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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Cardiology Journal of Maternal and Child Health Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran Makara Journal of Health Research Jurnal Penyakit Dalam Indonesia
Soroy Lardo
Universitas Pembangunan Nasional Veteran Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health

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KONSEP PATOGENESIS SEPSIS PADA VENTILATOR ASSOCIATED PNEUMONIA DI INTENSIVE CARE UNIT Febyan; Soroy Lardo
Majalah Kedokteran Indonesia Vol 68 No 12 (2018): Journal of The Indonesian Medical Association Majalah Kedokteran Indonesia Volu
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v68i12.209

Abstract

Sepsis berat didefinisikan sebagai sepsis dengan disfungsi satu atau lebih organ. Salah satu penyebab sepsis di Intensive Care Unit (ICU) adalah Hospital-Acquired Pneumonia (HAP). HAP terjadi 5-10 kasus per 1000 pasien yang memakai alat bantu napas mekanis. Ventilator Associated Pneumonia (VAP) merupakan bagian dari hospital-acquired pneumonia (HAP), terutama disebabkan oleh Pseudomonas aeruginosa. Beberapa faktor penting pada patogenesis VAP, antara lain sistem barier Na+-K+-Cl? transporter-1 (NKCC1), ETT tanpa antibiofilm. Upaya pencegahan VAP berupa oral higiene, alat ETT berbahan antibiofilm, elevasi kepala 30 derajat, evaluasi kemampuan batuk, dan fungsi menelan.
Kinetika Demam Berdarah Dengue dalam Spektrum Imunopatogenesis dan Klinis Lardo, Soroy; Soesatyo, Marsetyawan HNE; -, Juffrie; Umniyati, Sitti Rahmah
Cermin Dunia Kedokteran Vol 43, No 12 (2016): Kardiovaskular
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.299 KB) | DOI: 10.55175/cdk.v43i12.896

Abstract

Virus dengue adalah virus RNA termasuk genus Flavivirus dan familia Flaviviridae. Sampai saat ini dikenal empat serotipe yaitu DEN-1, DEN-2, DEN-3 dan DEN-4. Infeksi salah satu serotipe akan menimbulkan antibodi protektif seumur hidup, tetapi tidak untuk serotipe lain. Struktur virus memiliki 10.700 basa di dalam genomnya. Di dalam genom terdapat sebuah single open reading frame (SORF) yang mengkode dua macam protein yaitu protein struktural dan nonstruktural. Protein NS1 merupakan protein non struktural glikoprotein dan bukan bagian dari struktur virion, tetapi diekspresikan pada permukaan sel. Protein NS1 merupakan penanda awal infeksi dengue yang akan berperan baik untuk proses imunopatogenesis dan spektrum klinis.Dengue virus is a RNA virus, genus Flavivirus and family Flaviviridae. There are currently four known serotypes, namely DEN-1, DEN-2, DEN-3 and DEN-4. Infection of one serotype will produce a lifetime protective antibodies, but not for the other serotypes. The structure of the virus has a base of 10,700 in its genome. There is a single open reading frame (SORF) that encodes two different kinds protein that is stuctural and non structural protein. NS1 protein is a non structural protein glycoprotein, not part of the virion structure, but expressed on the cell surface. The kinetic profile of dengue virus NS1 protein is an early marker of dengue infection which would contribute both to the immunopathogenesis and clinical spectrum.NS1 protein has as important antigenecity as an early marker.
HUBUNGAN ANTARA HITUNG JUMLAH CD4 DENGAN KEJADIAN WASTING SYNDROME PADA PASIEN HIV/AIDS DI RSPAD GATOT SOEBROTO PERIODE JANUARI-DESEMBER 2020 Ramadhani Safira Gumarianto; Soroy Lardo; Aulia Chairani
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I2.16975

Abstract

Infeksi HIV masih menjadi ancaman dunia dibidang kesehatan. HIV ialah virus yang menyerang sistem kekebalan tubuh manusia terutama sel-sel imun yang memiliki marker CD4 dipermukaannya. Untuk menilai imunitas pasien HIV/AIDS, diperlukan hitung jumlah CD4. Seseorang dengan jumlah CD4 <200 sel/mm3 dianggap sebagai AIDS, yaitu sekumpulan gejala yang muncul akibat penurunan imunitas tubuh oleh infeksi HIV. Penurunan berat badan merupakan manifestasi yang sangat sering ditemukan pada pasien HIV/AIDS. Tahap akhir dari keadaan penurunan status gizi ini adalah Wasting Syndrome HIV. Tujuan penelitian ini adalah untuk menganalisis hubungan antara hitung jumlah CD4 dengan kejadian wasting syndrome pada pasien HIV/AIDS di RSPAD Gatot Soebroto tahun 2020. Desain penelitian yang digunakan adalah cross sectional menggunakan 53 rekam medik pasien HIV/AIDS di RSPAD Gatot Soebroto. Hasil penelitian ini menunjukkan sebanyak 47,2% pasien HIV/AIDS mengalami wasting syndrome dan 84% diantaranya memiliki CD4 <200 sel/?l. Analisis bivariat dengan uji Chi-Square didapatkan hasil p<0,05 yaitu sebesar 0,033 sehingga dapat disimpulkan bahwa adanya hubungan yang signifikan antara hitung jumlah CD4 dengan kejadian Wasting Syndrome.
Gangguan fungsi Jantung pada Keadaan Sepsis Kabul Priyantoro; Soroy Lardo; Yoga Yuniadi
Jurnal Kardiologi Indonesia Vol. 31, No. 3 September - Desember 2010
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v31i3.131

Abstract

Sepsis is a condition where bacteremia persist and precede by SIRS sign, in a severe condition sepsis can manifest as septic shock and refractory septic shock with very high mortality rate, up to 50% during hospitalization, almost equalize death due to myocardial infarction. In a severe sepsis at least one of organ dysfunction is present, cardiovascular is one of the most frequent affected organ system in severe sepsis and almost always affected during septic shock. During sepsis depression of cardiac systolic and diastolic func-tion characterized by bi-ventricular impairment of contractility, decrease in ventriclular compliance which manifest as subsequent reduction in left ventricular ejection fraction and LV stroke work index. The pathophysi-ology of cardiac depression during sepsis remain unclear up to now, but many evidence showed that circulating cardio toxic agent (IL – 1, IL – 8, C3a), endotoxin (LPS), cytokine (IL – 1, IL – 6, TNF – a), endothelin – 1 (ET – 1), nitric oxide (NO), prostanoid (Tromboxan & Prostasiklin), and adhesion molecule (intercellular adhesion molecule-1 & vascular cell adhe-sion molecule-1) play important role in depressing cardiac function during sepsis. Definitive therapy regarding cardiac dysfunction during sepsis is still unknown, but adequate supportive management in maintaining adequate preload continued by inotropic and or vasopressor with low dose cor-ticosteroid, low dose nitroglycerine (in selected patients) and statin are prove in clinical trial effective in providing better outcome. Poor cardiac function in sepsis is related to poor outcome during hospitalization. This article discus about cardiac dysfunction, pathophysiology and supportive management in adult with sepsis.
A Clinical Profile of Hepatitis A Patients in Jakarta, Indonesia Adiwinata, Randy; Kristanto, Andi; Richard, Timoteus; Edbert, Daniel; Angelina, Frida; Eppy, Eppy; Mauleti, Ifael Y; Lardo, Soroy; Firmansyah, Iman; Bur, Rika; Ahimsa, Titos; Nelwan, Erni J
Makara Journal of Health Research Vol. 21, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: To determine the incidence of hepatitis A infections and the clinical profiles of adult patients admitted to public hospitals in Jakarta, Indonesia. Methods: This was a cross-sectional study that utilised consecutive secondary data from internal medicine wards of seven public hospitals in Jakarta between 2011 and 2013. Eligibility criteria included patients over the age of 18 years and an ICD-10 diagnosis code of B15, acute hepatitis A. Case proportion was reported per 1000 people by dividing incidence per year to total in-ward patients. Clinical profiles were reported descriptively. Laboratory results were compared and categorised into groups of patients aged below and above 25 years old. Results: Data revealed that hospitalisations of patients with hepatitis A had decreased from 2011 to 2013. 289 patients were studied, the majority were young adults (18-25 years old) and their common chief complaints were nausea (36%), fever (24%), and jaundice (21%). Higher bilirubin levels were seen in older patients. There were 13 patients coinfected with hepatitis B, one patient coinfected with hepatitis C, and one patient coinfected with HIV. Conclusions: The proportion of hepatitis A infection amongst adults admitted to public hospitals in Jakarta was low and had decreased during the study period. Most of the patients reported classical clinical manifestations. This study found that the targeted age group may benefit from receiving routine hepatitis A vaccinations.
Social Determinants in Association with Postpartum Blues during the Transition Period of COVID-19 Pandemic Mujab, Salwa Tsabitah Althaf; Theresa, Ria Maria; Saleh, Arman Yurisaldi; Lardo, Soroy
Journal of Maternal and Child Health Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.88 KB) | DOI: 10.26911/thejmch.2023.08.02.10

Abstract

Background: The COVID-19 pandemic has considerably impacted individuals' lives, extensively from mental and socioeconomic aspects, that requires someone to adapt. For postpartum mothers who also need to go through the maternal psychological adaptation phase, the pandemic could impose overwhelming emotional tension on them, increasing the risk of experiencing postpartum blues. This study aims to analyze the relationship between social factors that are affected during a pandemic with the incidence of postpartum blues on screening test results during the transition period of the COVID-19 pandemic in Banyumanik, Semarang. Subjects and Method: This was a cross-sectional study conducted in Banyu­manik, Semarang, from November to December 2022. 39 subjects were selected using a conse­cutive sampling tech­nique. The dependent variable is postpartum blues. The independent variables include marital status, employment status of the mother, employment status of the spouse, and family income level. The study instrument was EPDS questionnaire. The data were analyzed used Chi-square.  Results: Out of 39 subjects, 13 (33.3%) were experiencing postpartum blues, and 26 (66.7%) were not experiencing it. Mother’s employment status associated with postpartum blues. Mothers who unemployed have a risk of experiencing postpartum blues 1.65 times compared to employed, but these were not statistically significant (OR= 1.65; 95% CI= 0.40 to 6.77; p= 0.727). Family in­come level associated with postpartum blues. Mothers with low to moderate family income reduced postpartum blues by 0.73 times compared to mothers with high income levels, but these were not statistically significant (OR= 0.73; 95%CI= 0.19 to 2.80; p= 0.908). Meanwhile, mari­tal status and spouse employment status were not related to the incidence of postpartum blues. Conclusion: Mother’s employment status and family income status associated with postpartum blues. Meanwhile, marital status and spouse employment status were not related to the incidence of postpartum blues. Keywords: social factors, postpartum blues, screening test results, COVID-19 pandemic. Correspondence: Salwa Tsabitah Althaf Mujab. Medical Bachelor Program, Faculty of Medicine, UPN Veteran Jakarta, Indonesia. Jl. Rumah Sakit Fatmawati, Pondok Labu, Jakarta Selatan, DKI Jakarta 12450. Email: salwatsabitaham@upnvj.ac.id. Mobile: +628122608388.
Correlation of the Quality of Antibiotic Usage by Utilising Gyssens Flow and The Success of Treatment in Negative Gram MDR Sepsis in Tertiary Hospital Lardo, Soroy; Chen, Lie Khie; Santoso, Widayat Djoko; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Multi Drug Resistance (MDR) antibiotics have become a global health threat to the community. The use of appropriate antibiotics makes preventive and curative measures very important for the success of overcoming MDR and intervening the complexity of resistance, at least slowing the rate of occurrence of MDR. This study aimed to identify the difference in the quality of antibiotic use quality of use using gyssens flowchart and the success in sepsis patients’ treatment due to gram-negative MDR bacteria with non-MDR bacterial infections in tertiary hospitals. Methods. A retrospective cohort study was conducted using secondary data from patient with age more or equal than 18 years who were hospitalized in inpatient unit or ICU in Indonesia Army Central Hospital Gatot Soebroto from 2017-2019. Both the MDR and non-MDR gram-negative inclusion groups were assessed for the quality of antibiotic using the Gyssen flowchart. Results. There was a significant difference between antibiotic quality on gram negative MDR bacteria and non-MDR (20.6% vs. 13.6%; RR 1.517 (CI 95% 1.1 – 2.1); p value = 0.015) which showed that gram-negative MDR experienced 1.517 times better quality than non-MDR. This study also found that there was a significant difference between therapeutic success on gram negative MDR bacteria and non-MDR (57.4% vs. 39.1%; RR 1,431 (CI 95% 1.0 – 2.1); p value = 0.02). Conclusions. There is a better quality on the utilization of antibiotics with Gyssens index patients resulted from MDR negative gram bacterial infection in comparison to non-MDR in tertiary hospital. There is also a better success in treating the sepsis patient with MDR negative gram bacterial infection in comparison with non-MDR.
Co-Authors -, Juffrie Ahimsa, Titos Andi Kristanto Andi Kristanto Angelina, Frida Anna Ariane, Anna Arman Yurisaldi Saleh Aulia Chairani Cleopas Martin Rumende Cleopas Martin Rumende Daniel Edbert Daniel Edbert, Daniel Eppy Eppy Eppy Eppy Erni J Nelwan Erni J Nelwan, Erni J Febyan Frida Angelina Ifael Y Mauleti Iman Firmansyah Iman Firmansyah Juffrie, Juffrie Kabul Priyantoro Khie Chen Lie Khie Chen Lie Khie Chen Marsetyawan HNE Soesatyo Mauleti, Ifael Y Mujab, Salwa Tsabitah Althaf Ramadhani Safira Gumarianto Randy Adiwinata Randy Adiwinata, Randy Ria Maria Theresa Rika Bur Rika Bur Sitti Rahmah Umniyati Timoteus Richard Timoteus Richard, Timoteus Titos Ahimsa Widayat Djoko Santoso Widayat Djoko Santoso, Widayat Djoko Yoga Yuniadi