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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Media Penelitian dan Pengembangan Kesehatan ASPIRATOR Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran Meditek Jurnal Ilmu Ternak dan Veteriner Folia Medica Indonesiana Majalah Kedokteran The Indonesian Biomedical Journal Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Media Ilmu Kesehatan Majalah Kedokteran Andalas BioEksakta : Jurnal Ilmiah Biologi Unsoed The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Riset Informasi Kesehatan Jurnal Kedokteran Meditek

Heri Wibowo

Department Of Parasitology, Faculty Of Medicine, Universitas Indonesia, Jakarta

Author-ID : 3289437

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Perbandingan Uji Diagnostik Mini FLOTAC dengan Kato-Katz Sebelum dan Sesudah Pengobatan Albendazol Dosis Tunggal pada Anak yang Terinfeksi Cacing Usus Sari, Monica Puspa; Supali, Taniawati; Wibowo, Heri
Jurnal Kedokteran Meditek Vol. 21 No. 55 Januari - April 2015
Publisher : Jurnal Kedokteran Meditek

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AbstrakUntuk memantau pengobatan anthelmintik, diperlukan teknik pemeriksaan yang lebih akurat dan sensitif dibandingkan denganÃÂ Kato-Katz yang merupakan teknik standar yang ada saat ini.ÃÂ Penelitian ini merupakan uji diagnostik yang dilakukan terhadap anak sekolah dasar dilakukan pada bulan Maret 2013 di Kelurahan Kalibaru, Kecamatan Cilincing, Jakarta Utara. Sampel tinja diperiksa menggunakan metode Kato-Katz dan Mini FLOTAC sebelum dan sesudahÃÂ pemberian obat albendazol 400 mg dosis tunggal pada hari ke 7,14, dan 21. Dari 209 subyek penelitian, terjaring 197 subyek yang bersedia ikut serta. ÃÂ Sebelum pengobatan, sensitivitas dan NPV (negative predictive value)ÃÂ ÃÂ Kato-KatzÃÂ ÃÂ ÃÂ ÃÂ danÃÂ Mini FLOTAC masingÃ¢â¬âmasing 94%, 96%ÃÂ dan 81%, 88% terhadap infeksi A. lumbricoides. Terhadap T. trichiura 88%, 92% dibandingkan Mini FLOTAC 100%. Nilai kappa agreement antara teknik Kato-Katz dan Mini FLOTAC adalah 0.773 untuk diagnosis infeksi A. lumbricoides dan 0.895 untukÃÂ infeksi T. trichiura. Terhadap Ascaris,ÃÂ 19.79% tergolong infeksi ringan dengan Kato-Katz. Sedangkan 25.88% tergolong infeksi ringan dengan Mini FLOTAC. Terhadap Trichuris,ÃÂ 34.51% tergolong infeksi ringan dengan Kato-Katz dan 42.13% tergolong infeksi ringan dengan Mini FLOTAC. Setelah diberikan pengobatan, Kato-Katz lebih sensitif dibandingkanÃÂ Mini FLOTAC dalam mendeteksi infeksi A. lumbricoides, terutama pada hariÃÂ 7 dan 14 dan sebaliknya Mini FLOTAC lebih sensitif terhadap infeksi T. trichiura.Teknik Mini FLOTAC dapat dipakai sebagai alternatif dari teknik Kato-Katz dalam mendeteksi infeksi cacing usus dan lebih sensitif mendeteksi T. trichiura dibanding Kato-Katz. ÃÂ Kata Kunci : Kato-Katz, Mini FLOTAC, Albendazol, Infeksi cacing ususÃÂ ÃÂ AbstractÃÂ ÃÂ ÃÂ ÃÂ ÃÂ ÃÂ ÃÂ ÃÂ ÃÂ ÃÂ ÃÂ To monitor anthelmintic treatment, will require examination techniques that are more accurate and sensitive than the Kato-Katz technique which is the current standard. This study is a diagnostic examination performed on primary school children. It was conducted in March 2013 inÃÂ ÃÂ Kalibaru village, Cilincing Sub-District, North Jakarta. Stool samples were examined using the Kato-KatzÃÂ and Mini FLOTAC methods on day 7,14, and 21 after the administration of a single dose of 400 mg albendazole. Of the 209 study subjects, 197 subjects were willing to participate. Before treatment, the sensitivity and the NPV (negative predictive value) against A. lumbricoides infection were 94%,96%, respectively for Kato-Katz and 81%, 88%, respectively for Mini FLOTAC. For T. trichiura, sensitivity and the NPV of Kato-Katz were 88%, 92%, respectively,while for Mini FLOTAC both values were 100%. Kappa value of agreement between Kato-Katz and Mini FLOTAC techniques was 0.773 for the diagnosis of A. lumbricoides infection and 0.895 for T. trichiura. For Ascaris, 19.79% versus 25.88% of infected children have light infection by Kato-Katz and Mini FLOTAC, respectively. For Trichuris, 34.51% versus 42.13% of infected children have light infection with Kato-Katz and Mini FLOTAC, respectively. After the treatment was given,ÃÂ Kato-KatzÃÂ was more sensitive compared to Mini FLOTAC in detecting A. lumbricoides infection, especially at day 7 and day 14. On the contrary, Mini FLOTAC was more sensitive in detecting T. trichiura infection. The Mini FLOTAC technique can be used as an alternative for Kato-Katz in detectingÃÂ helminth infections. Mini FLOTAC was more sensitive to detect T. trichiura compared to Kato-Katz. ÃÂ Keywords ÃÂ :ÃÂ Kato-Katz, Mini FLOTAC, Albendazole, Soil transmitted helminthesÃÂ ÃÂ

Hubungan antara Infeksi Cacing dan Alergi Yolazenia Yolazenia; Taniawati Supali; Heri Wibowo
Jurnal Ilmu Kedokteran Vol 4, No 2 (2010): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Many researches showing the evidence of a reverse relation between helminthiasis and allergic diseases in tropicaldeveloping countries, supported by hygiene hypothesis. There is relationship between the inflammation caused byallergic and helminthiasis. Both, allergic and helminthiasis, show the increase of IgE level, eosinophilia, mastocytosis,and release of IL-4, IL-5 and IL-13 cytokines by Th2. Several mechanisms explaining the decrease of allergicmanifestation in people with helminthiasis are polyclonal IgE blocking, suppression of anti-inflammatory cytokines(IL-10 and TGF-â), and IgG4 blocking antibody.

Cytokines profile of mice infected by high and low virulences of Indonesian T. evansi isolates Dyah Haryuningtyas Sawitri; April Hari Wardhana; Heri Wibowo
Jurnal Ilmu Ternak dan Veteriner Vol 22, No 3 (2017): SEPTEMBER 2017
Publisher : Indonesian Center for Animal Research and Development (ICARD)

Surra in livestock is caused by Trypanosoma evansi, a homoflagella blood protozoa that circulate in extracellular. This disease is widespread in Asia, Africa, South and Central America. According to the immunological aspect, the severity of surra in livestock and mice which infected by trypanosoma is associated with an inflammatory response. On the other hand, the survival time of mice depends on the regulation of Th1 synthesis and proinflammatory cytokines such as IFN-γ and TNF-α. The aim of this study was to observe the responses of proinflammatory cytokines IFN γ, TNF-α and anti-inflammatory IL-10 which result from interaction with parasites. This information is needed for improvements in the management of prevention of Surra in animals. A total of 30 mice were divided into 3 groups. The group was infected with a low virulency T. evansi (Pml287); high virulence (Bang87) respectively and one group was not infected as control. Mice sera were collected in every 4 days for cytokine measurement using an Enzyme Link-Immunosorbent Assay (ELISA). The result showed a difference response of proinflammatory and antiinflammation cytokine profile between the infected mice by isolates Bang 87 and Pml 287. Early deaths in mice infected by Bang 87 isolate were suspected as a result of the response of systemic inflammation syndromes characterized by elevated IFN-γ levels that were not adequately compensated by anti-inflammatory. Anemia contributes to the cause of death in mice that support multiple organ failures (multiple organ disfunction).

The effect of dadih in BALB/c mice on pro-inflammatory and anti-inflammatory cytokine productions Ria Kodariah; Hadits Lissentiya Armal; Heri Wibowo; Andi Yasmon
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 4 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The normal microflora formed as commensal bacteria have roles in maintaining homeostasis in the intestine tract. The reduction in the amount and on the diversity of the commensal bacteria lead to gastrointestinal dysbiosis which increase number of pathogens, induce inflammatory and can drive to colorectal cancer. Probiotics can be used to prevent, regulate, and modulate immune response by triggering the development of pathogen-specific memory. Currently, many foreign probiotic products are available in the market that cause the domestic products are less well known. Dadih is an original probiotic’s products originally from West Sumatra, Indonesia. It is made from fermented buffalo milk containing lactic acid bacteria (LAB). The objective of the study was to investigate the effect of dadih pro-inflammatory and anti-inflammatory cytokine production. The study was conducted using male BALB/c mice aged 6-8 weeks with body weight (BW) 20-30 g. Mice were given dadih at doses of 112 mg/20g BW for eight weeks. The results indicated that LAB bacteria in dadih are coccus, Gram-positive bacteria with 3x107 colony-forming units (CFU) and dominated by Lactococcus lactis subsp. lactis. In addition, the increase of both the anti-inflammatory cytokines (IL-10) and pro-inflammatory cytokines (TNF-α and IL-1β) was observed. In conclusion, the dadih can be used to maintain the immune system of mice.

Vitamin D suppresses inflammatory responses in insulin resistance Rona Kartika; Heri Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Vitamin D has been known as a vitamin for bone health and mineral homeostasis. However, since the discovery of vitamin D receptor (VDR) in various types of cell, that statement has changed. Immune cells are known to express VDR and enzyme 1α-hydroxylase that could convert vitamin D into its active form, 1.25 dihydroxyvitamin D. In immune cells, vitamin D works as an immunomodulator which affects various levels of immune response. The net effects of vitamin D are increasing mucosal immunity, but dampening the adaptive immune system. Vitamin D deficiency is commonly found in people with diabetes mellitus (DM) and obesity. It is also associated with increased insulin resistance and poor glucose control. This review will explain how vitamin D as immunomodulator dampens insulin resistance. In immune cells from subjects with insulin resistance, administration of vitamin D could reduce the expression of pro-inflammatory cytokines through the NF-κB and MAPK pathways, thus the levels of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6 are decreased. The same thing happens in preadipocytes and mature adipocytes cells. In these cells, vitamin D suppresses the expression of pro-inflammatory mediators such as IL-6 and MCP-1. Although in the invitro studies, the administration of vitamin D showed a promising effect in modulating the immune system, the clinical effect of vitamin D supplementation in reducing insulin resistance in individuals with type 2 DM (T2DM) and prediabetes is still inconclusive

FLOTAC Technique for Soil-Transmitted Helminth Infection Diagnosis Helena Ullyartha Pangaribuan; Taniawati Supali; Heri Wibowo
Majalah Kedokteran Bandung Vol 53, No 4 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2545

Human helmintiasis is a neglected disease with significant economic impacts caused by its effects on performance and cognition. The burden of many helminth infections is not well understood due to the lack of progress in detecting low-intensity infection in elimination programs. Furthermore, the decision for individual and community treatments, as well as the community-based control program evaluation, obviously depends on the technics used for parasitological diagnostic. A well-established diagnostic technic will be beneficial to detect and eliminate the disease. Therefore, this study aimed to compare the performance of FLOTAC and FECT technics for detecting helminth infections in human stool. A total of 149 fecal specimens were collected from schoolchildren in Nangapanda village, Ende District, East Nusa Tenggara Province in 2012. The sensitivity of both technics was analyzed using the kappa analysis. Positive results from both technics were used as the gold standard. The sensitivity of FLOTAC for diagnosing T. Trichiura, A. lumbricoides and hookworm infections were 100%, 100%, and 82%, respectively, while the sensitivity of FECT was 80%, 7%, and 18%, respectively. FLOTAC yielded considerably higher mean faecal egg counts (11,452, 1,038, and 19 eggs per gram stool (EPG) for A. lumbricoides, T. Trichiura, and hookworm). FLOTAC technique was considerably more sensitive than FECT in diagnosing soil-transmitted helminth infections. In conclusion, FLOTAC can be used as a diagnosis tool for future helminth control programs.

Hubungan Trombositopenia, Parasitemia serta Mediator Pro dan Anti Inflamasi pada Infeksi Malaria, Timika 2010 Armedy Ronny Hasugian; Heri Wibowo; Emiliana Tjitra
Media Penelitian dan Pengembangan Kesehatan Vol 28 No 3 (2018)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/mpk.v28i3.110

AbstractTrombocytopenia is related with severity of malaria. Parasitaemia and immune system have important roles for the reactions that occur in malaria infections including thrombocytopenia. Therefore, we conducted a study to determine the association between thrombocytopenia, parasitaemia and cytokines in Plasmodium falciparum and P.vivax. This was a cross-sectional and hospital based study at Mitra Masyarakat Hospital,Timika, Papua, in 2010. Subjects were all age groups with uncomplicated malaria. On admission, characteristics subjects were recorded, parasitaemia was calculated by using microscope, platelets were measured by Hematology analyzer (Sysmex), and cytokines were measured by Multiplex Flow Cytometry Assay (Luminex).Thrombocytopenia was defined if platelet count <150,000/mm . Cytokines were presented in ratio of TNFα/IL10, IFNγ/IL10, and IL12/IL10. The association thrombocytopenia, parasitaemia and cytokines were determined by logistic multivariate analysis. A total 76 subjects were recruited, 51.3% infected with P. falciparum and 48.7% infected with P. vivax infection. The mean age of subjects was 15 (range: 5 – 55) years and 82.9% with thrombocytopenia (platelet range:18958-341123/mm ). The geometric mean of parasitemia was 3393 (43–412503) /mm , while the median of ratios TNFα/IL10, IFN γ/IL10 and IL12/IL10 were 1.05; 0.99; and 0.99, respectively. Bivariate anaylsis showed that trombocytopenia was associated with low level of TNFα/IL10 (p=0.015) and IL12/IL10 (0.020). The multivariate anaysis data also showed a relationship between thrombocytopenia and ratio of TNFα/IL10 with adjusted OR of 7,33 (95%CI: 1,5–35,8), p=0.014. Thrombocytopenia is associated with low ratio of TNFα/IL10 in patients with uncomplicated infection of P. falciparum and P.vivax. AbstrakTrombositopenia berhubungan dengan tingkat keparahan malaria. Parasitemia dan sistem kekebalan tubuh memiliki peran penting pada manifestasi infeksi malaria termasuk trombositopenia. Oleh karenanya penelitian ini bertujuan untuk menentukan hubungan antara trombositopenia, parasitemia, dan sitokin pada Plasmodium falciparum dan P.vivax. Disain studi adalah potong lintang, dilaksanakan di Rumah Sakit Mitra Masyarakat, Timika, Papua pada tahun 2010. Subjek penelitian adalah semua kelompok umur dengan malaria tanpa komplikasi. Pada perekrutan, karakteristik subjek akan dicatat, parasitemia dihitung dengan mikroskop, trombosit diukur dengan Hematology analyzer (Sysmex) dan sitokin diukur dengan Multiplex Flow Cytometry Assay (Luminex). Trombositopenia didefinisikan jika jumlah trombosit < 150.000 mm . Sitokin yang dipaparkan adalah rasio TNFα/IL10, IFNγ/IL10, dan IL12/IL10. Hubungan trombositopenia, parasitemia, dan sitokin ditentukan dengan analisis multivariat logistik. Sebanyak 76 subjek malaria mono-infeksi direkrut, 51,3% terinfeksi P. falciparum dan 48,7% P. vivax. Rata-rata umur subjek adalah 15 (kisaran : 5-55) tahun dan 82,9% dengan trombositopenia (kisaran : 18.958-341.123/ mm 3 3 ). Rerata geometrik parasitemia adalah 3393 (43-412503)/mm , sedangkan median masing–masing rasio TNFα/IL10, IFNγ/IL10 dan IL12/IL10 yaitu 1,05, 0,99; dan 0,99. Analsis bivariat menunjukkan bahwa trombositopenia berhubungan dengan rendahnya tingkat TNFα/IL10 (p = 0,015) dan tingginya rasio IL12/ IL10 (p=0,020). Hasil analisis multivariat menunjukkan adanya hubungan antara trombositopenia dan rasio TNFα/IL10 rendah (< 1,05) dengan OR: 7,33 (95% CI: 1,5-35,8), p = 0,014. Trombositopenia dikaitkan dengan rendahnya rasio TNFα/ IL10 pada pasien infeksi dari P. falciparum dan P. vivax tanpa komplikasi.

Uji Antimalaria Ekstrak Akar Pasak Bumi (Eurycoma Longifolia Jack) dan Pengaruhnya terhadap Ekspresi TNF-Î± pada Mencit yang diinfeksi Plasmodium berghei Muhammad I. Kahtan; Hendri Astuty; Heri Wibowo
Majalah Kedokteran UKI Vol. 34 No. 2 (2018): APRIL - JUNI
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

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AbstrakMalaria masih menjadi masalah kesehatan di dunia terutama negara tropis, karena angka kesakitan dan kematiannyayang tinggi. Gejala yang berat sampai kematian akibat malaria dipengaruhi respons imun setiap individu maupunketepatan pengobatan malaria. Penelitian ini bertujuan untuk mengetahui efek respons imun (TNF-Î±) mencitterinfeksi Plasmodium berghei yang diberi ekstrak akar pasak bumi (Eurycoma longifolia jack) sebagai antimalaria.Penelitian ini bersifat eksperimental laboratorik dengan desain post test control group only. Untuk pemeriksaanparasitemia digunakan pemeriksaan darah tipis yang dipulas dengan Giemsa. Teknik bead based multiplexingtechnique digunakan untuk mendapatkan nilai mean flourescence intensity (MFI) sebagai ukuran kadar TNF-Î±.Hasil penelitian ini menunjukkan kemampuan ekstrak akar pasak bumi sebagai antimalaria dengan rerata nilaihambatan pertumbuhan (growth inhibition) sebesar 88,93%. Hasil uji korelasi menunjukkan hubungan bermaknaantara tingkat parasitemia dengan TNF-Î± (uji Spearman, r = -0,872; p<0,005). Hal itu menunjukkan ekstrak akarpasak bumi (EAPB) dapat bekerja sebagai imunomodulator dengan mengaktivasi TNF-Î± yang bekerja sebagaiimunoprotektor. Dapat disimpulkan bahwa pemberian EAPB meningkatkan ekspresi TNF-Î± yang berhubungandengan penurunan tingkat parasitemia pada mencit yang diinfeksi P. berghei. Kata Kunci: Eurycoma longifolia jack, Plasmodium berghei, TNF-Î± AbstractMalaria is still the main health problem in the world, mainly in tropical countries where its incidence and mortalityremain high. The severe disease, which may lead to death, are affected not only by the immune response of eachindividual, but also by the efficacy of malaria treatment. The purpose of this research was to investigate the effect ofimmune response (TNF-Î±) of the Plasmodium berghei-infected mice, which was treated with the pasak bumi root(Eurycoma longifolia jack) extract as antimalaria. This was an in vivo experimental study in which the experimentalanimals were divided into five different groups (control, Plasmodium berghei and aquades, CMC, Plasmodiumberghei and CMC, Plasmodium berghei and pasak bumi root extract). The level of parasitemia were determinetedby using thin blood staining. The bead based multiplexing technique was used in the TNF-Î± examination in orderto obtain mean fluorescence intensity (MFI) which was later used as TNF-Î± standard. The results of this researchshowed the potential of the pasak bumi root extract as antimalaria with the mean percentage of growth inhibition of88.93%. The correlation analysis showed a meaningful inverse relation between the parasitemia level and TNF-Î±(Spearman test, r= - 0.872; p=0.001). This means that the pasak bumi root extract could activate TNF-Î±, which actsas immune protector. In conclucion, the pasak bumi root extract could enhance the TNF-Î± expression as shown bythe decline of the parasitemia level in the Plasmodium berghei infected mice. Keywords: Eurycoma longifolia jack, Plasmodium berghei, TNF-Î±

Activity of Ocimum sanctum Leaf Extract against Aedes aegypti Larvae: Midgut Histopathological Alteration Nurhadi Eko Firmansyah; Agus Aulung; Heri Wibowo; Rizal Subahar
ASPIRATOR - Journal of Vector-borne Disease Studies Vol 11 No 1 (2019): Jurnal Aspirator Volume 11 Nomor 1 2019
Publisher : Loka Litbang Kesehatan Pangandaran

Plant extracts can be used as biolarvacide to kill Aedes aegypti larvae, one of which is Ocimum sanctum leaf extract. The aim of the study was to analyze the effect of O. sanctum leaf methanol extract on Ae. aegypti larvae and histopathological alteration of midgut. The study used an experimental design. O. sanctum leaf extract was made by evaporation methods at 0.1%, 0.25%, 0.5%, 0.75%, and 1% concentration. The experiment was repeated four times for each concentration. Observation of larvae mortality was done after 24 hours of treatment. The results of histopathological observation showed that there was the alteration in epithelial midgut Ae. aegypti larvae. The LC50 value of O. sanctum was 0.66%, while the LC90 value obtained was 1.38%. The results showed that the mortality of Ae. aegypti larvae up to 90% required more than 1% of extract concentration.

Interleukin-13, Interleukin-10, Interferon-gamma and IDO Production in Response to Home Dust Mites in Allergic Asthma Cityta Putri Kwarta; Heri Wibowo; Yordan Khaedir; Iris Rengganis; Hanny Siti Nuraeni
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.714

BACKGROUND: Allergic asthma is a degenerative atopic disease caused by allergic or hypersensitivity type-1. More than 50% of people with allergic asthma are caused by the presence of house dust mites (HDMs) allergens.METHODS: The cellular immunity response was evaluated through a peripheral blood mononuclear cell (PBMC) culture isolated from blood, using the ficoll gradient technique. Subjects were atopic asthma groups and non-atopic asthma groups. PBMC from each subject cultured was stimulated with HDMs allergen, then incubated in a CO2 5% incubator, 37o C for 72 hours. With the multiplex assay method, interferon (IFN)-γ, interleukin (IL)-13 and IL-10 were measured, meanwhile indoleamine 2,3-dioxygenase level (IDO) was measured by the enzyme-linked immunosorbent assay (ELISA) sandwich methods.RESULTS: The IFN-γ production in the supernatant of PBMC cultures was stimulated by phytohemagglutinin (PHA), Roswell Park Memorial Institute (RPMI) medium and allergens. The IFN-γ production in allergen-stimulated supernatants showed higher level of IFN-γ in the nonatopic group (4,681,455±3,434,851) than atopic group (4,363,300±2,067,941) even though it was not statistically significant (p=0.078). There were no differences between the mean of IL-13 production in atopic asthma group and non-atopic group. The IL-10 production in allergenstimulated supernatants was shown to be higher in nonatopic group and were statistically significantly different (p=0.015). The IDO production in allergen-stimulated supernatants was shown to be higher in the non-atopic group (272,231±269,564) than in the actopic group (13,273±400), and it was significantly different (p=0.007).CONCLUSION: Cellular immune profile of subjects with allergic asthma to Dermatophagoides pterronyssinus (Der p) is characterized by a type-2 inflammatory response that is dominant compared to type-1 inflammation (higher IL-13 ratio compared to IFN-γ) and to the role of anti-inflammation (higher IL-13 ratio compared to IL-10). The decline in IDO production in allergic asthma subjects to Der p is thought to be related to the low cellular immune response in expressing IFN-γ compared to IL-13.KEYWORDS: interleukin-13, interleukin-10, IDO, PBMC, asthma

Co-Authors Agus Aulung Agus Aulung Alida Rosita Harahap Ambar Hardjanti Andi Yasmon Anna Rozaliyani Annisa Mulia Anasis April Hari Wardhana Arleni Bustami Armedy Ronny Hasugian Bambang Heru Budianto Ceisar Pawenang Aji Cicilia Febriani Hayuningrum Cityta Putri Kwarta Din Syafruddin Dini Aulia Cahya Dyah Haryuningtyas Sawitri Elita Donanti Emiliana Tjitra Endang Pratiwi Eti Herani Evy Yunihastuti Hamzah Shatri Hanny Siti Nuraeni Helena Ullyartha Pangaribuan Hendri Astuty Inge Sutanto Iris Rengganis Iris Rengganis Ismail E Prayitno Isna Indrawati Jeffry Adijaya Susatyo Marcellus Simadibrata Monica Puspa Sari Muhammad I. Kahtan Muharam Natadisastra Murdani Abdullah Nadar Sukri Ndaru Andri Damayanti Ni Ken Ritchie Ni Ken Ritchie Nora Harminarti Nurhadi Eko Firmansyah Oky Satiagraha Patra Patiah Perdana Heriyoko Puji Budi Setia Asih, Puji Budi Puspita Eka Wuyung Rheza Paleva Wijaya Ria Kodariah Ria Syafitri Evi G Rizal Subahar Rizal Subahar Rona Kartika Rona Kartika Santi Sumihar Rumondang Parhusip Sari, Monica Puspa Sheila Nurrahmah Suradi Suradi Suriyani Tan Sylvia Sance Marantina Talitha Vania Salsabella Taniawati Supali Taniawati Supali Taniawati Supali Taniawati Supali Wahyu Pangestuti Lestari Widiastuti Widiastuti Yolazenia Yolazenia Yordan Khaedir Zulhasril Zulhasril

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