AbstrakPenelitian ini merupakan penelitian kualitatif untuk menggali pengalaman partisipan mencari makna hidup. Partisipan penelitian berjumlah delapan parisipan dengan purposif sample. Pengalaman partisipan memberikan gambaran secara utuh diketahuinya perasaan partisipan dihadapi lupus dan perubahan nilai, kepercayaan, dan keyakinan penderita lupus. Hasil penelitian yang diperoleh mendapatkan respon penderita menghadapi penyakit lupus terhadap aktivitas fisik, psikologis, dan perubahan lingkungan serta perubahan nilai, kepercayaan dan keyakinan penderita lupus. Hasil penelitian menyarankan tenaga perawatan melakukan asuhan yang komprehensif, untuk tenaga pendidikan juga harus memberikan prosedur melakukan asuhan keperawatan holistik kepada peserta didik. Untuk peneliti lain agar menambah variasi jenis kelamin partisipan agar memperoleh variasi tema. AbstractThis research is a qualitative study to explore the experiences of participants to find meaning in life. Amount of research participants with a purposive sample of eight paricipants. The Experience gives participants how to life with lupus and how to find changes in value, trust, and confidence in people with lupus. The results are getting face lupus patients response to physical activity, psychological, and environmental changes and changes in values, trust, and confidence in people with lupus. The results suggest that nurse must do comprehensive care, to education personnel must also provide procedure to conduct a holistic nursing care to students. For another researchers in order to increase the participants’ gender variations in order to obtain variation on the theme.