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All Journal Folia Medica Indonesiana The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Oto Rhino Laryngologica Indonesiana International Journal of Nasopharyngeal Carcinoma Indian Journal of Forensic Medicine & Toxicology Asian Journal of Health Research

Romdhoni, Achmad Chusnu

Department Of Otorhinolaryngology-Head And Neck Surgery, Faculty Of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya

Author-ID : 3289799

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

Published : 12 Documents Claim Missing Document

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POLA KUMAN, HASIL UJI SENSITIFITAS ANTIBIOTIK DAN KOMPLIKASI ABSES LEHER DALAM DI RSUD DR. SOETOMO Arianto, Denny Rizaldi; Romdhoni, Achmad Chusnu
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 1 (2019): EDISI MARET 2019 (available online since April 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Penelitian ini bertujuan untuk mendapatkan data lokasi, etiologi, hasil kultur kuman dan uji sensitifitas antibiotik serta komplikasi dari penderita abses leher dalam yang di rawat ruang rawat inap bedah teratai THT-KL RSUD Dr. Soetomo periode Januari sampai Desember 2014. Bahan dan metode penelitian yaitu rekam medik penderita. Hasil: Didapatkan 41 penderita. Lokasi di submandibula 13(31,70%), ruang peritonsil 11(26,82%), kombinasi ruang submandibula, parafaring dan retrofaring 11 (26,82%). Etiologi infeksi gigi 14(34,14%), infeksi tonsil akut 8(19,51%), DM 8(19,51%), DM Tipe 2 dan infeksi gigi 10(24,39%), DM disertai infeksi orofaring 1(2,43%). Dari kultur pus didapatkan Staph. Aureus (33,33%), Strep. viridians (28,75%), Kleb. Pneumonia (9,52%). Dari kultur darah didapatkan kuman Strep. viridians (40,00%), Kleb. Pneumonia (20,00%), Acinobacter humanii (20,00%), Staph. Haemolyticus (20,00%). Kultur urin didapatkan Acinobacter humanii dan Staph. haemolyticus masing-masing 50%. Hasil uji sensitifitas antibiotik dari kultur pus didapatkan angka sensitive terhadap Meropenem (87,5%), Ceftriaxone (73,68%), Cefoperazone-sulbactam (70,00%), Cefotaxime (68,75%). Resitensi kuman terhadap antibiotika tersebut diatas secara berurutan 12,50%, 21,05%, 20,00%, 12,5%. Komplikasi sepsis 12(29,26%), obstruksi jalan napas atas (trakeotomi) 6(14,63%). Kesimpulan: Lokasi tersering di submandibula disusul peritonssil, kombinasi submandibula dan parafaring atau retrofaring. Etiologi tersering infeksi gigi disusul tonsil. Penyakit penyerta tersering yaitu DM. Kuman yang sering ditemukan dari kultur pus adalah Staph. aureus dan Strep. viridians. Kuman dari kultur darah terbanyak Strep. viridians, disusul Kleb. pneumonia, Acinobacter humanii, Staph. haemolyticus. Hasil uji sensitifitas terhadap antibiotik dari kultur pus didapatkan angka sensitif tertinggi adalah Meropenem disusul Ceftriaxone, Cefoperazone-sulbactam dan Cefotaxime. Komplikasi tersering sepsis disusul obstruksi jalan nafas atas dan mediastinitis. Sebanyak 4,87% penderita meninggal.

Sensorineural Hearing Loss and Cochlear Outer Hair Cell Function Nasopharyngeal Carcinoma Due to Influence of Cisplatin Fira Sofia; H.M.S Wiyadi; Achmad Chusnu Romdhoni
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 2 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i2.17955

Background: Nasopharyngeal carcinoma is a type of tumor sensitive to chemotherapy and radiotherapy.One of the various chemotherapy drugs is cisplatin. However, the cisplatin effects on sensorineuralhearing loss and cochlear outer hair cell dysfunction in patients with nasopharyngeal carcinoma have notbeen evidently discovered. Objective: This research aims to prove the cisplatin effects on sensorineuralhearing loss and cochlear outer hair cell dysfunction in patients with nasopharyngeal carcinoma.Materials and Methods: This research adopted analytical observation by employing a prospectivecohort study approach. In addition, the sampling technique implemented consecutive sampling. Thisresearch was conducted at the ENT-HN Outpatient Unit (URJ) of the Neuro-otology Division ofDr.Soetomo Public Hospital during September-November 2020 period. The auditory test was executedby Pure-Tone Audiometry (ANM) and Distortion Product Otoacoustic Emission (DPOAE). Meanwhile,the statistical analysis was assessed by the Wilcoxon and McNemar test. Results: This research involved22 samples. The cumulative dose of cisplatin up to chemotherapy series III ranged from 260-270 mgwith an average of 265.45+5.10 mg. The results of the ANM test before and after chemotherapy seriesIII employing Wilcoxon test indicated significant differences in frequency of 500 Hz (p-value =0.014),6000 Hz (p-value = 0.011), 8000 Hz (p-value = 0.019),10000 Hz (p-value = 0.000), and 12500 Hz(p-value = 0.002). The frequency of 125 Hz with a p-value = 0.343, the frequency of 250 Hz with ap-value = 0.690, the frequency of 1000 Hz with a p-value = 0.179, the frequency of 2000 Hz with ap-value = 0.459, and the frequency of 4000 Hz with a p-value = 0.125 indicated no significant differencewitha p-value greater than 0.05. Meanwhile, the DPOAE test results before and after chemotherapyseries III utilizing the McNemar test demonstratedthe frequency of 1000 Hz (p-value = 1.000), 2,000Hz (p-value = 0.453), 4000 Hz Hz (p-value = 1.000), 6000 Hz (p-value = 0.388), 8000 Hz (p-value =0.754), and 1000 Hz (p-value = 1.000). The comparative analysis of the DPOAE test results before andafter chemotherapy Series 3 suggested no significant difference, with a p-value greater than 0.05 at allfrequencies. Conclusion: There were cisplatin effects on sensorineural hearing loss in patients withnasopharyngeal carcinoma after chemotherapy series 3 based on ANM test at the frequencies of 500Hz, 6000 Hz, 8000 Hz, 10000 Hz, and 12500 Hz. There were no cisplatin effects on cochlear outer haircell dysfunction in patients with nasopharyngeal carcinoma after chemotherapy series 3.

Pseudomonas Pseudoalcaligenes Caused Otogenic Cerebellar Brain Abscess In Indonesian Child Prastiya Indra Gunawan; Achmad Chusnu Romdhoni
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15901

Otogenic brain abscess is a common intracranial complication from chronic supurative otitis media.Pseudomonas pseudoalcaligenes is a rare cause of brain abscess. Prompt diagnosis and decision making issignificant in order to decrease the mortality rate from this type of abscess. We described A 13-year-old boypresented with decreased consciousness, positive meningeal signs, and pathological reflexes. There was ahistory of chronic suppurative otitis media. A head CT scan revealed multiple left cerebellar abscesses andbrain edema. The abscess wall culture revealed P. pseudoalcaligenes. After being managed with surgicalabscess drainage, mastoidectomy, ear flushing, and antimicrobial therapy for six weeks, his consciousnesslevel improved. Cerebellar neurological impairment was still observed. Physical and neurologicalrehabilitation was performed in order to improve the patient’s condition.

NPC-Exosome Carry Wild and Mutant-type p53 among Nasopharyngeal Cancer Patients Hamsu Kadriyan; Eka Sunarwidhi Prasedya; Nova Audrey Luetta Pieter; Masyita Gaffar; Amsyar Akil; Agusalim Bukhari; Budu Budu; Andi Alfian Zainuddin; Rina Masadah; Achmad Chusnu Romdhoni; Abdul Qadar Punagi
The Indonesian Biomedical Journal Vol 13, No 4 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i4.1718

BACKGROUND: Nasopharyngeal cancer (NPC) is known to release a specific exosome. NPC-derived exosome (NPC-Exo) could carry p53. However, information regarding the type of p53 carrier on NPC-Exo remains limited. This study aims to introduce our important findings regarding the type of p53 NPC-Exo cargo.METHODS: Serum from patients with NPC were prepared for exosome isolation with Seramir Exoquick by following the manual instructions. RT-PCR was conducted to determine the expression levels of latent membrane protein 1 (LMP-1) and p53 in the exosome isolate. Partial sequencing of p53 amplicon was conducted to determine mutation type of p53.RESULTS: There were 8 patients enrolled in this study. According to RT-PCR results, the expression levels of LMP-1 and p53 varied in the NPC-Exo isolate. Based on sequencing analysis, 1 case of p53 mutation was noticeable.CONCLUSION: According to current results, the NPC-derived exosome potentially carries not only wild type but also mutant type p53. Further research is needed to explore deeper the effect of the mutant type p53 as an exosome carrier in the clinical application.KEYWORDS: Nasopharyngeal cancer, exosome, p53, mutation

Clinical and Radiological Study of Patients With Skull Base Fracture After Head Injury Puguh Oktavian; Achmad Chusnu Romdhoni; Linda Dewanti; Asra Al Fauzi
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

Traumatic brain injury (TBI) is the largest contributor to morbidity and mortality in various parts of the world. Skull base fracture (SBF) is one of the many manifestations that can occur in cases of mild to severe TBI. With varying patterns of TBI, it was necessary to review the characteristics of SBF, clinical manifestations, cerebrospinal fluid leakage, and complications. The data were taken from the medical records of SBF patients who were treated at RSUD (Regional Public Hospital) Dr. Soetomo in the period January 2014 - July 2019. Then, the data obtained were written on the collection sheet and analyzed descriptively using RKward. It was found that SBF most often occurs due to severe TBI (60.14%). 77.7% of SBF patients were male and 35.1% of all patients aged 15-24 years. The most frequent cause was traffic accidents (86.5%). The anterior cranial fossa (ACF) was the most frequently fractured part of the skull base (30.4%). There was a significant relationship between the severity of TBI with the occurrence of CSF leakage and complications. About 33 patients (22.3%) had complications such as pneumocephalus and 9 patients (6.1%) had meningitis. Complications in the form of brain abscess and hydrocephalus in 1 (0.7%) patient each. SBF often occurred in men of productive age 15-24 years. The ACF was the most frequently fractured part. The majority were caused by traffic accidents accompanied by severe brain injuries. The most common complications were pneumocephalus, meningitis, brain abscess, and hydrocephalus.

The Dizziness Handicap Inventory questionnaire scores before-and-after vestibular rehabilitation therapy of presbyastasis patients Etty Sekardewi; Achmad Chusnu Romdhoni; Haris Mayagung Ekorini
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i1.349

Background: Presbyastasis is multifactorial balance dysfunction that occurs in the elderly person. Presbyastasis can increase the risk of fall, anxiety, and decrease the quality of life. Vestibular rehabilitation therapy (VRT) has been proven effective to overcome balance disorders, and it is safe for the elderly. Several studies had reported the success of VRT for balance disorders. All this time, the accomplishment of VRT was assessed by using balance test, which had a risk of falling in elderly patients. Objective: To find out the outcome of Dizziness Handicap Inventory (DHI) questionnaire score in presbyastasis patients after VRT. Method: Ten presbyastasis patients in age range 60-75 years old who met the study criteria were taken by consecutive sampling. A longitudinal observational (pre and posttest) study by analyzing the DHI questionnaire scores. Assessment was performed twice, before and after VRT. The data was analyzed using paired T test and Wilcoxon signed rank test with outcome p<0.05. Result: The measurement of the emotional subscale DHI (DHI.E) showed the mean score before VRT was 4.00 (1.63), after therapy was 0.00 (0.63), p=0.004. The functional subscale (DHI.F) measurement showed the mean score before VRT was 10.40 (3.98), after therapy was 2.40 (2.07), p 0.00. The mean score of physical subscales (DHI.P) measurement before VRT was 9.00 (4.40), after therapy was 2.00 (1.58), p=0.008. The total DHI score (DHI.T) before VRT was 22.6 (7.67), after VRT was 4.20 (2.2) with p=0.000. Conclusion: There was an improvement in DHI questionnaire score before and after 6 weeks VRT.Keywords: Vestibular rehabilitation therapy (VRT), Dizziness Handicap Inventory (DHI), presbyastasis ABSTRAK Latar belakang: Presbiastasis dapat meningkatkan angka jatuh, kecemasan dan menurunkan kemandirian sehingga menurunkan kualitas hidup pada usia lanjut. Terapi rehabilitasi vestibuler (TRV) merupakan modal terapi yang terbukti dapat mengatasi gangguan keseimbangan, dan aman untuk usia lanjut. Beberapa penelitian melaporkan adanya keberhasilan TRV pada penderita gangguan keseimbangan. Keberhasilan dari TRV selama ini dinilai dengan menggunakan pemeriksaan keseimbangan yang memiliki risiko jatuh pada penderita usia lanjut. Tujuan: Membuktikan adanya perubahan skor kuesioner Dizziness Handicap Inventory (DHI) pada penderita presbiastasis sesudah TRV. Metode: Sepuluh penderita presbiastasis usia 60-75 tahun yang memenuhi kriteria penelitian diambil secara consecutive sampling. Studi observasi longitudinal (pre dan posttest) dengan menghitung dan menganalisis skor kuesioner DHI. Pengukuran dilakukan 2 kali yaitu sebelum TRV dan sesudah TRV. Analisis data dilakukan dengan paired T test dan Wilcoxon signed rank test, dengan hasil p<0,05. Hasil: Pengukuran skor kuesioner DHI subskala Emotional (DHI.E) sebelum TRV mempunyai mean 4,00 (1,63), 6 minggu sesudah TRV didapatkan mean 0,00 (0,63), p=0,004. Hasil subskala Functional (DHI.F) sebelum TRV didapatkan mean 10,40 (3,98), 6 minggu sesudah TRV, mean 2,40 (2,07), p=0,00. Pada subskala Physical (DHI.P) didapatkan mean 9,00 (4,40), dan 6 minggu sesudah TRV didapatkan mean 22,6 (7,67), sesudah TRV didapatkan mean 4,20 (2,2) dengan p=0,000. Kesimpulan: Terdapat perbaikan skor kuesioner DHI sesudah 6 minggu terapi rehabilitasi vestibuler (TRV).

Filogenetik Human papillomavirus (HPV) tipe 6 dan tipe 11 pada penderita recurrent respiratory papillomatosis Lenny Buana Wuriningtyas; Dwi Reno Pawarti; Achmad Chusnu Romdhoni
Oto Rhino Laryngologica Indonesiana Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014
Publisher : PERHATI-KL

Latar belakang: Papiloma saluran pernapasan berulang (recurrent respiratory papillomatosis/RRP) merupakan neoplasma jinak laring terbanyak akibat infeksi HPV tipe 6 dan tipe 11. RRP merupakan masalah terkait agresivitas dan terapi. Analisis genetik digunakan untuk membedakan varian HPV tipe 6 dan tipe 11. Filogenetik mengevaluasi evolusi sequen DNA virus. Tujuan: Penelitian bertujuan mengidentifikasi sequen DNA dan menganalisis pohon filogenetik HPV tipe 6 dan tipe 11 pada papiloma saluran pernapasan berulang. Metode: Penelitian merupakan observasional deskriptif cross sectional. Analisis menggunakan data pembanding dari GenBank. Filogenetik disusun menggunakan metodeUPGMA (Unweighted Pair Group Method with Arithmetic Mean). Didapatkan 15 sampel jaringan papiloma. Dilakukan pemeriksaan PCR dan analisis sequen DNA. Hasil: Dari 15 sampel penelitian (12 laki-laki, 3 perempuan) didapatkan 9 isolat HPV tipe 6 (8 varian dan 1 subtipe) dan 4 isolat HPV tipe 11 (3 varian dan 1 subtipe). Terdapat mutasi titik yang mengakibatkan munculnya varian dan subtipe HPV tipe 6 maupun tipe 11. Kesimpulan: sequen DNA sampel berasal dari L1 ORF (Late 1 Open Reading Frame) yang merupakan kapsid mayor virus. Proses mutasi level gen berupa substitusi, insersi, dan delesi.Subtipe HPV tipe 6 dan tipe 11 yang ditemukan diperkirakan sebagai subtipe baru dan belum pernah dilaporkan sebelumnya. Lima varian HPV tipe 6 membentuk satu cabang tersendiri pada nomenklatur filogenetik yang sudah ada sehingga diajukan sebagai sublineage baru (sublineage C). Seluruh isolat HPV tipe 11 membentuk cabang pohon tersendiri dan diajukan sebagai sublineage baru (sublineage B).Kata kunci: HPV tipe 6 dan 11, variasi sequen DNA, pohon filogenetik HPV tipe 6 and 11. ABSTRACTBackground: Recurrent respiratory papillomatosis (RRP) is the most common laryngeal benign neoplasm caused by infection of HPV type 6 and 11. RRP is still a serious problem related to agresivity and therapy. Genetic analysis used to determine the variant of HPV type 6 or 11. Phylogenetic tree used to evaluate the evolution of viral DNA squence. Purpose: This study aimed to identify DNA squences and analyse the phylogenetic tree of HPV type 6 and 11 in RRP. Methods: this was a descriptive observational cross sectional study. Data analysis used GenBank database and phylogenetic tree was constructed usedUPGMA (Unweighted Pair Group Method with Arithmetic Mean). 15 papillomas biopsies from RRP patients subjected HPV typing using PCR dan DNA sequensing analysis. Result: From 15 patients with RRP (12 male, 3 female), there were 9 isolates HPV type 6 (8 variants, 1 subtype) and 4 isolates HPV type 11 (3 variants, 1 subtype). There was a point mutation in HPV type 6 and 11. Conclusion: L1 ORF (Late 1 Open Reading Frame) sequensials DNA samples was virus major capsid. There were mutational process at gene level (substitution, insertion, deletion). Subtype of HPV-6 and 11, might be new ones, and had not been reported yet. Five variants of HPV type 6 constructed a different lineage in phylogenetic and it is proposed to be C sublineage. All samples HPV type 11 proposed as B sublineage. Keywords: HPV type 6 and 11, DNA sequences variations, phylogenetic trees HPV type 6 and 11.

Pemeriksaan EBER sebagai identifikasi infeksi virus Epstein-Barr pada karsinoma nasofaring Achmad Chusnu Romdhoni; Muhammad Noer Shoffi
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Latar belakang: Protein Epstein-Barr Virus Encoded Small RNA (EBER) ditemukan pada sebagian besar jaringan karsinoma nasofaring (KNF). Hal ini merupakan bukti bahwa infeksi virus Epstein-Barr (VEB) menjadi salah satu penyebab terjadinya KNF. Penurunan ekspresi EBER dipengaruhi oleh maturasi sel dan diferensiasi sel karsinoma. Tujuan: Mengidentifikasi hubungan ekspresi EBER dengan stadium dan jenis histopatologi pada penderita KNF. Metode: Penelitian observasional analitik dengan pendekatan cross sectional. Penelitian dilakukan di Unit Rawat Jalan Telinga Hidung Tenggorok - Bedah Kepala Leher Rumah Sakit Umum Daerah Doktorr. Soetomo Surabaya mulai bulan November 2015 hingga Oktober 2016 dengan consecutive sampling. Fisher exact test untuk melihat hubungan ekspresi EBER dengan stadium KNF. Hasil: Ekspresi EBER dari seluruh sampel didapati negatif sebanyak 23,33%, positif lemah sebanyak 10%, positif sedang sebanyak 33,33%, dan positif kuat sebanyak sebanyak 33,33%. Berdasarkan hasil uji statistik menunjukkan hubungan antara ekspresi EBER dengan stadium KNF didapatkan p=0,623, sedangkan ekspresi EBER dengan jenis histopatologi KNF diketahui p=0,204. Kesimpulan: Tidak terdapat hubungan antara ekspresi EBER dengan stadium KNF, maupun antara ekspresi EBER dengan jenis histopatologi KNF. Kata kunci: Karsinoma nasofaring, ekspresi EBER, stadium dan jenis histopatologi ABSTRACT Background: Protein of Epstein Barr Virus Encoded Small RNA (EBER) have found in most of the nasopharyngeal carcinoma (NPC) tissue which prove that NPC was caused by Epstein Barr Virus Infection (EBV). EBER expression decreased was triggered by maturation and differentiation cell EBER expression in NPC patients. Purpose: To identify association between EBER expression and histopathological type of NPC. Method: This study was an observational analytic with cross-sectional design. This study occured at Inpatients Unit of Otorhinolaryngology - Head and Neck Surgery of Dr. Soetomo Hospital Surabaya, November 2015 - October 2016. Samples were collected by consecutive sampling. Statistical analysis was using Fisher’s exact test. Result: The EBER expression from all sample there were 23.33% negative, 10.00% weak positive, 33.33% moderate positive, and 33.33% strong positive. Statistical analysis was obtained p=0.623 and the association between EBER expression with stage of NPC was obtained p=0.204. Conclusion: There was no association between EBER expression and stage NPC, nor histopathological type of nasopharyngeal carcinoma. Keywords: Nasopharyngeal carcinoma, EBER expression, stage and histopathological type

Purple Sweet Potato Reduces Malondialdehyde and TNF-a, Increases p53, and Protects Histopathological Appearance in Formaldehyde-induced Nasopharyngeal Carcinoma Rats Ni Ketut Susilawati; I Wayan Putu Sutirta Yasa; Wayan Suardana; Sri Maliawan; I Made Jawi; Achmad Chusnu Romdhoni; Hamsu Kadriyan; I Wayan Gede Artawan Eka Putra; I Gusti Kamasan Nyoman Arijana
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1906

BACKGROUND:Purple sweet potato tuber ethanol extract (PSPTEE) has been known to have benefits in various disease, including to prevent nasopharyngeal carcinoma (NPC). However, there has been no research on PSPTEE in preventing the proliferation of nasopharyngeal mucosal epithelial cells induced by formaldehyde through the oxidative stress mechanisms and inflammatory process. Studies have proven the effect of PSP on various cancer cells, but the carcinogenesis process of the nasopharyngeal mucosal epithelium is still limited. Hence, this study aimed to demonstrate the mechanism for preventing histopathology changes with PSPTEE due to formaldehyde exposure.METHODS: Thirty-two formaldehyde-induced Wistar rats were treated with or without 1g/kgBW/day PSPTEE for 16 weeks. Malondialdehyde (MDA) level were examined with spectrophotometry method, while tumor necrosis factor (TNF)-α and p53 with enzyme linked immunosorbent assay (ELISA) method. The histopathology appearance of the nasopharyngeal epithelium was observed with hematoxylin-eosin (HE) staining.RESULTS: MDA and TNF-α levels in control and treatment group were 22.89±2.84 μM; 9.83±0.89 μM and 84.18±11.58 ng/L; 73.92±10.59 ng/L, respectively, and they showed significant difference. Meanwhile, the level of p53 showed no significant difference. Histopathology appearance showed a significant difference. Path analysis for MDA, TNF-α and p53 levels contributed 28.7% to histopathology appearance. MDA have an effect on significant direct effect on TNF-α. TNF-α has a significant direct effect to histopathological appearance. Indirect influence MDA on histopatological appearance were smaller than the direct effect. TNF-α has the greatest influence on histopatological appearance.CONCLUSION: Formaldehyde induces the histopathology appearance in nasopharyngeal epithelium. This study also demonstrates the mechanism to prevent the nasopharynx epithelial histopathology appearance by administration of PSPTEE.KEYWORDS: PSP, MDA, TNF-α, p53, nasopharynx epithelial

RADIOTHERAPY EFFECT ON COMPLETE BLOOD COUNT PARAMETER IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA Achmad Chusnu Romdhoni; Firas Farisi Alkaff; Mega Kahdina; Melinda Masturina; Ristra Ramadhani
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3505

Introduction: Nasopharyngeal carcinoma (NPC) is the most common malignant tumor of the nasopharynx. Radiotherapy is a therapy of choice for NPC that has been recognized for a long time and used in various centers of the world. However, radiotherapy is known to still have an adverse effect. It is common practice to evaluate Complete Blood Count (CBC) before, during, and after radiotherapy. However, there has been no study regarding the effect of radiotherapy on all CBC parameters. This study aims to analyze the effect of radiotherapy on CBC in NPC patients before and after radiotherapy treatment. Material and methods: This study was an observational study using secondary data from medical records at the radiotherapy outpatient clinic at Dr. Soetomo General Hospital Surabaya. The subject of this study was patients with NPC who underwent a full cycle of radiotherapy treatment on radiotherapy outpatient clinic in 2016. Patients with incomplete medical records and did not finish the radiotherapy treatment were excluded. A paired T-test and Wilcoxon signed-rank test were used for statistical analysis. Results: There were 105 patients included in this study. Mean Corpuscular Hemoglobin Concentration (MCHC), total leucocyte, lymphocyte, and thrombocyte was significantly decreased after a full cycle of radiotherapy (all p <0.05). Eosinophil, basophil, neutrophil, monocyte, Neutrophil to Lymphocyte ratio (NLR), and Platelet to Lymphocyte ratio (PLR) was significantly increased after a full cycle of radiotherapy (all p <0.05). Conclusion: Radiotherapy had a significant effect on the CBC parameter in NPC patients.

Co-Authors Abdul Qadar Punagi Agusalim Bukhari Andi Alfian Zainuddin Andy Darma Arianto, Denny Rizaldi Aries Budianto Arya Satya Rajanagara Asra Al Fauzi Bambang Pudjo Semedi Budu Budu Burhan Mahendra Kusuma Dimas Setyanto Eka Sunarwidhi Prasedya Ekorini, Haris Mayagung Etty Sekardewi Fahrizal Rizky Muharram Fira Sofia Firas Farisi Alkaff Gaffar, Masyita H.M.S Wiyadi Hamsu Kadriyan I Gusti Kamasan Arijana I Made Jawi I Wayan Gede Artawan Eka Putra I Wayan Putu Sutirta Yasa Kamal Musthofa Lenny Buana Wuriningtyas Linda Dewanti Mega Kahdina Melinda Masturina Mohammad Hud Suhargono Muhammad Amsyar Akil Muhammad Noer Shoffi Muhammad Shoifi Muhammad Tidar Abiyu Muhammad Yusuf Ni Ketut Susilawati Nova Audrey Luetta Pieter Pawarti, Dwi Reno Prastiya Indra Gunawan Puguh Oktavian Rachmat Agung Widodo Rahardian Indarto Susilo Rina Masadah Ristra Ramadhani Siti Nur Faidah Sri Maliawan steven christian susianto Sutrisno Sutrisno Wayan Suardana

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