 0.001
EFFECT OF ETHANOLIC EXTRACT OF MELINJO PEEL (Gnetum gnemon) ON SERUM MALONDIALDEHYDE (MDA) LEVELS IN HYPERURISEMIA WISTAR STRAIN RATS Indra Priawan; Yetty Machrina; Ririe Fachrina Malisie
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 3 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i3.43187

Abstract

Hyperuricemia is a state of uric acid in the body that is higher than the body's tolerance limit. The formation of uric acid will be accompanied by the formation of Reactive Oxygen Species (ROS) by the changes of Xanthine Dehydrogenase to Xanthine Oxide with the help of NAD+ and Oxygen, which can trigger oxidative stress, causing cell damage and apoptotic cell, one of which is through lipid peroxidation followed by the release of Malondialdehyde (MDA) into the extracellular space. This study aims to analyze the effect of giving melinjo peel ethanol extract (Gnetum gnemon) on serum MDA levels in hyperuricemic Wistar strain rats. Rats were grouped into 4 treatment groups, namely K0 (without treatment), Kneg (hyperuricemia and CMC), Kpos (hyperuricemia and allopurinol), and P (hyperuricemia and ethanol extract of melinjo peel). Manufacture a hyperuricemic rat model by giving a high-fructose diet and then measuring uric acid levels to ensure that the rat is already in hyperuricemia. The high-fructose diet was continued until the rats were executed. Serum MDA was measured using the Thiobarbituric acid (TBA) method. The results showed differences in MDA levels between groups of hyperuricemic rats. Based on the examination of lower MDA levels after administration of melinjo peel ethanol extract compared to the CMC group and the allopurinol group, statistically significant differences were obtained (p = 0.001). Based on the analysis results, it was concluded that the ethanolic extract of melinjo peel (Gnetum gnemon) could reduce serum MDA levels in hyperuricemic Wistar rats.