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All Journal Padjadjaran Journal of Dentistry
Efa Ismardianita
Universitas Baiturrahmah
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The effect of ethanol extract of Sarang Semut plant (Hypnophytum formicarum) towards Angiogenesis for wound healing after tooth extraction: Experimental research on Marmot (Cavia cobaya) Sartika Amelia Putri; Efa Ismardianita
Padjadjaran Journal of Dentistry Vol 28, No 3 (2016): November 2016
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.601 KB) | DOI: 10.24198/pjd.vol28no3.13675

Abstract

Introduction: Tooth extraction causing injuries, to accelerate wound healing was given medication. Drugs commonly used for wound healing after tooth extraction is povidone iodine act as bacteriostatic for all germs. Excessive use of povidone iodine can cause side effects such as itching, pain in the area around the wound, swelling and dermatitis, so it sought a safe substitute drugs derived from herbs. One of the herbs are often used by people in the Mentawai Islands is a Sarang Semut's root species of Hypnophytum formicarum. This study was aimed to determine the effect of sarang semut’s extract orally for angiogenesis in wound healing after tooth extraction. Methods: This research was experimental with posttest only control group design. Subjects were 48-animal marmots were divided into 4 groups, will be deprived of his left mandibular insisivus. Group I (control 0,5% CMC, treatment group II, III, IV with 4,65mg, and 9.3 mg 6,2 mg dose tuber ethanol extract dissolved anthill in CMC 0.5%), were given 3 ml orally, 3 times a day until the day of decapitation. Futher histological preprations made by HE staining and the observed area is apex, medial, servical,and lateral used 400x magnification. The data was analyzed with parametric test One-Way ANOVA, and to see the significance between dose used LSD test. Results: The results showed that the extract of sarang semut effect (p<0,05) on the angiogenesis in wound healing after tooth extraction. Conclusion: The most effective concentration was 4,65 mg.
The effect of ant-plant (Hydnophytum formicarum) ethanol extract on collagen fibers for wound healing after tooth extraction in the guinea pig (Cavia cobaya) Siti Velanita; Efa Ismardianita; Andries Pascawinata
Padjadjaran Journal of Dentistry Vol 31, No 3 (2019): November 2019
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol31no3.19328

Abstract

Introduction: Tooth extraction causes tissue damage around the socket. Wound healing is essential for repairing damaged tissues. One of the medicinal plants often used is ant-plant (Hydnophytum formicarum), which contains flavonoids, triterpenoids, saponins and tannins. This research was aimed to determine the effect of ant-plant ethanol extract on the density of collagen fibers for wound healing after tooth extraction in the guinea pig (Cavia cobaya). Methods: The type of research was true experimental with a post-test only control group design. The study used 48 male guinea pig divided into 4 groups. Experimental groups received lower left incisor extraction, the control group was orally administered with 0.5% CMC, and the treatment group was administered with ant-plant extract dissolved with 0.5% CMC with dose of 4.65 mg, 6.2 mg, and 9.3 mg respectively; each guinea pig was given 3 cc of the extract 3 times a day until the termination day. On day 3, 7, 14, and 21 respectively, the guinea pigs were terminated and to make the histological preparations. The difference in collagen fibers density of the two observation groups was tested with one-way ANOVA, and the LSD test to analyse the significance between groups. Results: Application of ant-nest ethanol extract showed significant effects on the density of collagen fibers in the wound healing process after tooth extraction. Results of the one-way ANOVA test showed significant value on all treatment groups (p < 0.05). There were also found significant differences between the control group and the treatment group (p < 0.05). Conclusion: Ant-plant (Hydnophytum formicarum) ethanol extract increase the collagen fibers density on the wound healing after tooth extraction with the effective dose of 4.65 mg.Keywords: Ant-plant, Hydnophytum formicarum, wound healing, collagen, guinea pig, Cavia cobaya.
Co-Authors Andries Pascawinata Sartika Amelia Putri Siti Velanita