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All Journal Journal of Food and Pharmaceutical Science Jurnal Rekayasa Proses Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Pharmacon Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas (JFSK) Majalah Farmaseutik Jurnal Rekayasa Proses JFIOnline Media Farmasi Indonesia Media Farmasi Indonesia Jurnal Natural Aceh International Journal of Science and Technology Journal of Food and Pharmaceutical Sciences
Endang Lukitaningsih
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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ANALYSIS OF MACRONUTRIENCONTENT, GLYCEMIC INDEX AND CALCIUM OXALATE ELIMINATION IN Amorphophallus campanulatus (Roxb.) Endang Lukitaningsih; Rumiyati Rumiyati; Ika Puspitasari; Meti Christiana
Jurnal Natural Volume 12, Number 2, September 2012
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.539 KB)

Abstract

Recently, the research to find alternative sources of carbohydrates as a replacement for rice has been developed. Walur is one of the carbohydrate sources that can be explored because it can be grown in any area with out special treatment. However, walur has limitation for direct consumption, because it contains calcium oxalate. The purposes of this study were to determine the chemical character (macronutrient content), calculate glycemic index and get the proper washing techniques to elimin ate calcium oxalate of walur. Macro nutrients content studied in this research include carbohydrates, fats, protein, star chand crude fiber. Analysis of macronutrients has been chemically done, while the glycemic index was measured by in vivo using glucose as a standard. Elimination of calcium oxalate was conducted by washing the fresh walur tubers using a solution of0.01NHCl-NaOH, 5% NaCl, and solution of lemon-lime. The content of oxalate before and after washing was analyzed by permanganometry method. The results showed that walur containing 4.34 ±0.07% of reducingsugar,3.24 ± 0.06 % of not-reducing sugar, 11.27±0.40 % of crude fiber,0.03±1.05 % of starchand0.57±0.01 % of protein. Qualitative analysis of fatty acids showed that hexade canoicacid, octade cadienoicacid, and the acide icosatetranoic were detected in high concentrations. The glycemic index valueof walur was relative lylow, about of 16.9. In addition, washing technique using a solution of lemon-lime was the most excellent technique and can reduce the oxalate content up to61.82%.Fromthis research, it can be concluded that walur can be used as food substitute esrice after washing treatment using lemon-lime solution to remove the calcium oxalate content.
Tyrosinase Inhibition Type of Isolated Compounds Obtained from Pachyrhizus erosus Endang Lukitaningsih; Muhammad Bahi; Ulrike Holzgrabe
Aceh International Journal of Science and Technology Vol 2, No 3 (2013): December 2013
Publisher : Graduate Program of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.611 KB) | DOI: 10.13170/aijst.2.3.1063

Abstract

Abstract - In Indonesia, Bengkoang (Phacyrhizus erosus) have been used as one of cosmetics especially as sun screening and skin whitening materials. Six active compounds in Bengkoang with antioxidant and skin whitening activities have been isolated, namely daidzein, daidzin, genistin, (8,9)-furanyl-pterocarpan-3-ol, 4-(2-(furane-2-yl)ethyl)-2-methyl-2,5-dihydro-furane-3-carbaldehyde and 2-butoxy-2,5-bis(hydroxymethyl)-tetrahydrofurane-3,4-diol. According to literatures, the type of their tyrosinase inhibitory activity has not yet reported. The determination of whitening activity of each compound was evaluated by the evaluation of Lineweaver-Burk plot. The result showed that five compounds had competitive inhibitory activity and 8,9-furanyl-pterocarpan-3-ol showed a non-competitive inhibition. Keywords: Pachyrhizus erosus, tyrosinase, competitive inhibition and non-competitive inhibition
Analysis of Adulterated Pangasius Hypopthalmus Oil by ATR-FTIR Spectroscopy and Chemometric Lisa Andina; Revita Saputri; Aristha Novyra Putri; Endang Lukitaningsih; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.668

Abstract

In this recent study, ATR-FTIR spectroscopy and chemometrics have been successfully used for theclassification and quantitative analysis of adulterated Pangasius Hypopthalmus (P. hypopthalmus) oil. The aimof this research was to evaluate the ability of ATR-FTIR spectroscopy and chemometric to perform theclassification and quantitative analysis of adulterated P. hypopthalmus oil in a binary mixture with palm oil(PO) and coconut oil (CO). In the development of FTIR spectroscopy combined with chemometrics for theclassification and quantitative analysis of P. hypopthalmus oil, P. hypopthalmus oil (MP and LFP) mixed withother oils such as coconut oil (CO) and palm oil (PO) at concentrations of 1-99% v/v. Classification of P.hypopthalmus oil, PO and CO were performed by the principal component analysis (PCA) and thequantification analysis was carried out by partial least square (PLS). Based on the optimization process, thebest classification results were obtained using the first derivative spectra at wave numbers of 1400-1100 cm-1.The prediction of percentage adulterated oil by PLS method also showed very good values of R2 greater than0.9999 and low standard error values in the range of 0.0176-0.703. The prediction was also perform at1400-1100 cm-1 wavenumbers using the first derivative spectra.
Compartmental Modeling Approach: Application on Transdermal Delivery for In Vitro Drug Permeation Mechanism Analysis Sekar Ayu Pawestri; Akhmad Kharis Nugroho; Endang Lukitaningsih; Purwantiningsih
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2198

Abstract

Compartmental modeling analysis was used to understand the transport mechanism of drugs in biological systems by computation presented as intercompartmental flows or material. This study was aimed to implement compartmental modeling analysis for in vitro permeation studies in transdermal delivery. The cumulative drug transported versus time were obtained based on the previous report and implemented the two structural different proposed models. WinSAAM software (Windows-based Simulation Analysis and Modeling-WinSAAM Project Group, University of Pennsylvania) was used to analyze data with compartmental analysis. The chosen models were selected through visual and numeric evaluation. The best model had been chosen and could figure out the drug transport kinetics in the biological system. The compartmental modeling approach was helpful used in understanding drug transport mechanisms in transdermal delivery and effectively estimate the drug transport parameter.
Co-Authors -, Ariyanti -, Sutriyanto Abdul Rohman Abdul Rohman Aditya Wisnusaputra Aditya Wisnusaputra, Aditya Ag. Yuswanto Ag. Yuswanto Akhmad Kharis Nugroho Amalia Miranda Amanita K. Hana Annisa Novarina Ardian Widyatmoko Argandita Meiftasari Ari Sudarmanto Ari Sudarmanto Arief Nurrochmad Ariyanti - B. S. Ari Sudarmanto Bustomi, Tomy Bustomi, Tomy Devyanto Hadi Triutomo Dirman, Arifin Dwi Hastutik Etty Sulistyowati Hilda Ismail, Hilda I Gede Agus Juniarka I Gede Agus Juniarka, I Gede Agus Ika Puspita Sari Ika Puspita Sari Ika Puspitasari Indah Purwantini Indah Tri Nugraha Irfan Muris Setiawan Khairunissa Irnanda Kurnianto, Rifki Wahyu Laeli Muntafi'ah Lina Primadesa, Lina Lisa Andina Lora Johana Tamba Lucky Octavianus Saputra M, Suwaldi Melania Perwitasari, Melania Meti Christiana Mufrod, . Mufrod, . Muhammad Bahi Muhammad Bahi Muhammad Fahrurrozi Mustanir Mustanir Mutia Kusuma Wardani Nanang Fakhrudin, Nanang Noegrohati, Sri Pudjono Pudjono Purwantiningsih Purwantiningsih Purwantiningsih Radilla Mutia Ragil S. Dianingati Rahmawati, Adillah Ratih Kurnia Wardani Ratna Asmah Susidarti Ratna Budhi Pebriana Revita Saputri Rochmadi Rochmadi Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Salsabila Yusfita Fawzy Samsul Hadi Samsul Hadi Sekar Ayu Pawestri Sekar Ayu Pawestri Siti Mufidatul Khasanah Sri Noegrohati Sri Noegrohati Standie Nagadi Subagus Wahyuono Subagus Wahyuono Sudarmanto, B.S. Ari Sudarmanto, Bambang Sulistyo Ari Sudibyo Martono Sugeng Riyanto Sugeng Riyanto Suwaldi M Suwaldi Martodihardjo Suwaldi Martodihardjo Syamsu Nur Ulrike Holzgrabe Widyasari Putranti Wirasti, Wirasti Wiwik Supriati