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All Journal Majalah Kedokteran Bandung Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Martabe : Jurnal Pengabdian Kepada Masyarakat JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Jurnal Pandu Husada
Melviana Lubis
Universitas Muhammadiyah Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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UJI EFEKTIVITAS ANTIBIOTIK EKSTRAK DAUN CENGKEH (SYZYGIUM AROMATICUM) TERHADAP PERTUMBUHAN BAKTERI SALMONELLA TYPI SECARA IN VITRO Ristiansyah, Dilla Ulfa; Yenita, Yenita; Melviana, Melviana; Annisa, Annisa
JURNAL IBNU SINA BIOMEDIKA Vol 2, No 1 (2018)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.486 KB) | DOI: 10.30596/isb.v2i1.1901

Abstract

Typhoid fever is an enteric bacterial infection caused by Salmonella enterica serovar Typhi or Paratyphi. Salmonella typhi is a Gram negative rod which has no spores and moves with flagel peritric. Salmonella is facultative intracellular and facultative anaerobes. Clove leaves (Syzygium aromaticum) have antibiotic effects on bacteria and known can inhibit Salmonella typhi bacteria. Methodology: This study used an experimental method. The technique used in measuring antibiotic activity is the method of disk diffusion. Result: The concentration of 10%, 15%, 20% and 25% clove leaf extracts resulted in average of 11.89 mm, 11.40 mm, 16.76 mm, and 16.90 mm respectively. while the clear zone diameter of chloramphenicol is 20.74 mm.Conclusion: Clove leaf extract at 25% concentration has high clear zone in treatment group. Keywords: Salmonella typhi, Clove Leaf extractKeywords : Salmonella typhi, Cengke leaf’s extract    
ANALISIS DAN EKSPLORASI KOMPETENSI TATALAKSANA FARMAKOLOGI MAHASISWA PADA UJIAN SIMULASI OSCE UKMPPD DI FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA Lubis, Melviana
JURNAL IBNU SINA BIOMEDIKA Vol 3, No 1 (2019): (Mei 2019)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (633.113 KB) | DOI: 10.30596/isb.v3i1.3625

Abstract

Abstrak Latar Belakang Ujian OSCE merupakan salah satu bagian Uji Kompetensi Mahasiswa Program Profesi Dokter (UKMPPD)  yang bertujuan menjaga mutu lulusan dokter. Kompetensi farmakologi merupakan salah satu kompetensi yang diuji pada OSCE. Belum banyak publikasi mengenai analisis kompetensi OSCE khususnya farmakologi. Penelitian ini bersifat eksplorasi untuk menjadi dasar penelitian selanjutnya.  Metode Penelitian ini adalah penelitian deskriptif eksploratif yang dilakukan dengan menganalisis berkas ujian simulasi OSCE UKMPPD pada bulan Maret 2019 yang berasal dari 23 peserta. Berkas ujian yang dimaksud meliputi lembar jawaban yang ditulis mahasiswa (kertas resep), berkas soal OSCE,  dan lembar penilaian oleh penguji. Hasil Hanya 7,7% mahasiswa yang mendapat nilai sempurna untuk kompetensi farmakologi.dari total 10 station OSCE UKMPPD. Kesimpulan kekurangan mahasiswa pada kompetensi farmakologi dapat disebabkan berbagai hal antara lain, kesalahan diagnosis sejak awal, kesalahan pemilihan obat sesuai diagnosis, kesalahan pemilihan sediaan, kesalahan pemilihan dosis dan jumlah obat, dan kesalahan dalam cara penulisan resep.Kata Kunci: OSCE UKMPPD, kompetensi farmakologi, uji kompetensi dokter Indonesia 
Vitamin D Deficiency Prevalence And Its Association with Bacterial Load Sputum in Newly Diagnosed TB Patients Melviana Lubis; Bintang Yinke Magdalena Sinaga; Nita Andriani Lubis
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.813 KB) | DOI: 10.15395/mkb.v52n1.1937

Abstract

Vitamin D plays a role in innate and adaptive immune functions, and its deficiency has become a risk factor for TB infection. This study aimed to describe the prevalence of vitamin D deficiency in newly diagnosed TB patients and to examine the relationship between vitamin D levels and sputum smear positivity that reflects bacterial load. This is a cross-sectional study conducted at several primary health care facilities in Medan and Deli Serdang from November 2015 to June 2016. As many as 86 subjects adult TB patients with positive smear sputum who had not received therapy or had at most 1 week on therapy were recruited. Sputum examination were interpreted using IUATLD (International Union Against Tuberculosis and Lung Disease) grading scale. Serum 25 (OH) vitamin D level was estimated using enzyme-linked immunosorbent assay (ELISA) and interpreted as deficiency (<20 ng/ml), insufficiency (20–29 ng/ml), or optimum (30–100 ng/ml). The association between vitamin D level and positivity level of AFB sputum was analyzed using Spearman correlation test. The prevalence of VDD in new pulmonary TB patients with positive smear sputum was 17.4%.  There was a weak relationship between vitamin D level and positivity level of  AFB sputum (p = 0.014), with a correlation coefficient of (-0.264). Many of newly diagnosed TB patients had vitamin D deficiency despite the fact that Indonesia is an equatorial area with sufficient sunshine throughout the year. This study shows vitamin D indeed affect bacterial load and a low 25 (OH) vitamin D level is associated with higher bacterial load. Prevalensi Defisiensi Vitamin D pada Pasien TB Paru Baru dan Hubungan dengan Derajat Kepositifan Sputum Basil Tahan AsamVitamin D berperan dalam imunitas bawaan dan adaptif. Kekurangan vitamin D merupakan faktor risiko terinfeksi TB. Penelitian ini bertujuan menggambarkan prevalensi defisiensi vitamin D pada pasien TB baru dan mengetahui hubungan kadar vitamin D dengan derajat kepositifan sputum yang mencerminkan kepadatan bakteri. Penelitian potong lintang ini dilakukan di beberapa Puskesmas di wilayah Medan dan Deli Serdang pada November 2015 hingga Juni 2016. Subjek penelitian sebanyak 86 pasien TB dewasa dengan sputum basil tahan asam (BTA) positif, yang belum atau maksimal 1 minggu mengkonsumsi obat. Pemeriksaan sputum dinilai menggunakan skala IUATLD. Kadar vitamin D serum 25 (OH) dinilai dengan metode ELISA dan diklasifikasikan menjadi defisiensi (<20 ng/mL), insuffisiensi (20–29 ng/mL), optimum (30–100 ng/mL). Hubungan kadar vitamin D dengan tingkat kepositifan sputum BTA dilakukan dengan uji korelasi Spearman. Prevalensi VDD pada pasien TB paru baru dengan sputum positif adalah 17,4%. Terdapat  hubungan antara kadar vitamin D dan tingkat kepositifan sputum BTA (p=0,014), dengan koefisien korelasi (-0,264). Banyak pasien TB paru baru yang mengalami kekurangan vitamin D, meskipun Indonesia berada di khatulistiwa dengan kecukupan sinar matahari sepanjang tahun. Penelitian ini menunjukkan bahwa vitamin D berhubungan dengan kepositifan sputum dan kadar vitamin D yang rendah berhubungan dengan kepadatan bakteri yang lebih tinggi.
UJI EFEKTIVITAS DAYA HAMBAT PERTUMBUHAN JAMUR DERMATOFITA OLEH EKSTRAK BUAH NANAS ABDUL RAZAK; MELVIANA LUBIS
JURNAL ILMIAH MAKSITEK Vol 5 No 4 (2020): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Fungal infections are the most common skin disease in tropical and developing countries. Fungal infections caused bydermatophytes such as Tricophyton. Pineapple (Ananas comosus L.) contains flavonoids, saponins and polyphenols as antifungi. This study aims to know whether pineapple extract has growth inhibition effect on dermatophytic fungi which causetinea corporis, in vitro. This is an experimental study with post test only design, consists of 4 group: two intervention group(Pineapple extract 10% and 25%), positive control and negative control group. Four sample sources were taken from newpatient with tinea corporis which then identified as Microsporum and Tricophyton.In these test Saboroud Dextrose Agarplates were used and growth inhibition effect was measured by clear zone. In this study, none of the groups shown clearzones. Pineapple extract 10% and 25% cannot inhibit the growth of dermatophytes in tinea corporis patients.
PERBEDAAN KADAR GULA DARAH PADA PASIEN SKIZOFRENIA YANG MENGGUNAKAN OBAT HALOPERIDOL DAN RISPERIDON DI RSJ. PROF. DR. M. ILDREM ZAHRAH SAFIRA; NANDA SARI NURALITA; DAPOT PARULIAN GULTOM; MELVIANA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 4 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Schizophrenia is a severe mental disorder that often occurs in the world. Current treatments for schizophrenia are typicalantipsychotics and atypical antipsychotics. Typical antipsychotics such as haloperidol, chlorpromazine, sulpirid, andthioridazine, and atypical antipsychotics such as risperidone, and atypical antipsychotics such as risperidone, clozapine,olanzapine and zipracidone. In the long term use of the drug can cause extrapyramidal symptoms, metabolic disorders suchas increased blood glucose levels. To determine differences in blood glucose levels in schizophrenic patients usinghaloperidol and risperidone at the mental hospital. Prof. Dr. M. Ildrem Medan which took from September to December 2019.This study is a non-paired numerical analytic study with a non- probability sampling technique that was carried out using ablood sugar level check tool during easy touch. The number of samples used was 46 schizophrenic patients, of which 23people took the drug haloperidol, and 23 people took the drug risperidone. Then performed an analysis with the Mann-Whitney test. The Mann-Whitney test results showed that there were significant differences between the use of haloperidoland risperidone drugs in schizophrenic patients with a P value of 0.001 (p <0.05). Risperidone drug use is higher riskcompared with haloperidol drugs. The use of risperidone has a significant difference with haloperidol on blood glucose levelswhen in schizophrenia patients.
EFEKTIFITAS EKSTRAK DAUN SAMBILOTO (ANDROGRAPHIS PANICULATA NESS) DENGAN KLORAMFENIKOL TERHADAP PERTUMBUHAN BAKTERI SALMONELLA TYPHI SECARA IN VITRO FAJAR MUHAMMAD NASUTION; MUHAMMAD JALALUDDIN ASSUYUTHI CHALIL; ANNISA .; MELVIANA LUBIS
JURNAL ILMIAH SIMANTEK Vol 3 No 3 (2019): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

S. typhi is a stem bacteria, and gram-negative bacteria causes of typhid fever that until now became a health problem . Sambiloto (Andrographis paniculata Ness) is a potentially medicinal plants because it has antibiotic effect on bacteria. Objective: This study aims to determine the effectiveness of sambiloto’s leaf ectract on Salmonella typhi growth in vitro. Method: this research use experimental method. The technique used in measuring antibiotic activity is the method of disk diffusion. Result: The result showed that the sambiloto’s leaf extract (Andrographis paniculata Ness) with concentration of 80%, 40%, 20% and 10% yielded the mean of clear zone diameter ie 9.93 mm, 9.61 mm, 8.74 mm, and 7.49 mm. in this study showed that each concentration has different inhibitory power between the one with the other which obtained the value (p<0.05) but in the concentration ratio of 40% with 80% obtained value (p>0.05). Conclusion: Sambiloto’s leaf extract has an inhibitory power to the growth of Salmonella typhi bacteria and it can be seen in the result of the study. The higher the concentration of sambiloto’s leaf extract given, more higher the clear zone forme on the agar medium.
HUBUNGAN KUANTITAS TIDUR DENGAN TINGKAT KONSENTRASI PADA MAHASISWA STAMBUK 2014 FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA PADA TAHUN 2017 HUDDY ARTICA SINULINGGA; MELVIANA .; GUSBAKTI RUSIP; ANITA SURYA
JURNAL ILMIAH SIMANTEK Vol 3 No 3 (2019): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Sleep affects the ability to concentrate, speak, understand what we are reading, and conclude what we are hearing. If the sleep is disturbed, then it also disturbed mood, body functions and social relationships with people around. The concentration and understanding of a person are influenced by serotonin neurotransmitters whose concentration will decrease if lack of sleep. Therefore, to obtain adequate and balanced serotonin concentrations, an adequate quantity of sleep is required. Objective: the purpose of study is to determine the relationship of quantity of sleep with the level of concentration at student class of 2014. Method: analytical descriptive with the cross sectional design. A total of 96 respondents were selected with total sampling technique. Sleep quantity data were taken using the Pittsburgh quality sleep index (PSQI) and the concentration level of the Stroop test. At the end of the research, Gamma statistical test was done to find out the relationship between the two variables.Results:statistic analysis using spearman test, n =96, p = 0,001 (p <0,05), and r =0944.Conclusion: in this research, there is a correlation between quantity of sleep with the level of concentration at student class of 2014, in Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara.
PERBANDINGAN DAYA HAMBAT EKSTRAK DAUN KAYU MANIS (CINNAMOMUM BURMANNII) KONSENTRASI 10% DAN 20% TERHADAP PERTUMBUHAN JAMUR DERMATOFITA PADA PASIEN TINEA KORPORIS SECARA IN VITRO FITRI DYANA SIAGIAN; MELVIANA LUBIS
JURNAL ILMIAH SIMANTEK Vol 4 No 4 (2020): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Dermatophytosis is one of the superficial dermatomycosis groups caused by dermatophyte fungal infections of the skin,occurring as a reaction of the host to fungal metabolite products and due to invasion by an organism in a living tissue.Cinnamomum burmannii leaves have an antifungal effect on fungi. Flavonnoids, saponins, alkaloids, and tannins on theleaves of cinnamon are known to inhibit dermatophytic fungi. This type of research is an experimental research because inthis study the treatment was carried out, namely the administration of cinnamon leaf extract (Cinnamomun burmannii) with aconcentration of 10% and 20% and then the effect on the growth of dermatophytic fungi will be seen. This study uses a staticgroup comparative research method (Static Group Comparison) that is by making measurements (observations) made afterthe treatment group accepts the program or intervention. From the results of the study showed that the leaves of cinnamon(Cinnamomum burmannii) with a concentration of 10% and 20% can inhibit the growth of Microsporum sp. In the fourthpatient. Cinnamomun burmannii leaf extract with a concentration of 10% and 20% has the ability as an antifungal to thegrowth of microsporum sp. in the fourth patient and cinnamon burmannii leaf extract 20% concentration was the mosteffective in inhibiting the growth of microsporum sp. (highest clear zone).
Adherensi Pengobatan Asma Anak dan Tingkat Kontrol Asma di RSUD H. Abdul Manan Simatupang Asahan Sofie Devianti Wahyudi; Melviana Lubis
ANATOMICA MEDICAL JOURNAL | AMJ Vol 5, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v5i2.11106

Abstract

Asma merupakan penyakit saluran pernapasan tidak menular yang masih sering ditemukan pada anak-anak dan terus meningkat insidennya. Tingkat keadaan kontrol yang buruk dipengaruhi oleh beberapa faktor antara lain ketidakpatuhan pasien asma terhadap pengobatan. Penelitian mengungkapkan tingkat kepatuhan asma di Indonesia sangat rendah (30%-70%) sehingga tingkat pengendalian asma dan kualitas hidup menurun. Metode: Penelitian potong lintang dengan 35 sampel anak usia 6-18 tahun penderita asma yang berkunjung ke RS Abdul Manan Simatupang Asahan, untuk mengukur tingkat kepatuhan dan tingkat pengendalian asma. Tingkat kepatuhan diukur dengan menggunakan kuesioner Modified Morisky Adherence Scale (MMAS-8) dan tingkat kontrol asma diukur dengan Childhood Control Asthma Test (C-ACT). Hasil: Ada 91, 4% (32 dari 35) anak dalam kelompok asma tidak terkontrol dan sebagian besar anak memiliki tingkat kepatuhan yang rendah. Chi square menunjukkan ada hubungan tingkat kepatuhan pengobatan asma dengan keadaan tingkat kontrol asma (p = 0,01). Kesimpulan: Ada hubungan tingkat kepatuhan pengobatan asma dengan tingkat kontrol asma.Kata kunci: asma anak, kepatuhan asma, pengendalian asma
Overview of Ivabradine Drug: Use and History Melviana Lubis
Buletin Farmatera Vol 8, No 1 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i1.12751

Abstract

Despite the significant advances in management and prevention, heart failure still cause high mortality and morbidity. Ivabradine is one example of a new drug used in the treatment of heart failure with decreased ejection fraction. Ivabradine history and use is interesting that it can improve our understanding to cardiovascular pathophysiology. There may also be extended indications for Ivabradine use in the future.
Co-Authors ABDUL RAZAK Anita Surya ANNISA . Annisa, Annisa Bintang Yinke Magdalena Sinaga CHAIRIYAH ATIQAH PUTRI DAPOT PARULIAN GULTOM FAJAR MUHAMMAD NASUTION Fitri Dyana Siagian FITRI DYANA SIAGIAN GUSBAKTI RUSIP HUDDY ARTICA SINULINGGA Muhammad Jalaluddin Assuyuthi Chalil Nita Andriani Lubis Nuralita, Nanda Sari Ristiansyah, Dilla Ulfa Safira Qisthina Awanis Sofie Devianti Wahyudi Widia Syahfitri Yenita Yenita ZAHRAH SAFIRA