Hadiarto Mangunnegoro
Department of Pulmonology, Faculty of Medicine, Universitas Indonesia, Jakarta.

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Asthma prevalence among high school students in East Jakarta, 2001, based on ISAAC questionnaire Yunus, Faisal; Antaria, Ratnawati; Rasmin, Menaldi; Mangunnegoro, Hadiarto; Jusuf, Anwar; Bachtiar, Adang
Medical Journal of Indonesia Vol 12, No 3 (2003): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1017.856 KB) | DOI: 10.13181/mji.v12i3.103

Abstract

The aim of this study was to assess asthma prevalence in children between 13-14 years of age in East Jakarta. This study is a cross sectional study which surveyed 2234 high school students between the ages of 13 and 14 years in East Jakarta in 2001 using the ISAAC questionnaire. Bronchial challenge test was applied by using methacholine substance to 186 students. Reports based on the ISAAC questionnaire indicate that 7.2% of teenage have had wheezing experience, 4.1% have wheezing within the last 12 months, 1.8% have ever suffered severe asthma attack within the last 12 months, 3.3% have suffered wheezing after exercise, and 6.3% have got night cough while they were not suffering from cold. Prevalence of atopy diseases such as rhinitis and eczema were 14.2% and 3.9%, meanwhile rhinitis and eczema prevalence within the last 12 months according to this study were 10.6% and 2.9% respectively. Statistically, there is a significant correlation between wheezing symptom and atopy (p < 0.05). From indepth questionnaire, a significant value of kappa 0.84 related with wheezing within the last 12 months was found. Bronchial challenge test results indicate that sensitivity was 90%, specificity 83.58%, positive predictive value 68.12% and negative predictive value was 95.73%. Asthma prevalence in East Jakarta at 2001 based on ISAAC questionnaire was 8.9%, and cumulative prevalence 11.5%. The ISAAC questionnaire can be used to study asthma prevalence in children at multicenter in Indonesia. (Med J Indones 2003; 12: 178-86)Keywords: bronchial challenge, high school student, ISAAC questionnaire, East Jakarta, asthma prevalence
Safety and tolerability of moxifloxacin in the treatment of respiratory tract infections: a post-marketing surveillance conducted in Indonesia Setiawati, Arini; Darmansjah, Iwan; Mangunnegoro, Hadiarto
Medical Journal of Indonesia Vol 14, No 1 (2005): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.699 KB) | DOI: 10.13181/mji.v14i1.168

Abstract

Moxifloxacin 400 mg tablet has been marketed in Indonesia for several indications, i.e. acute exacerbation of chronic bronchitis (AECB), community-acquired pneumonia (CAP), and acute bacterial sinusitis (ABS). To assess the safety and tolerability of moxifloxacin, a post-marketing surveillance study was conducted in the year 2001 involving 589 physicians. Clinical efficacy was also evaluated, both by physicians and patients, using a 6-symptom total score, which was scaled 0-12. A total of 1715 patients with acute sinusitis, CAP, AECB, and other infections were treated with oral moxifloxacin 400 mg once daily. There were 151 (8.8%) patients with adverse events (AEs) and 5 (0.29%) patients with serious adverse events (SAEs) that were considered related to moxifloxacin treatment. The most common adverse reactions were nausea (4.96%), dizziness (1.52%), vomiting (0.64%), headache (0.47%), and weakness (0.47%). Twenty three (1.34%) patients discontinued treatment due to adverse events. Tolerance to treatment was rated very good and good by 647 (37.7%) and 919 (53.6%) of patients, respectively. Based on physicians’ clinical assessment, 57.7% of patients were cured and 39.9% were improved at the end of treatment. Mean total symptom score, as assessed by the patients, decreased from 6.43 on day-1 to 2.76 on day-3. Totally, 95.3% of patients felt better after receiving moxifloxacin and 97.6% of patients had good impression on moxifloxacin treatment. In conclusion, treatment of respiratory tract infections, mainly AECB, CAP and ABS, with moxifloxacin 400 mg once daily in this post-marketing surveillance was shown to be safe and well tolerated. Moxifloxacin was also shown to be highly effective in the treatment of these infections with rapid improvement of symptoms. (Med J Indones 2005; 14: 11-19)Keywords : post-marketing survtillance, PMS, moxifloxacin, respiratory tract infections
Cost effectiveness of the addition of inhaled corticosteroid in moderately persistent asthmatics treated with daily oral bronchodilator Mangunnegoro, Hadiarto
Medical Journal of Indonesia Vol 7, No 4 (1998): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (870.329 KB) | DOI: 10.13181/mji.v7i4.753

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[no abstract available]
The effect of salbutamol controlled release on bronchial hyperresponsiveness in patients with bronchial asthma Mangunnegoro, Hadiarto; Yunus, Faisal; Amrie, Yulino
Medical Journal of Indonesia Vol 3, No 2 (1994): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (743.895 KB) | DOI: 10.13181/mji.v3i2.953

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[no abstract available]
Comparison of the efficacy of nebulized and intravenous salbutamol in the initial treatment of acute severe asthma Katili, Antalia K.M.; Mangunnegoro, Hadiarto; Farid, Mohammad; Yunus, Faisal
Medical Journal of Indonesia Vol 4, No 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1147.353 KB) | DOI: 10.13181/mji.v4i4.926

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[no abstract available]