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Yora Nindita
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Medicine & Pharmacology

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THE EFFECT OF TURMERIC EXTRACT (Curcuma longa) ON THE IMPROVEMENT OF MUSCLE MASS IN SWISS DIABETES MELITUS MICE SKELETAL MUSCLE INDUCED BY STREPTOZOTOCIN Alfin Ihza Trimahendra; Yora Nindita; Vega Karlowee; Muhamad Thohar Arifin; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.964 KB) | DOI: 10.14710/dmj.v9i3.27510

Abstract

Backgrounds. Diabetes mellitus is a degenerative disease that has various complications. One of neglected diabetes mellitus complication is skeletal muscle atrophy. Turmeric and java turmeric extracts were need to be clarified due to those effect as antihyperglycemic agent which might affected muscle atrophy as one of diabetes mellitus complication. Aim. To compared the efficacy of turmeric and java turmeric extract on reducing the progression of skeletal muscle atrophy in streptozotocin-induced diabetes mellitus. Methods. We conducted experimental animal studies with a post test only control group design using 25-30 grams male Swiss mice aged 12 weeks. Diabetes mellitus was induced by streptozotocin (STZ) administration. All 28 samples were randomly divided into 4 groups : control + PBS, control + STZ, STZ + turmeric, and STZ + java turmeric groups. Before treatment, blood glucose and body weight were examined on 3rd day. Blood glucose, body weight, hindlimb muscle weight, and muscle diameter results were examined after treatment (on 21st day). Data was analyzed with statistical software after all procedures were done. Results. STZ + turmeric group showed insignificant decreased in blood sugar levels (p=0.107). Control + STZ group showed significantly reduced hindlimb muscle weight compared to other groups. Hindlimb muscle weight was significantly ameliorated by STZ + turmeric extract (p=0.048). There were no significant improvement on skeletal muscle diameter among groups. Conclusion. The administration of turmeric extract improved hindlimb muscle weight but may not mediated by glucose lowering effect in streptozotocin induced diabetic mice.
Association Between Stunting and Anemia Among Toddlers: Stratified by Characteristic of Family and Immunization Status in Mlonggo District, Jepara Regency Arwinda Nugraheni; Muflihatul Muniroh; Yora Nindita; Firdaus Wahyudi; Bambang Hariyana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 4 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i4.38561

Abstract

Background: The risk of anemia in stunted toddlers is higher than in normal toddlers. There is limited research on anemia in children under 3 years old in the community and there is a need for supporting research to prove the possibility of controlling stunting and anemia together. Previous studies have shown that family characteristics and immunization status are associated with the stunting and anemia.Objective: This study aims to analyze the association between anemia and stunting in toddlers that are stratified by characteristics of family and Immunization status.Methods: This study used a cross-sectional design study and was conducted on September-October 2020 in the Mlonggo District, Jepara Regency. One hundred two respondents were selected by cluster random sampling technique. The questionnaire was applied to collect the data on stunting, anemia, immunization status, age, mother's occupation and education status, SCREEM score, and APGAR score. This study used the Chi-Square statistic test.Results: The anemia status was measured by the Hb meter. The characteristics of stunting status (stunting = 17.7%, no stunting= 82.3%), anemia status (Yes = 63.7%, No = 36.3%). The association between stunting and anemia was stratified by the child age (6-23 months) (PR=1.667; 95%; CI=1.103-2.519; P=0.123), employed mother (PR=1.593; 95%CI=1.265-2.005; P=0.154), incomplete and inappropriate immunization status (PR=1.636; 95%CI= 1.132-2.366; P=0.133) and highly internal family function; (PR=1.512; 95% CI=1.270-1.799; P=0.029).Conclusion: There was an association between stunting and anemia in toddlers from child age of 6-23 months, employed mother, incomplete and inappropriate immunization, and highly family function groups.
Co-Authors Alfin Ihza Trimahendra Arwinda Nugraheni Bambang Hariyana Firdaus Wahyudi Mochamad Ali Sobirin Muflihatul Muniroh Muhamad Thohar Arifin Vega Karlowee