Herlina Herlina
Pharmacy department, faculty of Mathematics and natural sciences,Sriwijaya University

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Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil Herlina Herlina; Budi Untari; Indah Solihah; Merie Santia
Science and Technology Indonesia Vol. 4 No. 1 (2019): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (670.916 KB) | DOI: 10.26554/sti.2019.4.1.24-30

Abstract

Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p>0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW
Antidiabetic Activity Test of Ethanolic Seri Leave’s (Muntingia Calabura L.) Extract in Male Rats Induced by Alloxan Herlina Herlina; Annisa Amriani; Indah Solihah; Rizky Sintya
Science and Technology Indonesia Vol. 3 No. 1 (2018): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.13 KB) | DOI: 10.26554/sti.2018.3.1.7-13

Abstract

Antidiabetic activity test of ethanol extract of seri leave (Muntingia calabura L.) rats induced by alloxan has been done. Male wistar albino rats are used as animal models which divided into 6 groups, normal group (aquadest), negative control group (Na CMC 0,5%), positive control group (glibenclamide 0,43 mg/200 gBB), and 1, 2, and 3 treatment groups (ethanol extract of seri leave 65, 130, dan 260 mg/kgBB). Rats blood glucose level after induced intraperitoneally by alloxan 130 mg/kgBB can be stated as diabetes when >200 mg/dL. Preprandial blood glucose levels are measured using DTN-410-K photometer, on day 0, 5, 10, and 15. The average result of AUC0-15 and percentage of decreasing blood glucose level for positive control group are 2732,5 and 37,43%, and 3 treatment groups (65 mg/kgBB, 130 mg/kgBB, and 260 mg/kgBB) 3105 and 28,90%; 2962,5 and 32,16%; 2810 and 35,66%. This point indicated that the ethanol extract of seri leave has an antidiabetic activity and there is no significant difference compared with glibenclamide (p<0,05). Percentage of blood glucose decrease level the third treatment group there is no significant difference compare with positive control group. According to the relation between percentage of blood glucose decrease level with dose, value of ED50 of ethanol extract of seri leave is 692,424 mg/kgBB.
The Standardization of Ethanolic Extract of Tahongai Leaves (Kleinhovia hospita L.) Indah Solihah; Mardiyanto Mardiyanto; Soilia Fertilita; Herlina Herlina; Oktia Charmila
Science and Technology Indonesia Vol. 3 No. 1 (2018): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.941 KB) | DOI: 10.26554/sti.2018.3.1.14-18

Abstract

Extract is basic material for herbal drug. The formulation of herbal drugs requires consistent of biological activity, a consistent chemical profile, or simply a quality assurance programs that can be achieved by standardizing extracts. The leaves of tahongai (Kleinhovia hospita L.) have been traditionally used in Komering tribes as phytotherapy to cure the inflammation related diseases including cancer, furuncles, polyps and tonsillitis. The aim at this study was to standardize the quality of tahongai leaves ethanolic extract by determining the specific and non specific parameters of ethanolic extract of Tahongai leaves (Kleinhovia hospita L.). The Preliminary phytochemical analysis revealed presence of alkaloids, flavonoids, saponins, tanins, and steroids in extract. The result of specific parameters extracts showed that the organoleptic properties of ethanolic extract of tahongai leaves were thick, brownish black in color, has characteristic odor, astringent with slightly bitter taste, the water and ethanol soluble extractive content were 19.263% ± 0.95 and 18.30% ± 0.51 respectively. The non specific parameters of tahongai leave ethanolic extract showed the density of extract was 1.413 g/mL ± 0.04, the water content value of 21.16% ± 0.55, total ash content 15.64% ± 0.75, acid insoluble ash content 8.282% ± 0.28, Pb contamination content 3,67 ppm, Cd contamination content <0,0043 ppm, total bacteria contamination 90.5 x 101 colony/g, and the total mold and yeast contamination of 1 x 101 colony/g.