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All Journal Indonesian Journal of Cancer Chemoprevention JFIOnline
Thomas Erwin Christian Junus Huwae
Department Of Orthopedics And Trumatology, Faculty Of Medicine , Unibraw , Syaiful Anwar Hospital Malang
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Efek penambahan parasetamol pada terapi ketorolak terhadap nyeri akut pascaoperasi orthopedi Santoso, Agustinus; Huwae, Thomas Erwin CJ; Idha, Arofa; Suprapti, Budi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

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Abstract

ABSTRACT : The aim of this research is to analyze pain control of paracetamol addition to ketorolac compared with ketorolac alone on patient’s pain response. Ketorolac group (K group) recieved ketorolac 10 mg i.v every 8 hours and Ketorolac and Paracetamol group (KP group) recieved ketorolac 10 mg i.v and paracetamol 1,000 mg orally every 8 hours. Observation of pain intensity with Face Scale at ½ hours before and after administration at the first, the fourth and the seventh analgesics. Observation quality of pain management with QUIPS at ½ hours after administration the seventh analgesics. As the results, paracetamol addition to ketorolac provide better pain control, shown at the mean pain intensity KP group was lower at post to 4, pre to 7 and post to 7 than K group, and the QUIPS results were side effects of paracetamol additional well tolerated, reduce needs for additional analgesics, but no difference at patient satisfactions. These results suggest that paracetamol addition to ketorolac had better pain control than ketorolac alone in patients with orthopedic postoperative acute pain.Keywords : ketorolac, paracetamol, postoperative, face scale, QUIPS ABSTRAK: Penelitian ini bertujuan untuk mengetahui pengendalian nyeri oleh penambahan parasetamol pada ketorolak dibandingkan dengan ketorolak tunggal berdasarkan respon nyeri pasien. Kelompok Ketorolak (Kelompok K) mendapatkan ketorolak 10 mg i.v setiap 8 jam dan kelompok Ketorolak dan Parasetamol (kelompok KP) mendapatkan ketorolak 10 mg i.v dan parasetamol 1000 mg per oral setiap 8 jam. Penilaian intensitas nyeri dengan Face Scale pada 30 menit sebelum (pre) dan sesudah (pasca) pemberian dosis analgesik pertama, ke empat dan ke tujuh. Pengamatan kualitas manajemen nyeri dengan QUIPS pada 30 menit setelah pemberian analgesik dosis ke tujuh. Hasil pengamatan menunjukkan bahwa penambahan parasetamol pada ketorolak memberikan kendali nyeri yang lebih baik, ditunjukkan oleh rerata intensitas nyeri kelompok KP pada pasca dosis ke 4, pre dosis ke 7 dan pasca dosis ke 7 lebih rendah dari kelompok K, serta hasil QUIPS bahwa efek samping penambahan parasetamol dapat ditoleransi, menurunkan kebutuhan analgesik tambahan, namun tidak berbeda pada kepuasan pasien. Hasil diatas menyatakan bahwa penambahan parasetamol pada ketorolak memberikan kendali nyeri lebih baik dari ketorolak tunggal pada pasien nyeri akut pascaoperasi orthopedi. Kata kunci: ketorolak, parasetamol, pascaoperasi, QUIPS  
Efek penambahan parasetamol pada terapi ketorolak terhadap nyeri akut pascaoperasi orthopedi Santoso, Agustinus; Huwae, Thomas Erwin CJ; Idha, Arofa; Suprapti, Budi
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.224 KB) | DOI: 10.35617/jfi.v8i1.224

Abstract

ABSTRACT : The aim of this research is to analyze pain control of paracetamol addition to ketorolac compared with ketorolac alone on patientâ??s pain response. Ketorolac group (K group) recieved ketorolac 10 mg i.v every 8 hours and Ketorolac and Paracetamol group (KP group) recieved ketorolac 10 mg i.v and paracetamol 1,000 mg orally every 8 hours. Observation of pain intensity with Face Scale at ½ hours before and after administration at the first, the fourth and the seventh analgesics. Observation quality of pain management with QUIPS at ½ hours after administration the seventh analgesics. As the results, paracetamol addition to ketorolac provide better pain control, shown at the mean pain intensity KP group was lower at post to 4, pre to 7 and post to 7 than K group, and the QUIPS results were side effects of paracetamol additional well tolerated, reduce needs for additional analgesics, but no difference at patient satisfactions. These results suggest that paracetamol addition to ketorolac had better pain control than ketorolac alone in patients with orthopedic postoperative acute pain.Keywords : ketorolac, paracetamol, postoperative, face scale, QUIPS ABSTRAK: Penelitian ini bertujuan untuk mengetahui pengendalian nyeri oleh penambahan parasetamol pada ketorolak dibandingkan dengan ketorolak tunggal berdasarkan respon nyeri pasien. Kelompok Ketorolak (Kelompok K) mendapatkan ketorolak 10 mg i.v setiap 8 jam dan kelompok Ketorolak dan Parasetamol (kelompok KP) mendapatkan ketorolak 10 mg i.v dan parasetamol 1000 mg per oral setiap 8 jam. Penilaian intensitas nyeri dengan Face Scale pada 30 menit sebelum (pre) dan sesudah (pasca) pemberian dosis analgesik pertama, ke empat dan ke tujuh. Pengamatan kualitas manajemen nyeri dengan QUIPS pada 30 menit setelah pemberian analgesik dosis ke tujuh. Hasil pengamatan menunjukkan bahwa penambahan parasetamol pada ketorolak memberikan kendali nyeri yang lebih baik, ditunjukkan oleh rerata intensitas nyeri kelompok KP pada pasca dosis ke 4, pre dosis ke 7 dan pasca dosis ke 7 lebih rendah dari kelompok K, serta hasil QUIPS bahwa efek samping penambahan parasetamol dapat ditoleransi, menurunkan kebutuhan analgesik tambahan, namun tidak berbeda pada kepuasan pasien. Hasil diatas menyatakan bahwa penambahan parasetamol pada ketorolak memberikan kendali nyeri lebih baik dari ketorolak tunggal pada pasien nyeri akut pascaoperasi orthopedi. Kata kunci: ketorolak, parasetamol, pascaoperasi, QUIPS  
Association between Vitamin D and Calcium Level and BMD Alteration in Post-Menopausal Osteoporosis Patients Treated with Bisphosphonate Therapy for at Least 1 Year in Saiful Anwar Hospital Malang Hamzah Hamzah; Thomas Erwin Christian Junus Huwae; Chodidjah Chodidjah
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp123-129

Abstract

Post-menopausal osteoporosis is a degenerative disease among post-menopausal women. In Indonesia, women over 50 years old get post-menopausal osteoporosis.The therapy should be comprehensive and continous. Bisphosphonate therapy is one of the most preferable therapeutic option for maintaining bone density. Calcium and vitamin D have a role in increasing osteoblastic activity. The objective of this study was to describe the vitamin D and calcium in bone mineral density (BMD) of hip and spine in postmenopausal woman with biphosphonat therapy. This study is a cross-sectional, observational analytic. The subject were female patients with post-menopausal osteoporosis treated in clinic of RSUD dr. Saiful Anwar Malang, who had received routine bisphosphonate for at least 1 year. The method was collecting the patient data, who received oral and injectie bisphosphonate therapy, serial BMD test,hip and spine, vitamin D and calcium level in serum test. Total sample 25 participan, the association between BMD change (Δ BMD), vitamin D and calcium level, were analyzed.with Chi Square test then continued using Spearman correlation test. Vitamin D levels in Δ BMD Spine in participants was less <30 ng/ml, mean 16.8+6.95 14 respondents (56%), and 6 respondens (24%) 10.05+5.28, normal vitamin D levels were 5 respondents (20%) mean 34.16+5.10. Vitamin D levels in Δ BMD Hip in participants was less <30 ng/ml, mean 15.19+7.7 12 respondents (48%), and 8 respondens (32%) 12.30+5.57, normal vitamin D levels were 5 respondents (20%) 33.66+5.40. Calcium levels in BMD spine 9.60+0.45, 14 respondents (56%), and 11 respondens (44%) 9.59+0.52. There is a significant and moderate relationship between vitamin D levels with Δ BMD spine (p=0.009, r=0.564) and Hip (p=0.039, r= 0.480) T Blood calcium levels with Δ BMD changes unrelated (normal). There is a significant association between vitamin D levels spine and Hip Δ BMD. Blood calcium levels with Δ BMD changes unrelated.Keywords: Osteoporosis, Bisphosphonate, Vitamin D levels, Calcium levels.
Co-Authors Budi Suprapti Chodidjah Chodidjah Hamzah Hamzah Idha, Arofa Idha, Arofa Santoso, Agustinus Santoso, Agustinus