Mochamad Ali Sobirin
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COMPARISON OF THE EFFECTIVENESS OF CURCUMA DOMESTICA EXTRACT AND CURCUMA XANTHORRIZA EXTRACT AGAINST LIVER FUNCTION AND HEPATIC CELL INFLAMMATION ON STREPTOZOTOCIN-INDUCED DIABETES MELLITUS MICE Amira Naufal; Alfin Ihza Trimahendra; Astika Widy Utomo; Vega Karlowee; Awal Prasetyo; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.289 KB) | DOI: 10.14710/dmj.v9i3.27507

Abstract

Background: Diabetes mellitus can cause complications including liver damage, which has an impact on increasing levels of SGOT and SGPT in the blood, as well as inflamation and hepatic steatosis. Turmeric (Curcuma domestica) and java turmeric (Curcuma xanthorizza) are known to have high levels of curcumin and xanthorizzol as an antioxidant and proven to improve liver function. Antioxidant therapy in patients with NAFLD is known to improve liver function and histopathological features. The effects of turmeric and java turmeric extract on liver function in streptozotocin-induced diabetes mellitus mice are still unknown. Objective: Comparing effects of administered turmeric and java turmeric extract on liver function and histopathologic features of  streptozotocin-induced diabetes mellitus mice. Method: Research design Post Test Only Control Group Design are used. Male swiss mice around 25-30 gram are used. Streptozotocin-induced diabetes mellitus mice with a total samples (n = 20) divided into 4 groups, Control+PBS, Control+STZ, STZ+Turmeric, and STZ+Java Turmeric (an = 5). Blood glucose, weight, SGOT, SGPT levels and histopathologic features including percentage of inflamation and hepatic steatosis were examined at day 21. All the research data were analyzed using statistics program. Result: Turmeric and java turmeric extract cannot significantly reduce blood glucose level. Administration of java turmeric extract significantly reduce SGPT level against control+STZ group (84,12±17,53 vs. 36,3±27,4 u/L, p=0,018). Administration of turmeric extract significantly reduce hepatic cell inflamation against control+STZ group (30(26-68) vs. 20(15-30)%, p=0,035). Conclusion: Each turmeric and java turmeric extract can improve liver fuction and decreasing hepatic cell inflamation on streptozotocin-induced diabetes mellitus mice, but may not mediated by decreasing blood glucose level.
THE EFFECT OF TURMERIC EXTRACT (Curcuma longa) ON THE IMPROVEMENT OF MUSCLE MASS IN SWISS DIABETES MELITUS MICE SKELETAL MUSCLE INDUCED BY STREPTOZOTOCIN Alfin Ihza Trimahendra; Yora Nindita; Vega Karlowee; Muhamad Thohar Arifin; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.964 KB) | DOI: 10.14710/dmj.v9i3.27510

Abstract

Backgrounds. Diabetes mellitus is a degenerative disease that has various complications. One of neglected diabetes mellitus complication is skeletal muscle atrophy. Turmeric and java turmeric extracts were need to be clarified due to those effect as antihyperglycemic agent which might affected muscle atrophy as one of diabetes mellitus complication. Aim. To compared the efficacy of turmeric and java turmeric extract on reducing the progression of skeletal muscle atrophy in streptozotocin-induced diabetes mellitus. Methods. We conducted experimental animal studies with a post test only control group design using 25-30 grams male Swiss mice aged 12 weeks. Diabetes mellitus was induced by streptozotocin (STZ) administration. All 28 samples were randomly divided into 4 groups : control + PBS, control + STZ, STZ + turmeric, and STZ + java turmeric groups. Before treatment, blood glucose and body weight were examined on 3rd day. Blood glucose, body weight, hindlimb muscle weight, and muscle diameter results were examined after treatment (on 21st day). Data was analyzed with statistical software after all procedures were done. Results. STZ + turmeric group showed insignificant decreased in blood sugar levels (p=0.107). Control + STZ group showed significantly reduced hindlimb muscle weight compared to other groups. Hindlimb muscle weight was significantly ameliorated by STZ + turmeric extract (p=0.048). There were no significant improvement on skeletal muscle diameter among groups. Conclusion. The administration of turmeric extract improved hindlimb muscle weight but may not mediated by glucose lowering effect in streptozotocin induced diabetic mice.