Yora Nindita
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THE EFFECT OF TURMERIC EXTRACT (Curcuma longa) ON THE IMPROVEMENT OF MUSCLE MASS IN SWISS DIABETES MELITUS MICE SKELETAL MUSCLE INDUCED BY STREPTOZOTOCIN Alfin Ihza Trimahendra; Yora Nindita; Vega Karlowee; Muhamad Thohar Arifin; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.964 KB) | DOI: 10.14710/dmj.v9i3.27510

Abstract

Backgrounds. Diabetes mellitus is a degenerative disease that has various complications. One of neglected diabetes mellitus complication is skeletal muscle atrophy. Turmeric and java turmeric extracts were need to be clarified due to those effect as antihyperglycemic agent which might affected muscle atrophy as one of diabetes mellitus complication. Aim. To compared the efficacy of turmeric and java turmeric extract on reducing the progression of skeletal muscle atrophy in streptozotocin-induced diabetes mellitus. Methods. We conducted experimental animal studies with a post test only control group design using 25-30 grams male Swiss mice aged 12 weeks. Diabetes mellitus was induced by streptozotocin (STZ) administration. All 28 samples were randomly divided into 4 groups : control + PBS, control + STZ, STZ + turmeric, and STZ + java turmeric groups. Before treatment, blood glucose and body weight were examined on 3rd day. Blood glucose, body weight, hindlimb muscle weight, and muscle diameter results were examined after treatment (on 21st day). Data was analyzed with statistical software after all procedures were done. Results. STZ + turmeric group showed insignificant decreased in blood sugar levels (p=0.107). Control + STZ group showed significantly reduced hindlimb muscle weight compared to other groups. Hindlimb muscle weight was significantly ameliorated by STZ + turmeric extract (p=0.048). There were no significant improvement on skeletal muscle diameter among groups. Conclusion. The administration of turmeric extract improved hindlimb muscle weight but may not mediated by glucose lowering effect in streptozotocin induced diabetic mice.
EVALUATION OF ANTIBIOTIC USAGE IN ISKEMIC STROKE PATIENTS WITH INFECTIONS IN RSUP DR. KARIADI SEMARANG PERIOD 2018 Wibowo, Shafa Nahdah; Budisulistyo, Trianggoro; Sunarsih, Endang Sri; Nindita, Yora
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.30137

Abstract

Abstract Background: According to WHO stroke is the second leading cause of death in the world. Ischemic stroke is the type of stroke with the highest population reaching (80%). Data at RSUP Dr. Kariadi in 2015 showed that the most common complication in stroke was infection (37.9%). The most common cause of infection was bacteria with antibiotics as the main therapy. It is necessary to monitor the use of antibiotics due to increased cases of antibiotic resistance.Objective: To determine the rationality of antibiotic use in ischemic stroke patients with infections in RSUP Dr. Kariadi Semarang Period 2018..Method: This research is a descriptive observational study. The sample consisted of 41 medical records of inpatient male ischemic stroke patients at RSUP Dr. Kariadi Semarang in 2018. The use of antibiotics was evaluated using the Gyssens method.Results: The results of evaluation of antibiotics by the Gyssens method showed antibiotic rationality (53%). The most widely used antibiotics are ampicillin sulbactam (30.4%) and levofloxacin (27.5%). Giving empirical therapy (57.5%), and diagnosis of infection in patients including pneumonia (50,8%), sepsis (19.3%), UTI (17.5%), pressure sores (5.3%), abscesses mandible (3.5%), ulcerative colitis (1.7%), cellulitis (1.7%), gasteroeneritis (1.75%).Conclusion: The use of antibiotics in ischemic stroke patients hospitalized in RSUP. Dr. Kariadi Semarang in 2018 is rational. Its users have the right antibiotics, indications, dosage, administration, route, time, interval and patient.