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Perdarahan Gingiva Sebagai Indikator Penyakit SistemikKasus pada Individu yang Sebelumnya Tak Terdeteksi Menderita Demam Berdarah Dengue Erawati, Satrya Ayu; Tampoma, Selviana; Hendarti, Hening Tuti
Insisiva Dental Journal Vol 6, No 2 (2017)
Publisher : Insisiva Dental Journal

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Latar belakang: Perdarahan gingiva dapat disebabkan oleh trombopati. Kondisi medikokompromais seperti DBDmerupakan salah satu faktor predisposisinya. Demam Berdarah Dengue (DBD) adalah penyakit sistemik yang seringterlambat terdiagnosis dan berisiko kematian, banyak dijumpai pada daerah tropis seperti Indonesia. Insidensi DBDdi Jawa Timur sebesar 29,25/100.000 dengan risiko kematian sebesar 0,88%. Tujuan: Penulisan laporan kasusini bertujuan untuk melaporkan perdarahan gingiva pada pasien yang sebelumnya tidak terdeteksi DBD. Kasus:Seorang laki-laki 26 tahun dirujuk untuk melanjutkan pembersihan karang gigi dengan diagnosis gingivitis akut.Pada awalnya, pasien mengeluhkan perdarahan gingiva selama seminggu terakhir saat menyikat gigi dan bau mulut.Pasien merasakan badan lelah dan lemah sejak 1 bulan yang lalu. Tiga minggu sebelum datang, pasien terdiagnosis fludengan gejala demam dan pusing. Ekstra-oral tampak konjungtiva dan kuku pucat serta petechiae pada lengan kanansaat pemeriksaan tekanan darah. Intra-oral terlihat perdarahan gingiva spontan dan ekimosis pada mukosa labial dangingiva. Penanganan: Pemeriksaan darah dilakukan pada hari yang sama dan diketahui adanya trombositopenia yangparah. Hasil anamnesis mengacu pada dugaan adanya penyakit sistemik. Pasien dirujuk ke spesialis penyakit dalamdan terdiagnosis DBD. Kesimpulan: Temuan klinis perdarahan gingiva dapat digunakan sebagai indikator penyakitsistemik, pada kasus ini adalah DBD tanpa gejala demam. Identifikasi dini lesi mulut terkait penyakit sistemik dapatmembantu penderita untuk memperoleh perawatan lebih awal dan mengurangi angka kematian akibat keterlambatanpenanganan.

Perdarahan Gingiva Sebagai Indikator Penyakit SistemikKasus pada Individu yang Sebelumnya Tak Terdeteksi Menderita Demam Berdarah Dengue Erawati, Satrya Ayu; Tampoma, Selviana; Hendarti, Hening Tuti
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 6, No 2 (2017)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.6285

Latar belakang: Perdarahan gingiva dapat disebabkan oleh trombopati. Kondisi medikokompromais seperti DBDmerupakan salah satu faktor predisposisinya. Demam Berdarah Dengue (DBD) adalah penyakit sistemik yang seringterlambat terdiagnosis dan berisiko kematian, banyak dijumpai pada daerah tropis seperti Indonesia. Insidensi DBDdi Jawa Timur sebesar 29,25/100.000 dengan risiko kematian sebesar 0,88%. Tujuan: Penulisan laporan kasusini bertujuan untuk melaporkan perdarahan gingiva pada pasien yang sebelumnya tidak terdeteksi DBD. Kasus:Seorang laki-laki 26 tahun dirujuk untuk melanjutkan pembersihan karang gigi dengan diagnosis gingivitis akut.Pada awalnya, pasien mengeluhkan perdarahan gingiva selama seminggu terakhir saat menyikat gigi dan bau mulut.Pasien merasakan badan lelah dan lemah sejak 1 bulan yang lalu. Tiga minggu sebelum datang, pasien terdiagnosis fludengan gejala demam dan pusing. Ekstra-oral tampak konjungtiva dan kuku pucat serta petechiae pada lengan kanansaat pemeriksaan tekanan darah. Intra-oral terlihat perdarahan gingiva spontan dan ekimosis pada mukosa labial dangingiva. Penanganan: Pemeriksaan darah dilakukan pada hari yang sama dan diketahui adanya trombositopenia yangparah. Hasil anamnesis mengacu pada dugaan adanya penyakit sistemik. Pasien dirujuk ke spesialis penyakit dalamdan terdiagnosis DBD. Kesimpulan: Temuan klinis perdarahan gingiva dapat digunakan sebagai indikator penyakitsistemik, pada kasus ini adalah DBD tanpa gejala demam. Identifikasi dini lesi mulut terkait penyakit sistemik dapatmembantu penderita untuk memperoleh perawatan lebih awal dan mengurangi angka kematian akibat keterlambatanpenanganan.

Managementof squamos cell carcinoma of tongue in young men: case report Israyani Israyani; Ayu F. Argadianti; Hening Tuti Hendarti; Adiastuti E. P
Journal of Case Reports in Dental Medicine Vol 1, No 1 (2019)
Publisher : Hasanuddin University

Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap

Herpes-associated erythema multiforme in a postmenopausal woman Hendri Susanto; Nurhilailah Nurhilailah; Raziv Ganesha; Hening Tuti Hendarti; Priyo Hadi
Majalah Kedokteran Gigi Indonesia Vol 7, No 1 (2021): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.43299

Herpes-associated erythema multiforme (HAEM) is an acute inflammatory mucocutaneous disease which is characterized by ulcerative lesion on oral mucous membrane with or without skin involvements. The etiology of erythema multiforme (EM) is probably hypersensitivity reaction to human herpes simplex virus tipe 1 (HSV-1). Lesions on lips with HAEM can be treated by corticosteroid and acyclovir topically and/or orally. The objective of this study wasto report the case of HAEM with painful ulcers accompanying with crust on lips. A 55 years old woman complained painful ulcers with crust on lips since the last five months. She had visited a primary health care service and received several medications such as antibiotic (ciprofloxacin), anti-inflammatory drug (corticosteroid), analgesic (mefenamic acid) but her complaint was never healed completely because it was always recurring. The lesion on her lips got worse when she ate hot and spicy food and after she went out for outdor activities. She had a history of herpes virus infection seven months before but it was completely healed after treated by acyclovir topically and amoxicilin orally. An extra oral examination found black brown crust on her upper lip vermillion, well-demarcated, irregular margin, rough surface, erythematous surrounding area, accompanied with pain. An intra oral examination identified ulcers, yellowish, 4-5 mm in size, well-demarcated, irregular margin, redness in surronding area, accompanied with pain. Acomplete blood count examination, serology test for HSV-1 (IgM and IgG) were taken and the result showed that only IgG was reactive. The therapies given to the patient were topical medications with a combination of corticosteroid, chloramphenicol and moisturizer, followed by methyl prednisolone and acyclovir orally. After 6-week treatment, the lesions were completely healed.Herpes-associated erythema multiforme (HAEM) caused by hypersensitivity reactionto herpes simplex virus type 1 (HSV-1) may have a characteristic of painful ulcers accompanied with crust on the lips. The combination of both anti-inflammatory and antiviral drugs can be a choice for the therapy.

CORRELATION OF Ki67 EXPRESSION TO DEGREE OF DYSPLASIA IN LINGUAL EPITHELIAL DYSPLASIA IN Rattus norvegicus EXPOSURED BY CIGARETTE SMOKE (Hubungan Ekspresi Ki67 Terhadap Derajat Displasia Pada Epitel Mukosa Lidah Rattus norvegicus yang Dipapar Asap Rokok) Rina Kartika Sari; Hening Tuti Hendarti; Bagus Soebadi; Priyo Hadi; Desiana Radithia; Adiastuti Endah P
ODONTO : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.2.76-87

Background: Dysplasia is malignant transformation of stratified squamous epithelium characterized by cellular atypia and loss of stratification and maturation. It can caused by cigarette smoke. Measuring the activity of cell proliferation as the beginning of dysplasia is very useful to know the development of malignancy. One of proliferation marker is Ki67 that expressed in all cell cycle phase except G0.Methods: 30 male wistar rats divided into: control grup (n=10), exposed to cigarette smoke for 4 weeks (n=10), 8 weeks (n=10) as much as 20 cigarettes/group/day/exposure used smoking pump. Specimen were stained HE to see dysplasia and Ki67 expression seen immunohistochemically. Statistical analyzed by Spearman correlation.Result: There was an increase in mean of Ki67 expression and significant differences between groups (p=0,000) and also significant difference of degree of dysplasia between groups (p=0,000). There was a strong correlation between Ki67 score to degree of dysplasia (p=0.001).Conclusion: Increased of Ki67 expression proportional to the Increase in degrees of dysplasia

TATALAKSANA STOMATITIS ALERGICA PADA PENDERITA YANG MENGALAMI STRESS (Management of Allergic Stomatitisin Patient with Stress) Raziv Ganesha; Diah Savitri E; Hening Tuti Hendarti
ODONTO : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.2.134-140

Introduction: Allergic stomatitisis ahypersensitivity reaction caused by allergens, such as drugs, food, and dental materials. Manifestation allergic reaction to food in oral cavity can be recurrent ulcer. Purpose: This case report pupose to report management allergic stomatitis in Stress condition.Case: female was a 44-year-old with complaintmany stomatitis in oral cavity. Patients say often since ± 6 years ago without knowing the cause. Stomatitis often moving location but also in the same site. On intra oral examination found ulcer multiple, variant size, irregular shape, paintfull.Management: the patient performed examination of total IgE with a result of 642.98 (normal<150), skin prick test in patients results positive on dust house, dog hair, cotton, beef, cow's milk, chicken egg yolk, shrimp, milkfish, pindang, chocolate, and peanuts.Patients given aloe vera extract oral rinse at the first visit, then after skin prick test was given methylprednisolone, hepaprotector caplet, multivitamin B-Complex plus Zinc. Patients are also given education and instruction to avoid a food become allergic. Conclusion: Allergic Stomatitis diagnosis requires a complete history and supportive examination. In this case, the treatment requires good cooperation between the patient and the dentist so that treatment can be done thoroughly.

Sensitivity difference of Streptococcus viridans on 35% Piper betle linn extract and 10% povidone iodine towards recurrent apthous stomatitis Maharani Laillyza Apriasari; Bagus Soebadi; Hening Tuti Hendarti
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 3 (2011): September 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Oral ulceration often becomes the main reason for the patients to see a dentist. Therapy of the oral ulceration is by giving the palliative therapy with topical antiseptic. Nowadays, there are many researches concerning with the traditional medicines as alternative therapy. One of them is Piper betle linn which contains the antiseptic agent. Purpose: This research is aimed to observe the sensitivity difference of Streptococcus viridans on 35% Piper betle linn extract and 10%povidone iodine. Methods: This laboratory research was conducted by the post test only design with random complete design. The research sampel is Streptococcus viridans culture that was scrapped from the ulcer of the recurrent aphthous stomatitis patient, then it was replicated by using the Federer theory. Results: Inhibitory zone of 35% Piper betle linn extract is bigger than 10% povidone iodine. Conclusion: Streptococcus viridans are more sensitive to 35% Piper bittle linn extract than 10% povidone iodine. 35% Piper betle linn extract has more antibacterial effect than 10% povidone iodine.Latar belakang: Ulserasi rongga mulut seringkali menjadi alasan utama bagi pasien untuk memeriksakan diri ke dokter gigi. Terapi ulserasi rongga mulut adalah pemberian terapi paliatif kepada penderita, seperti: pemberian obat topikal yang mengandung antiseptik. Saat ini banyak penelitian dalam pengembangan obat tradisional yang dapat dijadikan sebagai obat alternatif. Salah satu diantaranya adalah daun sirih yang mengandung zat antiseptik. Tujuan: Penelitian ini bertujuan mengetahui perbedaan sensitivitas Streptococcus viridans terhadap ekstrak daun sirih 35% jika dibandingkan dengan povidone iodine 10%. Metode: Penelitian laboratoris yang dilakukan dengan post test only design dengan rancangan acak lengkap. Sampel penelitian adalah kultur Streptococcus viridans yang diambil melalui swab dari hapusan ulser pada pasien yang menderita stomatitis aftosa rekuren, kemudian dilakukan replikasi dengan rumus Federer. Hasil: Zona hambat ekstrak daun sirih 35% lebih besar daripada zona hambat povidone iodine 10%. Kesimpulan: Streptococcus viridans lebih sensitif terhadap ekstrak daun sirih 35%. Ekstrak daun sirih 35% memiliki efek daya antibakteri yang lebih tinggi jika dibandingkan dengan povidone iodine 10%.

Effects of citrus limon essential oil (Citrus limon L.) on cytomorphometric changes of Candida albicans Rina Prabajati; Iwan Hernawan; Hening Tuti Hendarti
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 1 (2017): March 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: The most common fungal infection found in oral cavity is oral candidiasis, largely caused by Candida species, particularly Candida albicans (C. albicans). Candida infection can get worse since it is difficult to be treated and resistant with antifungal drugs. Therefore, new drugs and compounds as well as alternative therapies involving natural sources that have antifungal activities have continually been developed. Limonene, β-pinene, and ɣ-terpinene contained in Citrus limon essential oil have been known to have quite good antifungal activities against C. albicans. Purpose: This research aimed to examine and analyze the effects of Citrus limon essential oil on cytomorphometric changes of C. albicans. Method: The research used post test only control group design. Based on the results of the pre-elementary research on antifungal activities of Citrus limon essential oil against C. albicans, Citrus limon essential oil used in this research was on concentrations of 1.56%, 1.37%, 1.17%, 0.98%, and 0.78%. Citrus limon essential oil by C. albicans inoculum and incubated for 24 hours and 48 hours. After the incubation, those C. albicans cells were fixed, dried, and then observed using a scanning electron microscopy. Result: The most effective concentrations of Citrus limon essential oil triggering cytomorphometric changes of Candida albicans were at 1.37% and 1.56% with the incubation period of 48 hours. Conclusion: C. albicans can undergo necrosis process through cytomorphometric changes after the administration of Citrus limon essential oil at concentrations of 1.56% and 1.37% with the incubation period of 48 hours.

Hyperplasia of Wistar rat tongue mucosa due to exposure to cigarette side-stream smoke Nurina Febriyanti Ayuningtyas; Grahania Octaviono Mahardika; Bagus Soebadi; Adiastuti Endah Permadiati; Saka Winias; Hening Tuti Hendarti; Rosnah Binti Zain
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 3 (2019): September 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p133-137

Background: Hyperplasia, a condition whereby an excessive number of cells are produced due to their uncontrolled division, represents a common symptom of carcinogenesis. Cancer is a physical manifestation of cell malignancy resulting from abnormal proliferation. Globally, oral cancer currently constitutes the sixth largest lethal form of the condition. The most common etiology of oral cancer is tobacco of which cigarettes are the most popular related product. The health risks associated with cigarette smoke not only affect active smokers but also individuals who ingest it passively. Sidestream smoke comes from the lighted end of a burning tobacco product such as a cigarette, pipe or cigar and contains nicotine and many harmful cancer-causing chemicals. Inhaling sidestream smoke increases the risk of lung and other types of cancer. Purpose: The purpose of this study was to understand how sidestream cigarette smoke initiates precancerous changes, in this case hyperplasia, in the oral mucosa epithelium of Wistar rats. Methods: The subjects were divided into three groups, a 4-week treatment group (P1), an 8-week treatment group (P2), and a control group (K), each consisting of ten subjects. The subjects were exposed to a daily two-cigarette dose of smoke. The experiment used a post-test only control group design. All samples were sacrificed during the fourth and eighth weeks. Haematoxylin-eosin staining was performed on the tongues of the Wistar rats to establish the presence of hyperplasia. Data was analyzed using a one-way ANOVA test. Results: After the Wistar rats had been exposed to cigarette smoke, an increased degree of epithelial cell proliferation (hyperplasia) showed a significant difference with a p-value <0.05 during the eighth week. Conclusion: Exposure to cigarette sidestream smoke induces increased epithelial cell proliferation (hyperplasia) in Wistar rats.

Effects of sidestream tobacco smoke on P53 expressions in Rattus novergicus tongue epithelial mucosa Dian Angriany; Diah Savitri Ernawati; Adiastuti Endah Parmadiati; Hening Tuti Hendarti; Rosnah Binti Zain
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 3 (2019): September 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p138-141

Background: Smoking, both active and passive, has been widely recognised as toxic to the human body, since it induces several forms of cancer, including that affecting the oral cavity. Benzopyrene, the carcinogen contained in tobacco smoke, can even lead tocarcinogenesis which potentially affects the regulation of cell apoptosis in both active and passive smokers. Purpose: This study aims to investigate the carcinogenic effects of cigarette smoke on apoptosis of rat tongue mucosae through p53 expression. To determine the risk of malignant transformation through tumor suppressor genes in the apoptotic pathway. Methods: Rattus norvegicus subjects were divided into four groups, namely Treatment Group 1 exposed to sidestream cigarette smoke for four weeks (P1), Treatment Group 2 exposed to sidestream cigarette smoke for eight weeks (P2), Control Group not exposed to sidestream cigarette smoke for four weeks (K2), and Control Group (K) not exposed to sidestream cigarette smoke for eight weeks (K2). The exposure process was conducted using a smoking pump and alternating exposure. Four micron-thick sections of formalin were subsequently fixed together with paraffin embedded biopsy material from tongue mucosa of Rattus norvegicus. The tissue sections from the treatment groups were then analyzed immunohistochemically to compare the expressions of p53 and Bcl-2 proteins with those of the control groups. Results: The T-test results indicated statistically significant differences in the expressions of p53 between the 4-week control group (K1) and the 4-week treatment group (P1) (p=0.01, p<0.05) as well as between the 8-week control group (K2) and the 8-week treatment group (P2) (p=0.03, p<0.05). Conclusion: Exposure to cigarette smoke can induce changes in tumor suppressor genes and also affect the regulation of cell apoptosis, thus changing cell structure and leading to malignancy.

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