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All Journal Indonesia Chimica Acta
Syadza Firdausiah
Hasanuddin University
Chemical Engineering, Chemistry & Bioengineering

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A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells Firdaus Firdaus; Nunuk Hariani Soekamto; Syadza Firdausiah; Musrifah Tahar
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.10962

Abstract

Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.
The Comparison of Three Different Methods on Extraction of Cigarette Butt as Natural Insecticide Syadza Firdausiah; Firdaus; Hamdayanty; Taufik Hidayat; Muhammad Alfliadhi
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11812

Abstract

Background: Cigarette butt could be used as an insecticide due to the present of alkaloid compounds in high yield, especially nicotine and eugenol. To maximize the extraction process of cigarette butt, the study related to the effect of extraction method to the effectivity of extraction process should be performed. Objective: The main purpose of this study was to identify the effect of extraction methods on the total yield and the nicotine and eugenol content of the extract of cigarette butt. Methods: In this study, maceration (CB-1), soxletation (CB-2), and microwave-assisted extraction (MAE) (CB-3) methods were conducted and compared the yield and the nicotine and eugenol content of the extracts by LC-MS. Results: The results showed that the extract CB-3 has the highest yield (26,77%), which compared to CB-1 and CB-2, which are 11.72% and 14.56%, respectively. Furthermore, the nicotine content of all extracts are 54.15%, 36.43%, and 48.51% for extract CB-1, CB-2, and CB-3, respectively, while eugenol content of CB-1, CB-2, and CB-3 are 5.09%, 6.35%, and 8.41%, respectively. Conclusion: Based on the results, it can be concluded that MAE method was more effective to extract the cigarette butt compared to maceration and soxletation method. This method was also reduced the time consuming and the volume of the solvent used in the extraction process which follow green chemistry rule. Thus, MAE method is potential to be used in extraction process of cigarette butt in order to produce a biopesticide.
Chemical Properties of Fish Gelatin from Skin and Bone of Yellowfin Tuna (Thunnus Albacares) Syadza Firdausiah; Nur Madya; Seniwati; Meidistria Tandi Rapak
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 14, No 2: December 2021
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v14i3.18397

Abstract

This study aims to extract and compare the chemical properties of gelatin from the skin and bone of yellowfin tuna (Thunnus albacares) by using the acid method. The proximate and FTIR analyses of tuna skin and bone gelatin (TSG and TBG) were conducted to determine their chemical properties. The acid condition successfully produced gelatin, which is 3.24% of TSG and 2.61% of TBG yields. The proximate properties revealed that both extracted gelatin BEG and CG fulfil the Indonesian standard quality of gelatin, with a high level of total protein and low lipid content. Amide A, I, II, and III were shown at 3452.58, 1637.56, 1517.98, and 1240.23 cm-1 respectively in TSG FTIR spectra, and at 3493.09, 1660.71, 1533.41, and 1238.30 cm-1, respectively in TBG spectra. Both skin and bone of yellowfin tuna can potentially be used in the production of gelatin for industrial and pharmaceutical purposes with further optimation.
Co-Authors Firdaus Firdaus Firdaus Hamdayanty Hamdayanty Meidistria Tandi Rapak Muhammad Alfliadhi Musrifah Tahar Nunuk Hariani Soekamto Nur Madya Seniwati Taufik Hidayat