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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kimia Terapan Indonesia
Nina Artanti
Research Center of Chemistry, Indonesian Institute of Scinces, Kawasan Puspiptek Serpong, Tangerang 15314, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology

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PENGARUH LOKASI DAN PELARUT PENGEKSTRAKSI TERHADAP KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK PEGAGAN (Centella asiatica L. Urb) Nina Artanti; Rizna Triana Dewi; Faiza Maryani
Jurnal Kimia Terapan Indonesia Vol 16, No 2 (2014)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1479.245 KB) | DOI: 10.14203/jkti.v16i2.13

Abstract

Pegagan (Centella asiatica Linn Urb.) merupakan jenis tanaman yang biasa digunakan dalam industry farmasi dan kosmetik.Penelitian ini ditujukan untuk mengevaluasi pengaruh tiga lokasi asal sampel dan tiga jenis larutan pengekstraksi (methanol, etanol 96% (v/v), dan etanol 70% (v/v)) terhadap aktivitas antioksidan herbal pegagan (Centella asiaticaLinn Urb).Sampel pegagan yang digunakan pada peneltian ini berasal dari Lembang, Bandung, dan Solo.  Pada ekstrak yang diperoleh dilakukan penentuan kadar fenol total, flavonoid total, dan triterpenoid total. Aktivitas antioksidan dari ekstrak dievaluasi berdasarkan metoda peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH).  Hasil yang diperoleh menunjukkan bahwa simplisia pegagan asal Lembang yang diekstrak dengan etanol 70% mempunyai aktivitas antioksidan tertinggi serta kandungan fenol total dan flavonoid total tertinggi. Sedangkan simplisia pegagan asal Bandung yang diekstrak dengan pelarut metanol memiliki kandungan triterpenoid total tertinggi tetapi memiliki kandungan fenol total dan flavonoid total serta aktivitas antioksidan yang terendah.  Hasil analisa statistik menunjukkan bahwa lokasi asal simplisia pegagan dan polaritas pelarut yang digunakan untuk ekstraksi secara signifikan (p<0,05) mempengaruhi kandungan fenol total, flavonoid total dan triterpenoid total serta aktivitas antioksidan dari ekstrak pegagan.Kata kunci: ekstrak pegagan, antioksidan, polaritas pelarut Pegagan (Centella asiatica Linn Urb.) is a plant species that commonly used in the pharmaceutical and cosmetic industry. Objective of this study is to evaluate the effect of different source location and solvent polarity for the extraction to the content of total phenolic, total flavonoid total triterpenoids as well as antioxidanti activity of pegagan ((Centella asiatica (Linn.) Urb.)extracts.  Pegagan materials for this study are from three different locations: Bandung, Lembang and Solo.  Based on polarity differences methanol, ethanol 96% and ethanol 70% were used as solvent for extraction.  Antioxidant activity of the extract was evaluated based on the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.  Results showed that the highest total phenolic content and flavonoid content and antioxidant activity were from 70% ethanol extract from Lembang. Materials from Bandung extracted with methanol gave the highest content of total triterpenoid, however has the lowest content of total phenolic, total flavonoid and antioxidant activity.  Statistic  analysis showed that there is significant differences (p<0,05) of results of total phenolic, total flavonoid, total triterpenoid and antioxidant activity due to source location and solvent polarity. Keywords:Centella asiatica (Linn.) Urb extract, antioxidant, polarity solvent
CHEMICAL CATALYTIC AND BIOCATALYTIC PROCESS OF CLOVE OIL DERIVATIVES REVIEW Silvester Tursiloadi; Nina Artanti; Anny Sulaswatty
Jurnal Kimia Terapan Indonesia Vol 17, No 1 (2015)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (826.256 KB) | DOI: 10.14203/jkti.v17i1.24

Abstract

In 2011, Indonesian clove oil supply reached about 75 % (4,500 of 6,000 tons) of the world market. Utilization of clove oil and clove oil derivatives in aromatic chemical industry primarily as a mixture or additive of fragrances in the daily consumed product, such as perfumes, skin care products, deodorant, soap, shampoo, detergent, besides it is also used as an ingredient in the production of synthetic vanilla.  The content of eugenol as the main compound in the essential oil in the clove flower, flower stalk and leaf have a range of 90-95 %, 83-95 % and 82-87 % respectively.  The compounds content in clove oil is divided into two categories, phenolics (eugenol) and non-phenolic (beta-caryophyllene) that can be derivatized with various chemocatalytic and biocatalytic processes. Separation of the compounds in clove oil can be conducted by adding NaOH with repeated distillation. This process produces two layers product, the first layer contains eugenol and NaOH, while the second layer contains beta-caryophyllene. Derivatization of eugenol are conducted to produce various products such as vanilla, eugenyl ether, methyl ether eugenyl, eugenyl ethyl ether, eugenyl acetate, eugenyl cinnamate, dimmer eugenol and eugenyl benzoate, whereas derivatization of beta-caryophyllene are conducted to produce products such as caryophyllene oxide, kobusan, glycols, alcohols caryophyllene, β-caryolanylformate and kovanilformate, klovanildiformate, caryophyllene ketol.  Biocatalysis or biotransformation can be defined as the use of biological systems (intact cells, cell extracts or isolated enzymes) to catalyze the conversion of a compound into another. Besides the common chemocatalysis system for derivatization of clove oil and clove oil compound such as eugenol into other compounds some biocatalysis systems were also described in this paper.Keywords: Clove oil, eugenol, beta-caryophyllene, derivatization, chemical catalysis, biocatalysis
AKTIVITAS ANTIOKSIDAN DAN BIOAKTIVITAS IN VITRO EKSTRAK AIR DAN EKSTRAK ETANOL DAUN DAN RANTING BENALU Macrosolen cochinchinensis (Lour.) van Tiegh. PADA INANG NANGKA ( Artocarpus heterophyllus) Nina Artanti; Akhmad Darmawan
Jurnal Kimia Terapan Indonesia Vol 11, No 2 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4264.483 KB) | DOI: 10.14203/jkti.v11i2.160

Abstract

Study on antioxidant activity and bioactivity of water and ethanol extracts from the leaves and twigs of mistletoe (Macrosolen cochinchinensis (Lour.) Van Tiegh) that grew on jackfruit (Artocarpus heterophyllus) tree as the host have been conducted. Water extracts of the M. cochinchinensis leaves andtwigs were active as antioxidant with IC50 23.08 ug/mL dan 21.56 ug/mL respectively. Whereas the ethanol extracts of both leaves and twigs was not active because the ICso higher than 100 ug/mL (not active as antioxidant against DPPH). Both water and ethanol extracts of M. cochinchinensis leaves and twigs did not showed bioactivity against Artemia salina Leach brine shrimp with each extracts has LCso higher than 1000 pg/mL.Key words Antioxidant, Bioactivity, Macrosolen cochinchinensi (Lour.) van Tiegh., Artocarpus heterophyllus. Artemiasalina Leach.
STANDARDISASI EKSTRAK PEGAGAN, CENTELLA ASIATICA SEBAGAI OBAT HERBAL TERSTANDAR HEPATOPROTEKTOR Puspa Dewi N Lotulung; Sri Handayani; Teni Ernawati; Tri Yuliani; Nina Artanti; Tjandrawati Mozef
Jurnal Kimia Terapan Indonesia Vol 17, No 2 (2015)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v17i2.34

Abstract

Herbal medicinal products would be affected by the quality of raw materials. In turn, the quality of raw material will also be influenced by various factors such as soil conditions, cultivation, post-harvest processing, and the processing of raw materials into crude drug or extract. Therefore, in order to make good herbal medicines, it is necessary to make standardization of herbal extracts that produced herbal medicines that have the same quality and functions of effectiveness in each process. From preliminary studies that have been done, Centella asiatica is one of the potential plants as a source of hepatoprotective compounds. Test in vivo and in vitro against Centella asiatica extracts have shown very good results. Ethyl acetate extract with 17.5 mg/kg of doses body weight and butanol 228.8 mg/kgof doses body weight has been applied for in vivo test using mice induced by CCl4; theydemonstrated hepatoprotective effects. Ethyl acetate extracts were able to reduce levels of the enzyme alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by 56 % and 44 % respectively while butanol extract can reduce the enzymes AST levels by 3%. Standardizationof Centella asiatica extract performed in this study was the characterization of the extract in the form of non-specific and specific parameters corresponding to the reference of PPOMN (Ministry of health Republic of Indonesia, 2000) such as levels of drying shrinkage, ash content, total plate count microbial contamination, levels of water-soluble compounds, levels of compounds that are soluble in ethanol, phytochemical test, total phenolic content, total flavonoid content and the determination of Pb and Cd weight.The results showed that non-specific parameters for the ethanol extract of Centella asiatica were requirements based on Herbal Pharmacopoeia in 2008 which includes parameters such as determination of shrinkage on drying ≤ 10%, ash content ≤ 16.6% and negative microbial contamination. Specific parameters for the ethanol extract of Centella asiatica have met the requirements of Herbal pharmacopeia in 2008.Keywords: Centellaasiatica, hepatoprotective, standardized herbal medicine, specificparameters, and non-specific parameters
AKTIVITAS ANTIOKSIDAN DAN TOKSISITAS EKSTRAK AIR DAN ETANOL DAUN BENALU (Dendrophthoe pentandra L. Miq) YANG TUMBUH PADA BERBAGAI INANG Nina Artanti; Retno Widayati; Sofa Fajriah
Jurnal Kimia Terapan Indonesia Vol 11, No 1 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2843.157 KB) | DOI: 10.14203/jkti.v11i1.175

Abstract

Mistletoes are used traditionally in Indonesiaas medicinal plant, one of this as anticancer. Cancer isone of degenerative diseases could be triggered by toomuch free radicals in the body, whereas antioxidantcould reduced the risk of degenerative diseases.Mistletoes reposted content flavonoids which known have antioxidant activity. Mistletoe potency as drugmaterial should be studied sa the utilization ofmistletoe could be developed. Antioxidant activitytest using "DPPH free radical scavenger" methodand toxicity test using BSLT (Brine Shrimp LethalityTest) method had been conducted on water andethanol extracts of mistletoe Dendropthoe pentandra(L.) Miq.) that grown on various trees (star fruit,mango, cananga, 'duku, sour-sop, kepel, mahkotadewa, and tea). The result showed that ethanol andwater extracte-ofD, petandra on all host plants haveantioxidant activity (IC50 value between 6.4 - 51.8ug/mL). The result of toxicity test showed that ethanolextract of mistletoe on cananga, starfruit, kepel andmahkota dewa host plants have toxicity effect againstA. salina larvae with LCso value below 1000 ug/mL,nevertheless ethanol extract on others host plants andwater extract didn It give toxicity effect against A.salina larvae (LC50 > 1000 ug/mL).Key words: mistletoe, D. petandra, DPPH, antioxidant,toxicity, degenerative disea.
Effect of Liquid Media Composition on Alpha-Glucosidase Inhibitory Activity from Aspergillus elegans SweF9 Hani Mulyani; Rizna Triana Dewi; Euis Filailla; Nina Artanti
Jurnal Kimia Terapan Indonesia Vol 21, No 2 (2020)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v21i2.426

Abstract

This study aims to determine the effect of liquid media composition on the inhibitory activity of α-glucosidase from endophytic fungus Aspergillus elegans SweF9 isolated from seaweed (Macroalgae Euchema sp). Fermentation was carried out in three types of liquid media, namely: potato dextrose broth (PDB), potato malt peptone (PMP), and Czapek-dox broth (CDB), which was incubated for 10 days at room temperature, with static conditions. Ethyl acetate solvents were used to extract active metabolites from fungal biomass and filtrate from each media. Antidiabetic activity was measured based on inhibition of enzyme α-glucosidase. The results showed that filtrate extract of A. elegans SweF9 which was cultured on the media PDB showed highest inhibitor activity to the α-glucosidase enzyme with an IC50 value of 1.74 µg / mL compared to other extracts. Based on these results, the PDB media is an appropriate medium for culturing A. elegans SweF9  to produces secondary metabolites that can be used as a new source of antidiabetic agents.
Bioactivity of Antibacterial Compounds Produced by Endophytic Actinomycetes from Neesia altissima Rina Hidayati Pratiwi; Muhammad Hanafi; Nina Artanti; Rosa Dewi Pratiwi
Journal of Tropical Life Science Vol. 8 No. 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.08.01.07

Abstract

Identification of alternate bioactive compounds isolated from microbial endophytes from plants may lead to better solution against antibiotic resistance. Main objective of this research is to determine the bioactivity of antibacterial compounds produced by endophytic actinomycetes, which was isolated from stem bark of Neesia altissima Bl. at Halimun Salak Mount. Detection of bioactive compounds was assayed using Thin Layer Chromatography (TLC) by employing bioautography. Bioactivity was assayed using crude extract against five microorganisms using agar diffusion methods. Tetracycline was used as a positive control. The result of antibacterial activity from endophytic actinomycetes isolate revealed that the bioactive compounds were effective in inhibiting the growth of bacteria Bacillus cereus (1.25 mm), Salmonella typhimurium (5.75 mm), and Shigella flexneri (4.37 mm). Bioactivity of ethyl acetate extract from bioactive compounds of endophytic actinomycetes has an antibacterial activity against bacteria Bacillus cereus (13.00 mm) and Staphylococcus aureus (15.90 mm), at a concentration of 250,000 ppm. Each of TLC fraction was able to inhibit growth of B. cereus at a minimum concentration of 10,000 ppm. In conclusion, the bioactive compounds produced by endophytic actinomycetes can have inhibitory effect towards B. cereus. The category of that compounds are narrow spectrum. The bioactive compound isolated from endophytic actinomycetes may have other implications such as anticancer, antifungal, and antioxidant.
Co-Authors Akhmad Darmawan ANNY SULASWATTY Euis Filailla Faiza Maryani Hani Mulyani Muhammad Hanafi Puspa Dewi N Lotulung Puspa Dewi N Lotulung Retno Widayati Rina Hidayati Pratiwi Rizna Triana Dewi Rosa Dewi Pratiwi Silvester Tursiloadi Sofa Fajriah Sri . Handayani Teni Ernawati Tjandrawati Mozef Tri Yuliani