Ely Setiawan
Jurusan Kimia FMIPA Universitas Jenderal Soedirman

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

POTENSI EKSTRAK METANOL DAUN MANGGA BACANG (Mangifera foetida L.) SEBAGAI ANTIBAKTERI TERHADAP Enterobacter aerogenes DAN IDENTIFIKASI GOLONGAN SENYAWA AKTIFNYA Ely Setiawan; Tien Setyaningtyas; Dwi Kartika; Dian Riana Ningsih
Jurnal Kimia Riset Vol. 2 No. 2 (2017): Desember
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (600.709 KB) | DOI: 10.20473/jkr.v2i2.5753

Abstract

AbstrakEnterobacter aerogenes merupakan bakteri penyebab berbagai macam infeksi. Salah satu pengobatan berbagai penyakit infeksi yaitu dengan pemberian antibiotik. Penggunaan  antibiotik  sintetik  secara  terus  menerus  dapat menyebabkan resistensi, sehingga untuk mengatasinya diperlukan pencarian bahan obat alami seperti ekstrak tanaman yang berpotensi sebagai antibakteri, salah satunya yaitu ekstrak daun mangga bacang (Mangifera foetida L.). Penelitian ini bertujuan untuk mengetahui potensi ekstrak daun mangga bacang sebagai antibakteri terhadap E. aerogenes, penentuan konsentrasi   hambat tumbuh minimum (KHTM) dan mengidentifikasi golongan senyawa aktif dari  ekstrak daun mangga bacang. Ekstrak daun mangga bacang diperoleh dengan cara maserasi menggunakan metanol. Ekstrak yang diperoleh diuji aktivitas antibakteri dengan menggunakan metode difusi sumur. Konsentrasi  yang digunakan 1000 ppm, kontrol positif tetrasiklin 1000 ppm dan kontrol negatif aquades. Penentuan konsentrasi hambat tumbuh minimum menggunakan konsentrasi 1000 ppm, 500 ppm, 250 ppm, 125 ppm, 65 ppm, 30 ppm, 15 ppm, 10 ppm, 5 ppm. Ekstraksi daun mangga bacang menunjukan rendemen sebesar 10,61% (b/b) dan diameter zona hambat aktivitas antibakteri konsentrasi 1000 ppm sebesar 5,46 mm. KHTM ekstrak  metanol daun mangga bacang   terhadap E. aerogenes yaitu pada konsentrasi 5 ppm dengan diameter zona hambat sebesar 1,78 mm. Berdasarkan hasil uji fitokimia ekstrak metanol daun mangga bacang menunjukkan adanya senyawa golongan alkaloid, flavonoid, stereoid, polifenol, tanin, dan saponin.AbstractEnterobacter aerogenes is causes various bacterium infections. One of the treatment of various infectious diseases is by antibiotics treatment. The long-term use of synthetic   antibiotics causes antibiotic resistance, so that research exploration of new antibiotic is needed, such as plant extracts potentially as an antibacterial, one of them is leaves extract of mango bacang (Mangifera foetida L.). This study aimed to examine the potential of leaves mango bacang extract as an antibacterial againts E. aerogenes, the determination of minimum inhibition concentration (MIC) and active compounds of leaves mango bacang extract. Leaves mango bacang extract obtained methanol maceration. The extract obtained was tested antibacterial activity by using the diffusion wells method. Concentration used was 1000 ppm, tetracycline of 1000 ppm as positif control and aquades as negative control. The determination of MIC was used various concentrations of 1000 ppm, 500 ppm, 250 ppm, 125 ppm, 65 ppm, 30 ppm, 15 ppm, 10 ppm, and 5 ppm. The extraction mango bacang leaves with yielded 10.61 % (b/b) and diameter of zone of the antibacterial activity extract of 1000 ppm was 5.46 mm. The MIC of the methanol extract against E. aerogenes was 5 ppm with the zone diameter of 1.78 mm. Phytochemistry analysis of mango bacang leaves extract using methanol result the alkaloid, flavonoid, stereoid, catakin, tannin, and saponin. 
SINTESIS NATRIUM PENTAGAMAVUNONAT DAN UJI STABILITASNYA MENGGUNAKAN SPEKTROFOTOMETER UV-Visible Ely Setiawan; Trisnowati Trisnowati; Dadan Hermawan
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.058 KB) | DOI: 10.20884/1.jm.2006.1.1.19

Abstract

A research on the synthesis of sodium pentagamavunonat (Na-PGV-0) and its stability test using UV-Visible spectrophotometer were carried out. The synthesis of Na-PGV-0 carried out by reacting PGV-0 in tetrahydrofuran solvent refluxed with sodium ethoxide in mol comparison (1:2) for two hours. Structure elucidation by spectroscopic methods using UV-Visible, IR, 1H-NMR, 13C-NMR and stability test in water using UV-Visible spectrophotometer. The reaction yields 107,21 % (% w/w) products. A products was soluble in water and methanol. Structure elucidation results indicated that the formed compound where the OH phenolic of pentagamavunon-0 was replaced by sodium ions. Stability test shows that decreasing of sodium