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Pacasarjana Universitas Padjadjaran (UNPAD) Bandung

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An Urinary Excretion Profile of 500 mg Ascorbic Acid in Healthy Adults Mutakin, Mutakin
Indonesian Journal of Clinical Pharmacy Vol 1, No 2 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.069 KB)

Abstract

High doses of ascorbic acid have been commercially available as adjuvant. However, the pharmacologicalimportance of this supplement is yet questionable. The aim of this study is to investigate the 24 hours excretion profile of ascorbic acid after oral administration of 500 mg single dose in healthy volunteer. The urine samples were collected at 2, 4, 6, 8, and 24 hours after administration. The samples were extracted with trichloroacetic acid, followed by colorimetric measurement. The excretion profile showed a curve with concentrations of 14.4, 15.2, 15.6, 14.9, and 14.2% at 2, 4, 6, 8, and 24 hours, respectively. This suggests that 74.3% of ascorbic acid to be excreted via urine as an excessive amount and a high adjuvant dosage should be reconsidered.Key words: Ascorbic acid, oral administration, single dose, excretion profileProfil Ekskresi 500 mg Asam Askorbat dalam Saluran Urin pada Orang Dewasa SehatAbstrakAsam askorbat dosis tinggi telah tersedia secara komersil sebagai suplemen. Akan tetapi, kegunaan secara farmakologi pada suplemen ini masih dipertanyakan. Tujuan dari penelitian ini adalah untuk mengetahui profil ekskresi asam askorbat selama 24 jam setelah pemberian oral 500 mg dosis tunggal pada sukarelawan sehat. Sampel urin dikumpulkan pada jam ke-2, 4, 6, 8, dan 24 setelah pemberian. Sampel diekstraksi dengan asam trikloroasetat lalu diukur dengan metode kolorimetri. Profil ekskresi menunjukkan bahwa terbentuk kurva pada konsentrasi secara berurutan 14,4; 15,2; 15,6; 14.9; dan 14,2% pada jam ke-2, 3, 6, 8 dan 24. Hal ini menunjukkan bahwa 74,3% asam askorbat diekskresikan melalui urin dalam jumlah besar dan pemakaian dosis tinggi suplemen seharusnya dipertimbangkan.Kata kunci: Asam askorbat, pemberian oral, dosis tunggal, profil ekskresi
EFEKTIVITAS PROGRAM NASIONAL PEMBERDAYAAN MASYARAKAT MANDIRI PEDESAAN (PNPM-MP) DALAM MENUNJANG PEMBANGUNAN PERTANIAN DI KECAMATAN NGAMBUR KABUPATEN LAMPUNG BARAT Mutakin, Mutakin; Gitosaputro, Sumaryo; Adawiyah, Rabiatul
Jurnal Ilmu-Ilmu Agribisnis Vol 1, No 2 (2013)
Publisher : Lampung University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.961 KB) | DOI: 10.23960/jiia.v1i2.%p

Abstract

This study aims to determine (1) the effectiveness of rural community empowerment national program (PNPM-MP) and (2) factors related to the level of the effectiveness of the program in supporting agricultural development. Research was conducted in Ngambur sub district of West Lampung Regency from February to April 2012. Respondents were 68 farmers taken proportionally from 21 farmer groups. Method used was a descriptive analysis. The correlation between variables was tested using Rank Spearman correlation analysis. Result showed that the PNPM-MP was quite effective in supporting agricultural development in Ngambur Subdistrict of West Lampung Regency. The factors related to the level of the effectiveness in supporting agricultural development were the level of knowledge of the group members, the role of facilitator and district management team activities, and the amount of the PNPM-MP fund. The factor not related to the effectiveness of the PNPM-MP in supporting agricultural development in sub Ngambur West Lampung Regency was the level of participation of group members. Keywords: agricultural, effectiveness, independent, program, empowerment
The Oral Health and Comorbid Diseases Knowledge Between Urban and Rural Community during Pandemic Wahyuni, Indah Suasani; Herawati, Irma Erika; Puspitasari, Irma Melyani; Mutakin, Mutakin; Milanda, Tiana; Levita, Jutti
KEMAS: Jurnal Kesehatan Masyarakat Vol 18, No 1 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i1.31454

Abstract

The restriction of social mobility and activity during the COVID-19 pandemic has been implemented to stop the deadly transmission of the SARS-CoV2 virus. People are forced to stay at home and strictly perform the COVID-19 health protocol in their daily activities. Currently, a continuous self-maintenance of the health, including oral health, is considered the best strategy worldwide. This community service activity aimed to assess the knowledge of the urban and rural adult community about oral health, comorbidity, and the quality of life (QoL) during this pandemic situation by using a pre-and post-test quasi-experimental design with an intervention of health-knowledge sharing using leaflets and videos, and a WHOQOL 2012 questionnaire to study the QoL. Paired t-test was used as statistical analysis. Total respondents were 131 (n = 76 for urban and n = 55 for rural), selected using the purposive sampling method. There was a significant difference between the results of the pre-test and post-test in both urban and rural groups (t count ranged from 1.69 to 5.98; p 0.05). Based on the WHOQOL 2012 questionnaire, both urban (90.79%) and rural (87.27%) respondents indicated a good QoL, while the remaining was scored as medium. Physical conditions/pain was the main domain that directly affects the QoL in both communities. It could be concluded that the knowledge-sharing intervention to the community gave a good impact in enhancing the knowledge of the respondents, however, a continuous program should be further carried out for better results.