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LAPORAN KASUS POTENSI INTERAKSI OBAT DAN PENINGKATAN EFEK HIPOTENSI PADA PERAWATAN INTENSIVE PASIEN SKIZOFRENIA DENGAN HIPERTENSI Julaeha Julaeha; Intan Nada Nugrahani
Jurnal Insan Farmasi Indonesia Vol 4 No 2 (2021): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v4i2.717

Abstract

Schizophrenia is a serious and chronic mental disorder, that can reduce the quality of human life. In Indonesia, almost 70% of those treated in the psychiatry department were due to schizophrenia. Prevalence The incidence of schizophrenia in men is greater than in women, the incidence in men is 1.4% greater than women. In this case, a 58-year-old male patient came to the hospital, the initial diagnosis was unspecified schizophrenia and Hypertension. The patient was restless when he entered the hospital, beat his wife, broke household appliances, and threw stones at a neighbor's house. Patient's vital signs upon admission to hospital Blood pressure 160/95 mmHg, 37.7oC of temperature, pulse 99x/minute Breathing 17x/minute. The patient was treated with risperidone 1 mg, lorazepam 0.5 mg, candesartan 8 mg, and amlodipine 5 mg. From the results of monitoring drug therapy, potential drug interactions might be occurred i.e drug interaction between lorazepam and risperidone, both of which can increase sedation effect. The interaction between risperidone and trihexyphenidyl might be enhance the anticholinergic effect. In addition, antipsychotics could potentially enhance the hypotensive effect and SGPT serum elevated. Close monitoring of psychosis symptoms and blood pressure should be done to ensure the efficacy and safety of medications
Pengaruh Program Terapi Rumatan Metadon untuk Mengurangi Dampak Buruk akibat Penggunaan Narkotika Julaeha Julaeha; Rustamaji Rustamaji; Nunung Priyatni
Indonesian Journal of Clinical Pharmacy Vol 7, No 4 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.006 KB) | DOI: 10.15416/ijcp.2018.7.4.294

Abstract

Program Terapi Rumatan Metadon (PTRM) merupakan salah satu program pengurangan dampak buruk (harm reduction) akibat penggunaan narkotika. Tujuan dari PTRM adalah mengurangi perilaku berisiko akibat penggunaan narkotika secara suntik. Penelitian ini bertujuan untuk mengetahui pengaruh PTRM bagi pasien pengguna narkotika yang mengikuti PTRM. Penelitian ini merupakan penelitian deskriptif dengan desain cross-sectional. Penelitian dilakukan pada bulan Oktober–Desember tahun 2012 di satelit pelayanan PTRM di DIY. Subjek penelitian yang dilibatkan adalah seluruh pasien aktif PTRM hingga tahun 2012 yang telah mengikuti PTRM minimal 1 bulan. Pasien yang dilibatkan dalam penelitian ini adalah 32 pasien. Indikator pencapaian dampak PTRM dari setiap parameter dampak PTRM yang diukur berupa persentase tidak menggunakan narkoba, penurunan penggunaan narkoba, tidak menggunakan jarum suntik, tidak menggunakan jarum suntik secara bergantian, tidak terlibat dalam tindak kriminal, berkurangnya perilaku kriminal, membaiknya status pekerjaan, membaiknya kondisi tempat tinggal, mendapatkan dukungan keluarga, dan meningkatnya dukungan keluarga. Sebanyak 97% pasien tidak menggunakan jarum suntik secara bergantian dan tidak terlibat dalam tindak kriminal sejak mengikuti PTRM. PRTM memberikan pengaruh signifikan terhadap pengurangan penggunaan narkotika, perilaku berisiko, dan tindakan kriminalitas, serta meningkatkan produktivitas peserta PTRM.Kata kunci: Harm reduction, metadon, narkotika, PTRM Effect of Methadone Maintenance Treatment Program for Reducing Drug Related Harm AbstractMethadone Maintenance Therapy Program (MMTP) is one of harm reduction programs which aim to reduce behavior risk due to injecting narcotics. The purpose of this study was to determine the effect of MMTP on patients using narcotics who participated in MMTP. This research was a descriptive study with cross-sectional design. The study was conducted in the period of October–December 2012 on the MMTP satellite services in Yogyakarta, Indonesia. Subjects involved were all active MMTP patients until 2012 who had attended MMTP for at least 1 month. Thirty-two patients voluntarily participated in this study. Some indicators used to measure the impact of MMTP on patients, including a reduction in drug use, risk behavior, and crime, as well as better productivity, housing conditions, and family support. A total of 97% patients did not share needles and not involved in criminal activities since joined the MMTP. There was a significant positive relationship between MMTP services with the impact of MMTP on patients, such as reduction in drug use, risk behavior, and crime, along with increased productivity.Keywords: Drug, harm reduction, MMTP, methadone
Pengelolaan sedıaan metadon pada Program Terapı Rumatan Metadon (PTRM) dı satelıt pelayanan PTRM Julaeha Julaeha; Nunung Priyatni; Rustamaji Rustamaji
Journal Borneo Vol. 2 No. 1 (2022): Volume 2 Issue 1 tahun 2022
Publisher : Politeknik Kaltara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.674 KB) | DOI: 10.57174/jborn.v2i1.17

Abstract

Methadone is a type of synthetic narcotic that is used as substitution therapy in the Methadone Maintenance Therapy Program (MMTP). Therefore, methadone must be treated as narcotics in general. Pharmacists in MMTP have responsibility for the management of methadone. This study aims to evaluate the suitability of the management of methadone preparations at the MMTP satellite service in the Special Region of Yogyakarta (DIY) based on the MMTP guidelines issued by the Ministry of Health which include requests, storage, dispensing, and reporting of methadone use. This study is a mixed-methods study (qualitative and quantitative) with prospective data collection. The quantitative measurement instrument in the study was in the form of a checklist table for the suitability of methadone management based on applicable guidelines. Qualitative data sourced from interviews with MMTP officers. The results of this study indicate that the demand, storage, and reporting of the use of methadone are in accordance with the MMTP service guidelines. However, for the dispensing of methadone on the MMTP service satellites, it is still carried out by health workers other than pharmacists.
Laporan kasus selulitis pedis pada diabetes melitus tipe 2 dengan terapi antibiotik dan insulin Julaeha Julaeha; Nadya Farisma
Journal Borneo Vol. 2 No. 1 (2022): Volume 2 Issue 1 tahun 2022
Publisher : Politeknik Kaltara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.387 KB) | DOI: 10.57174/jborn.v2i1.18

Abstract

Diabetes mellitus (DM) is called the silent killer which can cause microvascular and macrovascular complications. Cellulitis is a form of microvascular complication of uncontrolled DM. A 49-year-old female patient came to the hospital with complaints of sores and pain in the right big toe. The patient has a history of type 2 diabetes mellitus, with the result of a current blood sugar level of 582 mg/dL. The patient received insulin therapy novorapid® and levemir®, paracetamol injection, ceftriaxone injection, metronidazole injection and amlodipine. From the results of monitoring drug therapy, administration of combination therapy with antibiotics and insulin is the right and safe choice of therapy in overcoming gangrenous infections with uncontrolled blood glucose conditions. However, in monitoring drug therapy, it was found that there was a potential for minor drug interactions between metronidazole and paracetamol. Metronidazole can increase the level or effect of paracetamol by affecting the metabolism of the liver enzyme CYP2E1 so there must be a delay in administration. Topical antibiotics should be considered in the long-term treatment of complications of cellulitis pedis in type 2 DM patients.
INTERAKSI OBAT PENGGUNAAN ANTIPSIKOTIK PADA PASIEN SKIZOFRENIA julaeha qosim
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 2, No 2 (2017)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v2i2.1181

Abstract

Skizofrenia merupakan suatu penyakit psikiatrik kronis yang paling banyak menimbulkan masalah secara psikologis maupun sosial. Penyakit ini memerlukan terapi pemberian antipsikotik dalam waktu yang cukup lama yang diberikan secara tunggal maupun kombinasi, sehingga sangat mungkin dalam proses pengobatan dapat ditemukan interaksi obat dalam penggunaan antipsikotik. Penelitian ini bertujuan untuk mengetahui profil demografi pasien, profil penggunaan antipsikotik, dan untuk menganalisa interaksi obat penggunaan antipsikotik pada pasien skizofrenia di RS X. Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional deskriptif. Pasien yang dilibatkan dalam penelitian ini adalah pasien skizofrenia di Rumah Sakit X periode 2007-2009 yang memenuhi kriteria inklusi, jumlah pasien yang diambil dalam penelitian ini adalah sebanyak 300 pasien dengan metode stratified sampling. Pengambilan data dilakukan secara retrospektif melalui rekam medik meliputi karakteristik pasien dan data penggunaan obat. Dari data yang ada didapatkan mengenai profil pasien, profil penggunaan antipsikotik (jenis, dosis, cara pemberian) yang diberikan secara tunggal maupun kombinasi. Hasil penelitian menunjukan bahwa pemberian kombinasi klorpromazin dan haloperidol, merupakan antipsikotik yang paling banyak digunakan untuk pengobatan skizofrenia dengan persentase selama periode 2007,2008, dan 2009 yaitu 60 %, 70 %, dan 47 %. Persentase interaksi obat penggunaan antipsikotik pada periode 2007, 2008, dan 2009 yaitu 100 %, 99 % dan 96.97 % interaksi obat.
DAMPAK PROGRAM TERAPI RUMATAN METADON (PTRM) TERHADAP PASIEN PTRM DI SATELIT PELAYANAN PTRM PROVINSI DIY julaeha qosim
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 1, No 1 (2016)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v1i1.279

Abstract

Background: Methadone Maintenance Treatment Program (MMTP) is one of the harm reduction program due to injecting drug use. The purpose of MMTP is replacing the use of narcotics (heroin) injection, was replaced with the use of oral methadone. MMTP expected to reduce drug use, risk behavior, crime, and increase productivity, housing conditions, and family support for injecting drug users (IDUs). MMTP in Yogyakarta has been implemented since 2006. Currently have been provided four MMTP satellite services are: Grhasia hospital, Gedongtengen primary health care (PHC), Umbulharjo I PHC and Banguntapan II PHC. As of November 2012 there were 39 actively registered patients (35 males, 4 females). Thirty-two patients voluntarily participated in this study. Objective: To determine the impact of MMTP on patients, including a reduction in drug use, risk behavior, crime, and increase productivity, housing conditions, and family support in the MMTP satellite services Yogyakarta. Method: Descriptive research with case study design and cross-sectional approach. This research conducted in October - December 2012. Subjects were 32 MMTP active patients. The independent variable is implementation of MMTP services and dependent variable is the impact of MMTP. The research instruments use questionnaires and interview guides. The data source are patient’s medical record, MMTP active patients, and MMTP teams (physicians, nurses, and pharmacists). Analysis of descriptive data in the form of percentage achievement of MMTP impacts on patients and pearson correlation analysis to determine the relationship between MMTP services with the impact of MMTP on patients. Result: thirty-two (100%) patients had been decrease in their criminal behaviour since admission to the MMTP. Seventeen (53%) patients they were not using alcohol and/or drug since their admission in the MMTP. The analysis result of Pearson correlation was found significance level of 0,001 (< 0,05). With relationship value of 0,588. There was a significant positive relationship between  MMTP services with the impact of MMTP on patients. Conclusion: MMTP is useful in harm reduction due to injecting drug use. to improve counseling services in MMTP, MMTP teams should make scheduling of counseling time.
MOBILE HEALTH APPLICATION UTILIZATION AND E-HEALTH LITERACY AMONG MEDICAL AND HEALTH STUDENTS Julaeha Julaeha; Devi Solikhati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.811 KB) | DOI: 10.36387/jiis.v6i1.571

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Fast changing technology application in industry 4.0 technology era implicated on teaching and health services face to face paradigm to virtual services. Excellence health services influenced by good health literacy. The propose of this study is to evaluation knowledge, attitude, and practice medical and health students toward mobile health application and e-health literacy.The study adopted a descriptive cross sectional survey design was conducted in medical and health students in Indonesia during March-July 2020. An Indonesian Electronic Health Literacy Scale (IEHLS) was developed to evaluate Knowledge, Attitude, and Practice (KAP) about e-health literacy and mobile health apps among medical and health students. The full response rate was 99% (n=301). Half of respondents are mobile health apps active user (52.6%). Hallodoc apps was th e most mobile health apps used (60.5%), followed by Medscape (41.5%) and MIMS (23.6%). Diseases information, side effect, indication, and regimen dose of drugs were the most favourite information accessed among medical and health students. Around 80% of medical and health students agree that mobile health apps improve patient’s knowledge on their own disease and medication and helped healthcare professionals on giving education and counseling. In other hand, only 60% medical and health students agree mobile health apps might be use full in learning process and healthcare services. Knowledge, attitude, and practice medical and health students toward mobile health application will be elevated with improving level of health literacy.
Assessment of Drug Therapy Problems Among Type 2 Diabetes Patients with Hypertension Comorbidity in Indonesia Julaeha Julaeha; Ery Fudjiati; Aprilita Rina Yanti Eff
Borneo Journal of Pharmacy Vol 3 No 3 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i3.1359

Abstract

Type 2 diabetes mellitus (T2DM) is a major chronic disease that affects a large number of people worldwide. Hypertension is a common disease comorbidity among T2DM patients, and often those patients received polypharmacy and complex treatment in long term duration. This condition may lead to an increased risk of drug therapy problems (DTPs). This study aimed to assess and determine potential drug therapy problems in type 2 diabetic patients with hypertension comorbidity. Retrospective cross-sectional design was conducted in a hospital setting, especially data sources from the prescription of ambulatory T2DM patients with hypertension. A total of 190 patients were studied. More than half of the participants were female (53.68%). The majority age range of participants was 50-59 years (46.84%). Almost all antidiabetic agents were prescribed as polypharmacy (73.16%). Metformin was the most antidiabetic agent prescribed as monotherapy and combination therapy (63.16%). Almost all antihypertensive agents were prescribed as polypharmacy (63.26%). Amlodipine was the most antihypertensive agent prescribed as monotherapy and combination therapy (34.74%). Among the study participants, 56.84% have at least one of DTPs. Adverse drug reaction was the most frequent (47.22%), followed by ineffective drug therapy (29.63%). Since the potential of DTPs in T2DM patients with hypertension comorbidity is relatively high, early identifying, resolving, and preventing drug therapy problems by the pharmacist is needed to achieve goals of treatment.
GAMBARAN EFEK SAMPING ANTIPSIKOTIK PADA PASIEN SKIZOFRENIA RAWAT INAP DI RS. GRHASIA YOGYAKARTA julaeha jualeha; vitarani ananda; dimas pradana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.715 KB)

Abstract

This study aimed to profile the use of antipsychotics, the prevalence of DRPs events, and to compare the prevalence of DRPs use of antipsychotics in patients with schizophrenia in Grhasia hospital. This study is an observational study with cross sectional descriptive. Patients who were included in this study were patients with schizophrenia in the period 2007-2009 Grhasia Hospital who met the inclusion criteria, number of patients who were taken in this research are as many as 300 patients with a stratified sampling method. Data collection was performed retrospectively through medical records included patient characteristics, drug use data, and side effect event. From the data were collected regarding the percentage of use of antipsychotics. The results showed that administration of combination klorpromazin and haloperidol, an antipsychotic of the most widely used for the treatment of schizophrenia with a percentage over the period 2007, 2008, and 2009 are 60%, 70%, and 47%. Percentage side effect event over the period 2007, 2008, and 2009 are 31%, 28 % dan 14 %.
Potensi peningkatan efek sedasi dan gangguan ritme jantung pada pengobatan skizofrenia Julaeha Julaeha; Nurhaliza
Journal Borneo Vol. 2 No. 2 (2022): Volume 2 Issue 2 tahun 2022
Publisher : Politeknik Kaltara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.989 KB) | DOI: 10.57174/jborn.v2i2.26

Abstract

Skizofrenia paranoid merupakan tipe skizofrenia yang paling banyak diderita di berbagai negara.   Gejala psikosis yang dialami berupa delusi yang secara relatif stabil, seringkali bersifat paranoid, biasanya disertai dengan halusinasi, terutama halusinasi pendengaran, dan gangguan persepsi. Pasien “X” berumur 22 tahun dirawat dan didiagnosa skizofrenia paranoid dengan keluhan gelisa selama 4 hari terakhir, emosi labil, teriak-teriak, memukul, mengancam akan membunuh. Pasien mendapatkan terapi risperidon 2 mg, lorazepam 1 mg, trifluoferazin 5 m, dan olanzapin 5 mg. Masalah terkait obat yang ditemukan adalah adanya interaksi obat risperidon dengan lorazepam, yaitu dapat meningkatkan sedasi dan trifluoferazin dengan risperidon dapat memperpanjang interval QT. Pemantauan perbaikan gejala psikosis, efek sedasi dan gangguan ritme jantung perlu dilakukan utuk memastikan keberhasilan dan keamanan dari terapi yang diberikan.