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All Journal Dentino: Jurnal Kedokteran Gigi
Nelly Nainggolan
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Dentistry

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PREVALENCE OF HUMAN PAPILLOMA VIRUS IN CANCEROUS AND PRE-CANCEROUS ORAL LESIONS USING SALIVA, SERUM, AND PLASMA ASSAY Nelly Nainggolan; Wahyu Hidayat
Dentino : Jurnal Kedokteran Gigi Vol 6, No 1 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i1.10641

Abstract

ABSTRACTIntroduction: As many as 90%-95% cases of oral cancer are oral squamous cell carcinoma. In South and Southeast Asia, the prevalence of oral cancer is high. Oral cancer is ranked sixth for the most frequent malignancies in Asia with nearly 274,300 new cases occurring every year. Head and Neck Squamous Cell Carcinoma is one of the main public health concerns with 1-2% incident of all cancers worldwide and is also the sixth most common malignant tumor. Human Papillomavirus (HPV) is a DNA virus which is also known as the cause of head and neck cancer. Among all malignancies, oral cancer is one of the conditions where salivary examination can be used to detect oral cancer because it contacts directly with the lesions. The relationship between human papilloma virus (HPV) and oral squamous cell carcinoma has been extensively studied and shows that HPV-16 & 18 can be detected in saliva, serum or plasma samples and patient biopsies. Purpose: This systematic review aims to reveal the presence of human papilloma virus in cancerous and pre-cancerous lesions of the oral cavity by examining saliva, serum or plasma. Methods: Systematic Review was carried out using the PRISMA method. Articles with clinical trial types sourced from electronic searches were obtained through the PubMed, Research Gate and Google Scholar portals using keywords: Human Papilloma Virus, Oral Cancer, and Saliva. Conclusion: Based on the results, it is concluded that HPV is detected in oral cavity cancers, oropharyngeal, oral squamous cell carcinoma and Oral Potentially Malignant Disorders.Keywords : Human Papilloma Virus, Oral cancer, Saliva
IDIOPATHIC TASTE IMPAIRMENT IN A YOUNG WOMAN: A CASE REPORT Tenny Setiani Dewi; Nelly Nainggolan; Dewi Zakiawati
Dentino : Jurnal Kedokteran Gigi Vol 7, No 2 (2022)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v7i2.14620

Abstract

ABSTRACT  Background: The underlying cause of taste impairment includes damage in the central or peripheral nervous system, nutrition deficiency, systemic disease, or idiopathic. This condition usually occurs with advancing age. Taste alteration may affect the patient’s psychological aspect and causing malnutrition or even develop into more serious health problems. Purpose: This report aims to evaluate an unusual partial ageusia in a young woman and to review articles with idiopathic taste disorders. Case: A 33-year-old woman was referred to the Department of Oral Medicine from the neurology department with a primary diagnosis of migraine and median nerve mononeuropathy. The patient also complained of loss of tastes (salty, bitter, and sour) accompanied by numbness on the palate and left buccal mucosa for the past two weeks. Case Management: The patient was given a 0.12% chlorhexidine digluconate mouthwash and 25 mg zinc tablets twice a day. After 2 weeks, she can identify bitter, and followed by sweet and sour in the next few weeks, as well as improvement of the numbness. Eighteen studies of idiopathic taste disorders from 1991-2021 have been reported in the literature. Conclusion: Taste disorders with unknown aetiology may happen in young individuals. Zinc has been proven as a beneficial micronutrient to treat patients with idiopathic taste impairment. Dentists should consider this approach to resolve the symptoms and accelerate the healing process of possible co-occurrence systemic diseases.  Keywords: Ageusia, idiopathic, Taste dysfunction, Treatment
Co-Authors Dewi Zakiawati Tenny Setiani Dewi Wahyu Hidayat